A PET study to assess brain α-synuclein deposition using [11C] MK-7337
Research type
Research Study
Full title
An open-label study to evaluate brain α-synuclein deposition using Positron Emission Tomography (PET) and [11C]MK-7337
IRAS ID
334626
Contact name
Frans van den Berg
Contact email
Sponsor organisation
Invicro
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Parkinson’s disease (PD) has a significant impact on quality of life and increased mortality. A protein called alpha-synuclein (ASYN) is strongly implicated in PD, but currently we do not have a reliable way to detect this protein and which brain areas are affected by it, apart from at post-mortem. Positron emission tomography (PET) is a non-invasive imaging technique that can quantify the concentration of particular molecules using radioactively tagged probes called radiotracers, (when a viable tracer exists). This study will analyse deposition of ASYN using a novel PET tracer called [11C]MK-7337 in people with PD and compare this to the brains of people with Alzheimer’s disease (AD) and healthy elderly participants who do not have PD or AD.
Male and female participants aged 55-80 will have a screening visit, a baseline imaging visit involving a PET scan and MRI and some subjects will have a follow-up imaging visit involving a further PET scan. The study will take part at 1 imaging centre.
REC name
Wales REC 7
REC reference
23/WA/0306
Date of REC Opinion
22 Nov 2023
REC opinion
Further Information Favourable Opinion