A clinical scoring tool 0-4 for the severity of AN predictive of IR
Research type
Research Study
Full title
To establish whether the severity of insulin resistance and risk of Type 2 Diabetes is effectively indicted by the corresponding score for the severity score of Acanthosis Nigricans of the skin
IRAS ID
272268
Contact name
Neil Wright
Contact email
Sponsor organisation
Sheffield Children's Hospital NHS Foundation Trust
Clinicaltrials.gov Identifier
NA, NA
Duration of Study in the UK
0 years, 5 months, 24 days
Research summary
Acanthosis Nigricans (AN) is a dark brown velvety discolouration of the skin typically on the back of the neck and in the armpit. It is thought to be caused by high levels of insulin in the blood and is strongly associated with Type 2 Diabetes and with obesity. Insulin is a hormone in your body that controls your blood sugar, levels of insulin can become too high if the body is unable to respond how to It should to insulin. Whilst not all individuals with obesity and Type 2 Diabetes have Acanthosis, those individuals with Acanthosis have almost double the risk of Type 2 Diabetes compared to those who do not.
Acanthosis is therefore a highly visible risk marker for Type 2 Diabetes. As such it may be an appropriate area in which to consider whether a public health campaign or self-assessment tool may help identify previously undetected cases of Type 2 Diabetes and identify individuals at higher risk of Type 2 Diabetes in whom early interventions may prevent progression to Diabetes.
The development of the clinical scoring tool to be validated has been in development through the previous streams of research involved in this research study.
Participants will consist of child participants aged 11-18 years of age with AN. It is intended that 60-70 participants will be recruited. Participants will attend an appointment whereby: AN severity will be recorded; blood tests will be performed; risk factors for type 2 diabetes will be recorded. This appointment will last no longer than 1 hour.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
20/EE/0023
Date of REC Opinion
19 Feb 2020
REC opinion
Further Information Unfavourable Opinion