ABCaP: Anaerobic Bacteria and Prostate cancer.

  • Research type

    Research Study

  • Full title

    ABCaP Study: A Study to Evaluate the Role of Anaerobic Bacteria in Prostatic Inflammation and the Pathogenesis of Prostate Cancer.

  • IRAS ID

    215060

  • Contact name

    Frances Chinegwundoh

  • Contact email

    frank.chinegwundoh@nhs.net

  • Sponsor organisation

    Joint research Management Office (QMUL and Barts Health NHS Trust)

  • Clinicaltrials.gov Identifier

    internal reference number ( ReDA Ref) , 011605

  • Duration of Study in the UK

    0 years, 6 months, 1 days

  • Research summary

    Prostate cancer is the most common male cancer and the second leading cause of cancer related deaths in men in the UK and the US. The overall incidence of CaP in the UK has increased from 65-70 per 100,000 males in 1993-1995 to 89-116 per 100,000 males in 2008-2010.

    This study aims to assess the role of anaerobic bacteria in prostatic inflammation and prostate cancer

    We plan to recruit 60 patients presenting to Barts Health NHS Trust with raised PSA. Currently these patients are investigated with a transrectal ultrasound guided biopsy of the prostate. As part of clinical assesment (in clinic) and as part of this procedure patients undergo a digital rectal examination and are asked to provide a urine sample. We plan to perform a short prostate massage at the time of the digital rectal examination and collect the first 5-10 mls of urine before and after their prostate massage. The patient will not be required to undergo any additional clinic visits or procedure (except short prostate massage). The urine will then be cultured and studied with the MOLDI-TOFF mini-mass spectroscopy machine to identify bacteria.

    We will also recruit additional 60 patients who have normal PSA but have Lower Urinary Tract Symptoms. Approximately 3/4 of all patients with LUTS will have a normal PSA as this is due to benign enlargement of the prostate. However these patients require a Digital Rectal Examination as part of their normal assesment. We plan to identify these patients in outpatient clinics and consent them for a short prostate massage which will be done at the time of the digital rectal examination. We will collect 5-10 mls of urine before and after the prostate massage. The urine will be analysed as discussed above.

  • REC name

    London - Camden & Kings Cross Research Ethics Committee

  • REC reference

    17/LO/0109

  • Date of REC Opinion

    16 Feb 2017

  • REC opinion

    Further Information Favourable Opinion