Are macrolide antibiotics effective in chronic cough? version 1.0

• Research type

  Research Study

• Full title

  Are macrolide antibiotics effective in chronic idiopathic cough?

• Contact name

  David Hodgson

• Eudract number

  2008-004143-11

• ISRCTN Number

  n/a

• Clinicaltrials.gov Identifier

  n/a

• Research summary

  Chronic cough is a common and disabling condition. Although there are a number of treatable causes many patients have a severe cough which does not respond to our current medication. We plan to determine whether a class of antibiotics called macrolides can effectively treat such patients. We plan to recruit patients with chronic cough (over 8 weeks in duration) which has not responded to trials of standard treatment, and who have no other identified cause for their cough (idiopathic). Participants will take either azithromycin 250mg three times daily or placebo for 8 weeks. The main outcome measure will be change in Leicester Cough Questionnaire score.We plan to recruit 60 patients over 2 years.

• REC name

  East Midlands - Nottingham 2 Research Ethics Committee

• REC reference

  08/H0408/121

• Date of REC Opinion

  11 Dec 2008

• REC opinion

  Further Information Favourable Opinion