Registration of clinical trials is the focus of #MakeitPublic week 2024, taking place from Monday 18 March this year.
Promoting research transparency is a key part of our work to facilitate safe and ethical research. When research is carried out openly and transparently, everyone benefits.
This year, for the first time, we are publishing on our website a full list of clinical trials that received a favourable opinion from a Research Ethics Committee (REC) in 2022, with the registration details that we hold for them. There is an expectation that following a favourable opinion from a REC, the clinical trial sponsor will register this on a World Health Organisation (WHO) compliant registry and update the HRA with these details. Read more about the work RECs do.
Information about these trials is already available in our research summaries database, but this list provides a quick reference to all those which received a REC favourable opinion in 2022 with their registration numbers. There are a total of 1545 trials.
Over the last few months we've asked research sponsors and chief investigators, who are responsible for registering clinical trials, for their trial’s registration number if we didn’t already have this information. It is a condition of favourable opinion of a REC that clinical trials are registered in a public registry before the first participant is recruited and no later than six weeks after.
If we did not receive a reply, we searched online to see if the trial was registered on a public registry. If we found a registration number by searching, we’ve put this in the tables below.
Being transparent with the data we hold about clinical trials - even if this is sometimes incomplete - helps us to build trust in research. We will continue to work with trial sponsors and others involved in health and social care research to improve the information we hold and share.
Read a blog from our Deputy Director of Policy and Partnerships, Naho Yamazaki, on the importance of research transparency and what we’re doing to improve our own systems and processes.
What we are publishing
We have published data about clinical trial registration every year since 2015. This has usually been a snapshot audit to show the proportion of trials that are registered. We have not published registration information on a trial-by-trial basis before.
This year we are sharing data on clinical trials in the UK that received a favourable opinion from RECs in 2022, with details on their registration number or an explanation for non-registration when this has been shared with us. Where there is no information displayed, it is because we do not hold registration details or an explanation for non-registration.
The tables you see below contain data we held in March 2024. Updates after this date will be used in future lists. This one remains a snapshot of the position this week.
Thank you to everyone who has been involved in collecting, collating, checking, and responding to this request for data.
Why we are publishing this data now
By publishing this information we can work towards improving research transparency more widely, and support our vision of making information from health and social care research studies publicly available for the benefit of all.
If you are a sponsor for a clinical trial, and you didn’t receive an email asking for your data, this might be because we don’t have the correct contact details for you.
Please note it is a requirement for you to keep us up to date with any changes to your contact details. Please take a moment to check that we hold the correct details for you, and please also contact us with any further updates on your clinical trial.
Making it easier to be transparent about your research
We are holding a workshop on Thursday 21 March, which will highlight best practice in research transparency and discuss how to make registration as easy as possible for people running a clinical trial. Find out more on the Make it Public week 2024 page.
We want to hear from you about any barriers you experience in registering a trial, to better understand how we can improve our systems and processes. This will also be an opportunity to find out more about the transparency requirements, and how you can meet them.
This event is now fully booked, but we’ll share more information afterward including a summary of the feedback and discussions from the day.
Our handy map follows your study from idea to publication with guidance on research transparency every step of the way.
What we found
More than nine out of 10 clinical trials met their registration requirements, an increase on previous years.
Two thirds of clinical trials were registered on ClinicalTrials.gov. The total is over 100% as some studies are included on more than one registry.
For almost all of the registered clinical trials, the sponsor informed us it was registered.
The most common explanation for non-registration was because the sponsor no longer considered the study a clinical trial. Over three quarters of those we contacted regarding the registration status of their trials did not respond.
Registration data
We have arranged the studies in the tables below by the month in which they given favourable opinion by a Research Ethics Committee (REC). The tables are long, you can jump to a specific month by using the menu. Within each month the studies are arranged by IRAS number, in order. This is a number given to a study when the first application for approvals is made and which follows the study through its lifecycle, until the results are published.
The full data set is also available as a CSV file.
There is not one single registry for clinical trials. The format of the number in the table below can tell you which register the study has used.
ISRCTN - Numbers beginning ISRCTN
Clinicaltrials.gov - Numbers beginning NCT
EudraCT - Numbers in three parts beginning with a year, for example 2019-xxxxx-xx
ANZCTR - Numbers beginning ACTRN
DRK - Numbers beginning DRK
If there is no data in the registration number column, we do not have a record of the study being registered. If the study's sponsor responded to us with information about why their study is not registered, we have included their explanation in the final column. Where we have noted 'found through search', we mean the study's registration details were found when we looked for them online using a search engine.
Clinical trials given a REC favourable opinion in January 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 256101 | Tolerance, compliance and acceptability to a new nutritional feed comprising real food ingredients | Nutricia | NCT05269992 | |
| 261868 | Phase I/II, non-randomised, open-label study of pCCLChimp47 (Lentiviral vector transduced CD34+ cells) in patients with p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD) | Great Ormond Street Hospital for Children NHS Trust | NCT05207657; 2019-001210-42 | |
| 262719 | Calcium Supplementation for Prevention of Pre-eclampsia in High Risk Women: CaPE Trial | University of Birmingham | ISRCTN12033893; 2020-004435-25 | |
| 277601 | Clinical and patient reported outcomes following treatment of grade III furcation involved molars. A single-centre single-masked randomised controlled feasibility trial with a Sequential, Multiple Assignment Randomised Trial (SMART) design | King’s College London | NCT05237739 | Found through search but HRA not notified |
| 278200 | To evaluate a parent-led, individualised sleep promotion package in children and young people having medium or long stay on the cardiac Paediatric Intensive Care Unit (PICU) | Newcastle Upon Tyne Hospitals NHS Foundation Trust | Sponsor no longer considers this a clinical trial | |
| 280020 | Complex intervention comprising text MEssaging anD HEalthcare professionaL training for imProving statin adherence in primary care: a pragmatic cluster-randomised controlled trial (MED-HELP) | University of Leicester | ISRCTN13245243 | |
| 283413 | International phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones | University of Milano-Bicocca | NCT03007147; 2017-000705-20 | |
| 284870 | Randomised Open-label Phase II study of induction standard of care Fulvestrant and CDK4/6 inhibition with the Addition of Ipatasertib in Metastatic ER+/HER2- breast cancer patients without ctDNA suppression | The Royal Marsden NHS Foundation Trust | NCT04920708; 2020-002825-27 | |
| 286685 | Efficacy of doravirine + dolutegravir dual therapy in the context of antiretroviral therapy switch | Chelsea and Westminster Hospital NHS Foundation Trust | NCT04892654; 2020-003928-17 | |
| 286785 | RATinG (Risk Adapted Therapy in acute GvHD): Investigating the use of lenzilumab for treating high-risk acute graft versus host disease following allogeneic stem cell transplantation | University of Birmingham | ISRCTN42585840; 2021-001193-29 | |
| 287123 | Near Infrared Fluorescence (NIRF) Imaging to prevent Post-surgical Hypoparathyroidism (PoSH)after Thyroid Surgery (NIFTy) - A phase II/III pragmatic, multicentre randomised controlled trial | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN59074092 | |
| 287151 | NanaBis™ An Oro–Buccal Administered Equimolar THC and CBD Formulation as Monotherapy for the Management of Opioid-Requiring Chronic Pain – Due to Metastatic Bone Cancer: A Phase 3 Multi-Centre, Double-Blind, Randomised-Withdrawal Active and Placebo-Controlled Clinical Study | Medlab Clinical | 2021-001540-98 | |
| 289862 | A multi-centre, controlled study to evaluate the efficacy and safety of an Endoscopic Sutured Gastroplasty (with Endonima device) in patients with non-alcoholic steatohepatitis (NASH) and fibrosis | Erasme University Hospital | NCT04653311 | |
| 290490 | Feasibility of a breakfast group intervention for acute stroke units, to provide intensive eating and drinking interventions as well as integrated multi-disciplinary team working and personalised care | Sheffield Teaching Hospitals NHS Foundation Trust | NCT05102812 | Found through search but HRA not notified |
| 290871 | First-in-Human Trial of the Safety and Performance of NU-MAX® (IEIK13) as a Hemostatic Agent in Intracranial Neurosurgery | 3-D Matrix | NCT04953949 | |
| 291027 | RCT of group CBT for men with intellectual and/or developmental disabilities and harmful sexual behaviour: the HaSB-IDD trial | University of Kent | ISRCTN21187053 | |
| 291170 | Biomarkers and Rapid Imaging in Dementia Diagnosis: B-RAPIDD | University College London | ISRCTN12777415 | |
| 292742 | Open-Label Extension Phase 3 Study to Evaluate the Long-Term Efficacy and Safety of LIB003 in Patients With Homozygous and Heterozygous Familial Hypercholesterolemia, Cardiovascular Disease, or at High Risk for Cardiovascular Disease, on Stable Lipid-Lowering Therapy Requiring Additional Low-Density Lipoprotein Cholesterol Reduction (LIBerate-OLE) | LIB Therapeutics | NCT04798430; 2020-004394-49 | |
| 293304 | Volume targeted versus pressure targeted non-invasive ventilation in amyotrophic lateral sclerosis: a randomised control trial | University Hospitals Coventry & Warwickshire NHS Trust | NCT05328492 | Found through search but HRA not notified |
| 293430 | A phase III randomized, double-blind, placebo-controlled parallel group trial to examine the efficacy and safety of BI 425809 once daily over 26 week treatment period in patients with schizophrenia (CONNEX-3) | Boehringer Ingelheim | NCT04860830; 2020-003726-23 | |
| 294469 | DIALOG+ in Primary Care: A Proof of Concept Study | Queen Mary University of London | ISRCTN46897021 | |
| 294830 | Pilot of EMG-Directed Virtual-Reality Experience Training for Motor Stroke Rehabilitation | Imperial College London | NCT05253989 | |
| 295260 | Optical Coherence Tomography Angiography for the detection of Neovascular Age-related Macular Degeneration: a Comprehensive Diagnostic Accuracy Study | Moorfields Eye Hospital NHS Foundation Trust | ISRCTN18313457 | |
| 296162 | Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications Including Bronchial and Thymic Neuroendocrine Tumour, Paraganglioma/ Phaeochromocytoma, Medullary Thyroid Carcinoma, and Those Requiring Repeat Peptide Receptor Radionuclide Therapy (Phase 2 trial) | University College London | 2021-002925-12 | |
| 296622 | Endometriosis Fertility Index: A Non-Surgical Approach | Guy's & St Thomas' NHS Foundation Trust | ||
| 297060 | Reirradiation Options for Previously Irradiated Prostate cancer (RO-PIP): Feasibility randomised clinical trial investigating toxicity outcomes following reirradiation with ultra-hypofractionated external beam radiotherapy vs. high dose rate brachytherapy | University of Leeds | ISRCTN12238218 | |
| 298246 | Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing | Boston Scientific | NCT04798768 | |
| 298683 | Mechanisms & Innovations in Right Ventricular Pacing for Hypertrophic Obstructive Cardiomyopathy (HOCM) | Imperial College London and Imperial College Healthcare NHS Trust | NCT05257772 | |
| 298740 | A Phase 2 Open-Label Clinical Trial of ADP-A2M4CD8 in Subjects with Advanced Esophageal or Esophagogastric Junction Cancers | Adaptimmune | NCT04044859; 2020-005802-24 | |
| 298952 | Respiratory Infections - Rapid Test Evaluation: a platform study for clinical validation of novel rapid devices in respiratory infection | Imperial College London | ||
| 300145 | HEmodynamic effects of Reducing lv Afterload with impella or intra-aortic balloon CounterpuLsation during veno-arterial Extracorporeal membrane oxygenation in cardiogenic Shock | King’s College London | ISRCTN82431978 | |
| 300383 | 129Xe Mri Assessment Of Disease Progression In Patients With Chronic Obstructive Pulmonary Disease Treated With Standard-Of-Care Medications With Or Without Daily Open-Label Azithromycin Treatment To Prevent Acute Exacerbation | Genentech | 2020-000852-36 | |
| 300828 | Salaso Moving More: The impact of digitally delivered precision exercise in helping people to move more | Bangor University | NCT05918926 | |
| 300829 | A Phase 3 Multicenter, Open-Label, Randomized Study of Navicixizumab Plus Paclitaxel and Navicixizumab Monotherapy in Comparison to Paclitaxel Monotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer | OncXerna Therapeutics | NCT05043402; 2021-001933-38 | |
| 300914 | Advance Statements for Black African and Black Caribbean people (AdStAC) | King’s College London | Sponsor no longer considers this a clinical trial | |
| 301026 | A single case experimental design study of a reminder app for supporting adherence to personalised treatment goals in Parkinson’s Disease | NHS Greater Glasgow & Clyde | NCT05106985 | |
| 301126 | Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation after Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT | Mercator MedSystems | NCT04862468; 2021-002798-24 | |
| 301477 | A Phase 3, Randomized, Placebo-Controlled, Double-Blinded, Multicenter Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients with C3 Glomerulopathy or Immune-Complex Membranoproliferative Glomerulonephritis | Apellis | NCT05067127; 2020-003767-25 | |
| 301526 | A Randomized, Double-Blind, Placebo-Controlled Multiple-Center, Efficacy and Safety Study of ZYN002 Administered as a Transdermal Gel to Children, Adolescents, and Young Adults with Fragile X Syndrome - RECONNECT | Zynerba | NCT04977986; 2021-002542-33 | |
| 301776 | RESPOND study (Rescue for Emergency Surgery Patients Observed to uNdergo acute Deterioration) Work Package 3: Feasibility Trial | University of Oxford | NCT04919720 | |
| 302010 | Development Study to Undertake a Comprehensive Performance Evaluation of Prototype Non-Invasive Blood Glucose Measurement Systems Compared to a Standard (Invasive) Measurement Method of Blood Glucose | Afon Technology | NCT05023798 | |
| 302061 | Sham controlled Randomized Control Trial evaluating the Safety, Acceptability and Efficacy of Autonomic neuromodulation using trans-cutaneous vagal sensory stimulation in uncontrolled hypertensive patients: a pilot study evaluating a novel non-invasive device-based strategy | Barts Health NHS Trust & Queen Mary University of London | ISRCTN14509154; NCT05179343 | |
| 302069 | Proactive review for people with diabetes in hospital: a cluster randomised feasibility study and process evaluation | Cambridge University Hospitals NHS Foundation Trust | ISRCTN70402110 | |
| 302079 | A Phase 1b, Open-label, Single-arm, Multicenter Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Multiple Doses of ELA026 in Adults and Adolescents with Secondary Hemophagocytic Lymphohistiocytosis (sHLH) | Electra Therapeutics | 2021-001387-20 | |
| 302216 | Emergency Medical Services Streaming Enabled Evaluation In Trauma | University of Surrey | ISRCTN11449333 | |
| 302239 | A Phase Ia study to assess safety and immunogenicity of the Plasmodium vivax malaria vaccine candidate Pvs25-IMX313 in Matrix-M1 adjuvant in healthy adults living in the UK | University of Oxford | NCT05270265; 2021-003550-23 | |
| 302310 | Investigating effects of mindfulness training on DMN connectivity and dynamics | University of Surrey | NCT05650177 | |
| 302371 | The Effect of Hepatic Impairment on The Pharmacokinetics of Seladelpar: An Open-Label Study Following Oral Dosing of Seladelpar to Subjects with Primary Biliary Cholangitis (PBC) and Hepatic Impairment | CymaBay Therapeutics | NCT04950764; 2020-005925-10 | |
| 302393 | Efficacy, tolerability and acceptability of the single tablet regimen (STR) Biktarvy® by trans people living with HIV (TPLWH) | Chelsea and Westminster Hospital NHS Foundation Trust | NCT04944654; 2020-001070-29 | |
| 302533 | An open-label trial of the long-term safety and tolerability of nintedanib per os, on top of standard of care, over at least 2 years, in children and adolescents with clinically significant fibrosing Interstitial Lung Disease (InPedILD™-ON) | Boehringer Ingelheim | NCT05285982; 2020-005554-23 | |
| 302606 | A Phase II, Double-blind, Placebo-controlled, Randomized, Dose-ranging, Parallel Group Study to Evaluate the Safety and Efficacy of PHA-022121 Administered Orally for Prophylaxis Against Angioedema Attacks in Patients with Hereditary Angioedema due to C1-Inhibitor Deficiency (Type I or Type II) | Pharvaris | NCT05047185; 2021-000227-13 | |
| 302650 | A multicenter, Phase 3, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the saftey and efficacy of PTX-022 in the treatment of moderate to severe Pachyonychia Congenita | Palvella Therapeutics | NCT05180708 ; 2021-003136-10 | |
| 302709 | PARABLE: Proton beam therapy in patients with breast cancer: evaluating early and late effects | Institute of Cancer Research | ISRCTN14220944 | |
| 302827 | ShorT stay Aneurysm Repair (STAR): A 23-hour endovascular abdominal aortic aneurysm repair pathway with evaluation of eligibility, uptake, viability, acceptability, safety and cost | Imperial College London | NCT05279274 | |
| 302833 | The role of an implantable Doppler vascular monitoring device in kidney transplant patients: a feasibility randomised controlled trial with an embedded qualitative study | University Hospital Plymouth NHS Trust | NCT05634863 | |
| 302967 | Utilising an innovative MCM5 Urine TEst foR the dIagnosis of eNdometrial cancEr (MCM5-UTERINE study) | Arquer Diagnostics | NCT05287048 | |
| 303172 | Utility of Novel Echocardiographic and Invasive Haemodynamic Measurements in the assessment of patients with Low Flow Low Gradient Aortic Stenosis undergoing TAVI; A pilot study. | The Royal Wolverhampton NHS Trust | NCT05196815 | |
| 303213 | Myopia Control Contact Lenses Non-Dispensing Phase Generic Application for a Family of Prototypes | CooperVision | ||
| 303831 | Personalised Primary care for Patients with Multimorbidity (PP4M) – a primary care service improvement initiative | University of Bristol | ISRCTN40295449 | |
| 303839 | A Phase 3, Open-Label, Randomized Study of Amivantamab and Lazertinib in Combination with Platinum-Based Chemotherapy Compared with Platinum-Based Chemotherapy in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer After Osimertinib Failure | Janssen-Cilag International | NCT04988295; 2021-001825-33 | |
| 303876 | STOP- Successful Treatment Of Paranoia: Replacing harmful paranoid thoughts with better alternatives | King’s College London | ISRCTN17754650 | |
| 304233 | Influence of vitamin D and a probiotic on inflammation and gut bacteria | University of Southampton | ISRCTN10131460 | |
| 304242 | An Open-Label, Multicenter, Outpatient Extension Study to Evaluate the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures | UCB | NCT05076617; 2021-002637-42 | |
| 304379 | A Phase 1, Open-Label, Parallel-Group Study to Evaluate the Safety, Immunogenicity, and Reactogenicity of Heterologous and Homologous Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in B-Cell Deficient Patients | Gritstone bio | 2021-004179-14 | |
| 304419 | Early identification of Pre-diabetes and evaluation of Lifestyle Therapy in Children and Adolescents with Obesity using Continuous Glucose Monitoring System | Alder Hey Children's Hospital | ||
| 304706 | Corcym Mitral, Aortic aNd Tricuspid post-maRket Study in a reAl-world setting | Corcym | NCT05002543 | |
| 304770 | An open label, multi-centre study to evaluate the long-term safety and tolerability of REN001 in subjects with primary mitochondrial myopathy (PMM) | Reneo Pharma | NCT05267574; 2021-003471-34 | |
| 304976 | The Evaluation and Performance of the Raspberry Pi Bone conduction hearing device for adults with hearing loss at an ENT/Audiology outpatient clinic | Liverpool School of Tropical Medicine | ||
| 305153 | To establish whether the Occuity device is non inferior in its measurement of central corneal thickness compared to Accutome ultrasound pachymeter and Lenstar | Portsmouth Hospitals University NHS Trust | ||
| 305546 | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2b Dose-Ranging Study to Evaluate the Efficacy and Safety of Orismilast in Adults with Moderate-to-Severe Plaque-Type Psoriasis | UNION Therapeutics | NCT05190419; 2021-003209-22 | |
| 305684 | A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety and Tolerability of QR-421a in Subjects with Retinitis Pigmentosa (RP) due to Mutations in Exon 13 of the USH2A Gene with Early to Moderate Vision Loss | ProQR Therapeutics | NCT05176717; 2021-002728-19 | |
| 305709 | Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial, with Cross-Over, of Posoleucel (ALVR105) for the Treatment of Adenovirus Infection in Pediatric and Adult Participants Receiving Standard of Care Following Allogeneic Hematopoietic Cell Transplantation | AlloVir | NCT05179057; 2021-003450-22 | |
| 305777 | A Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib and Panitumumab Versus Investigator’s Choice (Trifluridine and Tipiracil, or Regorafenib) for the Treatment of Previously Treated Metastatic Colorectal Cancer Subjects with KRAS p.G12C Mutation | Amgen | NCT05198934; 2021-004008-16 | |
| 305781 | Adult-caregiver Supported Positive psychology intervention to Increase Resilience (ASPIRE): developing and refining a caregiver-delivered positive psychology intervention to increase the resilience of children who have experienced adversities (Work Package 2) | Norfolk and Suffolk NHS Foundation Trust | ||
| 305798 | A Wearable Device for Cueing for the management of drooling, and monitoring of symptoms, in people with Parkinson’s | Northumbria Healthcare NHS Foundation Trust | ISRCTN59284050 | |
| 305919 | A Randomized, Double-blind, Placebo-controlled, Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of CSL312 in Subjects with Idiopathic Pulmonary Fibrosis | CSL Behring | NCT05130970; 2021-003162-12 | |
| 306258 | BEhaviour change to reduce Pain in Knee Osteoarthritis (BEPKO-2) - Feasibility study | University of Salford | ISRCTN25291958 | |
