Access to the TEDDY dataset in dbGaP
Research type
Research Study
Full title
Access to The Environmental Determinants of Diabetes in the Young (TEDDY) dataset in the NIH database of Genotypes and Phenotypes (dbGaP)
IRAS ID
329424
Contact name
Trevor Lawley
Contact email
Sponsor organisation
Wellcome Sanger Institute
Duration of Study in the UK
3 years, 2 months, 28 days
Research summary
The research team wishes to access and use the dataset generated from The Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a longitudinal study that investigates genetic and genetic-environmental interactions, including gestational events, childhood infections, dietary exposures, and other environmental factors after birth, in relation to the development of islet autoimmunity and type 1 diabetes (T1D). This dataset is currently held in the database of Genotypes and Phenotypes (dbGaP: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001442.v4.p3) at the US National Institutes of Health (NIH https://www.nih.gov/).
As part of the data access measures in place for this dataset, the data access committee has requested that approval is obtained from an Institutional Review Board (IRB) registered with the NIH. Cambridge South NHS REC is the IRB registered with the NIH to review applications from researchers from the Wellcome Sanger Institute.
This application is a request for Cambridge South REC to review the research team's access to and use of the TEDDY dataset. It is proposed that the data generated by the TEDDY study is used by the research team at the Wellcome Sanger Institute to explore the changes in microbial communities at both a general and high-resolution level, while considering important factors such as the age, disease status (like T1D), and geographical location of the research participants. This work could provide valuable insights into potentially beneficial and pathogen micro-organisms within the population, which could guide the translation of these findings into promising treatments and therapies.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
23/EE/0142
Date of REC Opinion
23 Jun 2023
REC opinion
Further Information Favourable Opinion