Antidepressant effects on emotion and motivation in healthy volunteers

• Research type

  Research Study

• Full title

  Evaluation of the effects of agomelatine (25mg and 50mg) and escitalopram 20mg during 8 weeks on emotional blunting, emotional processing and motivation in healthy male and female volunteers.

• IRAS ID

  80502

• Contact name

  Guy Goodwin

• Sponsor organisation

  Servier Research and Development Ltd

• Eudract number

  2010-024570-19

• ISRCTN Number

  n/a

• Clinicaltrials.gov Identifier

  n/a

• Research summary

  This is an exploratory study with no primary criteria. The study will assess the effects of two doses of antidepressants (agomelatine 25mg or 50mg and escitalopram 20mg) on emotional blunting, emotional processing and motivation during 8 weeks of treatment. The study will recruit 128 healthy male and female volunteers aged between 18 and 45 years (both inclusive). They must also be non smokers or moderate smokers (=10 cigarettes per day) with ability and/or willingness to undergo neuropsychological and motivation tests batteries and self-rating or clinician-rated questionnaires. All participants will be asked to attend one of two sites on 9 occasions.

• REC name

  South Central - Berkshire Research Ethics Committee

• REC reference

  11/SC/0383

• Date of REC Opinion

  2 Nov 2011

• REC opinion

  Further Information Favourable Opinion