ARGO-1
Research type
Research Study
Full title
ARGO-1: Study of Anterior segment imaging based Risk stratification of childhood secondary GlaucOma
IRAS ID
315591
Contact name
Ameenat Lola Solebo
Contact email
Sponsor organisation
Great Ormond Street Hospital
Clinicaltrials.gov Identifier
Data protection registration , Z6364106/2023/05/67
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Glaucoma (damagingly high eye pressure) is a blinding, hard to manage eye problem. In children, as in adults, glaucoma can happen due to other eye problems. This is called secondary glaucoma. Secondary glaucoma can be very difficult to treat, and the best way to manage it is to pick it up very early, or, even better, to prevent it from ever happening.
We need to be better at predicting which children at risk will go on to developing glaucoma.
We aim to use cameras to take highly detailed images of internal structures of the eyes of children with three disorders which can lead to glaucoma (cataract, uveitis, phakomatoses), and then analyse the images to find the most reliable measurements. We will assess each measurement to make sure that they are reliable, and repeatable, so that we know that the measurements are good enough to use in studies which work towards predicting which children will go on to develop glaucoma.
We will ask families of children affected by uveitis, congenital cataract and phakomatoses for their permission to take additional images of their children’s eyes. Images will be analysed and different areas of the eye will be measured (by multiple people, so that we can understand how reliable the image analysis is). Each area will also be imaged at least twice, so that we know that the images are repeatable, and precise. The measurements will then be compared for those children who do, versus those who do not go on to develop glaucoma, so that we can start to understand whether those measurements might be helpful to predict glaucoma risk in future children.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
23/NW/0188
Date of REC Opinion
31 Aug 2023
REC opinion
Further Information Favourable Opinion