1958 Birth Cohort Research Tissue Bank vsn2
Research type
Research Tissue Bank
IRAS ID
149323
Contact name
Susan Ring
Contact email
Research summary
1958 Birth Cohort Research Tissue Bank
REC name
North West - Haydock Research Ethics Committee
REC reference
14/NW/1179
Date of REC Opinion
15 Sep 2014
REC opinion
Favourable Opinion
Data collection arrangements
The 1958 Birth Cohort (also know as the National Child Development Study) is a unique and powerful longitudinal epidemiological study which recruited over 17,000 individuals who were born in one week in 1958. The subjects have been well characterised (phenotyped) for a variety of quantitative complex traits and been assessed for a variety of sociodemographic, socioeconomic and life style variables. The resource is widely used for research in genetic and genomic epidemiology, in particular as a platform for genetic association studies. Biological samples were collected from study participants including saliva, plasma and serum samples as well as DNA and lymphoblastoid cell lines. The samples were collected with generic consent for future research. Requests to use the material are assessed by the Access Committee for CLS Cohorts (ACCC) (see http://www2.le.ac.uk/projects/birthcohort).
Research programme
The 1958 BC resources are available to bona fide research scientists (biomedical, psychosocial, educational or ethicolegal) from anywhere in the world. The resource is used widely for research in genetic and genomic epidemiology – in particular as a platform for genetic association studies. To that end, it provides a source of subjects that have been well characterised (phenotyped) for a wide variety of quantitative complex traits and have also been carefully assessed for a wide variety of sociodemographic, socioeconomic and life style variables that are outcomes in their own right, and may be important determinants in relevant causal pathways leading to disease. It also provides a source of “cases” and “controls” for common binary traits. Finally – and possibly most importantly – it provides a geographically representative sample of British people (of primarily European origin) that represents the premier source of national controls that can be used in a wide variety of genetic casecontrol studies. For example, the 1958BC was used as one of two sets of national controls in the Wellcome Trust Case Control Consortium, that studied more than 12 complex diseases . The 1958BC Biomedical Survey has already played a major role in national and international bioscience.
RTBTitle
1958 Birth Cohort Research Tissue Bank
Establishment organisation
University of Bristol
Establishment organisation address
Oakfield House
Oakfield Grove
Bristol
BS8 2BN