| 306483 | Avelumab Master Protocol: An Open-Label Continuation Study For Participants Continuing From Pfizer Sponsored Avelumab Clinical Studies | Pfizer | NCT05059522; 2021-002457-29 | |
| 306756 | Cognitive Stimulation Therapy for people with Intellectual Disabilities and Dementia (CST-IDD). A mixed methods feasibility study | North East London NHS Foundation Trust | ISRCTN88614460 | |
| 306797 | The effect of low-dose interleukin-2 on the immune landscape of human atherosclerotic plaques at single cell resolution | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | NCT05975554 | |
| 306840 | The effect of inorganic nitrate supplementation on brown fat activation and quantity in people with type 2 diabetes mellitus | Bournemouth University | NCT05342012 | |
| 306901 | An open-label, multicenter Phase I dose escalation study to characterize safety, tolerability, preliminary antitumor activity, pharmacokinetics and maximum tolerated dose of VIP152(BAY 1251152) in subjects with advanced cancer | Vincerx Pharma | NCT02635672; 2014-004808-30 | |
| 306930 | Comprehensive Assessment of Nutrition & Dietary Intervention in Hypermobile Ehlers Danlos Syndrome (hEDS/HSD): a personalised approach: Phase 2 & 3 | Queen Mary University of London | NCT05148039 | |
| 306939 | A pilot study of the ketogenic diet in bipolar disorder | University of Edinburgh | ISRCTN61613198 | |
| 306940 | An Open-label, Fixed Sequence Study in Healthy Subjects to Assess the Pharmacokinetics of AZD4831 when Administered Alone and in Combination with Rifampicin | AstraZeneca | 2021-005695-19 | |
| 306941 | An Open-label, Fixed Sequence Study in Healthy Subjects to Assess the Pharmacokinetics of AZD4831 when Administered Alone and in Combination with Itraconazole | AstraZeneca | 2021-005727-21 | |
| 307070 | A randomised, double-blind, placebo controlled, parallel group study in healthy adult volunteers to determine the safety and tolerability of pyronaridine (PYR) co-administered with piperaquine (PQP) under fasted conditions | Medicines for Malaria Venture | NCT05160363; 2021-005698-21 | |
| 307348 | Does domiciliary Nasal High Flow (NHF) therapy improve patient outcomes in Chronic Hypercapnic Respiratory Failure (CHRF) in the UK?: A pre and post interventional study | Royal Free London NHS Foundation Trust | NCT05167201 | |
| 307830 | Building positive self-concept in patients with psychosis: a single-case experimental design series testing a targeted psychological treatment | University of Oxford | ||
| 308063 | A Phase I, Single-site, Open-label, Partially Randomized Study to Evaluate the Relative Bioavailability and Pharmacokinetics of Evobrutinib Following Administration of Different Formulations in Healthy Participants | Merck KGaA | NCT05245396; 2021-005056-11 | |
| 308193 | A Phase I, open-label, fixed-sequence, two-period, crossover, drug-drug interaction study to evaluate the effect of multiple doses of ganaplacide and lumefantrine combination on the pharmacokinetics of midazolam, repaglinide, dextromethorphan, metformin, rosuvastatin and dolutegravir in healthy participants | Novartis | NCT05236530; 2021-000926-87 | |
| 308539 | “AveirTM DR i2i Study” Aveir Dual-Chamber Leadless i2i IDE Study | Abbott | NCT05252702 | |
| 310206 | A proof of principle (PoP) study to evaluate the ability of an experimental combination toothpaste formulation to protect sensitive teeth from dentine hypersensitivity | GlaxoSmithKline | NCT05243745 | Found through search but HRA not notified |
| 310749 | A multicentre Cluster Randomised pilot study comparing current Endoscopic (keyhole) vein harvesting training with Structured Training - The CREST trial | Manchester University NHS Foundation Trust | ISRCTN27493194 | |
| 310753 | A Fixed-Sequence, Drug-Drug Interaction Study Evaluating the Effect of the Cytochrome P450 3A Inhibitor Itraconazole on DNL343 in Healthy Participants | Denali | 2021-006382-37 | |
| 311335 | Evaluation of the diagnostic performance of the Rapid SARS-CoV-2 Antigen Test Card for Covid-19 | Sante Group | ISRCTN12682933 | |
| 1003784 | A Phase 2, Open-Label, Single-Arm, Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Sparsentan Treatment in Pediatric Subjects with Selected Proteinuric Glomerular Diseases (EPPIK) | Travere Therapeutics | NCT05003986; 2021-000621-27 | |
| 1003876 | A proof-of-concept randomised intervention trial to establish the impact of prasugrel versus aspirin on the proinflammatory and prothrombotic effects of experimental hypoglycaemia in type 2 diabetes | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN53525957; 2021-002906-28 | |
| 1003970 | A stratified randomised controlled trial to evaluate the clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit/hyperactivity disorder and a history of Psychosis or biPolar disordER | University of Birmingham | ISRCTN79796233; 2021-000302-21 | |
| 1003972 | FEDORA: A phase II study to evaluate the tolerability, safety and activity of fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis | University of Birmingham | ISRCTN88102629; 2021-004056-42 | |
| 1003976 | A Randomized, Double-blind, Placebo-controlled, Repeat-dose, Multicenter Trial to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients with Diffuse Cutaneous Systemic Sclerosis | Horizon Therapeutics | NCT04781543; 2020-005764-62 | |
| 1003994 | A prospective, open-label, genotype-match controlled, multicenter clinical trial to investigate the efficacy and safety of intra-amniotic ER004 as a prenatal treatment for male subjects with X-linked hypohidrotic ectodermal dysplasia (XLHED) | EspeRare Foundation | NCT04980638; 2021-002532-23 | |
| 1004044 | A Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of the DNA Polymerase Theta Inhibitor ART4215 Administered Orally as Monotherapy and in Combination to Patients with Advanced or Metastatic Solid Tumours | Artios | NCT04991480; 2021-002574-69 | |
| 1004059 | A Phase 2, Multicenter, Randomized, Double-blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of BMS-986256 in Participants with Active Systemic Lupus Erythematosus | Bristol-Myers Squibb | NCT04895696; 2019-004021-25 | |
| 1004066 | Pembrolizumab in combination with R-ICE chemotherapy in relapsed/refractory diffuse large B-cell lymphoma | University Hospital Southampton NHS Foundation Trust | ISRCTN86607306; NCT05221645; 2018-001886-18 | |
| 1004073 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Sotatercept When Added to Maximum Tolerated Background Therapy in Participants With Pulmonary Arterial Hypertension (PAH) World Health Organization (WHO) Functional Class (FC) III or FC IV at High Risk of Mortality | Acceleron Pharma | NCT04896008; 2021-001498-21 | |
| 1004084 | A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) versus Bendamustine plus Rituximab in Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-313) | Loxo Oncology | NCT05023980; 2021-001234-20 | |
| 1004109 | A Pivotal Trial Of Envafolimab, And Envafolimab In Combination With Ipilimumab, In Patients With Advanced Or Metastatic Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma Who Have Progressed On Prior Chemotherapy | TRACON Pharma | NCT04480502; 2021-004319-22 | |
| 1004175 | A 6-month multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety and PK/PD of an age-and body weight-adjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children, 6 months to <18 years of age, with chronic kidney disease and proteinuria | Bayer | NCT05196035; 2021-002071-19 | |
| 1004197 | Phase 2, Double-blind, Randomized, Placebocontrolled Study to Evaluate the Effects of Sotatercept versus Placebo-Controlled for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) due to Heart Failure with Preserved Ejection Fraction (HFpEF) | Acceleron Pharma | NCT04945460; 2021-003020-32 | |
| 1004198 | Open-label study investigating efficacy, safety and pharmacokinetics of concizumab prophylaxis in children below 12 years with haemophilia A or B with or without inhibitors | Novo Nordisk | NCT05135559; 2020-000504-11 | |
| 1004213 | A Modular Phase II, Open-label, Multicentre Study to Assess AZD4573 Efficacy and Safety as Monotherapy or in Combination with Anti-cancer Agents in Patients with Relapsed/Refractory Peripheral T-cell Lymphoma or classical Hodgkin Lymphoma | AstraZeneca | NCT05140382; 2021-002570-54 | |
| 1004224 | Phase III, Double-blind, Randomised, Placebo-Controlled, International Study to Assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Participants with EGFR mutation positive Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumour Resection | AstraZeneca | NCT05120349; 2021-004135-89 | |
| 1004228 | A Two-Part, Seamless, Multi-Center, Randomized, Placebo-Controlled, Double-Blind Study To Investigate The Safety, Tolerability, Pharmacokinetics, Pharmacodynamics And Efficacy Of Ro7204239 In Combination With Risdiplam (Ro7034067) In Ambulant Patients With Spinal Muscular Atrophy | Roche | NCT05115110; 2021-003417-19 | |
| 1004246 | A Phase II, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study To Evaluate The Safety, Efficacy, And Pharmacodynamics Of 52 Weeks Of Treatment With Basmisanil In Children With Dup15Q Syndrome | Roche | NCT05307679; 2021-003791-13 | |
| 1004247 | A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication | Alnylam | NCT05103332; 2021-003776-13 | |
| 1004257 | A Phase III, Randomized, Open-Label, Multicenter Study Of Lurbinectedin In Combination With Atezolizumab Compared With Atezolizumab As Maintenance Therapy In Participants With Extensive-Stage Small-Cell Lung Cancer (Es-Sclc) Following First-Line Induction Therapy With Carboplatin, Etoposide And Atezolizumab | Roche | NCT05091567; 2021-001930-20 | |
| 1004258 | A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of MEDI3506 in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (TITANIA) | AstraZeneca | NCT05158387; 2021-003771-34 | |
| 1004290 | The FINESSE Study: A randomised phase 3 trial evaluating the role of Finasteride in increasing compliance with Active surveillance, in men with a new diagnosis of low and intermediate risk prostate cancer, when compared with usual care | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN16867955; 2021-004004-17 | |
| 1004301 | A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Lumasiran in Patients with Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate Levels | Alnylam | NCT05161936; 2021-001519-10 | |
| 1004313 | A Phase IIb, Randomised, Double Blind, Placebo Controlled, Parallel Group, Multicentre Dose Ranging Study of a Subcutaneous Anti-OX40L Monoclonal Antibody (KY1005) in Moderate to Severe Atopic Dermatitis | Kymab | 2021-000725-28 | |
| 1004329 | A Phase 3, Multi-center, Open-label Extension Study to Assess the Safety and Efficacy of Viltolarsen in Ambulant Boys with Duchenne Muscular Dystrophy (DMD) | NS Pharma | NCT04768062; 2021-000122-10 | |
| 1004334 | An Open-Label, Phase I Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Preliminary Efficacy Of Ro7443904 In Combination With Glofitamab In Participants With Relapsed/Refractory B-Cell Non-Hodgkin’S Lymphoma | Roche | 2021-003757-33 | |
| 1004390 | A double-blind, randomized, Phase 1, single ascending dose study to evaluate the safety, tolerability and pharmacokinetic profile of intranasal BPL-003 (5-Methoxy-N,N-dimethyltryptamine benzoate) in healthy subjects | Beckley Psytech | NCT05347849; 2021-006225-22 | |
| 1004421 | A 2-year randomized, 3-arm, double-blind, non-inferiority study comparing the efficacy and safety of ofatumumab and siponimod versus fingolimod in pediatric patients with multiple sclerosis followed by an open-label extension | Novartis | NCT04926818; 2020-002700-39 | |
| 1004424 | A Single-Dose Study To Assess The Pharmacokinetics, Tolerability, And Food Effect Of Ptc923 In Healthy Japanese And Non-Japanese Subjects | PTC Therapeutics | 2021-005897-25 | |
| 1004506 | A Phase 2a, Randomised, Double-blind, Placebo-controlled Study to Evaluate the Prophylactic Efficacy, Safety and Tolerability of INNA-051 in Healthy Adult Participants Challenged with Influenza A/Perth/16/2009 (H3N2) Virus | ENA Respiratory | NCT05255822; 2021-005701-27 | |
| 1004587 | A Phase II, Multicenter, Randomized, Double Masked, Active Comparatorcontrolled Study To Investigate Theefficacy, Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Ro7200220 In Combination With Ranibizumb Administered Intravitreally In Patients With Diabetic Macular Edema | Roche | NCT05151744; 2021-004390-31 | |
| 1004619 | A Phase II, Multicenter, Randomized, Double Masked, Active Comparatorcontrolled Study To Investigate The Efficacy, Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Ro7200220 Administered Intravitreally In Patients With Diabetic Macular Edema | Roche | NCT05151731; 2021-003756-16 | |
| 1004698 | A pragmatic, multi-centre, cluster-randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID | University College London | ISRCTN10665760; 2021-006598-47 |
Clinical trials given a REC favourable opinion in February 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 226746 |
A study to establish and modulate the relationship between the microbiome-microglia axis in ALS: an observational study with a subsequent randomised, double-blind, placebo-controlled, faecal microbiota transplant intervention (BIOMAX-ALS) |
University College London | 2017-004841-26 | |
| 262072 | A Single Centre, Prospective, Single Arm Open Label Case Series of the TRICENTO, a Transcatheter Tricuspid Valved Stent Graft for Reduction of Tricuspid Regurgitation and Improved Patient Reported Outcomes in Patients with Carcinoid Heart Disease | Queen Mary University of London | NCT05064514 | |
| 268597 | Personalised assessment and intervention packages for children with conduct problems in Child Mental Health Services: A randomised controlled trial | Tavistock & Portman NHS Foundation Trust | ISRCTN15678369 | |
| 270767 | ACcomplisH: A Phase 2, multicenter, double-blind, randomized, placebo-controlled, dose escalation trial evaluating safety, efficacy, and pharmacokinetics of subcutaneous doses of TransCon CNP administered once weekly for 52 weeks in prepubertal children with achondroplasia followed by an Open-Label Extension Period | Ascendis Pharma | 2019-002754-22 | |
| 271218 | Randomised Double-Blind Placebo-Controlled Phase 3 Trial Of Triumeq In Amyotrophic Lateral Sclerosis | King's College London and South London and Maudsley NHS Foundation Trust | ISRCTN88446415; 2020-005069-15 | |
| 280257 | A randomised controlled trial to assess the clinical-, technical- and cost-effectiveness of a cloud-based, ARtificially Intelligent image fusion system in comparison to standard treatment to guide endovascular Aortic aneurysm repair (ARIA) | King’s College London | ISRCTN13832085 | |
| 280567 | STABILITY 2: ACL Reconstruction +/- Lateral Tenodesis with Patellar vs. Quad Tendon | University Hospital Coventry & Warwickshire | NCT03935750 | |
| 286722 | The use of PET-MRI scan in radiotherapy planning of patients with head and neck cancer: A single centre pilot study | Sheffield Teaching Hospitals NHS Foundation Trust | NCT06032663 | |
| 286908 |
PNEUMACRIT (Preterm Neonate / neonatal Embedded Universal Microelectronic wearable Acquisition for Cardio Respiratory Intensive Therapy) |
NHS Greater Glasgow & Clyde | ||
| 288415 | Pharmacokinetic study of a novel lipid formulation of cannabidiol compared to a standard formulation | King’s College London | ISRCTN18067579; NCT05032807; 2020-004551-33 | |
| 289043 | Prospective, Randomized Trial Comparing En Bloc with Piecemeal Resection of Neoplasia in Barrett’s Oesophagus | University Hospital Hamburg-Eppendorf | NCT03427346 | |
| 291873 | Shear Load In-shoe Plantar Sensing/sTRain analysEs And Mapping in diabetic foot ulcers: SLIPSTREAM | Leeds Teaching Hospitals NHS Trust | NCT05687643 | |
| 292091 | Use of a novel SUBCUTaneous preparation of furosemide to facilitate early supported discharge of patients with Heart Failure: a multicentre, phase II, randomised, parallel group, active comparator controlled trial | NHS Greater Glasgow & Clyde | 2020-004833-19 | |
| 293938 | Robotic versus Laparoscopic Colon - a Randomized Trial: An international randomised phase II trial comparing robotic-assisted right hemicolectomy versus laparoscopic-assisted hemicolectomy for resection of adenocarcinoma of the caecum, ascending or proximal transverse colon | Australasian Gastro-Intestinal Trials Group (AGITG) | ACTRN12620001378910 | |
| 295131 | To assess the postoperative changes in fibrinolysis and the utility of tranexamic acid in patients with inherited bleeding disorders | Guy's & St Thomas' NHS Foundation Trust | Withdrawn before any participants recruited | |
| 295564 | Invest-CTO: Effectiveness and Safety of a Planned Investment Procedure in High-Risk CTO PCI | Haukeland University Hospital | NCT04774913 | |
| 295616 | Safety and Performance of FibroFix Cartilage P Implant and Drill Set for Articular Cartilage Repair within the Knee Joint | Orthox | ISRCTN13615940; NCT05560490 | |
| 295973 | A randomised double-blind, placebo-controlled, trial of rhythmic 10Hz median nerve stimulation for the suppression of the urge-to-tic and reduction of tics in individuals with Tourette syndrome and chronic tic disorder | Nottingham University Hospitals NHS Trust | NCT05269953 | |
| 296205 | A Sensorimotor Prosthesis of the Upper Limb | University Hospitals Coventry & Warwickshire NHS Trust | NCT05220552 | |
| 296584 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study Evaluating the Efficacy and Safety of Subcutaneous Anifrolumab in Adult Patients with Systemic Lupus Erythematosus | AstraZeneca | 2020-004529-22 | |
| 296640 | PROSpECT-PRIOR-2-CHEMO: A pilot RCT efficacy, mechanistic & process evaluation of a novel dental intervention PRIOR (Proactive Intensive Oral Review & Treatment) in patients scheduled for chemotherapy for myeloma-ASCT, breast or colorectal cancer to mitigate febrile episodes and oral mucositis (OM) | University of Leeds | Currently registering | |
| 296694 | POSE-D: Providing Online guided Self-help for Eating disorders in adults with type 2 Diabetes: a pilot study | University of Leeds | ISRCTN12377526 | |
| 298619 | STOP-OHSS (Shaping and Trialling Outpatient Protocols for Ovarian HyperStimulation Syndrome): A randomised controlled trial to assess the clinical and cost-effectiveness of active management of Ovarian HyperStimulation Syndrome | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN71978064 | |
| 298679 | Feasibility of slow continuous ultrafiltration for deresuscitation in critically ill patients | Belfast Health and Social Care Trust | NCT05431491 | Found through search but HRA not notified |
| 299011 | Erector Spinae Plane blocks for the Early Analgesia of Rib fractures in trauma: a multicentre pilot randomised controlled trial with feasibility and embedded qualitative assessment | Nottingham University Hospitals NHS Trust | ISRCTN49307616 | |
| 300047 | Early diAgnosis Real-Time Healthcare System for CANcer Trial (EARTH SCAN) | University College London | NCT05064124 | |
| 300440 | Evaluation of circulating endothelial inflammatory biomarkers in response to GLP-1 agonist Semaglutide in acute pulmonary embolisms | Imperial College London | ||
| 300541 | Double blind comparison of optimised Deep Brain Stimulation for severe Tourette syndrome (Op-TICS) | University College London | ISRCTN17008820 | |
| 300550 | Impact of Semaglutide in Amyloid Positivity | University of Oxford | ISRCTN71283871; 2021-003328-34 | |
| 300605 | Non-Invasive Brainstem Modulation for the Treatment of Non-Motor Symptoms in Parkinson’s Disease: A Randomized Controlled Trial (RCT) and an Open Label Extension (OLE) Study | Scion NeuroStim | NCT04797611 | |
| 300650 | Improving in-patient experiences of autistic adults by identifying and increasing knowledge about sensory reactivity differences | University of Reading | Sponsor no longer considers this a clinical trial | |
| 301042 | Evaluation of the feasibility of a RCT of Empowered Conversations: a training to enhance relationships and communication between family carers and people living with dementia | University of Manchester | ISRCTN15261686 | |
| 301118 | Inhibition of Bradykinin in SARS-CoV-2 infection with Icatibant (ICASARS) | Belfast Health and Social Care Trust | NCT05407597; 2021-005851-35 | |
| 301120 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined with Abiraterone Acetate and Prednisone (AA-P) versus Placebo Combined with AA-P as First-Line Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer | Jiangsu Hengrui Pharmaceuticals | NCT04691804; 2020-006063-28 | |
| 301163 | An IPA exploration of parents’ experiences of their child receiving a diagnosis of autism using a reframed approach | NHS Greater Glasgow & Clyde | ||
| 301384 | A Phase 2, Open-label, Multicenter, Cohort Study of Nemvaleukin Alfa (ALKS 4230) Monotherapy Administered Subcutaneously in Patients With Advanced Cutaneous Melanoma or Intravenously in Patients With Advanced Mucosal Melanoma Who Have Previously Received Anti-PD-[L]1 Therapy - ARTISTRY-6 | Alkermes | NCT04830124; 2021-001557-31 | |
| 301757 | A prospective, multi center, international, open label study of the use of Magseed Pro® markers and Sentimag® Gen3 system to localise breast lesions and suspicious/biopsy-proven positive lymph nodes in breast cancer patients | Endomagnetics | NCT05142787 | |
| 302654 | Empagliflozin to prevent worsening of left ventricular volumes and systolic function after myocardial infarction (EMPRESS-MI): a multi-centre, randomized, placebo-controlled trial | NHS Greater Glasgow & Clyde | NCT05020704; 2021-006086-38 | |
| 302657 | Actuate 1902: Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK - 3β) Inhibitor, as a Single Agent or with Irinotecan, Temozolomide/Irinotecan or Cyclophosphamide/Topotecan in Pediatric Patients with Refractory Malignancies | Actuate Therapeutics | NCT04239092; 2021-003552-17 | |
| 303373 | The Bedside Evaluation of Sensitive Troponin 2 Study | Manchester University NHS Foundation Trust | ISRCTN48377837 | |
| 303611 | A Trial investigating the Accuracy of Continuous Glucose Monitor systems (“Supersapiens” Abbott Libre Sense and Dexcom G6) During Exercise in People with Normal Glucose Tolerance (SuperComEx) | Imperial College London and Imperial College Healthcare NHS Trust | NCT06034574 | Found through search but HRA not notified |
| 304283 | A Randomised, Double-Blind, Placebo-Controlled Phase 3 Clinical Trial to Assess the Efficacy and Safety of Lebrikizumab in Combination With Topical Corticosteroids in Adult and Adolescent Patients With Moderate-To-Severe Atopic Dermatitis That Are Not Adequately Controlled With Cyclosporine or For Whom Cyclosporine is Not Medically Advisable | Almirall | 2021-002967-23 | |
| 304466 | Improving the accuracy of chronic kidney disease monitoring using postal finger prick iohexol measured GFR | Northern Care Alliance NHS Foundation Trust | ISRCTN14717076 | |
| 304570 | Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation (RESOLVE-MR) (Tendyne™ PMCF Study) | Abbott | NCT04818502 | |
| 304738 | Evaluation of Joint Academy Digital Treatment Programme Intervention for Osteoarthritis Patients in the North of Scotland | NHS Highland | ||
| 304800 | Phase 1/2 FIH Study Of Regn5458 (Anti-Bcma X Anti-Cd3 Bispecific Antibody) In Patients With Relapsed Or Refractory Multiple Myeloma | Regeneron | NCT03761108; 2018-003188-78 | |
| 304857 | intEgrating Smoking Cessation treAtment into usual online Psychological care for people with common mEntal illness: an Online randomised feasibility and pilot study (ESCAPE-O) | University of Bath | ISRCTN10612149 | |
| 305026 | A Pilot of a Co-Produced Intervention to Increase Hope and Connection for People with Eating Disorders | Sussex Partnership NHS Foundation Trust | Withdrawn before any participants recruited | |
