Adolescent hip disease. Version 1
Research type
Research Study
Full title
Functional outcomes in adolescents with osteonecrosis secondary to treatment of developmental dysplasia of the hip.
IRAS ID
149750
Contact name
Andreas Roposch
Contact email
Sponsor organisation
UCL Institute of Child Health
Research summary
Developmental dysplasia of the hip (DDH) occurs in 40-60/1000 newborns. It is a major cause of debilitating hip disease in adulthood, underlying up to 9% of hip replacements. Osteonecrosis of the femoral head is a major complication in the treatment of DDH for which there is no cure. Osteonecrosis is associated with pain and stiffness of the hip in childhood or young adulthood, often ending in early hip replacement.
Presently, osteonecrosis is defined purely by X-ray criteria. As X-ray features cannot be directly perceived by patients, more meaningful ways to understand and define osteonecrosis are essential to give patients the best possible information about what to expect when osteonecrosis has developed.
In this research we will delineate the relationship between severity of osteonecrosis as seen on X-rays and patient-reported outcomes of hip function, daily living activities, quality of life—outcomes that patients can perceive directly are more meaningful when counselling affected patients about their prognosis and options of treatment.
We will re-examine 108 patients with osteonecrosis who took part in 2006 study (REC 06/Q0508/40) plus 90 new patients with and without osteonecrosis. They will have one standardised assessment of their hip done in our hospital, one X-ray and complete several questionnaires.
We will determine (1) how 108 patients with osteonecrosis and examined in 2006 have changed in terms of their well-being and X-rays, (2) how patients with and without osteonecrosis compare in terms of patient-reported outcomes, and (3) how X-ray findings of osteonecrosis correspond to patient-reported outcomes such as quality of life.
This information will enable better counseling of parents of young children with DDH about what to expect when their children grow older. It will drive better clinical decisions in affected children and enable the development of risk-tailored care pathways, especially in the transition from childhood to adult services.REC name
London - Fulham Research Ethics Committee
REC reference
14/LO/1267
Date of REC Opinion
28 Jul 2014
REC opinion
Favourable Opinion