Angular Pregnancy Study, version 1
Research type
Research Study
Full title
Angular pregnancy – ultrasound definition and correlation with clinical outcomes
IRAS ID
221321
Contact name
Jackie Ross
Contact email
Sponsor organisation
King's College Hospital
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Angular pregnancy (AP) has been described as a pregnancy implanted within the uterine cavity but directly over the tubal opening. In modern practice, ultrasound is the primary diagnostic method used in pregnancy, usually transvaginal ultrasound during the first trimester. Ultrasound-based diagnostic criteria for AP have not been established to date. The differential diagnosis is between an interstitial ectopic pregnancy implanted more laterally, actually within the proximal fallopian tube (with almost inevitable rupture if the pregnancy is ongoing) and a normal intrauterine pregnancy more medially.
The aim of this study is to establish clinically meaningful ultrasound-based diagnostic criteria for AP. To this end, we will prospectively collect clinical and ultrasound data (both 2D and 3D scan information) from early intrauterine pregnancies and correlate this data with pregnancy outcomes (particularly with risk of miscarriage), to establish whether there are any diagnostic criteria that can be used to make the diagnosis, facilitate increased surveillance of at risk pregnancies and reassure those with normally located pregnancies. The collected data will also be used to correlate incidence of angular pregnancy and clinical variables such as maternal age, uterine fibroids, assisted conception, multiple pregnancy, ethnicity, previous uterine and adnexal surgery.
REC name
London - Hampstead Research Ethics Committee
REC reference
17/LO/1677
Date of REC Opinion
25 Oct 2017
REC opinion
Further Information Favourable Opinion