| 305058 | A prospective investigation of the concordance of smartphone-based self monitoring, imaging, and blood-based biomarkers with clinical disability in patients with multiple sclerosis within the TONiC program | Roche | ISRCTN11088592 | |
| 305381 | A Phase 1b Study of the MALT1 Inhibitor JNJ-67856633 and Ibrutinib in Combination in Relapsed or Refractory B cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia | Janssen-Cilag International | NCT04876092; 2021-000191-12 | |
| 305425 | A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety and Tolerability of QR-421a in Subjects with Retinitis Pigmentosa (RP) due to Mutations in Exon 13 of the USH2A Gene with Advanced Vision Loss (Sirius) | ProQR Therapeutics | NCT05158296; 2021-002729-74 | |
| 305462 | The Cognitive Daisy (COG-D) in care homes to support person-centred care: A feasibility CRT | University of Lincoln | ISRCTN15208844 | |
| 305508 | Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR guided revascularization | European Cardiovascular Research Institute (ECRI) | NCT04931771 | |
| 305542 | A Pragmatic Proof of Concept Study to Evaluate the Effect of Dupilumab on Mannitol Challenge in Severe Asthma with Type 2 Inflammation | University of Dundee | ISRCTN70810039; 2021-005593-25 | |
| 305557 | Effectiveness and cost effectiveness of an automated text message intervention for weight management in postpartum women with overweight or obesity: the Supporting MumS Randomised Controlled Trial | Queen's University Belfast | ISRCTN16299220 | |
| 305610 | Should we ligate haemodialysis fistulas in patients after they have been transplanted successfully: the COBALT feasibility study (Cardiorespiratory Optimisation By AVF Ligation after Transplantation) | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | ISRCTN49033491 | |
| 305622 | A Randomized, Double Blind, Multicenter, Multinational, Placebo Controlled, Parallel Group, Single Dose, Adaptive Efficacy And Safety Study Of Glenzocimab Used As An Add-On Therapy On Top Of Standard Of Care In The 4.5 Hours Following An Acute Ischemic Stroke | Acticor Biotech | NCT05070260; 2021-002148-56 | |
| 305714 | A Phase 3, Multicenter, Open-label, Long-term, Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects with Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP) | Mitsubishi Tanabe Pharma Development America (MTDA) | NCT04402489; 2021-001831-17 | |
| 305840 | PATHWAY-RCT: Preventing Admission To Hospital with Attr cardiomyopathy using Remote Cardiac Telemonitoring | Richmond Research Institute | NCT05098665 | Found through search but HRA not notified |
| 305911 | A Multi-Center, Randomized, Double-Blinded Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 versus Placebo in Adults with Relapsing Multiple Sclerosis (ENSURE-2) | Immunic Therapeutics | NCT05201638; 2021-000029-28 | |
| 306045 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial: Multiple Independent Sub-studies of Setmelanotide in Patients with POMC/PCSK1, LEPR, NCOA1 (SRC1), or SH2B1 Gene Variants in the Melanocortin-4 Receptor Pathway | Rhythm Pharmaceuticals | NCT05093634; 2021-002873-24 | |
| 306188 | Rollover Study; Multicentre, Phase III, Open-label Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years with Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed Study PVO-1A-301 or PVO-1A-202/PVO-1A-204 and May Benefit from Palovarotene Therapy | Ipsen | NCT05027802; 2021-002244-70 | |
| 306383 | A Multi-arm Phase 1b Study of Talquetamab With Other Anticancer Therapies in Participants with Multiple Myeloma | Janssen-Cilag International | NCT05050097; 2020-004502-55 | |
| 306439 | Phase 1 Study Evaluating the Safety and Immunogenicity of COVI-VAC as a Booster Dose in Adults Previously Vaccinated Against COVID-19. (21-012) | Codagenix | NCT05233826; 2021-005909-27 | |
| 306514 | Open-Label, Global, Multicenter, Randomized, Phase 3 Study of Sacituzumab Govitecan Versus Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Progression on or After Platinum-Based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy | Gilead | NCT05089734; 2021-003578-30 | |
| 306652 | Investigating the application of Narrative Exposure Therapy (NET) to reduce Symptoms of Traumatic Stress in Cancer Patients not in active treatment: a naturalistic single case study series | University of Nottingham | NCT05272553 | |
| 306675 | Feasibility of implementation of a novel risk calculator informed by natural language processing of electronic health records in the Clinical Records Interactive Search (CRIS) system to enhance routine detection, early intervention and targeted prevention in people at high risk for severe mental illness (SMI) | Sussex Partnership NHS Foundation Trust | Sponsor no longer considers this a clinical trial | |
| 306711 | Pilot clinical study to evaluate efficacy of a professionally delivered fluoride varnish on erosive tooth wear in an In-Situ model | Colgate-Palmolive | NCT06136754 | |
| 306761 | Pharyngeal Electrical stimulation for Acute Stroke dysphagia Trial (PhEAST) | University of Nottingham | ISRCTN98886991 | |
| 306799 | Multimodal Augmented Reality for Operative Guidance in Oncoplastic Breast Surgery (MAROG - OBS) | Imperial College Healthcare NHS Trust | ||
| 306837 | A phase 1-2 multicenter study (2 stages) to evaluate the safety and efficacy of intravenous GNT0006, adeno-associated viral vector carrying the FKRP gene, in patients with FKRP-related limb-girdle muscular dystrophy (LGMD R9, formerly LGMD2I) | Atamyo Therapeutics | NCT05224505; 2021-004276-33 | |
| 306846 | An open label trial of BI 765063 in combination with BI 754091 (ezabenlimab) alone or with BI 836880, chemotherapy, or cetuximab, in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) or hepatocellular carcinoma (HCC) | Boehringer Ingelheim | NCT05249426; 2021-003473-59 | |
| 306964 | Exploring Pleural Effusion Research Tools and Drainage Study | North Bristol NHS Trust | ||
| 307764 | A feasibility, multicentre randomised control trial assessing the treatment options for patient with major low anterior resection syndrome to establish a Pathway Of Low Anterior Resection syndrome relief after Surgery | Cardiff & Vale University Health Board | ISRCTN10442425; NCT05319054 | |
| 307766 | Glasses in Classes Pathfinders | University of Bradford | Sponsor no longer considers this a clinical trial | |
| 307879 | Determination of feasibility of reversible conduction block generated using StimWave Peripheral nerve stimulator in treatment of focal spasticity and the stimulation parameters for the same. | Walton Centre NHS Foundation Trust | ||
| 308088 | A Clinical Evaluation of the DiamondTemp™ System TempeRAture Controlled Ablation for the Treatment of Ventricular Tachycardia. | Medtronic | NCT03334630 | Found through search but HRA not notified |
| 308690 | Community-based transcranial direct current stimulation treatment for bipolar depression | University of East London | NCT05436613 | Found through search but HRA not notified |
| 308893 | Clinical Assessment of Essential Remote Monitoring Functions in Pacemakers | MicroPort CRM | NCT05165095 | |
| 309011 | Multicentric, randomized, comparative clinical study on the evaluation of the efficacy and safety of Neovis® Total Multi versus Systane® Balance on the treatment of ocular dryness associated with meibomian gland dysfunction | Eurofins | NCT05191771 | |
| 309115 | Alternative CErvical Screening (ACES) Over 65's | University of Manchester | ISRCTN39388293 | |
| 309287 | Trialling an optimised social groups intervention in services to enhance social connectedness and mental Health in vulnerable young people: A feasibility study | University of Sussex | ISRCTN12505807 | |
| 309305 | Treating Post-Operative Thirst with Flavoured Ice Lollies or Water - a comparative study to improve post-operative discomfort | Gloucestershire Hospitals NHS Foundation Trust | NCT06014216 | |
| 310020 | A feasibility study to assess the design of a multi-centre randomised controlled trial of the clinical and cost-effectiveness of a caregiving intervention for people with chronic musculoskeletal pain | University of East Anglia | ISRCTN78169443 | |
| 310124 | Prospective Pilot/Feasibility study on the diagnostic applicability of a Computer-aided detection device (CADU system) for detection of neoplasia in Barrett’s Oesophagus and the use of bio-impedance in risk-stratification | Leeds Teaching Hospitals NHS Trust | ||
| 310265 | A randomised controlled feasibility trial protocol comparing face-to-face and video delivery of a specialist preoperative clinic for older people | North Bristol NHS Trust | ISRCTN95833238 | |
| 310422 | Increasing physical activity levels using e-bikes to enhance breast cancer survival: A randomised pilot study | University of Bristol | ISRCTN39112034 | |
| 1003734 | A Phase III study of JR-141 in Mucopolysaccharidosis type II (Hunter Syndrome) patients. | JCR Pharmaceuticals | NCT04573023; 2020-003200-14 | |
| 1003737 | An Open-label, Randomized, Phase 3 Study of MK-6482 in Combination with Lenvatinib (MK-7902) vs Cabozantinib for Treatment in Participants with Advanced Renal Cell Carcinoma Who Have Progressed After Prior Anti-PD-1/L1 Therapy | MSD | NCT04586231; 2020-002075-35 | |
| 1003843 | A pilot Study of the Use of 129Xe and 1H MRI to measure the Modulation of Eosinophil-Related inflammation by mepolizumab In COPD (SUMMER) | Sheffield Teaching Hospitals NHS Foundation Trust | NCT05138250; 2021-002901-84 | |
| 1003910 | An Open Label Randomised Trial to Assess the Efficacy of Post-Operative Ferric Maltol Vs Standard Care for Anaemia Following Colorectal Cancer Surgery | The Royal Wolverhampton NHS Trust | ISRCTN12290106; 2021-006004-32 | |
| 1003989 | Open-label Uncontrolled Trial to Evaluate Pharmacokinetics, Pharmacodynamics, Safety, and Activity of Efgartigimod in Children From 2 to Less Than 18 Years of Age With Generalized Myasthenia Gravis | argenx | NCT04833894; 2020-005841-18 | |
| 1003996 | A Randomized, Blinded, Placebo-controlled, Phase 2 Study of INBRX-109 in Unresectable or Metastatic Conventional Chondrosarcoma | Inhibrx | NCT04950075; 2021-002635-35 | |
| 1004081 | A Phase 1b/2, multicenter, single arm study of RBN-2397 in combination with pembrolizumab in patients with Squamous Cell Carcinoma of the Lung (SCCL) | Ribon Therapeutics | NCT05127590; 2021-003829-30 | |
| 1004117 | A Phase 1b Randomized, Double-Blind, PlaceboControlled, Multiple-Ascending Dose Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of ACE-1334 Plus Standard of Care in Participants with Systemic Sclerosis | Acceleron Pharma | NCT04948554; 2021-001004-15 | |
| 1004135 | A Phase 2, Double-Masked, Placebo-Controlled, Dose Range Finding Study of Danicopan (ALXN2040) in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) | Alexion | NCT05019521; 2021-001198-22 | |
| 1004142 | A 52-week, open-label, single arm study to investigate the efficacy and safety of mepolizumab SC in participants aged 6 to 17 years with hypereosinophilic syndrome | GlaxoSmithKline | NCT04965636; 2021-000933-15 | |
| 1004150 | A 2-stage, Adaptive, Randomised, Double-blind, Placebo-controlled, Multicentre Study to Evaluate Dose and Treatment Effect of Pentosan Polysulfate Sodium Compared with Placebo in Participants with Knee Osteoarthritis Pain | Paradigm | NCT04809376; 2021-004030-11 | |
| 1004155 | A Phase 1b Open-Label Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination with Other Anti-cancer Agents in Patients with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7) | ADC Therapeutics | NCT04970901; 2021-001071-16 | |
| 1004165 | A randomised open-label phase III trial of REduced Frequency pembrolizumab immuNothErapy for first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) utilising a novel multi-arm frequency-response optimisation design | Imperial College London | ISRCTN70247820; NCT05085028; 2021-004908-18 | |
| 1004166 | A Randomised Placebo-Controlled Trial of Antenatal Corticosteroids for Planned Birth in Twins: STOPPIT-3 | University of Edinburgh | ISRCTN12345678; NCT12345678; 2021-002876-38 | |
| 1004177 | A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Apremilast in Children From 5 to Less Than 18 Years of Age With Active Juvenile Psoriatic Arthritis (PEAPOD) | Amgen | NCT04804553; 2019-002788-88 | |
| 1004199 | A Phase 3b/4, Double-masked, Randomized, International, Parallel-assignment, Multicenter Trial in Patients with Thyroid Eye Disease to Evaluate the Safety and Tolerability of Different Dosing Durations of Teprotumumab | Horizon Therapeutics | NCT05002998; 2020-005999-36 | |
| 1004202 | A randomized, open-label, parallel-group, 18-month Phase 3 study to evaluate the effect of venglustat compared with usual standard of care on left ventricular mass index in participants with Fabry disease and left ventricular hypertrophy | Sanofi-Aventis | NCT05280548; 2021-002320-20 | |
| 1004226 | A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of SBT-272 Administered via Subcutaneous Injection in Healthy Subjects | Stealth BioTherapeutics | ISRCTN12414966; 2021-004584-27 | |
| 1004307 | A Phase 2, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, Multicenter Trial to Evaluate the Safety and Tolerability, Efficacy, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of 2 Dose Regimens of ARGX-117 in Adults With Multifocal Motor Neuropathy | argenx | NCT05225675 ; 2021-003302-50 | |
| 1004315 | A Phase I study for formulation selection and subsequent optimization of two different oral formulations of Nintedanib in healthy male subjects (open-label, randomised, single-dose study in three parts) | Boehringer Ingelheim | NCT05262751; 2021-003152-16 | |
| 1004337 | A multicentre, open-label, non-randomized, phase 1a/1b study of NG 641, a tumour-selective and transgene-expressing adenoviral vector, in combination with nivolumab in patients with metastatic or advanced epithelial tumours (NEBULA) | Akamis Bio | NCT05043714; 2021-005570-26 | |
| 1004344 | A Phase II/III, multicentre, 8-week run-in phase followed by a 12- week, prospective, parallel-group, double-blind, randomized withdrawal, placebo-controlled study, with a 52 week open label extension, to evaluate the efficacy and safety of daily 1.5 to 3.5 mg basimglurant in patients with pain associated with trigeminal neuralgia with suboptimal response to their current anti-pain therapy | Noema Pharma | NCT05217628; 2021-001866-39 | |
| 1004368 | An Open-Label, Randomised, Phase 4 Study of Continuing Sodium Zirconium Cyclosilicate (SZC) after Discharge in Participants with Chronic Kidney Disease treated for Hyperkalaemia | AstraZeneca | NCT05347693; 2021-003527-14 | |
| 1004426 | A controlled, open-label post-authorisation efficacy and safety study in imlifidase desensitised kidney transplant patients with positive crossmatch against a deceased donor prior to imlifidase treatment, including non-comparative registry and concurrent reference cohorts | Hansa Biopharma | NCT05369975; 2021-002640-70 | |
| 1004469 | Adjuvant encorafenib & binimetinib vs. placebo in fully resected stage IIB/C BRAF V600E/K mutated melanoma: a randomized triple-blind phase III study in collaboration with the EORTC Melanoma Group | Pierre Fabre | NCT05270044; 2021-004310-19 | |
| 1004519 | A Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study of Subcutaneously and Intravenously Administered ALXN1910 in Healthy Adult Participants | Alexion | NCT05307978; 2021-005847-58 | |
| 1004521 | Roll Over StudY for Patients Who Have Completed a Previous Oncology Study with Durvalumab and Are Judged by the Investigator to Clinically Benefit From Continued Treatment | AstraZeneca | NCT05303532; 2021-003031-29 | |
| 1004536 | A Phase 1, Randomized, Double-blind, Placebo-controlled, Single- and Multiple-dose Escalation Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Oral VX‑708 in Healthy Subjects | Vertex | 2021-005559-35 | |
| 1004538 | A FIRST-IN-HUMAN, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE ASCENDING DOSE STUDY TO ASSESS THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF INS-3001 IN HEALTHY SUBJECTS AND PATIENTS WITH MODERATE AORTIC VALVE STENOSIS | Inositec | ISRCTN76722400Â ; 2021-001969-20 | |
| 1004561 | A Phase 1, Open-Label, Dose Finding Study of CC-95251 Alone and in Combination with Antineoplastic Agents in Subjects with Acute Myeloid Leukemia and Myelodysplastic Syndromes | Celgene | NCT05168202; 2021-002799-38 | |
| 1004578 | A Phase 1/2, Randomized, Double-blind, Placebo-controlled, Single Ascending and Multiple Dose Study of the Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of ALN-XDH in Healthy Adult Subjects and Adult Patients with Gout | Alnylam | NCT05256810; 2021-005773-68 | |
| 1004612 | Efficacy and safety of COMP360 psilocybin therapy in anorexia nervosa: a proof-of-concept study | COMPASS Pathfinder | NCT05481736; 2021-006233-19 | |
| 1004636 | Open-Label Study to Investigate Pharmacokinetics, Mass Balance and Metabolite Profiles of NRD135S.E1 in Healthy Adult Male Volunteers | Novaremed | ISRCTN51059297; 2021-006502-76 | |
| 1004656 | A randomised phase 2 study of ASTX727 versus best supportive care in MDS/MPN Overlap Syndromes | University of Birmingham | ISRCTN30808508; 2021-004585-35 | |
| 1004766 | A Phase 3 Open-label Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Triple Combination Therapy in Cystic Fibrosis Subjects 2 Years and Older | Vertex | NCT05153317; 2020-002239-31 | |
| 1004941 | A Phase 2/3, Randomized, Observer-blind, Active-controlled, Multicenter Study to Evaluate the Immunogenicity and Safety of mRNA-1273.529 (B.1.1.529, Omicron Variant) in Comparison with mRNA-1273 (Prototype) Booster Vaccine | ModernaTX | ISRCTN99890480; 2022-000063-51 | |
| 1004956 | A multi-part, adaptive Phase 1, first time in human, single centre study in human volunteer subjects to assess safety, tolerability, Pharmacokinetics (PK) of single ascending (SAD) and multiple ascending doses (MAD) of MTX652, including optional study parts to assess effect of food, formulation, potential drug-drug interaction liability and a comparison of elderly versus non-elderly participants | Mission Therapeutics | 2021-006764-24 | |
| 309578/312087 | Evaluation of a nutritionally complete, plant-based, high energy, high protein, enteral tube feed in adults | Nutricia | NCT05411848 |
Clinical trials given a REC favourable opinion in March 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 239047 | Does relative hypoglycaemia &/or sleep disturbance contribute to the lethargy observed in Addison’s disease | Leeds Teaching Hospitals NHS Trust | NCT05515055 | |
| 253369 | SMART composite (Self-bonding Material for Atraumatic Restorative Treatment) restoration of children’s primary molar teeth after minimal caries removal: Class IIa device in a single site, single arm study | University College London | ISRCTN14233369 | |
| 257601 | InGReS: Intra-treatment Image Guided Adaptive Radiotherapy Dose-escalation Study - a Phase 1 multicentre feasibility study | Guy's & St Thomas' NHS Foundation Trust | NCT05393297 | Found through search but HRA not notified |
| 269464 | The feasibility of a multi-phasic exercise-based intervention utilising the Health Action Process Approach and wearable technology in women before and after surgery for breast cancer | Royal Derby Hospital | NCT05901142 | |
| 274384 | Reducing the impact of diabetic foot ulcers (REDUCE): A effectiveness and cost-effectiveness Randomised Controlled Trial | University Hospitals Derby & Burton NHS Foundation Trust | ISRCTN15570706 | |
| 274984 | Analysis of endotracheal tube biofilm (including type of bacteria, biofilm architecture and structural components) in patients who have been intubated for 5 or more days | University College London | ||
| 276445 | Performance and Function of the Trident® II 3D printed Acetabular Component | South Tees Hospitals NHS Foundation Trust | ISRCTN57876689 | |
| 278006 | Safe and Effective Above Cuff Tracheostomy Vocalisation (SEA CtV) | Manchester University NHS Foundation Trust | NCT04647786 | |
| 279630 | The effects of an innovative Glycomacropeptide based protein supplement purified to lower the phenylalanine content for the treatment of paediatric patients with Phenylketonuria | Cambrooke | Currently registering | |
| 279799 | A study of medical device Dermastat® to assess its suitability as a new autonomic neuropathy testing device, in the diabetes clinical setting | Manchester University NHS Foundation Trust | ||
| 280185 | Management of impacted maxillary central incisors: a multicentre randomised clinical trial | King’s College London | ISRCTN12709966 | |
| 281209 | The Growth Hormone Deficiency Reversal Trial: Effect on final height of discontinuation vs continuation of growth hormone treatment in pubertal children with isolated growth hormone deficiency – A non-inferiority randomised controlled trial | University College London | ISRCTN12552768; 2020-001006-39 | |
| 282624 | Risk reduction intervention for raised blood pressure (REVERSE): A feasibility study exploring the use of blood pressure self-monitoring | University of Central Lancashire | ISRCTN13649483 | |
| 287604 | Evaluation of Pre-hospital use of a Valsalva Assist Devise (VAD) in the Emergency treatment of supraventricular tachycardia (SVT). A stepped-wedge cluster randomised controlled trial [EVADE SVT] | South Western Ambulance Service | ISRCTN16145266 | |
| 288108 | Eye gaze technology for endoscopic inspection of the gastrointestinal tract | Imperial College London | ||
| 288219 | In vivo molecular mapping of adult primary brain tumour activity using novel magnetic resonance imaging (MRI): a pilot study | Erasmus MC | NCT05140785 | |
| 290012 | Measuring biomarkers using aptamers | Imperial College London | Currently registering | |
| 291671 | Diagnostic accuracy of WEARable TECHnology single-lead ECG in detecting cardiac arrhythmias: WEAR-TECH ECG | Oxford University Hospitals NHS Foundation Trust | NCT05298553 | |
| 292085 | Post Delivery intervention in women with previous gestational diabetes mellitus for glycaemia and cardiovascular health | Imperial College London | NCT06022601 | |
| 292170 | Evaluating the test performance of Aspergillus antigen detection using a lateral flow device (LFD) on broncho-alveolar lavage (BAL) fluid for the diagnosis of invasive pulmonary Aspergillosis in Paediatrics: A Pilot Study | St George’s University Hospitals NHS Foundation Trust | NCT05569824 | Found through search but HRA not notified |
| 292873 | A double-blinded feasibility study of intraoperative electron radiotherapy in patients with locally advanced or locally recurrent rectal cancer | University Hospital Southampton NHS Foundation Trust | ISRCTN48105173 | |
| 293244 | Computed Tomography Coronary Angiography (CTCA) prior to Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) - a feasibility study | Sandwell and West Birmingham NHS Trust | NCT05364827 | |
| 294362 | Production of expanded autologous regulatory T cells to treat patients with aplastic anaemia: A phase I study | King’s College London | NCT05386264; 2021-000082-33 | |
| 294369 | The RAPID 2 study. Reducing Anxiety in Pregnancy: Intervention Development phase 2. A feasibility study of a midwife facilitated supportive intervention | Nottingham University Hospitals NHS Trust | ISRCTN12834758 | |
| 294387 | BASELINE Trial: Balloon Expandable versus Self Expanding Transcatheter Valve for Degenerated Bioprosthesis | Leeds Teaching Hospitals NHS Trust | NCT04843072 | |
| 294429 | Echocardiographic assessment of cardiotoxicity in adult cancer patients receiving trastuzumab and other HER2-targeted cancer therapies: comparison of manual and with automated analyses | Ultromics | Trial did not open in the UK | |
