ADVANCE

• Research type

  Research Study

• Full title

  ADVANCE: Advancing and evaluating a breakthrough Diagnostic interVention for Acute uriNary traCt infEction

• IRAS ID

  275298

• Contact name

  Christopher Butler

• Contact email

  christopher.butler@phc.ox.ac.uk

• Sponsor organisation

  University of Oxford

• Duration of Study in the UK

  0 years, 11 months, 2 days

• Research summary

  Research Summary

  Urinary tract infection (UTI) is a painful, uncomfortable, and potentially dangerous condition which affects almost half of all women at least once in their lifetime. Most patients are prescribed antibiotics to treat this condition. However, many types of bacteria which cause these infections are no longer sensitive to commonly used antibiotics. It is important to prevent this problem from worsening by ensuring that only patients with genuine infections receive antibiotics, and that the antibiotics they receive will work. Current tests for this infection are slow or inaccurate, so doctors usually rely on clinical judgement alone to decide about antibiotic treatment.
  A number of rapid diagnostic tests for UTI are under development for use in primary/acute care to help clinicians by confirming a diagnosis and the correct antibiotic to treat infections, thus empowering clinicians and patients to make immediate appropriate treatment decisions. Staff from the Nuffield Department of Primary Care at the University of Oxford with collaborators from the Public Health Wales Specialist Antimicrobial Chemotherapy Unit are aiming to test the performance of one of the more developmentally advanced prototype rapid diagnostic tests in urine samples surplus to clinical care, provided by women who visit their GP with suspected UTI. This test could identify if a true infection is present as well as the best antibiotic to use all within 30 minutes, thus potentially revolutionising the way this condition is managed world-wide. But before any decisions about its use are made we need to establish the accuracy of the test, comparing it with other tests. The project will help to define the clinical performance of the innovative diagnostic in a European primary care patient population.

  Summary of Results

  Due to the COVID-19 pandemic, this study was placed on hold as additional funding was to be secured. Further applications have been made to obtain funding, but these have been unsuccessful. As this is the case, this study was closed before any participants were recruited and any data was collected. Therefore no results are available.

• REC name

  London - Surrey Research Ethics Committee

• REC reference

  20/LO/0314

• Date of REC Opinion

  22 Jul 2020

• REC opinion

  Further Information Favourable Opinion