ABPM on HFpEF Global Registry
Research type
Research Study
Full title
Evaluation of Ambulatory Blood Pressure Measurement (ABPM) related haemodynamic biomarkers on the progression of Heart Failure with preserved ejection fraction (HFpEF)
IRAS ID
272997
Contact name
Sandosh Padmanabhan
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Heart failure is a complex condition resulting from the impaired ability of the heart to cope with the energy needs of the body. There are two types of heart failure that can be differentiated by the amount of blood that heart pumps out with each heartbeat; this is called the ejection fraction. When the heart is weak and does not pump normally, the amount of blood that is pumped out with each heartbeat is reduced (heart failure with reduced ejection fraction, HFrEF). If the heart is too stiff, the amount of blood pumped out with each heartbeat is normal or near normal, but the heart does not relax and fill back up with blood normally (heart failure with preserved ejection fraction; HFpEF). This can lead to symptoms of shortness of breath, leg swelling and tiredness.
HFpEF is less well studied than HFrEF and the treatment of HFpEF is less well established. HFpEF is more common in women and as people get older. High blood pressure is commonly found in patients with HFpEF and changes in blood pressure patterns have been associated with higher risk of hospital admission due to heart failure.
Ambulatory blood pressure monitoring (ABPM) is when the blood pressure is measured during usual daily activities, over the course of 24 hours. ABPM is considered to be give better reflection of true blood pressure values and has been shown in studies to be a better predictor of adverse cardiac events than a single reading taken in the hospital or GP surgery. There are few studies that have investigated the relationship between ABPM in HFpEF and patient outcomes.
This study aims to identify measurements from ABPM which may influence admission to hospital with heart failure, decline in general function and risk of death in patients with HFpEF.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
20/PR/0114
Date of REC Opinion
29 Jul 2020
REC opinion
Further Information Favourable Opinion