| 295171 | Feasibility study: An investigation of frailty and glycaemic control in older adults with Type 1 diabetes mellitus | University Hospitals Sussex NHS Foundation Trust | ISRCTN30513341 | |
| 295297 | Olanzapine for young PEople with aNorexia nervosa: An open-label feasibility study to test recruitment, treatment acceptance, adherence, safety, and outcome measures assessment and patients' experience to prepare for a definitive randomised placebo-controlled trial | King’s College London | ISRCTN80075010; 2021-004598-30 | |
| 295968 | Virtual 3D modelling for improved surgical planning of robotic-assisted partial nephrectomy | King’s College London | NCT05109182 | |
| 297102 | Using a diffuse reflectance spectroscopy probe in-vivo to identify tumour and non-tumour tissue in the gastrointestinal tract to aid margin assessment | Imperial College London | NCT05830292 | |
| 298364 | A Pilot Study to Investigate the Use of Remote Thermovisual Monitoring in Patients with a Previous Diabetic Foot Ulcer, during the COVID-19 pandemic | Bluedrop Medical | NCT05039645 | |
| 298827 | ACHIEVE - An adaptive trial of the efficacy and effectiveness of Adoptive Cellular tHerapy wIth Ex-Vivo Expanded allogeneic γδ T-lymphocytes (TCB008) for patients with refractory or relapsed acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) or myeloproliferative neoplasms (MPNs) | TC BioPharm | NCT05358808; 2021-000744-22 | |
| 299052 | IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH) | Aerovate Therapeutics | 2021-001910-13 | |
| 299128 | BARI-STEP: A double-blinded, randomised, placebo-controlled trial of semaglutide 2.4 mg in patients with poor weight-loss following bariatric surgery | University College London | NCT05073835; 2021-004568-83 | |
| 299687 | Is intensive upper limb rehabilitation effective in chronic stroke patients? A randomised controlled trial (INTENSE) | University College London & University College Hospital Hospitals NHS Foundation Trust | NCT05527262 | |
| 300753 | Multi-centre, randomised controlled trial of Vinehealth® digital health cancer solution for cancer patients commencing chemotherapy | University of Surrey | ISRCTN44293246 | |
| 301154 | A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Efficacy of ABBV-154 in Subjects with Polymyalgia Rheumatica (PMR) Dependent on Glucocorticoid Treatment | AbbVie | NCT04972968; 2021-000648-23 | |
| 301186 | Validation and implementation of a Digital Assessment Routing Tool (DART) as an alternative to physiotherapy-led triage: A Pilot Randomised Crossover Non-Inferiority Trial | QMUL and Bart's Health NHS Trust | NCT04904029 | |
| 301301 | MEsenteric Excision and Kono-S Anastomosis Trial (MEErKAT) | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN16900055 | |
| 301656 | Prospective evaluation of clinical and radiographic outcomes after Anterior Cervical interbody fusion surgery using a TRYPTIK® Ti-Life cage | Spineart | ISRCTN63972735 | |
| 301682 | Psychosis Immune Mechanism Stratified Medicine Trial: The PIMS Trial | University of Bristol | ISRCTN23256704 | |
| 301730 | Feasibility Randomised Controlled Trial of Remotely Delivered EMDR versus Face to Face EMDR for Post Traumatic Stress Disorder (PTSD) in Military Veterans | Cardiff University | ISRCTN13912752 | |
| 301795 | A Combined Home-Based Exercise and Nutritional Approach to Improve Frailty Status in Kidney Transplant Recipients: A Randomised Controlled Feasibility Study | University of Birmingham | Currently registering | |
| 301966 | Efficacy of a Streamlined Heart failure Optimisation pRoTocol for patients with severely impaired left ventricular systolic function, a randomised controlled trial (SHORT trial) | Queen Elizabeth Hospital NHS Foundation Trust | NCT05021419 | |
| 302276 | Early detection of bladder cancer in Yorkshire: Feasibility assessments for implementing a targeted study in populations with high disease specific mortality risk | University of Sheffield | ISRCTN34273159 | |
| 302295 | EAGLET: EEG vs CFM (aEEG) to improve the diagnosis of neonataL seizures and Epilepsy – a randomised Trial | Cambridge University Hospitals NHS Foundation Trust | NCT05079971 | |
| 302587 | Providing Emotional Support Around the Point of Multiple Sclerosis Diagnosis: PrEliMS 2 | University of Nottingham | NCT05225012 | |
| 302666 | PROMIZE: A Phase I/II Trial to Assess the Safety, Tolerability and Preliminary Anti-tumour Activity of Oral Combination antibiotic therapy to modulate the microbiome in combination with enzalutamide in metastatic castration resistant prostate cancer (mCRPC) | The Institute of Cancer Research | 2021-004559-18 | |
| 303042 | Fasting or non-fasting before cardiac catheterization | Blackpool Teaching Hospitals NHS Foundation Trust | NCT05133206 | |
| 303093 | DISCOVER "Getting the Life You Want" Workshop Programme for Care Experienced young people aged 16-19: A feasibility and acceptability pilot study | South London and Maudsley NHS Foundation Trust | NCT05220436 | |
| 303180 | A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Mitapivat in Subjects With Sickle Cell Disease | Agios | NCT05031780; 2021-001674-34 | |
| 303421 | DOLFIN - Developmental Outcomes of Long Term Feed Supplementation in Neonates | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN62323236 | |
| 303525 | A randomised, multi-centre, double-blind, placebo-controlled, single ascending dose, multiple dose study to assess safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of intravenous infusion doses of ONO-4685 in patients with plaque psoriasis (21-502) | ONO Pharma | NCT05332704; 2021-002151-10 | |
| 304193 | A Phase 2 Study Evaluating the Efficacy, Safety, Tolerability, and Pharmacokinetics of Tarlatamab in Subjects with Relapsed/Refractory Small Cell Lung Cancer After Two or More Prior Lines of Treatment | Amgen | NCT05060016; 2021-002566-40 | |
| 304235 | A Phase 1b/2, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 (pINN Sotorasib) in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation | Amgen | NCT04185883; 2020-004721-23 | |
| 304351 | Phase 1/2 Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT7480 in Patients With Nectin-4 Associated Advanced Malignancies | BicycleTx | NCT05163041; 2021-004468-80 | |
| 304633 | Hydrotherapy for health in boys and adolescents with Duchenne muscular dystrophy | Lancashire Teaching Hospitals NHS Foundation Trust | Currently registering | |
| 304723 | Dynamic susceptibility contrast MRI Perfusion assessment of brain metastases: baseline characteristics and the study of pattern of perfusion change in suspected radionecrosis post-stereotactic radiosurgery (STARBEAM-X) | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN62305334 | |
| 304762 | Promoting Restoration of Function of Co-ordinated Bladder Storage and Voiding following SCI by Combination of tSCS and Bladder & Pelvic Floor Muscle Training | Royal National Orthopaedic Hospital NHS Trust | NCT05504200 | |
| 304807 | A Phase I, Multi-Center, Open-Label Study To Assess The Safety, Pharmacokinetics, And Preliminary Efficacy Of An Orally Available Small Molecule, Cc-99282, Alone And In Combination With Anti-Lymphoma Agents In Subjects With Relapsed Or Refractory Non-Hodgkin Lymphomas (R/R Nhl) | Celgene | NCT03930953; 2018-003235-29 | |
| 304825 |
PROSAIC-DS Study (PROState AI in Cancer - Decision Support) Evaluation of the Deontics AI platform for personalised, evidence-based treatment planning in multidisciplinary cancer care: Increasing compliance with national standards of care and streamlining MDTs in prostate cancer. |
Guy's & St Thomas' NHS Foundation Trust | NCT05355727 | Found through search but HRA not notified |
| 304974 | Clinical Impact of the iBox as an early Intervention tooL: A prospective randomized controlled trial to assess the use of a software predicting allograft survival in the follow-up of kidney transplanted patients | Predict4Health | NCT05112315 | |
| 305174 | Improving care for patients living with persistent non-cancer pain and taking opioid medicines long-term: A multicentre cluster randomised controlled trial of proactive clinical review led by practice pharmacists in primary care. The PROMPPT Trial. | Keele University | ISRCTN45616481 | |
| 305313 | Implementation of a medicines management plan (MMP) to reduce medication related harm (MRH) in older people post hospital discharge: a randomised controlled trial | University of Sussex | ISRCTN16864276 | |
| 305446 | A Phase 2, Randomized, Open-Label Study Evaluating the Safety and Efficacy and of Magrolimab in Combination with Nab-Paclitaxel or Paclitaxel versus Nab-Paclitaxel or Paclitaxel in Previously Untreated Patients with Metastatic Triple-Negative Breast Cancer | Gilead | NCT04958785; 2021-001074-27 | |
| 305449 | Virtual Evaluations of joint health using wearable Sensors in Persons with haemophiliA (VESPA) | East Kent Hospitals University NHS Trust | NCT06046235 | Found through search but HRA not notified |
| 305731 | Prehabilitation of swallowing difficulties in people with head and neck cancer: A pilot cluster randomised trial and process evaluation | University College London | ISRCTN12377415 | |
| 305899 | A Randomized, Double-blind Study to Investigate the Safety, Pharmacokinetics, and Antitumor Activity of ASC-201 Plus Trifluridine/Tipiracil Compared With Trifluridine/Tipiracil in Patients With Advanced Gastric Cancer in a Third Line Treatment Setting After an Initial Dose Escalation Phase | Ascelia Pharma | 2021-003799-15 | |
| 305929 | Upper Limb Telerehabilitation Using Brain-Controlled Functional Electrical Stimulation | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN42991002 | |
| 305973 | The CALM trial: the clinical and cost-effectiveness of a guided self-help cognitive behavioural therapy intervention to reduce dental anxiety in children | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN27579420 | |
| 306043 | A Phase 1/2 Study of the Oral RET Inhibitor LOXO-292 in Pediatric Patients with Advanced RET-Altered Solid or Primary Central Nervous System Tumors | Loxo Oncology | NCT03899792; 2019-000212-28 | |
| 306610 | Does Virtual Reality Reduce Pain and Anxiety During Outpatient Hysteroscopy? A Randomised Controlled Trial | Imperial College Healthcare NHS Trust | NCT05307887 | |
| 306642 | The Nurtured Heart Parenting Intervention for Children’s Behavioural Problems: A Single Case Design | University of Lincoln | NCT06195579 | |
| 306747 | Diabetes Risk Assessment and Medical Referral or Signposting (DRAMeRS) | NHS Education for Scotland | ISRCTN16798215 | |
| 307085 | Complex ePrescribing-based Antimicrobial Stewardship intervention for Hospitals (ePAMS+) Feasibility Trial | University of Edinburgh | ISRCTN13429325 | |
| 307122 | Exploring the potential of ‘JIA Toolbox’ in improving the independence and functional ability of Children and Young People (CYP) with Juvenile Idiopathic Arthritis (JIA) | Sheffield Children's NHS Foundation Trust | NCT05563194 | |
| 307220 | A Phase 1B, Adaptive, Multi-Center, Randomized, Double Blind, Placebo-Controlled, Parallel Design Study To Investigate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Ro7486967 In Participants With Early Idiopathic Parkinson’S Disease | Roche | ISRCTN85338453; NCT05924243; 2021-002345-15 | |
| 307429 | Immersive Virtual Reality for Dysphagia Treatment after Stroke | Sheffield Hallam University | Currently registering | |
| 307434 | Orthodontic Patient Experience of Intraoral Scanners Versus Alginate Impressions in the UK: a Single-Centre Randomised Controlled Crossover Trial | University Hospitals Derby & Burton NHS Foundation Trust | NCT05194956 | |
| 307439 | Tailored abdominal massage treatment for constipation in adults with learning disabilities – A Feasibility study and Pilot trial | Glasgow Caledonian University | NCT05490654 | |
| 307457 | A Phase 2, Long-Term Extension (LTE) Study with Elsubrutinib and Upadacitinib Given Alone or in Combination (ABBV-599) in Subjects with Moderately to Severely Active Systemic Lupus Erythematosus Who Have Completed the M19-130 Phase 2 Randomized Controlled Trial (RCT) | AbbVie | NCT04451772; 2020-001690-72 | |
| 307635 | Increasing physical activity levels using e-bikes to enhance prostate cancer survival: A randomised pilot study | University of Bristol | ISRCTN42852156 | |
| 307732 | Evaluation of the 24/7 EEG™ SubQ System for Ultra Long-Term Recording of Patients with Temporal Lobe Epilepsy | UNEEG Medical | NCT04526418 | |
| 307933 | IdeNtification of SPecific EleCTrophenotypes in Atrial Fibrillation – INSPECT-AF | Imperial College London | NCT05366530 | |
| 308038 | Stroke Biomarker Evaluation for Large Vessel Occlusion (StroBE-LVO) | Northumbria Healthcare NHS Foundation Trust | ISRCTN60633358 | |
| 308255 | A Phase 2a, Multicenter, Open-Label Study to Evaluate the Safety and Efficacy of AT-1501 in Patients with IgA Nephropathy | Eledon Pharma | NCT05125068; 2021-004795-34 | |
| 308546 | PASSION-HF (Patient Self-care uSing eHealth In chrONic Heart Failure) CAPITALISATION | University of Suffolk | ||
| 308605 | The feasibility of Frame Running as an exercise option for people with MS with impaired balance and mobility | Queen Margaret University | NCT05234879 | |
| 308680 | To evaluate the acceptability (including gastrointestinal tolerance and compliance) of an adult tube-feed formula with ingredients derived from food | Nestle Health Science | NCT06102122 | Found through search but HRA not notified |
| 308691 | A Phase 2, randomised, double-blind, placebo-controlled, dose escalation study to investigate the effects of IRL201805 in participants with moderately to severely active rheumatoid arthritis | Revolo Biotherapeutics | 2021-005771-39 | |
| 309178 | Randomised controlled trial of the Community Navigator programme to reduce loneliness and depression for adults with treatment resistant depression in secondary mental health services | Camden & Islington NHS Foundation Trust | ISRCTN13205972 | |
| 309506 | Validation of In Vitro Diagnostic Assays at External Clinical Laboratories | The Binding Site | ||
| 309738 | An interventional, prospective IVD device study for the testing of DNA extracted from tumor tissue biopsy samples from patients with Colorectal Cancer (CRC) who have previously tested positive for KRAS G12C mutation into the Amgen Phase III clinical trial (Protocol No 20190172) to demonstrate clinical performance of the therascreen® KRAS RGQ PCR Kit. | QIAGEN | NCT05347745; 2021-004008-16 | |
| 309915 | Transcranial Direct Current Stimulation In Major Depressive Disorder: A Double-Blind, Placebo-Controlled, Randomized, Superiority Trial | Flow Neuroscience | ||
| 309937 | Effect of immuno-nutrition on systemic inflammation in people receiving haemodialysis: a pilot study | University of Nottingham | NCT05700851 | |
| 310212 | A study to evaluate the performance of a Lab-on-Chip LAMP device for rapid SARS-CoV-2 diagnosis | University of Bath | ISRCTN58218165 | |
| 310426 | An open label, pilot study to determine the effect of weekly intra-cavernosal injections of Invicorp on male Erectile Dysfunction (ED) post radical prostatectomy | RestoriT | ISRCTN77251669; 2021-005456-11 | |
| 310662 | Investigating the viability and acceptability of an Interactive Virtual Reality (IVR) System on physiotherapy rehabilitation in paediatric Duchenne Muscular Dystrophy (DMD) patients | Sheffield Children's NHS Foundation Trust | NCT06274983 | |
| 310691 | A pragmatic randomised control trial comparing the efficacy of the “Free from Pain Exercise Book” versus “The Back Book” in decreasing back pain in adults over 60 years of age | Talita Cumi | NCT05359107 | |
| 311052 | SAPIEN SBRI 19 Impact of a remote lifestyle change program on length of stay and complications in patients undergoing elective knee and hip arthroplasty | Sherwood Forest Hospitals NHS Foundation Trust | ISRCTN12049495 | |
| 311106 | Randomised trial of intra-articular injection of lidocaine versus placebo in Inflammatory arthritis | Guy's & St Thomas' NHS Foundation Trust | NCT05302232 | Found through search but HRA not notified |
| 311663 | Investigating Value-Based Procurement and patient reported outcomes from adults with lymphoedema using a 12-week home-based programme of LymphAssistTM (intermittent pneumatic compression) | Swansea Bay University Health Board | NCT05456568 | |
| 311906 | Exploring Right vEntricular function applicability in a Prediction mOdel to identify pReterm infanTs with early BronchoPulmonary Dysplasia (REPORT – BPD Study): a mixed methods observational cohort feasibility study | University Hospital Plymouth NHS Trust | NCT05235399 | |
| 312115 | Sample collection for evaluation of the Panbio™ COVID-19/ Flu A&B Rapid Panel | Abbott | NCT05354115 | |
| 312287 | A Single-centre, Single-Blinded, Randomized, Crossover Study to Assess the Nicotine Pharmacokinetic Profile Following Use of two Variants of Logic Compact in Adult Healthy Electronic Cigarette Users | Japan Tobacco | ISRCTN97168882 | |
| 1003562 | A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Ulcerative Colitis Who Achieved Clinical Response Following Open–Label Vedolizumab Intravenous Therapy | Takeda | NCT04779307; 2020-004300-34 | |
| 1003594 | A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Crohn’s Disease Who Achieved Clinical Response Following Open–Label Vedolizumab Intravenous Therapy | Takeda | NCT04779320; 2020-004301-31 | |
| 1003686 | Phase 1/2 Study of Bempegaldesleukin in Combination with Nivolumab in Children, Adolescents, and Young Adults with Recurrent or Refractory Malignancies (PIVOT IO 020) | Bristol-Myers Squibb | NCT04730349; 2020-000854-85 | |
| 1003822 | AttackMS - Natalizumab for the treatment of people with inflammatory demyelination suggestive of multiple sclerosis, or definite multiple sclerosis, at first presentation | Queen Mary University of London | NCT05418010; 2021-002255-11 | |
| 1003956 | A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3, Pivotal Study With An Open-Label Extention Period To Evaluate The Efficacy And Safety Of Rozanolixizumab In Adult Participants With Myelin Oligodendrocyte Glycoprotein (Mog) Antibody-Associated Disease (Mog-Ad) | UCB | NCT05063162; 2021-000352-19 | |
| 1004038 | A randomized phase II trial evaluating Ibrutinib plus CD20 Ab and Ibrutinib-Venetoclax plus CD20 Ab in patients with untreated mantle cell lymphoma | Lymphoma Academic Research Organisation | NCT04802590; 2020-004910-37 | |
| 1004207 | A randomized, double-blind, placebo-controlled, 12 month Phase 3 study to evaluate the effect of venglustat on neuropathic and abdominal pain in male and female adults with Fabry disease who are treatment-naïve or untreated for at least 6 months | Sanofi-Aventis | NCT05206773; 2021-002350-90 | |
| 1004225 | A randomized, double-blind, parallel group, placebo-controlled, multicenter Phase 3 trial to evaluate the efficacy, safety and tolerability of ianalumab on top of standard-of-care therapy in patients with active lupus nephritis (SIRIUS-LN) | Novartis | NCT05126277; 2020-005830-14 | |
| 1004234 | A randomized, double-blind, phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for metastatic HER2+ breast cancer (HER2CLIMB-05) | Seagen | NCT05132582 ; 2021-002491-39 | |
| 1004264 | A Phase 3, Multicenter, Open-Label, Long-Term Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Crohn's Disease | Eli Lilly and Company | NCT04232553; 2019-002687-27 | |
| 1004294 | A Phase Ia/B Open-Label Study To Evaluate Safety, Pharmacokinetics, And Preliminary Clinical Activity Of Ro7276389 Alone And In Combination With Cobimetinib In Participants With Braf-V600 Mutation-Positive Advanced Solid Tumor Or Braf-V600 Mutation-Positive Melanoma With Central Nervous System Metastases | Roche | ISRCTN13713551; 2021-003426-77 | |
| 1004303 | Multimodal METformin and FINGER lifestyle intervention to prevent cognitive impairment and disability in older adults at risk for dementia: a phase IIb multi-national randomised, controlled trial | Imperial College London | NCT05109169; 2021-005213-14 | |
| 1004317 | Obeticholic acid for the Amelioration of Cognitive Symptoms trial - 3 | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN98936300; 2020-004958-30 | |
| 1004318 | An Open Label, Randomised, Phase 2 Study To Evaluate The Safety And Efficacy Of Mtl-Cebpa Administered In Combination With Sorafenib Or Sorafenib Alone, In Tki Naïve Participants With Previously Treated Advanced Hepatocellular Carcinoma (Hcc) And Hepatitis B Or Hepatitis C Virus (Outreach2) | MiNA Alpha | NCT04710641; 2021-005431-23 | |
| 1004379 | Phase 1 study of base edited CAR7 T cells to treat T cell malignancies (TvT CAR7) | Great Ormond Street Hospital for Children NHS Trust | ISRCTN15323014; 2021-004312-25 | |
| 1004384 | A Double-Blinded, Placebo-controlled, Multi-center Randomized, Phase 3 Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects with Type 2 Diabetes Mellitus with Inadequate Glycemic Control on Diet Control Alone or on Diet Control and Glucose-lowering Agents as Monotherapy | Oramed | NCT04754334; 2021-004226-30 | |
| 1004402 | A Phase 3 Multi-Center, One-Year, Open-Label study of Setmelanotide in Pediatric Patients Aged 2 to <6 years of age with Rare Genetic Causes of Obesity | Rhythm Pharmaceuticals | NCT04966741; 2021-004167-27 | |
| 1004415 | A Phase 2b Multicenter, Randomized, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis | Janssen-Cilag International | ISRCTN76915275; NCT05223868; 2021-003700-41 | |
| 1004430 | A phase III randomized, controlled, open-label, multicenter, global study of capmatinib in combination with osimertinib versus platinum - pemetrexed based doublet chemotherapy in patients with locally advanced or metastatic NSCLC harboring EGFR activating mutations who have progressed on prior EGFR-TKI therapy and whose tumors are T790M mutation negative and harbor MET amplification (GEOMETRY-E) | Novartis | NCT04816214; 2020-003677-21 | |
| 1004431 | A 24 week, randomised, assessor blinded, active-controlled, parallel group, phase 3, 2 arm trial to compare the efficacy and safety of delgocitinib cream 20 mg/g twice-daily with alitretinoin capsules once-daily in adult participants with severe chronic hand eczema | LEO Pharma | ISRCTN44123892; 2021-003543-16 | |
| 1004437 | A Phase 1b Open-Label, Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ARV-110 in Combination with Abiraterone in Patients with Metastatic Prostate Cancer | Arvinas | NCT05177042; 2021-003046-21 | |
| 1004443 | A Double-Blind, Placebo-Controlled, Dose Escalation Study to Assess the Efficacy, Safety and Pharmacokinetics of Voclosporin in Adolescents with Lupus Nephritis | Aurinia | NCT05288855; 2020-005807-37 | |
| 1004452 | A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Subjects With Pyruvate Kinase Deficiency Who Are Regularly Transfused, Followed by a 5-Year Open-label Extension Period | Agios | NCT05175105; 2021-003265-36 | |
| 1004459 | An Open-label Multicenter Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Inebilizumab in Pediatric Subjects with Neuromyelitis Optica Spectrum Disorder | Horizon Therapeutics | NCT05549258; 2021-003528-33 | |
| 1004471 | ATR inhibitor elimusertib (BAY 1895344) in combination with cisplatin or irinotecan in participants with advanced solid tumors | Bayer | 2021-004397-57 | |
| 1004477 | A Phase 2 Study of Galicaftor/Navocaftor/ABBV-119 Combination Therapy in Subjects with Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation | AbbVie | ISRCTN48897533; NCT04853368; 2020-005805-25 | |
| 1004490 | A phase 1/1b/2 study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of AMG 193 alone and in combination with docetaxel in subjects with advanced MTAP null solid tumors | Amgen | NCT05094336; 2021-004764-10 | |
