Are features of bone chemistry associated with Ankle Osteoarthritis?
Research type
Research Study
Full title
Are specific features of bone chemistry associated with Ankle Osteoarthritis?
IRAS ID
197575
Contact name
Allen Goodship
Contact email
Sponsor organisation
Royal National Orthopaedic Hospital NHS Trust
Duration of Study in the UK
1 years, 2 months, 3 days
Research summary
Ankle Osteoarthritis is debilitating condition causing severe pain and disability to the sufferer. More than 29,000 patients a year present to specialists with symptomatic osteoarthritis of the ankle, a condition which causes pain, disability and affects quality of life as much as end stage heart failure.
Our understanding of why people develop this condition is limited. Previous work on arthritic hip and knee joints have identified changes in the underlying bone matrix chemistry associated with the development of arthritis when compared to healthy joints. The bone matrix chemistry has not been investigated before on the ankle joint and our study hopes to address this by using a technique known as RAMAN spectroscopy.
We will be conducting a study comparing the bone matrix chemistry of patients diagnosed with ankle osteoarthritis who are due to have surgery (at the RNOH, Stanmore) in the form of fusion or ankle replacement against non-osteoarthritic specimens from cadaveric donors. The specimens of bone will be harvested from patients at the time of their surgery and will be analysed using a technique known as Raman spectroscopy and undergo biochemical analysis. This is a technique which allows us to determine and compare the chemical composition of bone.REC name
West of Scotland REC 1
REC reference
16/WS/0016
Date of REC Opinion
19 Jan 2016
REC opinion
Favourable Opinion