ACTIVATE
Research type
Research Study
Full title
Cardiac rehabilitation for people with chronic stable angina: a randomised controlled trial
IRAS ID
300485
Contact name
Nefyn Williams
Contact email
Sponsor organisation
University of Liverpool
ISRCTN Number
ISRCTN10054455
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Angina is chest pain caused by atherosclerosis of coronary arteries, which restricts blood flow to the myocardium, especially on exertion. Current management consists of behaviour change, drug treatment and revascularisation procedures. Cardiac rehabilitation is routinely offered to patients following myocardial infarction or revascularisation procedures, but not for chronic, stable angina. Cardiac rehabilitation consists of lifestyle change, exercise training, education and mental health interventions. The National Institute for Health and Care Excellence will not support cardiac rehabilitation for chronic stable angina until stronger evidence of effectiveness and cost-effectiveness is available. The aims of the project are to improve the health of people with long-term angina chest pain, that is not getting worse and does not require an operation, but which still limits daily activities. We aim to assess whether a rehabilitation programme is more effective than usual care in improving the health of people with long-standing stable angina, whether the programme is good value for money, and whether it is delivered as intended.The programme uses behaviour change techniques such as goal-setting, self-monitoring, providing feedback on behaviour, graded tasks, social reward, providing information about health consequences and reducing negative emotions. At the beginning of the programme, each user completes an online form providing information about their medical history and current cardiac risk factors. This information is used to set individualised tailored goals focussing on exercise, diet, emotions and smoking. The study aims to recruit 518 patients (259 per group) aged 18 years and older from four regions: Liverpool, Lancashire, Leicester and North Wales, which are all areas of high disease burden with socio-economic deprivation. Some of these areas include high proportions of BAME groups (Leicester, East Lancashire) and areas with low research activity in this field (Blackpool, North Wales).
REC name
North of Scotland Research Ethics Committee 2
REC reference
21/NS/0116
Date of REC Opinion
23 Sep 2021
REC opinion
Further Information Favourable Opinion