AKI-Recover

  • Research type

    Research Study

  • Full title

    Assessing levels of physical activity after hospitalisation for AKI

  • IRAS ID

    251123

  • Contact name

    Scott March

  • Contact email

    dsm12@le.ac.uk

  • Sponsor organisation

    University of Leicester

  • Duration of Study in the UK

    2 years, 0 months, 1 days

  • Research summary

    Research Summary

    Why?
    Acute Kidney Injury (AKI) is sudden damage to the kidneys that causes them to not work properly. In the recovery phase of AKI, patients have an increased chance of dying, however those patients who are able to recover kidney function tend to do better in the long run. It is not currently clear how levels of physical activity associate with recovery of kidney function following injury.
    What?
    This is a cross-sectional, proof of concept trial which will provide evidence for the efficacy of interventions to increase levels of physical activity in AKI patients. We will collect a number of outcomes including:
    Perceived levels of physical activity and quality of life using questionnaires
    Habitual physical activity levels using an accelerometer
    Relevant clinical information.

    Who?
    We will ask 50 patients following an episode of stage 3 AKI within University Hospitals of Leicester. We will include both patients who do, and do not, require haemodialysis.

    1. At least one eGFR measurement from the previous 12 months prior to AKI.
    2. Age 18 years or older.
    3. Able and willing to give informed consent.

    Where/how?
    Stage 3 adult AKI patients as defined by internationally accepted KDIGO guidelines who have had one eGFR measurement from the previous 12 months prior to AKI. Patients providing ongoing informed consent will be in the study for six months. Assessments will take place one, three and six months. Questionnaires will be completed at the patients convenience at one, three and six months and patients will be required to wear an accelerometer at one and six months.

    Summary of Results

    Acute kidney injury (AKI) can lead to chronic kidney disease, which results in poor long-term outcomes. There is a suggestion that increased levels of physical activity may promote kidney recovery following AKI. This study aimed to assess whether physical activity levels after AKI were associated with kidney recovery. We also aimed to see whether assessing physical activity after AKI was possible. Levels of physical activity were assessed immediately following hospital discharge after an episode of AKI, and then again at 6-months. Kidney function was assessed 12-months prior to AKI and at 1-, 3- and 6-months after discharge from hospital. This study showed that the greatest recovery in kidney function occurred prior to the individuals being discharged following their episode of AKI, with recovery continuing until 3-months. Individuals with AKI whom were inactive had consistently worse kidney function than those more active individuals at all measured timepoints. The conclusion of this study are that higher levels of physical activity are associated with improved renal recovery after 6- months following an episode of AKI. A future randomised controlled trial is feasible and would be required to confirm these initial findings.

  • REC name

    Wales REC 6

  • REC reference

    18/WA/0358

  • Date of REC Opinion

    5 Oct 2018

  • REC opinion

    Favourable Opinion