| 1004491 | A randomised feasibility study evaluating the effect of perioperative intravenous lIdocaine on colorectal cancer outcome after surgery | Imperial College London | ISRCTN29594895; NCT05250791; 2021-006185-20 | |
| 1004498 | Effects of N-Acetyl-L-Leucine on Niemann-Pick disease type C (NPC): A Phase III, randomized, placebo-controlled, double-blind, crossover study | IntraBio | NCT05163288; 2021-005356-10 | |
| 1004503 | A Phase I, Double-Blind, Placebo-Controlled, Ascending Single Intravenous Dose, Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in Healthy Participants and Non-Cystic Fibrosis Bronchiectasis Patients colonized with Pseudomonas aeruginosa administered INFEX702 | Infex Therapeutics | ISRCTN17978477; 2021-005018-32 | |
| 1004505 | A Multicenter, Double-blind, Randomized Phase 3 Study to Compare the Efficacy and Safety of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab, in the Adjuvant Treatment of Clear Cell Renal Cell Carcinoma (ccRCC) Post Nephrectomy (MK-6482-022) | MSD | NCT05239728 ; 2021-003436-92 | |
| 1004512 | A Randomized, Double-blind, Placebo-controlled Single Ascending Dose and Open-label Multi-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ALN-APP in Adult Patients with Early-onset Alzheimer’s Disease (EOAD) | IQVIA | NCT05231785; 2021-003198-74 | |
| 1004525 | A pivotal Phase 3, multicenter, randomized, double-blind, placebo-controlled study of the efficacy and safety of DMX-200 in patients with focal segmental glomerulosclerosis (FSGS) who are receiving an angiotensin II receptor blocker (ARB) | Dimerix | ISRCTN72772236; NCT05183646; 2021-004174-64 | |
| 1004548 | A Phase III, double-blind, placebo-controlled, Randomized, Multicenter, International Study of Durvalumab Plus Oleclumab and Durvalumab Plus Monalizumab in Patients With Locally Advanced (Stage III), Unresectable Non-small Cell Lung Cancer (NSCLC) Who Have Not Progressed Following Definitive, Platinum-Based Concurrent Chemoradiation Therapy (PACIFIC-9) | AstraZeneca | NCT05221840; 2021-004346-37 | |
| 1004579 | A Randomised Active-controlled Study to Compare Efficacy and Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) to Intravenous Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3 to 17 (Less than 18) Years Old | Sedana Medical | ISRCTN12741394; NCT04684238; 2020-000578-31 | |
| 1004590 | An open-label extension trial to evaluate the long-term safety of apraglutide in short bowel syndrome | VectivBio | NCT05018286; 2020-005513-41 | |
| 1004620 | A 12-week parallel group, randomized, placebo-controlled, doubleblinded, multi-center study to evaluate efficacy and safety of 2 concentrations of SAF312 eye drops (5 mg/ml and 15 mg/ml) used twice-daily in the treatment of post-operative corneal induced chronic pain (CICP) following Photorefractive Keratectomy (PRK) or Laser assisted in Situ Keratomileusis (LASIK) surgeries | Novartis | NCT04630158; 2021-005857-97 | |
| 1004650 | A double-blind, randomized, placebo-controlled, phase 1 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of single- and multiple-ascending doses of intravenously administered anti-LIGHT monoclonal antibody CBS001 in healthy volunteers | Capella Bioscience | NCT05323110; 2021-006484-21 | |
| 1004685 | A Randomized, Double-Blind, Phase 3 Study of Pembrolizumab/Vibostolimab Coformulation (MK-7684A) in Combination with Chemotherapy Versus Pembrolizumab Plus Chemotherapy as First Line Treatment for Participants with Metastatic Non-Small Cell Lung Cancer (MK-7684A-007/KEYVIBE-007) | MSD | NCT05226598; 2021-004564-94 | |
| 1004688 | An Open-Label, 3-Arm, Multicenter, Randomized Phase 3 Study To Evaluate The Efficacy And Safety Of Elranatamab (Pf-06863135) Monotherapy And Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone In Participants With Relapsed/Refractory Multiple Myeloma Who Have Received At Least 1 Prior Line Of Therapy Including Lenalidomide And A Proteasome Inhibitor | Pfizer | NCT05020236; 2021-000044-22 | |
| 1004711 | A Phase 1 Single- and Multiple-Ascending Dose Study of the Safety and Pharmacokinetics of a Gastro-Retentive Formulation of 5-Hydroxytryptophan (5-HTP) and Low-Dose Carbidopa (EVX-101) in Healthy Subjects Taking Escitalopram | Evecxia Therapeutics | ISRCTN42835524; 2021-006715-28 | |
| 1004748 | A TWINSS extension trial to evaluate the safety and tolerability of CFZ533 (iscalimab) at two dose levels administered subcutaneously in patients with Sjögren’s Syndrome | Novartis | NCT04541589; 2020-001942-20 | |
| 1004767 | Interventional, open-label, positron emission tomography (PET) study with [11C]-Lu AF88370 investigating blood-brain barrier penetration of Lu AF88370 in healthy men | Lundbeck | NCT05320302; 2021-005082-40 | |
| 1004785 | A Parallel-group (2-Arm), Randomized, Double-blind, 12 week Trial to Evaluate the Efficacy and Safety of MC2 25 Cream and MC2-25 Vehicle in Subjects with Chronic Kidney Disease-associated Pruritus (CKD aP) | MC2 Therapeutics | ISRCTN74524864; 2021-006971-40 | |
| 1004827 | A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-0616 in Adults With Hypercholesterolemia | MSD | NCT05261126; 2021-005221-24 | |
| 1004837 | An exploratory, single-centre, open-label, crossover study in healthy volunteers using scintigraphy to evaluate the absorption of buspirone\nhydrochloride from timed-release tablets | Cingulate | 2021-006396-42 | |
| 1004843 | A Phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of SAR443820 in adult participants with amyotrophic lateral sclerosis, followed by an open-label extension | Sanofi-Aventis | NCT05237284; 2021-004156-42 | |
| 1004853 | A Phase 1, Multiple Part, Open Label Trial to Evaluate the Pharmacokinetic Profile of KVD824 Following Administration of KVD824 Gastro Retentive Formulation Prototypes in Healthy Volunteers | KalVista Pharmaceuticals | ISRCTN14984568; 2021-006855-33 | |
| 1004864 | Four-part, Randomized, Double-blind (Parts 1, 2A, 3 and 4), Multi-center, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK3965193 Monotherapy in Healthy Participants and in Participants Living with Chronic Hepatitis B Infection; and GSK3965193 in Combination with Bepirovirsen in Participants Living with Chronic Hepatitis B Infection | GlaxoSmithKline | NCT05330455; 2021-005117-13 | |
| 1005009 | A Phase 1 Single Dose Study to Evaluate the Pharmacokinetics of CORT113176 Softgel Capsules in Healthy Subjects | Corcept Therapeutics | ISRCTN52169163; 2022-000181-18 | |
| 1005025 | A Phase I Study to Investigate the Absolute Bioavailability, Absorption, Metabolism, Distribution and Excretion of [14C]AZD5363 (Capivasertib) in Healthy Male Subjects | AstraZeneca | ISRCTN15620353; 2022-000277-59 | |
| 1005072 | A Phase 1, Randomized, Open-Label Trial Assessing Pharmacokinetics and Safety of Low-Dose CAM2038 q4w in Healthy Volunteers Under Naltrexone Blockade | Camurus | 2022-000393-26 | |
| 302989/314513 | The EXTEND trial: Fixed-extended-duration antibiotics (28 days) compared to standard care antibiotic durations in adult patients with complicated intra-abdominal infection and their impact on treatment failure - a phase III multicentre, open label, two-arm, parallel group, pragmatic, randomised controlled trial with internal pilot | University of Leeds | ISRCTN72819021; NCT05148702 | |
| 308830/299977 | The impact of REStrictive versUs Liberal Transfusion strategy on cardiac injury and death in patients undergoing surgery for Hip Fracture (RESULT-Hip) | University of Edinburgh | ISRCTN28818784 |
Clinical trials given a REC favourable opinion in April 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 263064 | CHARRT (Carcinoid Heart Disease and Radiotargeted Peptide Receptor Therapy): Pilot randomised trial to assess progression of carcinoid heart disease in patients treated with Lutathera therapy compared to best supportive care | King’s College Hospital NHS Foundation Trust | NCT04039516; 2019-001632-61 | |
| 269958 | Aspirin versus placebo in twin pregnancies for preeclampsia prevention: A multicenter, randomised, double-blind, placebo-controlled trial (ASPRE-T) | Fundación para la Formación e Investigación Sanitarias de la Región de Murcia | 2019-003341-15 | |
| 271346 | A Phase III, Multicenter, Open-Label, Uncontrolled Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In Pediatric Patients With Aqp4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (Nmosd) | Roche | NCT05199688; 2019-004092-39 | |
| 274003 | Muscle MRI in patients with McArdle Disease (Glycogen storage disease type V) | University College London & University College Hospital Hospitals NHS Foundation Trust | NCT03844022 | |
| 280900 | A single-centre, randomised, cross-over design feasibility study to assess the effectiveness of an app-based, assisted behavioural change techniques to improve HbA1c levels and support diabetes self-management in young adults and adolescents | Manchester University NHS Foundation Trust | NCT05217953 | |
| 288979 | Assessing metabolic profiling strategies for nutritional management in diabetic patients with Non-Alcoholic Fatty Liver Disease | Imperial College London | ||
| 290193 | To examine the effectiveness of physical activity, Quality of Life and Hospital Anxiety and Depression outcomes in Cardiovascular patients using an internet-based Cardiac Rehabilitation application compared with a conventional Cardiac Rehabilitation programme or a combination of both | University Of Chester | NCT05326529 | |
| 292223 | PROMETHEUS: Prospective tRial of Machine lEarning To Help fEtal Ultrasound Scanning | King’s College London | ISRCTN65824874 | |
| 294633 | Feasibility And Acceptability Of A Uk Based Remote Brain Health Clinic For Patients With Mild Cognitive Impairment (Mci) | South London and Maudsley NHS Foundation Trust | ||
| 295426 | A Phase IIb, Randomised-Controlled, Two-Centre Clinical Trial (Exalt) On The Efficacy Of A Home-Based Exercise And Motivational Programme In Patients Before And After Liver Transplantation | University of Birmingham | ISRCTN13476586 | |
| 295523 | Reducing Microvascular Dysfunction In Patients With Angina, Ischaemia And Unobstructed Coronary Arteries – A Pilot Study (Remedy-Pilot) | Imperial College London | NCT05492110 | |
| 295721 | TrueBlue Clinical Study - Investigating the use of a mobile phone app TrueBlue for monitoring Depression and Anxiety | BlueSkeye AI | Recruitment not yet started | |
| 296997 | SUCCESS (SelUtion, safety, effiCaCy, hEalth economicS and promS) PTA Study | M.A. Med Alliance | NCT04776434 | |
| 297292 | Diastolic function assessment with cardiac magnetic resonance imaging and echocardiography: a scan-rescan study | Imperial College Healthcare NHS Trust | NCT05438030 | |
| 298524 | An observational longitudinal cohort study to investigate Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer’s disease (CONGA) | University Hospital Southampton NHS Foundation Trust | NCT05579236 | |
| 298717 | A Feasibilty Study and Process Evaluation of an Integrated Support Programme for Adults Following a Diagnosis of Type 1 Diabetes- the Living with and ADapting to DiabetEs PRogramme (LADDER) | King’s College London | ISRCTN17358613 | |
| 299927 | A Prospective, Open Label, Cross-Over, Multi-Center Pilot Study To Evaluate The Safety, Feasibility And Usability Of The Intelligent Dialysis Assistant (Ida) In Subjects With Chronic Kidney Disease Stage V Treated With Peritoneal Dialysis | IiberDi Ltd. | NCT04808011 | |
| 299961 | PREhabilitation for Patients Awaiting liveR transplantation: development and feasibility testing of a remote multicomponent prEhabilitation intervention: PREPARE | Belfast Health and Social Care Trust | NCT06036225 | Found through search but HRA not notified |
| 300846 | A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Patients with Dravet Syndrome (ARGUS Trial) | Epygenix Therapeutics | NCT04462770; 2021-003425-30 | |
| 301143 | A pragmatic trial of an Artificial intelligence DRiven appOInTment maNagEment SyStem | London South Bank University | ISRCTN16329124 | |
| 301473 | Post market surveillance study to confirm the ongoing safety and performance of Silver II Non-woven dressing in chronic and acute wounds | Advanced Medical Solutions | NCT05045430 | |
| 301533 | A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of INCB000928 in Participants with Fibrodysplasia Ossificans Progressiva | Incyte | NCT05090891; 2021-002286-17 | |
| 301799 | Piloting a web-based personalised nutrition app (eNutriCardio) with patients offered cardiac rehabilitation | University of Reading | NCT05449769 | |
| 302075 | Non-inferiority of angiography-derived physiology guidance versus usual care in an All-comers PCI population treated with unrestricted use of the Healing-Targeted Supreme (HT SupremeTM) drug-eluting stent and P2Y12 inhibitor monotherapy after 1-month of dual-antiplatelet therapy: the PIONEER IV trial | National University of Ireland | NCT04923191 | |
| 302147 | Sensing OxygeN saturations usinG aBdominal NIRS with an Investigational Realtime Device (Songbird) – CTOM UK (Carag Tissue oxygenation Monitor System/CTOM) | CARAG | NCT05278247 | |
| 303347 | Effects of selective left subclavian ansae stimulation on human cardiac electrophysiological properties - a potential percutaneous target for neuromodulation in Atrial Fibrillation | Barts Health NHS Trust | NCT05133414 | |
| 303650 |
Phase Ib, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study To Assess The Safety Of Ro7486967 In Patients With Chronic Obstructive Pulmonary Disease |
Roche | 2021-000558-25 | |
| 303674 | A feasibility study examining the use of Mechanical Insufflation Exsufflation to promote extubation success in adult intensive care | University Hospitals Bristol and Weston NHS Foundation Trust | ISRCTN24603037 | |
| 305038 | Hypobaric Oxygen during cardiopulmonary bypass to reduce gaseous Micro-Emboli during cardiac surgery: a randomised controlled trial | University Hospitals Bristol and Weston NHS Foundation Trust | ISRCTN87042095 | |
| 305321 | Is Method of Levels (MOL) Therapy An Acceptable And Feasible Psychological Intervention For People Using Acute Mental Health Inpatient Services? A Case Series | University of Manchester | NCT05377294 | |
| 305393 | A Multicenter, Randomized, Double-Blind Phase 3 Study of HBI-8000 Combined with Nivolumab versus Placebo with Nivolumab in Patients with Unresectable or Metastatic Melanoma Not Previously Treated with PD-1 or PD-L1 Inhibitors | HUYABIO International | 2019-002521-30 | |
| 305395 | High Dose Steroids in Children with Stroke and Unilateral Focal Arteriopathy: A Multicentre Randomized Controlled Trial PASTA (Paediatric Arteriopathy Steroid Aspirin) trial | University Childrens Hopital Inselspital Bern | NCT04873583; 2021-005571-39 | |
| 305780 | A randomised controlled trial to evaluate heat therapy in the treatment of peripheral artery disease: clinical benefit and mechanisms of action | Coventry University | Recruitment not yet started | |
| 305839 | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Pediatric Subjects with Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment | Neurocrine Biosciences | NCT04806451; 2020-004381-19 | |
| 306062 | CANcer BEhavioural Nutrition and Exercise FeasibilIty Trial (CanBenefit): Phase II randomised controlled trial among older adults with lung cancer | University of Hull | NCT05404022 | |
| 306160 | A Randomised Control Trial of Power versus Temperature-controlled radiofrequency irrigated ablation for the treatment of Ventricular Tachycardia (VT) | University Hospital Coventry & Warwickshire | NCT06028919 | |
| 306291 | Improving sleep and learning in rehabilitation after stroke, part 2 | University of Oxford | NCT05511285 | |
| 306347 | Is there a dose response effect on bone characteristics in relation to drop jump height? | Nottingham Trent University | NCT06282705 | |
| 306485 | A Phase 2, Randomized, Double-blind, Placebo-controlled, Dose-finding Study to Evaluate the Efficacy and Safety of ALXN2050 in Adult Participants with Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN) | Alexion | NCT05097989; 2021-001426-22 | |
| 306772 | A feasibility study of a Behavioural Intervention for Opioid Reduction (BIOR) for chronic non-cancer pain patients in primary care | Liverpool John Moores University | ISRCTN30201337 | |
| 306954 | A Proof-of-Concept Study of The Complete Vocal Technique (CVT), a pedagogic technique used for Performers, in Improving the Voice and Vocal Function in Patients with Muscle Tension Dysphonia | Nottingham University Hospitals NHS Trust | NCT05365126 | |
| 307103 | Improving engagement and recovery in people with early psychosis through Method of Levels therapy delivered by care coordinators: Feasibility cluster randomised controlled trial | Greater Manchester Mental Health NHS Foundation Trust | ISRCTN14082421 | |
| 307116 | Determining the Effectiveness of a FeNO-guided asthma management intervention in primary care: a pragmatic randomised controlled trial with nested economic and process evaluations | University of Oxford | ISRCTN16411887 | |
| 307150 | Dietary Approaches to the Management Of type 2 Diabetes (DIAMOND) cluster randomised trial | University of Oxford | ISRCTN46961767 | |
| 307437 | Personalised Speech and Language Therapy for Children and Young People with Cerebral Palsy using Acoustic and Phonological Analytics | Newcastle University | Currently registering | |
| 307603 | A Phase 1 Study of Safety, Pharmacokinetics and Preliminary Activity of TAS1553 in Subjects with Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) and Other Myeloid Neoplasms | Astex | NCT04637009; 2021-003593-31 | |
| 307862 | Early vasopressors in Sepsis | NHS Greater Glasgow & Clyde | NCT05179499; 2021-006886-39 | |
| 308065 | A randomised trial comparing ‘self-etch primer’ and ‘conventional etch and primer’ for orthodontic bonding in the hospital clinical setting | Western Health and Social Care Trust | ||
| 308393 | A single-centre, open-label study testing the safety and performance of the Glyconics-SX System in assessment of glycated nail keratin, compared with a standardised glycated haemoglobin (HbA1c) assay, in individuals with or without type 2 diabetes | Glyconics Limited | NCT05198895 | |
| 308557 | Efficacy of Personalised Irradiation with Rhenium-Skin Cancer Therapy (SCT) for the treatment of non-melanoma skin cancer; a phase IV multi-centre, international, open label, single arm study | Oncobeta | NCT05135052 | |
| 308656 | Pilot study on the use of a Virtual Reality Tour to reduce anxiety in patients referred for PET/CT scans | Oxford University Hospitals NHS Foundation Trust | ISRCTN50051799 | |
| 308677 | A Phase 1b study in patients with acromegaly or functioning gastroenteropancreatic neuroendocrine tumors (GEP-NETs) to characterize the pharmacokinetics, pharmacodynamics, safety and tolerability of Debio 4126, a 12-week prolonged-release octreotide formulation | Debiopharm | NCT05364944; 2021-005035-23 | |
| 308755 | Best Endovenous treatment, including STenting, versus best non-endovenous treatment in chronic proximal deep venous disease – the BEST multi-centre randomised controlled trial | Imperial College London | NCT05622500 | |
| 308812 | A Phase 1, Open-Label, Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms | Incyte | NCT04279847; 2020-003532-25 | |
| 308883 | A Phase 1 Study of TAS0612 in Patients with Locally Advanced or Metastatic Solid Tumors | Taiho Oncology | NCT04586270; 2020-002304-39 | |
| 309110 | Post Marketing Study to Evaluate Millipede 088 Effectiveness for Clot Retrieval in Acute Ischemic Stroke | Perfuze | ||
| 309300 | Technical feasibility of neo-commissural alignment in Trans-Catheter Aortic Valve Implantation (TAVI): an exploratory study describing procedural outcomes and effect on coronary blood flow measured by cardiac computed tomography (CT) | University Hospitals Sussex NHS Foundation Trust | ISRCTN16090439 | |
| 309510 | Star-Life: A Post-Market Registry On Miniject | iSTAR Medical | NCT05269680 | |
| 310090 | A randomised, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (VeNS), together with a lifestyle modification program, compared to a sham control with a lifestyle modification program, as a means of improving glycaemic control in adults with type 2 diabetes mellitus | Neurovalens | NCT04595968 | |
| 310192 | Post-market Clinical Follow-up (PMCF) Study of the Infinity-Lock™ Button System for Acromioclavicular Joint Stabilisation | Xiros | NCT05397210 | |
| 310423 | Cognitive Remediation in Bipolar (CRiB2): a randomised trial assessing efficacy and mechanisms of cognitive remediation therapy compared to treatment as usual | King's College London and South London and Maudsley NHS Foundation Trust | ISRCTN10362331 | |
| 310455 | Efficacy of Energy Therapy in the management of chronic pain in children and adolescents | King’s College Hospital NHS Foundation Trust | NCT05394272 | |
| 310742 | Electrocorticography as a Neurophysiological Marker for Intraoperative Monitoring of Brain Retraction | University College Hospital Hospitals NHS Foundation Trust | ||
| 311121 | Smart Watch Insights for the Prevention of Exacerbations and Enhance Rehabilitation - Movement Study (SWIPER-MOVES) | Imperial College London | NCT06011356 | Found through search but HRA not notified |
| 311214 |
Multimorbidity in Older Adults with Depression Study (MODS) (Working Title: Managing Multiple Health Conditions in Older Adults) |
Tees Esk and Wear Valleys NHS Foundation Trust | ISRCTN44184899 | |
| 311569 | Project Verio Vue Enhancements Regulatory Clinical Evaluation – Professional Comparison to Validated Method - Arterial Study | LifeScan | NCT06121856 | |
| 311664 | Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Pilot 3-Arm Randomised Control Trial and Qualitative Study (SOLEFUL) | Hull University Teaching Hospitals NHS Trust | NCT05380544 | |
| 311795 | Upper Limb Rehabilitation using immersive Virtual Reality for people with Multiple Sclerosis; a feasibility trial | Glasgow Caledonian University | NCT05320237 | |
| 311902 | Development of an Artificial Intelligence System for the Automated Diagnosis of Otitis Media with Effusion in Children | Cardiff Metropolitan University | ISRCTN17082829 | |
| 312494 | CompreHensive GeriAtRician led MEdication Review (CHARMER) - Work Package 3 Feasibility Trial | University of Leicester | ISRCTN11899506 | |
| 313100 | IDEntifying pAtients with suspicion of infection in the ED who have Low disease severity using Midregional Proadrenomedullin (MR-proADM) - Pivotal study | B·R·A·H·M·S | NCT05108883 | |
| 1004052 | A Phase 1, Blinded, Randomized, Placebo-controlled Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of BIIB132 Administered Intrathecally to Adults With Spinocerebellar Ataxia 3 | Biogen | ISRCTN94357046; 2021-002223-37 | |
| 1004248 | A Phase III, Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Gantenerumab In Participants At Risk For Or At The Earliest Stages Of Alzheimer’S Disease | Roche | ISRCTN54460428; 2021-001184-25 | |
| 1004279 | A Phase 2 Trial of MRTX849 Monotherapy and in Combination withPembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer withKRAS G12C Mutation | Mirati Therapeutics | ISRCTN13464104; NCT04613596; 2020-003101-58 | |
| 1004338 | A Phase 1b/3 Study of Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab Alone in Subjects With Previously Untreated Advanced Gastric and Gastroesophageal Junction Cancer With FGFR2b Overexpression (FORTITUDE-102) | Amgen | NCT05111626; 2021-003477-61 | |
| 1004360 | A Randomized, Double-Blinded, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability, Effect of Food and Absolute Bioavailability of BMS-986238 in Healthy Participants | Bristol-Myers Squibb | ISRCTN17572332; 2020-004521-23 | |
