A PET study with 11C-BU99008 in Parkinson's disease dementia
Research type
Research Study
Full title
The role of astrogliosis in Parkinson’s disease dementia: a Positron Emission Tomography study with 11C-BU99008.
IRAS ID
207740
Contact name
Paola Piccini
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Duration of Study in the UK
0 years, 3 months, 31 days
Research summary
During Parkinson’s disease, the majority of patients experience problems in their memory caused by Parkinson’s disease. Unfortunately, there is no treatment to date that can prevent or cure these memory problems, while it is not clear what causes them. In this study we will explore the possible mechanisms in Parkinson’s disease in relation to the astrocyte cells of the human brain. In particular, we will assess the possibility that the astrocytes cause or aggravate these memory problems.
We will assess Parkinson's disease patients with memory problems through various clinical questionnaires. In addition, each patient will be asked to have a Positron Emission Tomography (PET) brain scan which will give more information about the role of the astrocyte cells in the human brain. The PET scan involves the injection of a chemical specific for the astrocyte cells called PET tracer. An MRI scan of the head will be also performed to facilitate the analysis of the PET data.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
17/NW/0009
Date of REC Opinion
2 Feb 2017
REC opinion
Further Information Favourable Opinion