4P Study
Research type
Research Study
Full title
BNP for personalised primary prevention in diabetes
IRAS ID
169374
Contact name
Allan Struthers
Contact email
Sponsor organisation
University of Dundee
Duration of Study in the UK
1 years, 9 months, 28 days
Research summary
Diabetes mellitus is known to affect various organs in the body including heart and this happens over the years despite good control of diabetes mellitus. This may also occur without the presence of any underlying symptoms.
On top of overt heart disease, a major problem in diabetes is the high incidence of silent cardiac abnormalities like silent ischemia, Left Ventricular hypertrophy (LVH), LV systolic dysfunction (LVSD), LV diastolic dysfunction (LVDD) and left atrial enlargement (LAE). These silent cardiac abnormalities could be together viewed as the “Big Five” and they all independently predict cardio-vascular (CV) events like myocardial infarction, heart failure, atrial fibrillation and embolic strokes. Hitherto primary prevention in diabetes has had a rather myopic focus on coronary artery disease only and ignores these silent abnormalities.
Indeed, amazingly, despite the high CV death rate in diabetes, there is not a single study with comprehensive enough phenotyping to document the prevalence of all of the “Big Five” within one study in diabetes. Our study will correct this deficiency, and assess, for the first time ever, how many people with type 2 diabetes have multiple silent cardiac abnormalities. Our main objective here is that, to improve primary prevention in diabetes, we need to know which of the above many silent cardiac abnormalities we are actually dealing with in each patient so that we can treat the underlying abnormality itself.
The purpose of our study is thus to assess how many people with asymptomatic type 2 diabetes have multiple silent cardiac abnormalities and is there a biomarker(s) which can early identify these silent abnormalities. To prove this, eligible participants will undergo physical assessment, blood investigations including Brain Natriuretic Peptide (BNP) and highly sensitive cardiac Troponin-T, urine test, 24 Hrs. ambulatory blood pressure monitoring and heart scan like dobutamine stress echocardiography and for a few myocardial perfusion imaging.REC name
East of Scotland Research Ethics Service REC 1
REC reference
15/ES/0042
Date of REC Opinion
7 Apr 2015
REC opinion
Further Information Favourable Opinion