ARTHR-IS (Arthroplasties' infections due to Staphylococcus aureus )
Research type
Research Study
Full title
Retrospective study to identify the incidence, risk factors and outcomes of prosthetic joint infection due to Staphylococcus aureus after a primary knee or hip joint replacement.
IRAS ID
265624
Contact name
Almudena de la Serna
Contact email
Sponsor organisation
FISEVI (Andalusian Public Foundation for Health Research Management in Seville)
Clinicaltrials.gov Identifier
NCT: NCT03826108, Clinical trials.gov
Duration of Study in the UK
0 years, 6 months, 8 days
Research summary
Hip and knee replacements have been proven to be highly successful procedures for improving quality of life in patients with advanced joint diseases and the number of these procedures is expected to rise significantly in the next few years.
About 1% of total joint replacements become infected during the first year after surgery .
Staphylococcus aureus (SA) is a primary cause of prosthetic joint infection (SA-PJI) resulting in serious problems for patients. This microorganism is frequently associated with treatment failure, hospitalizations and need of prosthesis removal, leading to an important morbidity and an increase in healthcare costs.
This study aims to identify the risk factors associated with Staphylococcus aureus prosthetic joint infection occurring within one year of a primary hip or knee replacement procedure and to estimate the outcome and burden to health care services over the following eighteen month period after the first joint infection.This will be a retrospective case control study using hospital records .
All patients who developed a staphylococcus aureus related prosthetic joint infection (SA-PJI) within one year of their primary joint replacement procedure will be identified. Medical record review will be performed for relevant data collection . For each case of SA-PJI, three non-infected controls will be selected matched by procedure type and date .REC name
N/A
REC reference
N/A