| 1004364 | Phase 1 Study of the PKMYT1 Inhibitor RP-6306 in Combination With Gemcitabine for the Treatment of Advanced Solid Tumors (MAGNETIC Study) | Repare Therapeutics | NCT05147272; 2021-006541-34 | |
| 1004373 | A Randomized, Double-Blind, Placebo-Controlled Study of ATH434 in Multiple System Atrophy | Alterity Therapeutics | NCT05109091; 2021-003231-29 | |
| 1004380 | Longwing: An Open-Label Extension Study for Patients with Dravet Syndrome who Previously Participated in Studies of STK-001 | Stoke Therapeutics | NCT04740476; 2021-005626-14 | |
| 1004406 | ENCORE - A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Mycobacterial (NTM) Lung Infection Caused by Mycobacterium avium Complex (MAC) | Insmed | ISRCTN15403905; NCT04677569; 2020-003079-16 | |
| 1004432 | An Open-Label, Multi-Center Phase 1 Study to Investigate the Safety and Tolerability of REGN1979, an Anti-CD20 x Anti-CD3 Bispecific Monoclonal Antibody, in Patients with CD20+ B-Cell Malignancies Previously Treated with CD20-Directed Antibody Therapy | Regeneron | NCT02290951; 2015-004491-30 | |
| 1004480 | A Randomized, Double-blind, Placebo-Controlled, Dose-Ranging Multicenter Study to Evaluate the Efficacy and Safety of ALN-AGT01 in Patients with Mild-to-Moderate Hypertension | Alnylam | NCT04936035; 2021-001248-82 | |
| 1004485 | Mifepristone Outpatient Labour Induction | Chelsea and Westminster Hospital NHS Foundation Trust | NCT05177510; 2021-004860-93 | |
| 1004546 | A Double-Blind, Randomised, Placebo Controlled, Two Period Cross-Over Study To Evaluate The Efficacy And Safety Of Orvepitant In Chronic Cough In Patients With Idiopathic Pulmonary Fibrosis | NeRRe Therapeutics | ISRCTN12372820; NCT05185089; 2021-006278-22 | |
| 1004562 | Randomized, Open Label, Phase 3 Study to Evaluate the Efficacy and Safety of Lerodalcibep (LIB003) compared to Inclisiran in Patients With Cardiovascular Disease, or at High Risk for Cardiovascular Disease, on Stable Lipid-Lowering Therapy Requiring Additional Low-Density Lipoprotein Cholesterol Reduction (LIBerate-VI) | LIB Therapeutics | NCT05004675; 2021-002871-20 | |
| 1004577 | A Multicenter, Randomized, Open-label, Parallel Phase 1 Comparability Study of Anifrolumab Administered using Accessorized Pre-Filled Syringe (APFS) or Autoinjector (AI) in Healthy Volunteers | AstraZeneca | ISRCTN93026854; 2021-004896-14 | |
| 1004593 | A Phase 2 Open-Label Study of the Safety, Tolerability and Efficacy of the Selective Inhibitor of Nuclear Export (SINE) Compound Eltanexor (KPT-8602) in Patients with Refractory Myelodysplastic Syndrome | Karyopharm Therapeutics | 2021-003810-38 | |
| 1004594 | IOCYTE AMI-3: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Intravenous FDY-5301 in Patients with an Anterior ST-Elevation Myocardial Infarction | Faraday Pharmaceuticals | NCT04837001; 2021-001924-16 | |
| 1004596 | A Phase Ib Dose Finding Study Assessing Safety and Activity of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination with Radiotherapy with or without Temozolomide and in Recurrent Glioblastoma as Single Agent | Novartis | NCT05109728; 2021-003672-14 | |
| 1004601 | A phase 1b/2, multicenter, adaptive, double-blind, randomized, placebo-controlled study to assess the safety, tolerability, immunogenicity, and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer’s disease and in adults with Down syndrome | AC Immune | NCT05462106; 2021-006195-17 | |
| 1004634 | A First-In-Human Phase 1b, Open-Label Trial to Evaluate Safety and Tolerability of a Novel Somatic Cell Therapy - AmnioPul-02 - in Subjects with Confirmed COVID-19 | Amniotics | 2020-004171-40 | |
| 1004639 | A Phase 3 Study to Evaluate the Efficacy and Safety of ARO-APOC3 in Adults with Familial Chylomicronemia Syndrome | Arrowhead Pharmaceuticals | ISRCTN12904794; 2021-003680-10 | |
| 1004672 | A Phase I/II Open-label, Multi-center Study to Assess Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of AZD7789, an Anti-PD-1 and Anti-TIM-3 Bispecific Antibody, in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma | AstraZeneca | NCT05216835; 2021-003569-36 | |
| 1004686 | Obicetrapib and Cardiovascular Outcomes: A Placebo-Controlled, Double-Blind, Randomized Phase 3 Study to Evaluate the Effect of 10 mg Obicetrapib in Participants With Atherosclerotic Cardiovascular Disease (ASCVD) Who are Not Adequately Controlled Despite Maximally Tolerated Lipid-Modifying Therapies | NewAmsterdam Pharma | NCT05202509; 2021-005092-39 | |
| 1004699 | Phase 1 Study of the PKMYT1 Inhibitor RP-6306 in Combination With FOLFIRI for the Treatment of Advanced Solid Tumors (MINOTAUR Study) | Repare Therapeutics | NCT05147272; 2021-006582-38 | |
| 1004740 | A Phase 2a, Randomized, Open-Label Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 702843 Administered to Patients with Phlebotomy Dependent Polycythemia Vera (PD-PV) | Ionis | NCT05143957; 2021-003704-40 | |
| 1004749 | A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus | UCB | NCT04294667; 2019-003407-35 | |
| 1004761 | ENHANCE-D: Enhancing Dental Health Advice | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN13158982; 2021-005440-30 | |
| 1004762 | A Phase 3, Multicenter, Randomized, Partially Blinded, Palivizumab-Controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of MK-1654 in Infants and Children at Increased Risk for Severe RSV Disease | MSD | NCT04938830; 2020-005996-11 | |
| 1004771 | A randomised, double-blind, parallel group Phase III study to assess the efficacy and safety of 100 mg SC depemokimab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) – ANCHOR-1 (depemokimAb iN CHrOnic Rhinosinusitis) | GlaxoSmithKline | NCT05274750; 2021-005037-16 | |
| 1004808 | A Phase 3, Randomized, Double-Blind Study of MK-7684A in Combination with Etoposide and Platinum Followed by MK-7684A vs Atezolizumab in Combination with Etoposide and Platinum Followed by Atezolizumab for the First-Line Treatment of Participants with Extensive-Stage Small Cell Lung Cancer (KEYVIBE-008) | MSD | NCT05224141; 2021-005034-42 | |
| 1004811 | A Phase 2, Open-Label, Multi-Center Study of PDS0101 (R-DOTAP [Versamune®] + HPVmix) and Pembrolizumab (KEYTRUDA®) Combination Immunotherapy in Subjects with Recurrent and/or Metastatic Head and Neck Cancer and High-Risk Human Papillomavirus-16 (HPV16) Infection | PDS Biotechnology | ISRCTN15021247; NCT04260126; 2021-004046-38 | |
| 1004844 | A Multi-arm, Open-label Phase I/IIa Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of AZD5305 in Combination with New Hormonal Agents in Patients with Metastatic Prostate Cancer (PETRANHA) | AstraZeneca | NCT05367440; 2021-006289-19 | |
| 1004851 | A Phase 1, Randomized, Double-blind, 3-arm, Parallel Design Study in Healthy Subjects to Evaluate Pharmacokinetics, Safety, Tolerability, and Immunogenicity of Bmab 1200 After Single Subcutaneous Injection inComparison with EU-approved Stelara® and US-licensed Stelara® | Biocon Biologics | ISRCTN11424009; 2021-006630-39 | |
| 1004852 | An open-label study in healthy male subjects to investigate the metabolism and excretion pathways of GLPG3667 following a single oral dose of [14C]-GLPG3667 and to determine the absolute bioavailability relative to an intravenous [14C]-GLPG3667 microtracer | Galapagos | NCT05335447; 2021-006730-39 | |
| 1004906 | Phase 3, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Apitegromab (SRK-015) in Patients with Later-Onset Spinal Muscular Atrophy Receiving Background Nusinersen or Risdiplam Therapy | Scholar Rock | NCT05156320; 2021-005314-34 | |
| 1004936 | Randomized, single-dose, open-label, two-part, two-period, cross-over study to compare the pharmacokinetics, safety and tolerability of the pediatric and adult formulation of branaplam and to investigate the adult formulation in fed and fasted state in healthy participants | Novartis | ISRCTN77772103; 2021-000298-10 | |
| 1004948 | A Phase 1, Open-Label, Dose finding Study of CC-95251, A Monoclonal Antibody Directed Against SIRPα, Alone and in Combination with Cetuximab or Rituximab in Subjects with Advanced Solid and Hematologic Cancers | Celgene | NCT03783403; 2020-000240-55 | |
| 1004972 | A Multicentre, Single-arm, Phase 3b Efficacy and Safety Study of Tezepelumab 210 mg Administered Subcutaneously to Reduce Oral Corticosteroid Use in Adult Participants with Severe Asthma on High-dose Inhaled Corticosteroid plus Long-acting β2 Agonist and Long-term Oral Corticosteroid Therapy (WAYFINDER) | AstraZeneca | NCT05274815; 2021-005457-85 | |
| 1004979 | A Phase 3 Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ISIS 721744 in Patients with Hereditary Angioedema (HAE) | Ionis | NCT05139810; 2021-002571-19 | |
| 1004984 | A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1 3 Alterations (FIGHT-209) | Incyte | NCT05267106; 2021-004740-24 | |
| 1004992 | A first-in-human, randomized, participant and investigator blinded, placebo controlled, single and multiple ascending dose study to assess the safety, tolerability and pharmacokinetics of EDI048 in healthy volunteers | Novartis | ISRCTN38693215; 2021-006567-19 | |
| 1005024 | A Phase 3 Randomized, Open-label, Active-comparator Controlled Clinical Study of Pembrolizumab versus Platinum Doublet Chemotherapy in Participants With Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma in the First-line Setting (KEYNOTE-C93/GOG-3064/ENGOT-en15) | MSD | NCT05173987; 2021-003185-12 | |
| 1005049 | A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending doses of SAR443765 in healthy adult participants and of a single dose of SAR443765 in participants with mild-to-moderate asthma | Sanofi-Aventis | NCT05366764; 2021-000356-19 | |
| 1005082 | A Phase 3, Open-label, Randomised Study of Datopotamab Deruxtecan (Dato-DXd) Versus Investigator’s Choice of Chemotherapy in Patients who are not Candidates for PD-1/PD-L1 Inhibitor Therapy in First-line Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast02) | AstraZeneca | NCT05374512; 2021-005223-21 | |
| 1005096 | An open label, multicenter roll-over extension program (REP) to characterize the long-term safety and tolerability of iptacopan (LNP023) in patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) who have completed PNH Phase 2 and Phase 3 studies with iptacopan | Novartis | NCT04747613Â Â ; 2020-004385-19 | |
| 1005098 | A Phase 1 Clinical Study to Determine the Safety and Immunogenicity of a Novel GMMA Vaccine Against Invasive Non-Typhoid Salmonella | University of Oxford | ISRCTN51750695; 2020-000510-14 | |
| 1005125 | A 52 week, multi-center, randomized, double-blind placebo-controlled study to assess the clinical efficacy and safety of ligelizumab (QGE031) in decreasing the sensitivity to peanuts in patients with peanut allergy | Novartis | ISRCTN04984876; NCT04984876; 2020-005339-56 | |
| 1005171 | A Phase 1, open-label trial in healthy participants to evaluate the drug-drug interaction potential of PRAX-562 | Praxis | 2022-000583-22 | |
| 1005228 | A Phase I, open-label, fixed-sequence, two-period, crossover, drug-drug interaction study to investigate the effect of efavirenz on the pharmacokinetics of ganaplacide and lumefantrine combination in healthy participants | Novartis | NCT05330273; 2021-000925-29 | |
| 1005259 | A Phase I, Open-Label, Single-Dose, Single-Period Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]AZD9833 After Oral Administration in Healthy Post-Menopausal Female Subjects | AstraZeneca | ISRCTN46127225; 2022-000834-40 | |
| 1005293 | A Phase 1, Randomised, Open-Label, Crossover Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of PBI-4050 compared to Sodium Phenylbutyrate in Healthy Subjects | Liminal BioSciences | NCT05349435; 2022-000804-36 |
Clinical trials given a REC favourable opinion in May 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 254656 | A 2-armed, parallel, randomised controlled trial to assess the effect of different modes of fluoride delivery, on enamel demineralisation, during orthodontic treatment with fixed appliances, in children and adolescents | Liverpool University Hospitals NHS Foundation Trust | NCT05005689; 2018-004335-76 | |
| 280123 | The effect of Semaglutide compared to metformin in obese women with polycystic ovary syndrome (PCOS): a randomised controlled trial (Semaglutide-PCOS study-SEMMET) | Hull University Teaching Hospitals NHS Trust | 2021-001361-20 | |
| 293364 | Phase two prospective observational single blind multi-site performance evaluation trial of serum Raman spectroscopy and supervised machine learning classification in FIT-positive bowel screening population | Swansea Bay University Health Board | ||
| 293754 | Determining Who Benefits Most from Cognitive Rehabilitation for Attention and Memory in Multiple Sclerosis: A Randomised Controlled Feasibility Trial | University of Nottingham | NCT05509426 | |
| 294635 | KEEP- A randomised feasibility study of a co-designed physical health education intervention to improve Knowledge, Exercise Efficacy and Participation for newly diagnosed people with Parkinson’s | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | NCT05253040 | |
| 297538 | Study of precision and reproducibility of non-invasive glucose testing with the LabClasp | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | ||
| 297626 | OUtcome following Tailored Education and Retraining: Studying Performance and Adherence in ChildrEn and young people with asthma: a Randomised feasibility Study (OUTER-SPACERS) | University Hospitals of North Midlands NHS Trust | NCT05366309 | |
| 298095 | OKKO Space Academy App: families checking their child's vision at home during amblyopia treatment | Moorfields Eye Hospital NHS Foundation Trust | NCT05313516 | Found through search but HRA not notified |
| 299054 | Validation of Innovative Scheimpflug topography derived RGP contact lens designs In Optometry Network (VISION Initiative) | Moorfields Eye Hospital NHS Foundation Trust | ||
| 299552 | An open label, single arm, extension trial to examine long-term safety of BI 425809 once daily in patients with schizophrenia who have completed previous BI 425809 Phase III trials.(CONNEX-X) | Boehringer Ingelheim | NCT05211947; 2020-003745-11 | |
| 300137 | Protection of Cardiac Function with Left Bundle Branch Pacing in Patients with Atrioventricular Block (OptimPacing) | The First Affiliated Hospital Nanjin Medical University | NCT04624763 | |
| 300243 | Multi-centre Prospective observational cohort study: To assess the performance of single use duodenoscope (aScope) | Nottingham University Hospitals NHS Trust | NCT05225909 | |
| 300545 | Defatting of donor transplant livers during normothermic perfusion - a randomised clinical trial | University of Oxford | ISRCTN14957538 | |
| 301345 | Imaging of tumour microvasculature using high resolution contrast enhanced ultrasound (CEUS) together with markers of proliferation/ angiogenesis/ vascular mimicry to characterise response to NACT in triple negative breast cancer | Maidstone & Tunbridge Wells NHS Trust | ||
| 301912 |
ROTATE Rotation of the fetal head at full cervical dilatation Randomised controlled trial of manual versus instrumental rotation of the fetal head in malposition at birth |
University College London | ISRCTN10193017 | |
| 303325 | Phase 3 Randomized, Controlled Study of Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia With Safety Run-in (Golden Gate Study) | Amgen | NCT04994717; 2020-004498-29 | |
| 303378 | DOLCE: Determining the Impact of Optellum’s LCP Artificial Intelligence Solution on Service Utilisation, Health Economics and Patient Outcomes | Nottingham University Hospitals NHS Trust | NCT05389774 | |
| 303690 | Imperial Prostate 7 - Prostate Assessment using Comparative Interventions – Fast mri and Image-fusion for Cancer | Imperial College London | NCT05574647 | |
| 303703 | Randomised investigation to evaluate Phe fluctuation after overnight fasting in PKU patients treated with PKU GOLIKE versus standard amino acid protein substitute | APR Applied Pharma Research | NCT05487378 | Found through search but HRA not notified |
| 303720 | A Phase 1/2a, Multicenter, Open-label Trial of TBio-6517, an Oncolytic Vaccinia Virus, Administered Alone and in Combination with Pembrolizumab, in Patients with Advanced Solid Tumors | Turnstone Biologics Corp | NCT04301011; 2021-001001-79 | |
| 303731 | A Phase 2 Multi-Arm Study of Magrolimab in Patients with Solid Tumors | Gilead | NCT04827576; 2020-005265-14 | |
| 305144 | Effectiveness and cost-effectiveness of a peer-led walking programme to increase physical activity in inactive older adults: “Walk with Me Study” | University of Ulster | ISRCTN73367347 | |
| 305172 | Utility of PET-MRI in post-treatment surveillance of paediatric brain tumours: a feasibility study | Sheffield Children's NHS Foundation Trust | NCT05553899 | |
| 305912 | A randomised phase II study to investigate the effectiveness of ACUpuncture for the relief of Long COVID related fatigue | The Royal Marsden NHS Foundation Trust | NCT05212688 | |
| 306620 | Cluster Randomised Controlled Trial of a Service to Support the Mental Health and Coping of Parents with Excessively Crying Infants | De Montfort University | ISRCTN73761296 | |
| 306658 | The effectiveness and acceptability of a guided self-help ACT intervention for individuals with a spinal cord injury (SCI) | University of Nottingham | ||
| 306829 | Financial incentives to improve adherence to inhaled asthma medications in children and young people with asthma | Imperial College London | NCT05322044 | |
| 306946 | SPIROmetry to Manage Asthma in Children (SPIROMAC) | University of Aberdeen | ISRCTN31849868 | |
| 306996 | Biomarker Driven Antifungal Stewardship (BioDriveAFS) in Acute Leukaemia – a Multi-Centre Randomised Controlled Trial to Assess Clinical and Cost Effectiveness | Hull University Teaching Hospitals NHS Trust | ISRCTN11633399 | |
| 307300 | Remote monitoring to predict and prevent asthma attacks in preschool children | Imperial College London | NCT05447832 | |
| 307759 | First in human study of Sirona: A study to determine safety, feasibility and tolerability of an expanding hydrogel tablet, designed to promote weight loss in adults with a body mass index of 30-40 | Oxford Medical Products | ISRCTN12345678 | |
| 307827 | Analysis of a motivational chairwork intervention for adults diagnosed with Anorexia Nervosa | Canterbury Christ Church University | Sponsor no longer considers this a clinical trial | |
| 307875 | A Phase 3 Study to Evaluate the Safety and Efficacy of a Single Dose of CTX001 in Pediatric Subjects With Transfusion-Dependent β-Thalassemia | Vertex | 2021-002172-39 | |
| 307888 | PACE-NODES: A phase III randomised trial of 5 fraction prostate SBRT versus 5 fraction prostate and pelvic nodal SBRT | The Institute of Cancer Research | NCT05613023 | |
| 307968 | Mechanisms driving headache in Idiopathic Intracranial Hypertension, a human physiology study | University of Birmingham | ISRCTN13251508 | |
| 308700 | A Prospective, Open-Label, Dose-Escalation Study to Evaluate the Safety and Efficacy of IRL201805 in Participants with Noninfectious, Active, Intermediate, or Posterior Uveitis or Panuveitis | Revolo Biotherapeutics | 2021-005755-37 | |
| 308702 | BD4QoL: Big Data for Quality of Life: A multicenter randomized trial for quality of life evaluation by non-invasive intelligent tools during post-curative treatment follow-up for head and neck cancer | University of Birmingham | NCT05315570 | |
| 308782 | An Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of ZYN002 Administered as a Transdermal Gel to Children and Adolescents with Fragile X Syndrome | Zynerba | NCT03802799; 2021-006459-33 | |
| 308872 | Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of ALVR105 (Viralym-M) Compared to Placebo for the Prevention of AdV, BKV, CMV, EBV, HHV-6, and JCV Infection and/or Disease, in High-Risk Patients After Allogeneic Hematopoietic Cell Transplant | AlloVir | NCT04693637; 2021-005105-27 | |
| 308989 | Effectiveness of supervised versus self-directed rehabilitation for people aged 50 years and over with ankle fractures: the AFTER trial | University of Oxford | ISRCTN11830323 | |
| 309018 | Responding to people in danger. A development and feasibility study to co-develop a community pharmacy response service for domestic abuse and suicidal ideation | University of Lincoln | ISRCTN95063724 | Found through search but HRA not notified |
| 309038 | Social Prescribing And Community rEsources for Children and Young People: "SPACE CYP" Pilot | Newcastle upon Tyne Hospitals NHS Foundation Trust | ISRCTN23306751 | |
| 309237 | A Clinical Performance Study using an Optical Fluorescence Test to Detect SARS-CoV-2 Virions | Paraytec | Currently registering | |
| 309311 | Liothyronine to normalise Thyroid Hormones in Heart Failure (T3-HF) – A feasibility study | Gateshead NHS Foundation Trust | ISRCTN10706683 | |
| 309409 | iMAgery focused therapy for PSychosis-2 (iMAPS-2): A feasibility randomised controlled trial | Pennine Care NHS Foundation Trust | ISRCTN81150786 | |
| 309521 | Frail2Fit: A feasibility and acceptability study of a virtual multimodal intervention delivered by volunteers to improve functional outcomes of frail older adults discharged from hospital | University Hospital Southampton NHS Foundation Trust | NCT05384730 | |
| 309748 | Outdoor swimming as a nature-based intervention for depression: a feasibility randomised control trial | Sussex Partnership NHS Foundation Trust | ISRCTN90851983 | |
| 309757 | A new therapy for post-stroke arm spasticity: Sheffield Adaptive Patterned Electrical Stimulation (SHAPES) - a co-designed system improvement followed by a powered multi-arm randomised control trial | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN26060261 | |
| 310182 | Patient experience and accuracy of finger prick blood testing kits | Northern Care Alliance NHS Foundation Trust | ISRCTN11333327 | |
| 310285 | Acceptability of a digital health intervention to empower and inform about postpartum contraception and facilitate access: a pilot study | University of Edinburgh | ISRCTN48521918 | |
| 310377 | Real world Randomised Controlled Trial of an artificial intelligence-enabled app as an early intervention and support tool in the mental health referral care pathway | University of Plymouth | ISRCTN14644939; NCT05533190 | |
| 310380 | Body image, psychological distress, shame and disordered eating in patients in Tier 3 weight management service receiving online delivered, a group based, Compassion Focused Therapy (CFT) informed psychological intervention | Canterbury Christ Church University | NCT05400096 | |
| 310607 | Stability of Antiepileptics in Serum and K2 EDTA Plasma Patient Samples In Cascadion™ SM Antiepileptics | Thermo Fisher Scientific | Trial did not open in the UK | |
| 310777 | Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge: a randomised controlled assessor-blind clinical and cost-effectiveness trial with internal pilot (iRehab) | Ulster University | ISRCTN11266403 | |
| 310827 | Activity as medicine in oncology for head and neck | University of Liverpool | ISRCTN82505455 | |
| 310850 | Transforming the management of hepatic encephalopathy using non-invasive breath ammonia, in patients with chronic liver disease | University Hospitals Bristol and Weston NHS Foundation Trust | Sponsor no longer considers this a clinical trial | |
| 310856 | Improving Hospital Opioid Substitution Therapy (iHOST): implementation and assessment of an intervention to reduce late presentations, discharges against medical advice and repeat admissions among people who use opioids | London School of Hygiene & Tropical Medicine | ISRCTN47320412 | |
| 310986 | Prospective randomised controlled trial comparing three splints for finger flexor tendon repairs (FIRST study) | University Hospitals Derby & Burton NHS Foundation Trust | ISRCTN10236011 | |
