(1) Comparing FRC in CF patients from two lung function tests
Research type
Research Study
Full title
The comparison of Functional Residual Capacity in Plethysmography and Multiple Breath Washout in children and adolescents with Cystic Fibrosis.
IRAS ID
216348
Contact name
James Moffatt
Contact email
Sponsor organisation
St George's UNiversity of London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 6 months, 5 days
Research summary
Title: The comparison of Functional Residual Capacity in Plethysmography and Multiple Breath Washout in children and adolescents with Cystic Fibrosis.
Cystic Fibrosis is an inherited disease that causes the lungs and digestive system to become clogged with sticky mucus, making those affected with the condition susceptible to chronic infections and inflammation of the lungs.
The primary aim of this study is to compare the FRC measures obtained from Plethysmography and Multiple Breath Washout techniques (Lung Volumes Tests) in children and adolescents with Cystic Fibrosis.
The secondary aim of this study is to determine whether there is a difference in FRC comparison in normal, severe, moderate and mild airflow obstruction as well as restrictive and mixed patterns.) Patients are divided into these groups by spirometry SR values and LCI raw values. Restrictive and Mixed patterns will need to be confirmed by a reduced TLC.
Objectives: The purpose of this study is to evaluate the clinical usefulness of different methods of measuring static lung volumes in children and adolescents with Cystic Fibrosis. I will be comparing FRC from Plethysmography and Multiple Breath Washout (Nitrogen) and evaluating the values as a measure of gas trapping and hyperinflation in Cystic Fibrosis.
This idea really captured my interest as I will be developing my knowledge on Cystic Fibrosis and hopefully results from this proposed study will be of benefit to these patients. I believe this project will improve the services for CF patients at GOSH as no matter what the outcome; the lung function department will gain information on how to interpret differences between the two methods for measuring FRC.
The study will be carried out in the Lung Function Laboratory at Great Ormond Street Hospital and it will last for approximately 7 months. The student leading the project will analyse data previously collected in routine testing.
REC name
London - Hampstead Research Ethics Committee
REC reference
16/LO/2169
Date of REC Opinion
1 Dec 2016
REC opinion
Favourable Opinion