Adaptation to ketosis
Research type
Research Study
Full title
Adaptation to prolonged nutritional ketosis
IRAS ID
222425
Contact name
David Dearlove
Contact email
Sponsor organisation
TdeltaS
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Our body produces ketones when our energy reserves are low, for example, during famine or prolonged exercise. In these instances, ketone bodies are used by vital tissues such as the brain, heart and muscle as an alternative fuel to spare our limited carbohydrate reserves. Ketone bodies are also signalling molecules, which act to reduce the amount of carbohydrate used by various tissues/organs. These actions significantly prolong survival during starvation. This study seeks to investigate the effects of prolonged ketosis, achieved through dietary manipulation or a ketone containing supplement, on how our body uses and stores fuels (carbohydrate, protein and fat).
We seek to recruit male and female participants, aged 18-45 years. The study is being conducted at the Department of Physiology, Anatomy and Genetics at the University of Oxford. Participants will make a minimum of 3 visits to the department over approximately 2 weeks. Participants will be asked to adhere to dietary interventions and perform exhaustive exercise on a static bike.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
17/SC/0297
Date of REC Opinion
19 Jul 2017
REC opinion
Further Information Favourable Opinion