ACE Inhibitor Clinical and Cost Effectiveness in Claudicants

• Research type

  Research Study

• Full title

  A double blind, randomised, placebo controlled trial to study the clinical and cost effectiveness of Angiotensin Converting Enzyme (ACE) inhibitors, ramipril,in patients with intermittent claudication

• IRAS ID

  34093

• Contact name

  Yousef Shahin

• Sponsor organisation

  Hull and East Yorkshire Hospitals NHS Trust

• Eudract number

  2009-016600-23

• ISRCTN Number

  N/A

• Clinicaltrials.gov Identifier

  N/A

• Research summary

  We are conducting a randomised controlled trial to investigate the clinical and cost Effectiveness of Ramipril which is an anti-hypertensive medication in patients with intermittent claudication. We aim to recruit 78 Participants in total. We will randomise the 78 Participants into two groups: Ramipril group with 39 Participants and Placebo group with 39 Participants. We will measure Ramipril's effect on walking by doing a simple treadmill test and measuring the maximum walking distance the participant can walk. We also want to examine Ramipril's effect on arterial function, cardivascular prognosis, quality of life and cost Effectiveness in these Participants.

• REC name

  Yorkshire & The Humber - Leeds West Research Ethics Committee

• REC reference

  09/H1307/109

• Date of REC Opinion

  27 Apr 2010

• REC opinion

  Further Information Favourable Opinion