| 311004 | A multi-levelled evidence-based creative psychological intervention to support NHS clinical staff affected by the COVID-19 pandemic: a feasibility study | Edge Hill University | Sponsor no longer considers this a clinical trial | |
| 311009 | Non-invasive self-management treatment for Ocular Cranial nerve PALSies: The OCPALS study | University of Liverpool | ||
| 311050 | Does stratifying patients into low or high risk prior to their initial consultation reduce breaches in head and neck cancer? | Liverpool University Hospitals NHS Foundation Trust | ||
| 311393 | Evaluation of the Feasibility and Reproducibility of 2 Point-of-Care Tests for SARS-Co-V-2 Antibodies (INSIGHT 017) | University of Minnesota | NCT05227404 | |
| 311621 | Evaluation of the GRI gentleheel® incision device for adult fingertip blood sampling - intended use extension | Mowgli Innovation | ISRCTN48548060 | |
| 311790 | To evaluate the acceptability and palatability of a hypoallergenic nutritionally complete powdered amino acid formula with HMO (Human Milk Oligosaccharides) for the dietary management of cows’ milk allergy (CMA) and multiple food protein allergies (MFPA) in children over ≥1 year | Nestle Health Science | ||
| 312084 | A feasibility study assessing the impact of at-home infrared temperature monitoring (AITM) supported by telemedicine in the management of patients at high risk of diabetes related foot ulceration | NHS Greater Glasgow & Clyde | NCT06032221 | |
| 312437 | Does mobilisation in the evening reduce the incidence of delirium in patients admitted to intensive care: a mixed-methods, randomised controlled feasibility study | University Hospitals Coventry & Warwickshire NHS Trust | NCT05401461 | |
| 312455 | Assessment of an electronic system of the impact on inhaler skills and technique | University of Manchester | ISRCTN14411274 | |
| 312539 | The Phoenix VR Self-Confidence Therapy Trial: A Case Series and a Randomised Controlled Trial of Automated VR Therapy to Improve the Self-Confidence of Young People Diagnosed with Psychosis | University of Oxford | ISRCTN10250113 | |
| 312585 | Early self-initiated upper-body exercise to improve volitional control below the level of injury after spinal cord injury | University of Birmingham | ISRCTN89333770 | |
| 312642 | FLowTriever All-Comer Registry for Patient Safety and Hemodynamics (FLASH) | Inari Medical | NCT03761173 | |
| 312684 | Evolut™ EXPAND TAVR II Pivotal Trial. Multi-center, international, prospective, randomized. Subjects will be randomized on 1:1 basis to Transcatheter Aortic Valve Replacement (TAVR) using the Medtronic Evolut PRO+ TAVR system + guideline-directed management and therapy (GDMT) or GDMT alone | Medtronic | NCT05149755 | |
| 312752 | Examining the benefit of graduated compression stockings in the Prevention of vEnous Thromboembolism in low-risk Surgical patients: a multicentre cluster randomised controlled trial | Imperial College London | ISRCTN13908683; NCT05347550 | |
| 312833 | Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiTED): A Randomised Controlled Trial | North Bristol NHS Trust | ISRCTN35574247 | |
| 312864 | The Hydrus® Microstent For Iop Reduction In Mild To Moderate Open-Angle Glaucoma (Frontier) | Ivantis | NCT05198297 | |
| 313119 | Optimal Prescribing of Levothyroxine Study (OPAL) | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN65030272 | |
| 313309 | Implementation of an artificial intelligence module on the online imaging portal MYO-Share for guiding the diagnosis of muscle diseases | Newcastle University | ISRCTN14323809 | |
| 313439 | An Open-Label Study To Evaluate Clinical Performance Of The Gedea Pessary In Adult Women With Vulvovaginal Candidiasis | Gedea Biotech | NCT05507333 | Found through search but HRA not notified |
| 313639 | Lancashire Objective Volume Evaluation of leg oedema in Heart Failure (LOVE-HF2) | Heartfelt Technologies | NCT04787393 | |
| 313662 | Assessing the feasibility of an evidence-informed digital intervention to support self-management in people with non-alcoholic fatty liver disease (VITALISE- interVention to promote lIfesTyle change in non-Alcoholic fatty LIver diseaSE) | Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University | ISRCTN12893503 | |
| 313805 | An Observational Follow-up Study to Evaluate Duration of Treatment Effect of Pentosan Polysulfate Sodium in Participants with Knee Osteoarthritis Pain | Paradigm | NCT04814719 | |
| 314923 | Cognitive Behaviour Therapy for Depersonalisation-Derealisation Disorder (CBT-f-DDD): A feasibility study | Camden & Islington NHS Foundation Trust | ISRCTN97686121 | |
| 315747 | Non Dispensing Clinical Evaluation of Customised OneFitTM MED Scleral Contact Lenses | CooperVision | ISRCTN16851376 | |
| 1003556 | A Phase 3 Multinational, Randomized, Double-Blind, Placebo-Controlled Systemic Gene Delivery Study to Evaluate the Safety and Efficacy of SRP-9001 in Subjects With Duchenne Muscular Dystrophy (EMBARK) | Sarepta Therapeutics, Inc. | NCT05096221; 2019-003374-91 | |
| 1003674 | A Phase II Non-Randomized, Open-label, Multi-centre Study of the Safety and Efficacy of Tebentafusp in Melanoma with Molecular Relapsed Disease | University of Oxford | NCT05315258; 2019-003946-36 | |
| 1003824 | A First In Human feasibility study of T regulatory cells (TR004) for Inflammatory Bowel Disease Using (ex vivo) Treg Expansion | Guy's & St Thomas' NHS Foundation Trust | ISRCTN97547683; 2017-000170-11 | |
| 1003872 | A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study of BLU-263 in Indolent Systemic Mastocytosis | Blueprint Medicines | NCT04910685; 2020-005173-28 | |
| 1004169 | A Randomized, Controlled, Multicenter Study to Evaluate the Safety and Efficacy of Paltusotine in Subjects with Non-pharmacologically Treated Acromegaly | Crinetics Pharmaceuticals | NCT05192382; 2021-001703-32 | |
| 1004221 | THE MICROBIAL EFFECT OF INHALED STEROIDS IN SEVERE COPD PATIENTS WITH ASSOCIATED BRONCHIECTASIS (TEMPESTAS) | University of Edinburgh & Lothian Health Board | ISRCTN15449782; 2022-000524-38 | |
| 1004222 | Pan Tumour Trial of Cox-Inhibitor and Immune Checkpoint Blockade | The Christie NHS Foundation Trust | ISRCTN73037722; 2021-005109-29 | |
| 1004239 | A Phase 2, Randomized, Parallel, Open-Label Study to Investigate the Safety, Efficacy, and Pharmacokinetics of Various Dosing Regimens of Single-Agent Belantamab Mafodotin (GSK2857916) in Participants with Relapsed or Refractory Multiple Myeloma (DREAMM-14) | GlaxoSmithKline | NCT05064358; 2021-004151-16 | |
| 1004252 | A Study of Cardiovascular Events iN Diabetes – PLUS (ASCEND PLUS) | University of Oxford | ISRCTN76193287; 2021-003792-33 | |
| 1004322 | A Phase 2, Randomised, Double-Blind, Placebo-Controlled, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Tolerability, and Effects on Tumour Biomarkers of the NOX1/4 Inhibitor Setanaxib, when Administered with the PD-1 Inhibitor Pembrolizumab, in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) | Genkyotex Suisse SA | ISRCTN63646763; 2021-004627-33 | |
| 1004362 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION582 in Patients with Angelman Syndrome | Ionis | NCT05127226; 2021-003009-23 | |
| 1004366 | A Multicenter Randomized Controlled Trial of Best Available Therapy versus Autologous Hematopoietic Stem Cell Transplant for Treatment-Resistant Relapsing Multiple Sclerosis | National Institute of Allergy and Infectious Disease | NCT04047628; 2020-000979-21 | |
| 1004383 | A Two-Part, Open-Label, Randomised, Cross-Over Study To Compare New Tablet Formulations Of Ro7486967 To The Capsule Formulation, To Perform A Preliminary Dose Proportionality Assessment And To Estimate The Effect Of Food On The Pharmacokinetics Of The Tablet Formulations In Healthy Participants | Roche | ISRCTN14438276; 2021-005215-31 | |
| 1004392 | Ambulatory Oxygen for Idiopathic Pulmonary Fibrosis | University of Birmingham | ISRCTN16366011; 2021-003535-29 | |
| 1004417 | A Phase 2 study of PHE885, B-cell maturation Antigen (BCMA)-directed CAR-T Cells in adult participants with relapsed and refractory multiple myeloma | Novartis | NCT05172596; 2021-003747-22 | |
| 1004442 | A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IBCAb002 in Persons with Early Alzheimer's Disease | ImmunoBrain Checkpoint | NCT05551741; 2021-006580-19 | |
| 1004444 | A randomised, double-blind, placebo-controlled, parallel group, dose-finding study evaluating efficacy, safety and tolerability of BI 1291583 qd over at least 24 weeks in patients with bronchiectasis | Boehringer Ingelheim | NCT05238675; 2021-003304-41 | |
| 1004456 | A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Subjects With Pyruvate Kinase Deficiency Who Are Not Regularly Transfused, Followed by a 5-Year Open-label Extension Period | Agios | NCT05175105; 2021-003333-11 | |
| 1004467 | A Phase 3, Randomized, Double-Blind Trial of Two Formulations of Setmelanotide (Daily and Weekly) with a Crossover to Open-Label Once Weekly Setmelanotide in Patients with Specific Gene Defects in the Melanocortin-4 Receptor Pathway Who Are Currently on a Stable Dose of the Once Daily Formulation | Rhythm Pharmaceuticals | NCT05194124; 2021-004597-65 | |
| 1004472 | An Open-Label Phase 1a/1b Dose Escalation and Expansion Cohort Study of SL-172154 (SIRPα-Fc-CD40L) in Combination With Azacitidine or With Azacitidine and Venetoclax for the Treatment of Subjects With Higher-Risk Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) | Shattuck Labs | NCT05275439; 2021-003255-42 | |
| 1004476 | Pharmacodynamic Activity Trial of JNJ-67484703 in Rheumatoid Arthritis, Ulcerative Colitis and Sjögren’s syndrome (PARIS) : A phase 2 proof of biology trial | University of Birmingham | ISRCTN31164692; 2021-005998-13 | |
| 1004493 | AURORA: Atezolizumab in patients with urinary tract squamous cell carcinoma: a single arm, open label, multicentre, phase II clinical trial | University Hospital Southampton NHS Foundation Trust | NCT05038657; 2021-004995-32 | |
| 1004513 | An Open-label Randomized Phase 3 Study of Tucatinib in Combination with Trastuzumab and mFOLFOX6 versus mFOLFOX6 given with or without either Cetuximab or Bevacizumab as First-line Treatment for Subjects with HER2+ Metastatic Colorectal Cancer | Seagen | NCT05253651; 2021-002672-40 | |
| 1004564 | Open-Label, Uncontrolled, Single dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of AZD7442 in Pediatric Participants Aged ≥ 29 weeks Gestational Age to < 18 years | AstraZeneca | NCT05281601; 2021-006056-13 | |
| 1004582 | An interventional, randomised, double-blind, parallel-group, placebo-controlled, flexible-dose, adaptive study of the efficacy of KL1333 in adult patients with primary mitochondrial disease | Abliva | 2021-002846-33 | |
| 1004591 | A Phase 1, First-in-Human Study of DS-9606a in Patients with Tumour Types Known to Express Claudin-6 (CLDN6) | Daiichi Sankyo | NCT05394675; 2022-000120-38 | |
| 1004607 | A Phase Ib Dose Finding Study Assessing Safety and Activity of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Extensive Stage Small Cell Lung Cancer (ES-SCLC) in Combination with Carboplatin, Etoposide and Tislelizumab in Induction, and Tislelizumab in Maintenance Treatment Phase | Novartis | NCT05142696; 2021-004155-16 | |
| 1004618 | An Open-Label, Multicenter, Phase Ib Trial Evaluating The Safety, Pharmacokinetics, And Activity Of Cevostamab In Patients With Relapsed Or Refactory Multiple Myeloma (Camma 1) | Genentech | ISRCTN53331091; NCT04910568; 2021-000238-33 | |
| 1004635 | Double-blind, randomised, placebo-controlled, phase II dose-finding study comparing different doses of norucholic acid tablets with placebo in the treatment of primary biliary cholangitis in patients with an inadequate response to ursodeoxycholic acid | Dr. Falk Pharma | 2021-001431-56 | |
| 1004666 | A Phase 3 Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Daily Subcutaneous Injections of Elamipretide in Subjects with Primary Mitochondrial Disease Resulting from Pathogenic Nuclear DNA Mutations (nPMD) | Stealth BioTherapeutics | ISRCTN92370847; NCT05162768; 2021-003907-16 | |
| 1004704 | A Phase 2/3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of mRNA-1345, an mRNA Vaccine Targeting Respiratory Syncytial Virus (RSV), in Adults ≥ 60 Years of Age | ModernaTX | NCT05127434; 2021-005026-20 | |
| 1004738 | An Open-label, Multicenter, Phase 2 Study of Sacituzumab Govitecan Combinations in First-line Treatment of Patients with Advanced or Metastatic Non−Small-Cell Lung Cancer (NSCLC) Without Actionable Genomic Alterations | Gilead | NCT05186974; 2021-004280-27 | |
| 1004813 | A 26 week, randomized, double blind, multinational, multicentre, active controlled, 2-arm parallel group trial comparing CHF 5993 100/6/12.5 μg pMDI (fixed combination of extra fine formulation of beclometasone dipropionate plus formoterol fumarate plus glycopyrronium bromide) to CHF 1535 200/6 μg pMDI (fixed combination of extra fine formulation of beclometasone dipropionate plus formoterol fumarate) in subjects with asthma uncontrolled on medium doses of inhaled corticosteroids in combination with long-acting ß2-agonists | Chiesi Farmaceutici | ISRCTN46960773; NCT05018598; 2021-002391-39 | |
| 1004817 | A Phase Ia study to assess safety and immunogenicity of the Plasmodium falciparum malaria vaccine candidate Pfs48/45 in Matrix-M adjuvant in healthy adults living in the UK | University of Oxford | NCT05400746; 2021-006763-26 | |
| 1004824 | Phase IIb, randomized, double-blind, placebo-controlled study in parallel groups assessing the efficacy and safety of two doses of SOM3355 in patients suffering from Huntington’s Disease with choreic movements | SOM Biotech | NCT05475483; 2021-003453-28 | |
| 1004828 | A Phase 2b, Randomized, Double-Mask, Placebo-Controlled, Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Linsitinib in Subjects with Active, Moderate to Severe Thyroid Eye Disease (TED) | VasaraGen | NCT05276063; 2021-005000-36 | |
| 1004834 | A Phase 3, Randomized, Double-blind, Placebo-controlled Multicenter Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients with Cold Agglutinin Disease (CAD) | Swedish Orphan Biovitrum (SOBI) | 2021-003160-27 | |
| 1004842 | Study of four-factor prothrombin complex concentrate, OCTAPLEX, in patients with acute major bleeding on direct oral anticoagulant (DOAC) therapy with factor Xa inhibitor | Octapharma | NCT04867837; 2021-000740-21 | |
| 1004868 | A Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants with Huntington's Disease | Sage Therapeutics | ISRCTN17896603; NCT05107128; 2021-005577-16 | |
| 1004890 | daNIS-3: An open-label, multi-center, phase II platform study evaluating the efficacy and safety of NIS793 and other new investigational drug combinations with standard of care (SOC) anti-cancer therapy for the second line treatment of metastatic colorectal cancer (mCRC) | Novartis | NCT04952753; 2021-000553-40 | |
| 1004934 | Randomised, open-label and parallel group trial to investigate the effects of oral BI 685509 alone or in combination with empagliflozin on portal hypertension after 8 weeks treatment in patients with clinically significant portal hypertension (CSPH) in compensated cirrhosis | Boehringer Ingelheim | NCT05282121; 2021-005171-40 | |
| 1004940 | A Randomized, Open-label, Phase 3 Trial of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in Treatment-naïve Subjects with Advanced or Metastatic PD-L1 High (TPS ≥50%) Non-small Cell Lung Cancer Without Actionable Genomic Alterations (Tropion-Lung08) | Daiichi Sankyo | ISRCTN24189848; 2021-002555-10 | |
| 1004960 | A Phase 2A, Randomized, Placebo-Controlled, Dose-Ranging Study To Evaluate The Safety And Efficacy Of Ptc518 In Subjects With Huntington'S Disease | PTC Therapeutics | ISRCTN97180769; NCT05551741; 2021-003852-18 | |
| 1004980 | iPREDICT Trial: A Phase IIB, Open Label, Study of 89Zr-Df-Crefmirlimab PET/CT in Subjects with Selected Advanced or Metastatic Malignancies including Melanoma, Merkel Cell, Renal Cell and Non-Small Cell LungCancers, Scheduled to Receive Standard-of-Care Immunotherapy (IOT) as a Single Agent or Combination, to Predict Response to Therapy | ImaginAb | NCT05013099; 2021-005610-33 | |
| 1004991 | A Phase 1 Study of SGN-B7H4V in Advanced Solid Tumors | Seagen | NCT05194072; 2021-002107-35 | |
| 1004998 | A Randomized, Double-Blind, Placebo-Controlled, Phase 3, Three-way Crossover Trial to Evaluate the Efficacy and Safety of Two Dose Levels of KVD900, an Oral Plasma Kallikrein Inhibitor, for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients with Hereditary Angioedema Type I or II | KalVista Pharmaceuticals | ISRCTN14762022; NCT05259917; 2021-001226-21 | |
| 1005000 | A Phase III Double-Blind, Randomised, Placebo-Controlled Study Assessing the Efficacy and Safety of Capivasertib + Docetaxel Versus Placebo + Docetaxel as Treatment for Patients with Metastatic Castration Resistant Prostate Cancer (mCRPC) | AstraZeneca | NCT05348577; 2021-005201-27 | |
| 1005002 | Niraparib Efficacy in patients with Unresectable Mesothelioma: A randomised phase II trial of Niraparib versus active symptom control in patients with previously treated mesothelioma | University Hospital Southampton NHS Foundation Trust | ISRCTN16171129; 2022-000198-26 | |
| 1005007 | A Phase II, Multicentre, Randomised, Double Blind, Placebo Controlled Parallel Group Study, Followed By A 36 Week Active Treatment Phase To Evaluate The Efficacy And Safety Of Secukinumab In Patients With Non-Ocular Behçet's Syndrome | Liverpool University Hospitals NHS Foundation Trust | ISRCTN94958652 ; 2022-000255-37 | |
| 1005023 | A Phase 2 Open-label Trial to Evaluate Safety, Efficacy, Tolerability, and Pharmacodynamics of a Combination of JNJ-73763989, Nucleos(t)ide Analogs, and a PD-1 inhibitor in Chronic Hepatitis B Patients | University of Leicester | ISRCTN15803686; 2021-005132-33 | |
| 1005027 | A randomized, multicenter, double-blind, Phase 3 study of amcenestrant (SAR439859) versus tamoxifen for the treatment of patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative or positive, stage IIB-III breast cancer who have discontinued adjuvant aromatase inhibitor therapy due to treatment-related toxicity | Sanofi-Aventis | NCT05128773; 2021-000398-10 | |
| 1005035 | A randomised, single-blind, placebo-controlled, first-inhuman study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of SLN501 administered to healthy volunteers | Silence Therapeutics | ISRCTN58651193; 2022-000511-31 | |
| 1005048 | A Phase 3, Open-Label, Multicenter Study to Evaluate Contraceptive Efficacy and Safety of Depot Medroxyprogesterone Acetate (150 mg/mL) Injected Subcutaneously Every Six Months | Family Health International 360 | ISRCTN62695528; 2021-004106-22 | |
| 1005052 | A multicentre, open-label, non-randomized, phase 1a/1b study of NG-350A, a tumour-selective anti-CD40-expressing adenoviral vector in combination with pembrolizumab in patients with metastatic or advanced epithelial tumours | Akamis Bio | NCT05165433; 2022-000335-22 | |
| 1005086 | A Phase 2b, Placebo-Controlled, Randomized Study of BPZE1 Intranasal Pertussis Vaccine in Healthy Adults to Assess Protection Against Colonization Following Challenge with Virulent Wild-Type Bordetella pertussis | ILiAD Biotechnologies | NCT05461131; 2022-000616-63 | |
| 1005109 | A Phase 2/3, Interventional Safety, Pharmacokinetics, And Efficacy, Open-Label, Multi-Center, Single-Arm Study To Investigate Orally Administered Pf-07321332 (Nirmatrelvir)/Ritonavir In Nonhospitalized Symptomatic Pediatric Participants With Covid-19 Who Are At Risk Of Progression To Severe Disease | Pfizer | NCT05261139; 2022-000075-39 | |
| 1005127 | A Phase 3, Multi-Center, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of CK-3773274 in Adults with Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction | Cytokinetics | NCT05186818; 2021-003536-92 | |
| 1005134 | A Phase Ib Randomized, Placebo-Controlled Study Evaluating The Safety, Pharmacokinetics, Pharmacodynamics, And Efficacy Of Crovalimab For The Management Of Acute Uncomplicated Vaso-Occlusive Episodes (Voe) In Patients With Sickle Cell Disease (Scd) | Roche | ISRCTN89975936; 2020-004840-27 | |
| 1005139 | A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated, MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON) | AstraZeneca | NCT05261399; 2021-006374-24 | |
| 1005149 | A multiple ascending dose (MAD) safety, tolerability and efficacy study of VRDN-001, a humanized monoclonal antibody directed against the IGF-1 receptor, in normal healthy volunteers (NHVs) and subjects with thyroid eye disease (TED) | Viridian | NCT05176639; 2021-006794-37 | |
| 1005155 | Randomised controlled trial evaluating effectiveness of neoadjuvant endocrine treatment in post-menopausal women | University of Oxford | ISRCTN11896599; 2022-000582-40 | |
| 1005160 | A 96-week, prospective, multicenter, randomised, double-blind, placebocontrolled, phase 3 study to compare efficacy and safety of masitinib dose titration to 4.5 mg/kg/day versus placebo in the treatment of patients with primary progressive or secondary progressive multiple sclerosis without relapse | AB Science | ISRCTN93303620; 2021-000639-30 | |
| 1005163 | A Phase 2 Open Label Pilot Study to Evaluate the Safety and Efficacy of Subcutaneously Administered ELX-02 in Patients with Alport Syndrome with Col4A5 and Col4A3/4 Nonsense Mutation | Eloxx Pharmaceuticals | ISRCTN12014920; 2022-000604-35 | |
| 1005180 | A Phase IIIb randomized open-label study of nirsevimab (versus no intervention) in preventing hospitalizations due to respiratory syncytial virus in infants (HARMONIE) | Sanofi-Aventis | NCT05437510; 2022-000099-20 | |
| 1005227 | A multi-center, randomized, double-blind, placebo controlled, parallel-group Phase IIIb study evaluating the effect of inclisiran on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of non-obstructive coronary artery disease without previous cardiovascular events (VICTORION-PLAQUE) | Novartis | NCT05360446; 2021-004601-47 | |
| 1005249 | A Phase 2, Randomized, Open-Label Study Of Encorafenib Andcetuximab Plus Pembrolizumab Versus Pembrolizumab Alone Inparticipants With Previously Untreated Braf V600E-Mutant,Msi-H/Dmmr Metastatic Colorectal Cancer | Pfizer | NCT05217446; 2021-003715-26 | |
| 1005285 | A Phase IIb/III Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Cotadutide in Participants with Non-cirrhotic Non-alcoholic Steatohepatitis with Fibrosis | AstraZeneca | NCT05364931; 2021-005484-53 | |
| 1005306 | A Phase 1, randomized, double-blind, placebo-controlled, multiple ascending dose study to assess the safety, tolerability, immunogenicity, pharmacokinetics and pharmacodynamics of UPB-101 in subjects with asthma | Upstream Bio | NCT05448651; 2022-000132-36 | |
| 1005333 | A Randomised, Double-blind, Placebo Controlled, Repeat Dose Phase 1b Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Inhaled GSK3923868 During Experimental Human Rhinovirus Infection in Participants with Mild Asthma | GlaxoSmithKline | ISRCTN15115094; 2021-006640-27 | |
| 1005346 | Prospective cohort study to monitor the emergence of SARS-CoV-2 spike viral variants in immunocompromised non-hospitalised patients exposed to sotrovimab in Great Britain: LUNAR study | GlaxoSmithKline | ISRCTN74418247 ; 2022-000754-29 | |
| 1005384 | A Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study of Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Subcutaneous ALXN2030 in Healthy Participants | Alexion | NCT05501717; 2022-000425-24 | |
| 1005455 | A Randomised Double-Blind Placebo-Controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of Cobitolimod as an Induction and Maintenance Therapy in Participants with Moderate to Severe Active Left-Sided Ulcerative Colitis | InDex Pharmaceuticals | NCT04985968; 2021-002549-13 | |
