ANTIRESDEV

• Research type

  Research Study

• Full title

  Effect of minocycline and amoxicillin administration on the prevalence of antibiotic resistant bacteria and on the indigenous oral, faecal, cutaneous and nasal microbiotas.

• IRAS ID

  34663

• Contact name

  Anthony Coates

• Sponsor organisation

  Helperby Therapeutics

• Eudract number

  2009-017647-34

• ISRCTN Number

  N/A

• Research summary

  This is a clinical trial in 42 male and female volunteers to find out the species of bacteria found in the mouth, gut, nose and on the skin, whether and how these bacteria are affected by the administration of antibiotics and how long any resistant bacteria remain in the body. Saliva samples and stool samples and will be collected on 5 occasions (immediately before administration, 1 month, 2 months, 4 months and 12 months post-dosing) for pharmacological and microbiological analyses. Samples will also be taken from the anterior nares and from the skin of the facial, neck and trunk areas on 5 occasions (immediately before administration, 1 month, 2 months, 4 months and 12 months post-dosing) for pharmacological and microbiological analyses. These samples will be analysed for the types of bacteria present as well as their resistance to the antibiotics tested. In addition we will also test whether these bacteria are resistant to other commonly used antibiotics. The benefit of this study is that it will provide background information on the development of antibacterial resistance and will inform health care provider to more effectively use available antibiotics.

• REC name

  London - Surrey Borders Research Ethics Committee

• REC reference

  10/H0806/12

• Date of REC Opinion

  29 Mar 2010

• REC opinion

  Further Information Favourable Opinion