Anti-psoriatic effect of TL01 light therapy.
Research type
Research Study
Full title
Studying the Effect of narrow band ultraviolet B phototherapy on skin dendritic (DCs) cells in psoriasis patients.
IRAS ID
158385
Contact name
Anthony Ormerod
Contact email
Clinicaltrials.gov Identifier
Rec Reference number, 14/LO/1610
Research summary
Psoriasis is a common inflammatory skin disease with marked negative effect on patients' quality of life. The pathogenesis of psoriasis is complicated and involve different cells of the immune system. Among the treatment options, narrow band ultraviolet B therapy is well known for its effectiveness and durability. This study aims at investigating the effect of light treatment on a special type of immune cells that is found in tissues such as the skin called dendritic cells (DCs). These cells are known to boost immune response by showing antigens on their surface to other effector cells of the immune system. Thus considered as a type of antigen-presenting cell (APC). Light treatment improves psoriasis by different mechanisms, however its precise effect on certain types of DCs and other cells called regulatory T (Treg)cells in the skin is not completely understood. Therefore we will investigate this effect by characterising a special type of DCs in the skin with known regulatory properties through induction of Treg cells. This will be achieved through testing the effect of narrow band UVB on CD141+dermal DCs before and after treatment with a three times weekly sessions of light treatment via exposing the patients' skin to light device equipped with UV fluorescent lamps.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
14/LO/1610
Date of REC Opinion
3 Sep 2014
REC opinion
Favourable Opinion