AID (Artificial Intelligence diagnostic Aid)
Research type
Research Study
Full title
Image analysis comparing the clinical recommendation for follow-up and treatment decisions in Wet Age Related Macular Degeneration (AMD), Diabetic Macular Oedema (DMO) and Retinal Vein Occlusion (RVO), between Consultant Ophthalmologists and Macusoft Artificial Intelligence (AI) software.
IRAS ID
308657
Contact name
Nigel Davies
Contact email
Sponsor organisation
Guy's and St Thomas' NHS Foundation Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
We have worked with software designers to develop a software that allows us to analyse current adherence to guidelines on Ophthalmic conditions such as Age related Macular Degeneration (AMD), Diabetic Macular Edema (DMO) and Retinal vein occlusion (RVO). National guidelines state that those patients with fluid accumulation in their central macular, meeting criteria, are eligible for injections into the vitreous cavity of the eye (intravitreal).(1) As these condition are common the trial is relevant to the public and patients as future management may be affected by the outcomes of this trial.
We will trial the software which uses Artificial Intelligence (AI) algorithms to determine the most suitable review required for patients being managed in clinics, based on 'Vision' and 'Retinal Thickness' demographics. This will be done prospectively, in real time.
The question to be addressed is 'Can medical and non-medical practitioners accurately determine treatment and follow-up for patients assisted by an AI clinical decision support system, for the three most common chronic macular diseases - Wet Age-Related Macular Degeneration (wAMD), Diabetic Macular Oedema (DMO) and Retinal Vein Occlusion (RVO) - in a safe and clinically cost effective way?'
Patients undergoing treatment for at least 12 months are eligible to participate, so long as they are able to provide consent for their data to be used. Participants will have no change to their care during the trial.
The study, will take place at Guy’s and St. Thomas’ NHS FT (GSTT) from where participants will be recruited, and will last approximately 6 months of data collection.
The software will be used by the research Fellow, alongside the masked consultant. Therefore the patient pathway and management will not be impacted by this trial. They will be consented for data use.
The results of the study will be shared as part of an MD project by the PI Rosina
REC name
South Central - Berkshire Research Ethics Committee
REC reference
23/SC/0128
Date of REC Opinion
24 Apr 2023
REC opinion
Further Information Favourable Opinion