Analysis of Prostate Calcification on CT & MRI for ultrasound ablation
Research type
Research Study
Full title
Retrospective analysis of prostate calcification on CT and MRI and modelling ultrasound ablation in phantom models. Using new MRI sequences to better characterise prostate calcification.
IRAS ID
246845
Contact name
Steven Bandula
Contact email
Sponsor organisation
University College London Hospital
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Prostate cancer is the most prevalent cancer among men and is one of the principal medical problems facing the male population. While conventional radical treatments for localised prostate cancer such as surgery or radiotherapy provide good local control of disease, they leave men with significant long term complications affecting urinary, bowel and sexual function which can reduce the patient's quality of life. New treatments are now able to treat only the cancer and not the entire prostate, theoretically lowering the risk of complications. Some of these new treatments uses ultrasound waves emitted from a probe placed in a patient's urethra (tube in the penis where urine is expelled) or their rectum (back passage) to heat the prostate where the cancer is.
Calcification in the prostate gland can affect the way the ultrasound waves travel through the prostate. However not much research has been carried out on this topic.
This study will use an anonymised database of patients who have had CT scans of their prostate gland to assess the calcification. This data will be used to produce labarotary models to study the way this effects the way ultrasound wave travel. Another aspect of the study is to see whether calcifcation that is seen on CT can only be seen on MRI which is what is normally used to diagnose prostate cancer.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
18/YH/0411
Date of REC Opinion
17 Oct 2018
REC opinion
Favourable Opinion