Air Pollution in Lung Transplantation
Research type
Research Study
Full title
A retrospective study on the effect of air pollution on the outcome after lung transplantation: A European multicenter project
IRAS ID
135862
Contact name
James Lordan
Contact email
Sponsor organisation
University of Leuven
Research summary
Lung transplantation is a life saving therapeutic option in selected patients with end stage lung disease but post operative complications such as acute and chronic rejection is a significant problem. The exact mechanism of rejection is still being investigated but one possible risk factor is that the lungs remain open to the air. Air pollution, taken into the lungs with normal breathing, may cause lung injury or exacerbate damage caused by other insults to the lung tissue thereby increasing the risk of rejection, loss of function and death. This study will look at ambient air pollution as well as details of post transplant complications such as acute and chronic rejection, infection episodes and death. Air pollution will be assessed from particulate information in the domiciliary area and distance from major roads to the transplant recipient residence. To evaluate the effect of chronic exposure it is planned to collect home address and clinical information of all the Lung Transplant patients transplanted up to 31 December 2011.
REC name
London - City & East Research Ethics Committee
REC reference
14/LO/0743
Date of REC Opinion
26 Apr 2014
REC opinion
Favourable Opinion