AceticA
Research type
Research Study
Full title
A pilot randomised controlled trial to examine the efficacy and optimal dose of Acetic Acid to treat colonised burns wounds.
IRAS ID
234132
Contact name
Naiem Moiemen
Contact email
Sponsor organisation
University Hospitals Birmingham NHS Foundation Trust
Eudract number
2017-003481-28
ISRCTN Number
ISRCTN11636684
Clinicaltrials.gov Identifier
XX2003, CAS Number (Internal)
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Burn wound infections (BWI) can cause delayed healing of burns, poor scarring and infection leading to sepsis. Acetic acid is more commonly known as vinegar and has been used as an antibacterial agent for thousands of years. More recently it has been a widely used antiseptic agent for use on skin for the treatment of burns wounds and has been shown to have activity against certain bacterial infections within the wounds. During the treatment of these wounds, it is important to maintain a balance between effective removal of bacteria and how well patients tolerate the acetic acid. It is documented that many patients complain of stinging and pain on application of acetic acid to wounds, in particular if a strength of 5% concentration is used. The study will assess how two different strengths of acetic acid (0.5 and 2% concentrations) are tolerated by patients who have been admitted to hospital with burn wound infections. Samples of the burns dressings will also be collected and analysed to see if the two strengths of acetic acid demonstrate any difference in the effects they have on the bacteria. If the lower concentration is shown to have similar effects in combating the bacterial infection and appear to be more tolerable for patients, this may lead to larger studies to investigate further.
REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
17/WM/0407
Date of REC Opinion
21 Dec 2017
REC opinion
Further Information Favourable Opinion