A new prospective Study in Clinically Isolated Syndrome
Research type
Research Study
Full title
A new prospective Clinical, Genetic and Imaging study of patients with Clinically Isolated Syndrome (CIS).
IRAS ID
118672
Contact name
Ahmed Toosy
Contact email
Research summary
We have planned a prospective study of patients with CIS who will be studied with MRI, OCT, and clinical assessments at study entry and after 6 and 12 months. Patients will have their bloods collected at baseline for a genetic analysis and a sub-group of patients will be recruited to a PET pilot study. As well as providing substantial insights into early pathological changes both at the lesion site and within the brain in demyelinating CIS, this investigation will determine which early changes in imaging and OCT metrics can predict later clinical conversion or disease activity at a more subject-specific level. PET imaging will help to eludicate in-vivo the role of the innate immune response using PET scanning, to see if the activation of microglial cells is necessary for the conversion to MS in patients who present with a clinically isolated syndrome. This will help to inform prognosis and target future therapies in CIS.
REC name
London - Queen Square Research Ethics Committee
REC reference
13/LO/1762
Date of REC Opinion
7 Jan 2014
REC opinion
Further Information Favourable Opinion