Angiogenesis in Cerebral AVMs
Research type
Research Study
Full title
Angiogenesis in cerebral arteriovenous malformations
IRAS ID
227479
Contact name
Hiren Patel
Contact email
Sponsor organisation
University of Manchester
Clinicaltrials.gov Identifier
Sponsor's reference number, NHS001375
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
Why? This project will assess if patients with arteriovenous malformation (AVM) in their brain have abnormal blood vessel growth. The condition is rare but can cause significant disability, particularly in young people. Early diagnosis and an improved understanding of the underlying causes could lead to targeted treatments which could reduce the risk of complications and improve outcome for patients.
What? A cerebral arteriovenous malformation (cAVM) is a tangle of abnormal blood vessels connecting arteries and veins in the brain. Sometimes, a cAVM can rupture and cause a haemorrhage (a bleed in the brain), which can lead to death or significant disability. Previous research has shown that a growth factor called vascular endothelial growth factor (VEGF) might play an important role in the development of a cAVM, as it is thought to encourage abnormal growth of blood vessels. This process, known as angiogenesis has not been well studied in relation to cAVMs.
Who / Where? No new patients will be recruited. We plan to look at existing clinical records of all patients who were referred to Salford Royal NHS Foundation Hospital with an untreated cAVM between 2009 and 2017 contained within a clinical database held by the neurosurgical team. Only the data for patients who underwent an angiogram (x-ray of blood flow) when they came into hospital will be included in the study in allow us to answer the following questions:
• How many patients who were admitted with a cAVM were diagnosed with angiogenesis?
• Was angiogenesis more likely in people who had also suffered a brain haemorrhage?
• Do clinicians agree on how to diagnose angiogenesis?How? The study is expected to take approximately six months to complete.
REC name
London - Surrey Research Ethics Committee
REC reference
18/LO/0856
Date of REC Opinion
13 Jun 2018
REC opinion
Further Information Favourable Opinion