Acute Mycoprotein
Research type
Research Study
Full title
A Double-Blind Randomised Controlled Trial Investigating the Acute Effects of Mycoprotein on Glycaemic Control and Appetite in South Asian and Caucasian Adults with Type 2 Diabetes Mellitus
IRAS ID
260347
Contact name
Gary Frost
Contact email
Sponsor organisation
Imperial College London
ISRCTN Number
ISRCTN11111111
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 0 months, 31 days
Research summary
Type 2 Diabetes (T2D) is affecting millions of people worldwide. Almost the 25% of the global cases of T2D are South Asians, which are 4 times more prone of developing T2D than Caucasians. Diet is the cornerstone treatment for T2D. A key nutrient that plays a major role in blood sugar control is fibre such as beta-glucan and guar gum. However, the majority of studies have been conducted in Caucasians. Only a few studies report the impact of diet on blood sugar levels in South Asian people with T2D. The small evidence available suggests that South Asians have a great blood sugar response to a same food than Caucasian counterparts.
Recent work on mycoprotein, which is a commonly consumed fibre containing beta-glucan, has shown to reduce blood sugar levels in healthy lean adults and to improve blood sugar levels by increasing insulin sensitivity in healthy overweight and obese people. Yet, no studies have been conducted in people T2D.
The aim of this study is to investigate the impact of mycoprotein alone and with guar gum on blood sugar levels in South Asian and Caucasian people with T2D.
To study this, South Asian and Caucasian adults with T2D non-insulin treated who are male or female aged 18-70 years will be recruited. Participants will be asked to attend NIHR/Wellcome Trust Imperial Clinical Research Facility at Hammersmith Hospital to undergo a double-blinded, cross-over, acute RCT.Participant will be asked to attend a total of six study visits to eat foods containing different types of protein with and without guar gum (soy, chicken and mycoprotein) in liquid and solid format. A total of 9 blood samples per study visit will be drawn to measure blood sugar, insulin and gut hormones. Study visit will last 5h approximately. This methodology has been already used by Bottin et al.,2016.
REC name
London - Bromley Research Ethics Committee
REC reference
19/LO/0476
Date of REC Opinion
26 Apr 2019
REC opinion
Further Information Favourable Opinion