ALL ACS- (Allopurinal in Acute Coronary Symptom)
Research type
Research Study
Full title
Allopurinol as a possible new therapy for acute coronary syndromes: The Next Steps
IRAS ID
90543
Contact name
Allan Struthers
Contact email
Sponsor organisation
University of Dundee
Eudract number
2011-004996-35
Clinicaltrials.gov Identifier
Research summary
Allopurinol is a drug commonly used to treat gout. However recent studies have shown it has the potential to help improve oxygen supply to heart muscle. In this study we aim to find out if allopurinol slows down the onset of chest pain (angina) symptoms, as seen by a doctor on a tracing of the heart (ECG- electrocardiogram), for patients who have been diagnosed with heart disease, when exercising on a treadmill. We also are trying to figure out the best dose of allopurinol to use and to see how quickly it begins working. To do this we are planning a trial where we will recruit patients with angina, exercise them on a treadmill, after giving different doses of allopurinol,to see if there is an improvement in their time to bring on angina symptoms and signs. Patients recruited to this trial will receive three different treatment regimes over a six week period. Each treatment regime will last for one week with a one week rest period between each regime. This will involve up to eleven visits to Ninewells Hospital Medical School, Dundee for testing.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
11/ES/0033
Date of REC Opinion
22 Nov 2011
REC opinion
Further Information Favourable Opinion