Antimicrobial Prophylaxis in the Surgical Treatment of Bone Tumours

• Research type

  Research Study

• Full title

  Pilot and Feasibility Pharmacokinetic Study of Antimicrobial Prophylaxis in the Surgical Treatment of Bone Tumours

• IRAS ID

  319010

• Contact name

  Tariq Azamagrhi

• Contact email

  tariq.azamgarhi@nhs.net

• Sponsor organisation

  The Royal National Orthopaedic Hospital

• Duration of Study in the UK

  0 years, 11 months, 31 days

• Research summary

  Bone tumours are treated with surgery involving excision of large segments of bone and joints and reconstruction with a massive endoprostheses (EPR). Deep infection is a devastating complication following surgery and occurs in 10% of patients. Antimicrobial prophylaxis is routinely administered, however, there are currently no studies demonstrating to what extent routinely used prophylactic antimicrobial agents penetrate the surgical site in EPR surgery. This study aims to evaluate the antimicrobial concentrations of routinely administered antimicrobials in the blood and bone of patients during EPR surgery.

• REC name

  South Central - Hampshire B Research Ethics Committee

• REC reference

  23/SC/0251

• Date of REC Opinion

  22 Aug 2023

• REC opinion

  Further Information Favourable Opinion