An exploration of white matter changes and otological status
Research type
Research Study
Full title
An exploration of white matter changes and otological status; a pilot study.
IRAS ID
312220
Contact name
Emma Richards
Contact email
Sponsor organisation
Swansea University
Clinicaltrials.gov Identifier
NA, NA
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
There is a collection of audiological symptoms that warrant further investigation using MRI scans. Through this pathway multiple scans of the internal auditory meatus and simultaneously the brain, have been captured. White matter changes in the brain are often found incidentally. Radiological reports identify the location and frequency of the white matter changes but can utilise different scales. The nature of reporting reduces continuity and makes quantitative analysis challenging. To combat this, we would like to utilise and develop machine learning algorithms combined with the Wahlund scale to reduce the subjectivity in radiological reports for research.
Currently, we have developed a preliminary machine learning algorithm. The aim of this pilot study is to adjust the sensitivity of the algorithm by analysing a group of the MRI scans manually and inputting this information into the algorithm. A retrospective comparison would be made between the white matter changes found in the scans and the otological status including tinnitus, hearing loss and vestibular symptoms. The algorithm will be tested and developed alongside expert clinical opinion.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
23/PR/1486
Date of REC Opinion
22 Dec 2023
REC opinion
Favourable Opinion