Application of microfluidics in Glioblastoma multiforme
Research type
Research Study
Full title
Application of microfluidics system for evaluating the biology of Glioblastoma multiforme tissues and testing their response to chemotherapy
IRAS ID
131630
Contact name
John Greenman
Contact email
Sponsor organisation
HEY NHS Trust
Research summary
A miniature device has been developed by the University of Hull to keep whole pieces of tumour viable and functional for up to 8 days. The aim of the current application is to apply the device to brain tumour (Glioblastoma multiforme) tissues, specifically to study the tumour biology and the effect of various cancer drugs on tumour tissues in vitro. The effect of various treatments in causing cell death and changes in tumour biology can ultimately be correlated with the patient’s clinical outcome to evaluate how well the effects of treatment in vitro represent the true clinical course. Thereby,this device offers a novel method of studying the tumour environment, and offers a pre-clinical model for creating personalised treatment regimens.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
13/YH/0238
Date of REC Opinion
13 Aug 2013
REC opinion
Favourable Opinion