alternative assessments of adequacy
Research type
Research Study
Full title
Pilot study to review alternative assessments of adequacy of dialysis in patients with kidney failure
IRAS ID
129559
Contact name
Andrew Davenport
Contact email
Sponsor organisation
Royal Free NHS Foundation Trust
Research summary
The dose or adequacy of dialysis treatments for kidney failure patients is currently assessed by the removal of urea, a waste product of protein turnover. However, simply changing dialysis treatments to increase the amount of urea removed, has not been shown to improve patient survival. Cardiac disease is the commonest cause of death for kidney failure patients, and additional risk factors for cardiac death have been reported for these patients. As such, newer treatment paradigms may well be required to treat patients with kidney failure by reducing these additional risk factors associated with heart disease.
In this pilot study we wish to measure three key risk factors reported to be associated with increased risk of death in different cohorts of kidney failure patients to determine whether any of the current treatments for kidney failure reduce these risk factors. Information from this pilot trial would then hopefully be used to develop a clinical trial using an intervention to reduce one or more of these 3 risk factors.REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
13/LO/0912
Date of REC Opinion
9 Jul 2013
REC opinion
Further Information Favourable Opinion