4D-RV
Research type
Research Study
Full title
4D Flow MRI to assess flow dynamics in the right ventricular outflow
IRAS ID
321519
Contact name
Alexander Fletcher
Contact email
Sponsor organisation
NHS GG&C Research & Innovation (R&I)
ISRCTN Number
ISRCTN00000000
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
ECG-1801-2022, MRS grant award number
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Around 1 in 2000 people in the United Kingdom are born with a problem of the heart valve which helps pump blood to the lungs effectively. Many of these people will need to have surgery to replace the problem valve.
Unfortunately, in many cases multiple surgeries are required because the first replacement breaks down. The reason this break down happens is not clear. We want to use a special heart scan, called a 4D flow MRI, that can show up stress points in the valve put in at the time of surgery. Twenty people who have had their valve replaced will undergo 4D flow MRI heart scans. Our study will then look to see if the stress points shown in the 4D flow MRI are linked to a quicker break down of the replacement valve. The new information from our study will help guide surgeons and doctors in making better replacement valves, and potentially lead to less operations for patients in the future.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
24/EE/0208
Date of REC Opinion
14 Oct 2024
REC opinion
Further Information Favourable Opinion