3Sm challenge study

• Research type

  Research Study

• Full title

  An immune challenge model using gp41 3Sm peptide in healthy human adults to characterise B cell responses to a model virus-neutralizing antibody-inducing motif in health versus chronic viral infection

• IRAS ID

  292553

• Contact name

  Katrina Pollock

• Contact email

  k.pollock@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Clinicaltrials.gov Identifier

  NCT04753892

• Duration of Study in the UK

  0 years, 6 months, 31 days

• Research summary

  The 3Sm challenge study is a small clinical study in eight healthy volunteers who will be injected with a protein which includes a short portion ('3Sm peptide') which is derived from a part (the '3S region') of the coat protein of HIV. The researchers believe that the 3Sm peptide might trigger an immune response which includes rare antibodies able to neutralise a wide range of different strains of HIV. The results will be useful in guiding the development of future vaccines against HIV, and other diseases.

• REC name

  London - Bromley Research Ethics Committee

• REC reference

  21/LO/0247

• Date of REC Opinion

  19 May 2021

• REC opinion

  Further Information Favourable Opinion