Acceptability and tolerability of MACE compared to gastroscopy

  • Research type

    Research Study

  • Full title

    Acceptability and tolerability of magnetic assisted capsule endoscopy compared to gastroscopy

  • IRAS ID

    216489

  • Contact name

    Mark McAlindon

  • Contact email

    Mark.McAlindon@sth.nhs.uk

  • Sponsor organisation

    Sheffield Teaching Hospitals NHS FT

  • Duration of Study in the UK

    1 years, 0 months, 1 days

  • Research summary

    Summary of Research
    Dyspepsia is a common presenting complaint that doctors have to manage both in the primary and secondary care setting. Gastroscopy is a useful test for investigating a variety of suspected upper gastrointestinal disorders including dyspepsia. However, it is uncomfortable for patients and incurs the risk of intubation and sedation. Capsule endoscopy is the investigation of choice for diseases of the small bowel. It is safe, non-invasive and well tolerated, the main risk being capsule retention occurring in up to 1-2% of procedures.

    We wish to undertake a prospective study comparing acceptability and tolerability of capsule endoscopy and gastroscopy in the investigation of dyspepsia. Patients presenting to general practice or the outpatients department with symptoms of dyspepsia who are referred for investigation are invited to take part in the study. Patients will undergo capsule endoscopy prior to gastroscopy performed by an endoscopist who will be blinded to the Capsule endoscopy findings. A comparison of tolerance and acceptance of both procedures will be measured by means of using structured and validated, qualitative questionnaires. The aim is to assess for whether there is a significant difference between the perception and experience of both modalities.

    Summary of Results

    Patient acceptability of conventional fibreoptic gastroscopy, transnasal endoscopy (TNE) and magnetic assisted capsule endoscopy (MACE) was compared. Sensations of gagging and choking related to instrumentation caused the most distress during gastroscopy, significantly moreso than during MACE. Intrumentation-related discomfort was also significantly greater during TNE than MACE. MACE was more acceptable to, and preferred by, patients than either gastroscopy or TNE.

  • REC name

    South Central - Berkshire B Research Ethics Committee

  • REC reference

    16/SC/0606

  • Date of REC Opinion

    24 Nov 2016

  • REC opinion

    Further Information Favourable Opinion