An immunological study of chronic rhinosinusitis. version 1
Research type
Research Study
Full title
An investigation into immunological causes of chronic rhinosinusitis in association with staphylococcal superantigens
IRAS ID
213877
Contact name
Qibo Zhang
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Research Summary
Rhinosinusitis is common, affecting around 15% of the population and causes significant reduction in quality of life. Chronic rhinosinusitis (CRS) is defined by the presence of sinonasal symptoms (discharge, obstruction, loss of smell, facial pain) for over 12 weeks, which is supported by endoscopy and/or radiological investigation.
The aetiology of CRS is unclear although it is thought that it is resulting from the interaction between the host and environmental factors.
In this study, we aim to investigate the inflammatory response of nasal mucosa induced by staphylococcal exotoxins in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and compared with those with chronic rhinosinusitis without polyps (CRSNP)Íž and to determine how the immune receptors of the nasal mucosa may regulate theinflammation induced by the toxins. The information from this study will help us to develop novel therapeutic strategies against this chronic disease.Summary of Results
The COVID-19 pandemic caused the suspension of the patients recruitment and the collection of surgical tissue samples which the study relied on. Therefore the study could not continue and finish following the outbreak of the COVID-19 pandemic.
Has the registry been updated to include summary results?: No
If yes - please enter the URL to summary results:
If no â why not?: The COVID-19 pandemic caused the suspension of the patients recruitment and the collection of surgical tissue samples which the study relied on. Therefore the study could not continue and finish following the outbreak of the COVID-19 pandemic.
Did you follow your dissemination plan submitted in the IRAS application form (Q A51)?: No
If yes, describe or provide URLs to disseminated materials:
If pending, date when dissemination is expected:
If no, explain why you didn't follow it: The COVID-19 pandemic caused the suspension of the patients recruitment and the collection of surgical tissue samples which the study relied on. Therefore the study could not continue and finish following the outbreak of the COVID-19 pandemic.
Have participants been informed of the results of the study?: No
If yes, describe and/or provide URLs to materials shared and how they were shared:
If pending, date when feedback is expected:
If no, explain why they haven't: The COVID-19 pandemic caused the suspension of the patients recruitment and the collection of surgical tissue samples which the study relied on. Therefore the study could not continue and finish following the outbreak of the COVID-19 pandemic, and no results obtained.
Have you enabled sharing of study data with others?: No
If yes, describe or provide URLs to how it has been shared:
If no, explain why sharing hasn't been enabled: The COVID-19 pandemic caused the suspension of the patients recruitment and the collection of surgical tissue samples which the study relied on. Therefore the study could not continue and finish following the outbreak of the COVID-19 pandemic, and no results/data obtained.
Have you enabled sharing of tissue samples and associated data with others?: No
If yes, describe or provide a URL:
If no, explain why: The COVID-19 pandemic caused the suspension of the patients recruitment and the collection of surgical tissue samples which the study relied on. Therefore the study could not continue and finish following the outbreak of the COVID-19 pandemic, and no tissue stored for sharing..REC name
East of England - Cambridge South Research Ethics Committee
REC reference
17/EE/0106
Date of REC Opinion
18 Apr 2017
REC opinion
Further Information Favourable Opinion