BSCMR Aortic Stenosis Outcome Study (formerly known as 'AS500 Study')

• Research type

  Research Study

• Full title

  CMR predictors of mortality in patients undergoing Surgical AVR or TAVI for severe Aortic Stenosis (AS): The BSCMR Aortic Stenosis Outcome Study

• IRAS ID

  141186

• Contact name

  Thomas Treibel

• Contact email

  thomas.treibel.12@ucl.ac.uk

• Sponsor organisation

  University College London

• Clinicaltrials.gov Identifier

  Z6364106/2024/10/81 health research , Data Protection

• Duration of Study in the UK

  15 years, 0 months, 1 days

• Research summary

  We aim to extend and complete a multicentre observational study (comprising groups from Leeds, Leicester, London, Oxford and Edinburgh) with the intention of collating and curating a cohort of ~2000 patients, all of whom have had cardiac MR prior to receiving a Surgical Aortic Valve Replacement (SAVR) or Transcatheter Aortic Valve Implantation (TAVI) for severe Aortic Stenosis (AS). The intended period of follow-up is 15 years. Studies using Cardiac Magnetic Resonance Imaging (CMR) to predict mortality in severe AS and in response to AVR are few; and in the response to TAVI completely lacking. Due to the lack of long-term results, TAVI remains restricted to high risk and inoperable patients based upon their STS (Society of Thoracic Surgeons) risk score or EuroSCORE.
  Neither of these systems are validated for the prediction of long-term prognosis or mortality post TAVI and at present there is no dedicated scoring system currently available.
  There are an estimated 8000 aortic valve replacements and 10,000 TAVI procedures per year in the UK. We hope to categorically identify specific MRI derived measures that hold prognostic significance in patients with severe AS undergoing intervention. Furthermore, we hope to test the hypothesis that cardiac MRI brings incremental value to commonly used scoring systems, and that as such cardiac MRI could be considered more routinely in the clinical management of severe AS.

• REC name

  North West - Liverpool Central Research Ethics Committee

• REC reference

  13/NW/0832

• Date of REC Opinion

  22 Nov 2013

• REC opinion

  Favourable Opinion