Adrenal Insufficiency & Covid Vaccination questionnaire
Research type
Research Study
Full title
Assessing the Impact of the Coronavirus Vaccine on Patients with Adrenal Insufficiency?
IRAS ID
304016
Contact name
Robert Murray
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 6 months, 3 days
Research summary
The adrenal hormone, cortisol, has multiple roles in the body from helping fight infections,maintaining blood pressure, involvement in gut function and getting over stressful events. Adrenal Insufficiency (AI) occurs when an individual can not make enough cortisol due to either adrenal or pituitary disease. The condition is treated with replacement steroids. When replacement steroid doses are insufficient to get through stresses or an infection an adrenal crisis can occur. This is characterised by nausea, vomiting, abdominal pain, low BP, increased temperature and confusion, and can be life threatening. Infections are the commonest cause of adrenal crises
We recently published a short series of five patients with adrenal insufficiency who developed symptoms of an adrenal crisis following the covid vaccination.
In the proposed study we will send a questionnaire to our patients with AI to qualify their experience with the covid vaccination. This will allow us to determine how frequently adrenal crises may occur, symptoms that precipitate these, and which vaccines are implicated, and any predisposition to developing a crisis with the vaccine.REC name
HSC REC B
REC reference
21/NI/0147
Date of REC Opinion
24 Aug 2021
REC opinion
Favourable Opinion