| 1005463 | A Two-Part Phase 1, First in Human Study to Evaluate the Safety and Tolerability of Single and Multiple Ascending Intravenous and Subcutaneous Doses of a Monoclonal Antibody (MB272) in Healthy Adults | MiroBio | 2021-006193-23 | |
| 1005490 | Phase2, double-blind, randomized, placebo-controlled, multicentre study to evaluation the safety, efficacy, and pharmacokinetics of TAK-242 and Granulocyte Colony-Stimulating Factor (G-CSF) (G-TAK) in subjects with severe alcoholic hepatitis (sAH) and acute-on-chronic liver failure (ACLF) | Yaqrit | ISRCTN36798599; 2022-000128-39 | |
| 1005630 | A Phase 1 Trial Evaluating The Pharmacokinetics, Pharmacodynamics, Safety, And Tolerability Of Imlifidase After Administration Of A Single Intravenous Dose In Healthy Japanese Men | Hansa Biopharma | ISRCTN45338135 |
Clinical trials given a REC favourable opinion in June 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 199623 | Hepatocytes co-Encapsulated with mesenchymal stromal cells in alginate microbeads for the treatment of acute Liver failure in Paediatric patients (HELP) | King’s College Hospital NHS Foundation Trust | NCT05491135; 2019-000316-29 | |
| 279668 | A feasibility study of the clinical and cost-effectiveness of the MATILDA intervention to support older adults with learning disability to their improve health, wellbeing and social networks compared to usual care | Ulster University | ||
| 283038 | An analysis of the effect of trauma on muscle tissue and laboratory analysis of potential novel therapies | University of Leeds | Sponsor no longer considers this a clinical trial | |
| 283821 | Observation of clinical routine care for patients with BIOTRONIK implantable cardiac monitors (ICMs) | Biotronik | NCT04075084 | |
| 287198 | Treating Depression with Self-Compassion using Virtual Reality: Feasibility and Acceptability Study | University College London | ISRCTN57462718 | |
| 287592 | Investigating the efficacy of foot sole vibration on balance and physical activity in people with Diabetic Peripheral Neuropathy: A prospective randomised cross-over clinical controlled trial | Walk With Path | Currently registering | |
| 290566 | Spinal Cord stimulation plus Usual Care vs. Usual Care alone in the management of non-reconstructable critical limb ischaemia: A feasibility randomised controlled trial | South Tees Hospitals NHS Foundation Trust | ||
| 290707 | A Phase I/II, Multicenter, Non-randomized, Open Label, Adaptive Design, 5-year Follow-up, Single Dose-escalation Study of VTX-801 in Adult Patients with Wilson's Disease | Vivet Therapeutics | NCT04537377; 2020-000963-22 | |
| 293653 | Breath Test To Predict Breast Cancer And Outcome Of Mammography | Menssana Research | NCT04755829 | |
| 294028 | Investigating the influence of an early postnatal mother and baby yoga programme on mothers’ feelings about their mental health and relationship with baby: a randomised feasibility study | York Teaching Hospital NHS Foundation Trust | NCT06056609 | |
| 297197 | Coating to Optimize Aneurysm Treatment In The New Flow Diverter Generation | phenox | NCT04870047 | |
| 298754 | e۰Sense® Clinical Investigation: Assessing the Performance, Safety and Usability of e۰Sense® Electronic Catheters for Performing Urodynamic Studies | Laborie | NCT04438499 | |
| 299857 | Does specialised life-coaching reduce the risk of neurodivergent individuals being drawn into terrorism and related activities? | Birmingham and Solihull Mental Health NHS Foundation Trust | ||
| 300414 | A Multi-Centre Randomised Controlled Trial of the Clinical and Cost Effectiveness of Pre-Hospital Whole Blood Administration versus Standard Care for Traumatic Haemorrhage | NHS Blood and Transplant | ISRCTN23657907; 2021-006876-18 | |
| 300501 | Effects of aspirin on specialised pro-resolving mediators (ASPIRE) | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | Sponsor no longer considers this a clinical trial | |
| 301636 | Comparison of health outcomes in a remote monitoring programme versus usual care in Interstitial Lung Disease | Imperial College Healthcare NHS Trust | NCT05662124 | |
| 302425 | A Phase 3 (Pivotal Stage) Study of NBTXR3 Activated by Investigator’s Choice of Radiotherapy Alone or Radiotherapy in Combination with Cetuximab for Platinum-based Chemotherapy-ineligible Elderly Patients with Locally Advanced Head & Neck Squamous Cell Carcinoma | Nanobiotix | NCT04892173 | |
| 302920 | Cognitive Impairment in Long Covid: PhEnotyping and RehabilitatiOn (CICERO) | University College London | NCT05731570 | Found through search but HRA not notified |
| 303057 | Feasibility of music therapy, neural processing and reduction of craving in Community Substance Misuse Treatment Services (CSMTS) | Anglia Ruskin University | NCT05180617 | |
| 303933 | A Phase 1b Dose Escalation Study of Lemzoparlimab in Combination with Venetoclax and/or Azacitidine in Subjects with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) | AbbVie | NCT04912063; 2021-000514-41 | |
| 304174 | A prospective randomised trial comparing radiofrequency ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism | Queen Mary University of London | ISRCTN11531672 | |
| 304321 | Raising quality of care for people with cognitive impairment through music therapy in care homes: A non-randomised control trial | Cambridge Institute for Music Therapy Research | NCT05176444 | |
| 304493 | The Minuteful Kidney test Evaluation: A Randomised Controlled Trial | University of Leicester | NCT05967312 | |
| 304674 | Guided self-help for anxiety among Huntington’s disease gene expansion carriers compared to treatment as usual: a randomised controlled feasibility trial (GUIDE-HD) | Leicestershire Partnership NHS Trust | ISRCTN47330596 | |
| 305136 | Transcutaneous blood gas (TCBG) analysis: Are transcutaneous blood gases a reliable alternative to capillary blood gas sampling, in the context of Long Term Oxygen Therapy Assessment (LTOT) adults, in a community setting? | North East London NHS Foundation Trust | ||
| 305302 | Body Surface Gastric Mapping to determine gastric motility patterns associated with delayed gastric emptying after pancreaticoduodenectomy | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ||
| 305564 | VOLCANO - Versius Or Laparoscopic Cancer and Non-cancer Operation outcomes. A single blinded randomised controlled trial comparing the ergonomics of laparoscopic and Versius robotic assisted colorectal surgery | Milton Keynes University Hospital NHS Foundation Trust | NCT05262296 | |
| 305830 | An Integrated Psychosexual Intervention for Sexual Difficulties in People with Multiple Sclerosis (PIMS): A Feasibility Study | King’s College London | ISRCTN12202900 | |
| 305842 | Case finding for depression in primary care: a regression discontinuity design CASCADE study | Tees Esk and Wear Valleys NHS Foundation Trust | ISRCTN11841241 | |
| 305848 | A Feasibility Randomised-Controlled trial of two online psychological interventions for stroke survivors | University of East Anglia | NCT05461937 | |
| 305860 | A 6-week knee moment and gait pattern biofeedback gait retraining programme in people with knee osteoarthritis and its translation in daily life | University of Bath | ISRCTN28045513 | |
| 305877 | A single centre, prospective, feasibility study of the iKOs™ coronary pressure and flow rapid-exchange microcatheter and iKOr™ console in patients with coronary heart disease undergoing coronary physiology investigations | Queen Mary University of London | NCT05346458 | |
| 306179 | Cardiovascular implications and physical activity in middle-age and older people with a history of COVID-19 | Coventry University | NCT05492552 | |
| 306477 | Get strong to fight childhood cancer: An exercise intervention for children and adolescents undergoing anti-cancer treatment | Oxford Brookes University | NCT05289739; DRKS00027978 | |
| 307135 | GLucose monitoring after Acute Myocardial infarct in people with diabetes | Imperial College London | NCT05431296 | |
| 307401 | Service staff and user experience of a 1-week wear of a transdermal alcohol sensor device: Acceptability of these devices within a clinical population | King’s College London | ISRCTN46845361 | Found through search but HRA not notified |
| 307657 | Remote psychosocial interventions to prevent avoidable psychiatric hospital admissions in people with serious mental health problems: a multi-arm multi-stage trial | University of Manchester | ISRCTN33079589 | |
| 308241 | Talking therapy for body awareness and managing emotions for people living with obesity: a multiple baseline study | Royal Holloway University of London | Forgot to register | |
| 308723 | Feasibility study of an adapted app-based anxiety intervention for autistic people | King’s College London | NCT05302167 | Found through search but HRA not notified |
| 308774 | An uncontrolled open label trial of a nutritional supplement to reduce measures of biological and immune ageing and improve physical function and quality of life in healthy older people | University of Birmingham | ISRCTN77611378 | Found through search but HRA not notified |
| 309606 | The effect of uninterrupted and interrupted sitting on vascular health and cognitive function in people with Long COVID | University of Winchester | NCT05453175 | |
| 309894 | WithHolding Enteral Feeds Around Blood Transfusion (WHEAT International Trial) | Imperial College London | NCT05213806 | |
| 310085 | Community-Based Behavioural Activation Training (ComBAT) for Depression in Adolescents: Randomised Controlled Trial (RCT) with Economic and Process Evaluations | Tees Esk and Wear Valleys NHS Foundation Trust | ISRCTN57377955 | |
| 310086 | Stratification Of LIver Disease (SOLID): Determining the optimum biomarker strategies for the detection of advanced liver disease at the primary-secondary care interface | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN31148824 | |
| 310197 | Phase 1/2a Open-label Clinical Trial of BI-1607, an Fc-Engineered Monoclonal Antibody to CD32b (FcγRIIB), in Combination with Trastuzumab in Subjects with HER2-positive Advanced Solid Tumors - CONTRAST | BioInvent | 2021-005646-15 | |
| 310211 | IMAGINATOR 2.0: Co-design and early evaluation of a novel blended digital intervention targeting self-harm in young people | Imperial College London | ||
| 310263 | A multicentre randomised controlled trial of guided self-help versus treatment as usual for depression for autistic adults | University of Bath | ISRCTN17547011 | |
| 310316 | Using Commonly Available Food Products To Treat Food Allergy | University of Southampton | NCT05503446 | |
| 310371 | A Phase 2, Multicohort Study of Daratumumab-Based Therapies in Participants with Amyloid Light Chain (AL) Amyloidosis | Janssen-Cilag International | NCT05250973; 2021-002639-48 | |
| 310527 | Development and piloting of a low intensity cognitive analytic–informed guided self-help for depression to be used within Increasing Access to Psychological Therapies (IAPT) | University of Sheffield | NCT05344326 | |
| 311108 | VOLTAIRE - Versius Or Laparoscopic TransAbdominal Inguinal hernia REpair. A single blinded randomised controlled trial comparing the ergonomics of laparoscopic and Versius robotic assisted inguinal hernia surgery | Milton Keynes University Hospital NHS Foundation Trust | NCT05262374 | |
| 311109 | VOLARE - Versius Or Laparoscopic Abdominal hernia REpair. A single blinded randomised controlled trial comparing the ergonomics of laparoscopic and Versius robotic assisted abdominal hernia surgery | Milton Keynes University Hospital NHS Foundation Trust | NCT05253586 | |
| 311123 | A randomised, controlled study to compare visual performance at distance, intermediate and near, refractive outcome, contrast sensitivity, stereoacuity, patient satisfaction, patient related health economics and rotational lens stability following bilateral, micro-monovision insertion of two toric, aspheric, hydrophobic acrylic intraocular lenses: The TECNIS Eyhance Toric II IOL and the Alcon Acrysof IQ Toric IOL | Guy's & St Thomas' NHS Foundation Trust | ||
| 311717 | Investigating the use of behavioural science informed messages to facilitate attendance at Breast Cancer Screening | Imperial College London | NCT05395871 | |
| 311959 | A single centre, open-label, feasibility randomised controlled trial to evaluate gastric microaspiration in critically ill patients intubated using the Venner PneuX system compared to standard of care using pepsin biomarker (VAP-X) | Cardiff & Vale University Health Board | NCT05410106 | |
| 312053 | Specialist pre-hospital redirection for ischaemic stroke thrombectomy: a cluster randomised controlled trial with included health economic and process evaluations | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN77453332 | |
| 312243 | Study of the Accuracy of the GTT@home Oral Glucose Tolerance Test Kit | Digostics | ISRCTN66273796 | |
| 312556 | A prospective human clinical pilot trial to assess primary stability and change in stability by resonance frequency analysis of immediately inserted and restored dental implants using Tetranite Dental Bone Adhesive Implant Stabilization Material (TN-ISM) | RevBio | NCT05535426 | |
| 312765 | Increasing access to CBT for psychosis patients: a randomized controlled trial evaluating brief, targeted CBT for distressing voices delivered by Assistant Psychologists | Sussex Partnership NHS Foundation Trust | ISRCTN12748453 | |
| 312768 |
Effectiveness of the SpaceOAR Vue System in Subjects with Prostate Cancer being Treated with Stereotactic Body RadiothErapy (SABRE) |
Boston Scientific | NCT04905069 | |
| 312801 | The Acceptability and Feasibility of 3D Reconstruction and Virtual Reality in addressing Body Image in Bariatric Surgery | Imperial College London | NCT05273515 | |
| 313025 | An investigator-initiated and conducted, international, multicentre, stepped-wedge cluster, randomised controlled trial comparing the effects of different intensities of nursing care monitoring for patients with acute ischaemic stroke without critical care needs after thrombolysis treatment | The George Institute for Global Health | NCT03734640 | |
| 313449 | Coronary - Product Surveillance Registry (Psr) Platform Base | Medtronic | NCT01524276 | |
| 313514 | A Prospective, Multicenter Masked Clinical Trial To Evaluate The Safety And Effectiveness Of The Miniject Cs627 Implant In Subjects With Open Angle Glaucoma | iSTAR Medical | NCT05024695 | |
| 313705 | DEXCOM One: Continuous glucose monitoring in the real world, utility of sustained high alerts | Sheffield Teaching Hospitals NHS Foundation Trust | NCT05453344 | |
| 313933 | Comparison of the taste and acceptability of a new ice cream based supplement (Nottingham-Ice cream) compared to standard hospital milkshake in older people in hospital who have suffered a broken bone: A randomised controlled crossover trial | Nottingham University Hospitals NHS Trust | NCT05711277 | |
| 314653 | Portico NG Approval Study - Evaluation of the Portico™ NG Transcatheter Aortic Valve in High and Extreme Risk Patients with Symptomatic Severe Aortic Stenosis | Abbott | NCT04011722 | |
| 315107 | Dietary nitrate supplementation to enhance daily physical activity in hypoxic COPD: a randomised controlled trial | Imperial College London | ISRCTN12474100 | |
| 315890 | Mobile Observation Of Depression (MOOD) | Emteq | NCT05815459 | |
| 1003524 | A Phase III, Randomized, Open-Label Study Evaluating The Efficacy And Safety Of Giredestrant In Combination With Phesgo Versus Phesgo After Induction Therapy With Phesgo.Taxane In Patients With Previously Untreated Her2-Positive, Estrogen Receptor-Positive Locally-Advanced Or Metastatic Breast Cancer | Roche | NCT05296798; 2022-500014-26 | |
| 1004001 | A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Tamibarotene Plus Azacitidine Versus Placebo Plus Azacitidine in Newly Diagnosed, RARA-positive Adult Patients with Higher-risk Myelodysplastic Syndrome | Syros | NCT04797780; 2020-004528-40 | |
| 1004057 | DETERMINE (Determining Extended Therapeutic indications for Existing drugs in Rare Molecularly defined Indications using a National Evaluation platform trial): An Umbrella-Basket Platform Trial to Evaluate the Efficacy of Targeted Therapies in Rare Adult, Paediatric and Teenage/Young Adult (TYA) Cancers with Actionable Genomic Alterations, including Common Cancers with Rare Actionable Alterations | Cancer Research UK | NCT05722886; 2021-003391-14 | |
| 1004164 | A Multicenter, Open-Label Phase Iv Study To Evaluate Overall Health, Physical Activity, And Joint Outcomes, In Participants Aged ≥ 13 And < 70 Years With Severe Or Moderate Hemophilia A Without Fviii Inhibitors On Emicizumab Prophylaxis | Roche | ISRCTN10101701; NCT05181618; 2020-005092-13 | |
| 1004278 | A Phase I, Randomised, Double-Blind, Placebo-Controlled Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Intravenous Doses of ELE-101 in Healthy Adult Participants | Eleusis | NCT05434156; 2022-000150-29 | |
| 1004331 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Magrolimab versus Placebo in Combination with Venetoclax and Azacitidine in Newly Diagnosed, Previously Untreated Patients with Acute Myeloid Leukemia Who Are Ineligible for Intensive Chemotherapy | Gilead | NCT05079230; 2021-003434-36 | |
| 1004367 | An open-label, single period, multiple dose study designed to assess the mass balance, metabolite profile and metabolite identification of [14C]-SPN-817 in healthy male subjects | Supernus Pharmaceuticals | ISRCTN21667877; 2021-004066-35 | |
| 1004374 | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABBV-154 in Subjects with Moderately to Severely Active Crohn's Disease (CD): AIM-CD | AbbVie | NCT05068284; 2021-002869-18 | |
| 1004389 | Preliminary assessment of safety and tolerability of Dostarlimab in combination antiretroviral therapy (cART) refractory HIV associated Kaposi Sarcoma | Imperial College London | NCT05646082; 2020-005047-23 | |
| 1004410 | A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia | Ionis | NCT05079919; 2021-002192-19 | |
| 1004425 | A multi-centre, randomised controlled, non-inferiority and cost effectiveness trial comparing Polyhexanide and Chlorhexidine with Neomycin to Mupirocin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation amongst adult hospital in-patients | South Tees Hospitals NHS Foundation Trust | ISRCTN12184897; 2021-006732-96 | |
| 1004436 | An open-label, single arm phase II study of DFV890 to assess the safety, tolerability and efficacy in participants with familial cold auto-inflammatory syndrome (FCAS) | Novartis | NCT04868968; 2020-005948-33 | |
| 1004438 | A Phase 3, Randomized, Double-Blind, Placebocontrolled, Fixed-Dose, Multicenter Study To Examine The Efficacy And Safety Of Zx008 In Subjects With Cdkl5 Deficiency Disorder Followed By An Open-Label Extension | Zogenix International | NCT05064878; 2021-003222-76 | |
| 1004614 | FELL-HD: A trial to assess the tolerability of using felodipine to upregulate autophagy as a treatment of Huntington’s disease | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | ISRCTN56240656; 2021-000897-27 | |
| 1004695 | A Phase 1b Proof of Concept Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients with a Sub optimal Response to the C5 inhibitor, Ravulizumab | Omeros | ISRCTN71522737; 2021-006930-37 | |
| 1004706 | An adaptive, randomized, double-blind, dose exploration, parallel group, placebo-controlled, multicenter phase 2 trial to evaluate the efficacy, safety and tolerability of LNP023 in combination with standard-of-care with and without oral corticosteroids in patients with active lupus nephritis Class III-IV, +/- V | Novartis | NCT05268289; 2021-002046-33 | |
| 1004724 | A Randomized, Open-Label Eculizumab And Ravulizumab Controlled Study To Evaluate The Efficacy And Safety Of Pozelimab And Cemdisiran Combination Therapy In Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Currently Treated With Eculizumab Or Ravulizumab | Regeneron | NCT05131204; 2020-002761-33 | |
| 1004739 | Phase 3 Study of Teclistamab in Combination with Lenalidomide versus Lenalidomide Alone in Participants with Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation | European Myeloma Network (EMN) | NCT05243797; 2021-002531-27 | |
| 1004763 | A Multicenter, Single-arm, Open-label, Extension, Rollover Study To Evaluate The Long-term Safety And Efficacy Of Ocrelizumab In Patients With Multiple Sclerosis | Roche | NCT05269004; 2021-005746-15 | |
| 1004782 | A Long-term, Single-Arm, Open-label, Multicenter, Follow-on Trial of ARGX-113-2006 to Evaluate Safety of Efgartigimod Administered Intravenously in Children With Generalized Myasthenia Gravis | argenx | NCT05374590; 2021-002460-46 | |
| 1004810 | A prospective randomized, double-blind, placebo-controlled, multi-center phase IIb study to evaluate the efficacy and safety of mocravimod as an adjunctive and maintenance treatment in adult in acute myeloid leukemia (AML) patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) | Priothera | ISRCTN12632431; NCT05429632; 2021-002864-36 | |
| 1004845 | A Phase 1/2, Multi-center, Open-label Study of IMGN632 Monotherapy Administered Intravenously in Patients with CD123-positive Acute Myeloid Leukemia and Other CD123-positive Hematologic Malignancies | ImmunoGen | NCT03386513; 2018-003210-40 | |
| 1004854 | An Open-label, Single-dose Study Designed to Assess the Mass Balance Recovery, Metabolite Profile and Identification of [14C]-REN001 in Healthy Male Subjects | Reneo Pharma | ISRCTN57533271; 2021-006892-41 | |
| 1004887 | A Randomized, Open-Label, C5 Inhibitor-Controlled Study To Evaluate The Efficacy And Safety Of Pozelimab And Cemdisiran Combination Therapy In Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Complement Inhibitor Treatment-Naive Or Have Not Recently Received Complement Inhibitor Therapy | Regeneron | NCT05131204; 2020-004486-40 | |
| 1004978 | A Phase 3 Study of PTC923 in Subjects with Phenylketonuria | PTC Therapeutics | NCT05099640; 2021-000474-29 | |
| 1004989 | A Phase 3, Open Label, Randomized, Non-Inferiority Pharmacokinetic Study of Nivolumab Administered Subcutaneously (Nivo SC) Versus Intravenous Administration of Nivolumab in Participants with Stage IIIA/B/C/D or Stage IV Adjuvant Melanoma Following Complete Resection | Bristol-Myers Squibb | NCT05297565; 2021-003208-42 | |
| 1004999 | A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study with an Open-Label Extension Assessing the Efficacy, Safety, and Pharmacokinetics/Pharmacodynamics of Tirzepatide inPediatric and Adolescent Participants with Type 2 Diabetes Mellitus Inadequately Controlled with Metformin, or Basal Insulin, or Both (SURPASS-PEDS) | Eli Lilly and Company | NCT05260021; 2021-003612-31 | |
| 1005037 | A Phase III randomised, placebo-controlled, double-blind, multi-centre, clinical trial to determine the efficacy and safety of Presendin in idiopathic intracranial hypertension | Invex Therapeutics Ltd. | NCT05347147; 2021-006664-24 | |
| 1005044 | A phase 3 clinical trial to evaluate efficacy and safety of twice daily applications of delgocitinib cream 20 mg/g compared with cream vehicle for a 16-week treatment period in adolescents 12-17 years of age with moderate to severe chronic hand eczema | LEO Pharma | NCT05355818; 2021-006340-27 | |
| 1005045 | A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid | argenx | NCT05267600; 2021-003087-27 | |
| 1005050 | A phase 1 study of SGN-PDL1V in advanced solid tumors | Seagen | NCT05208762; 2021-003517-19 | |
| 1005057 | Interventional, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of IV eptinezumab in adolescents (12-17 years) for the preventive treatment of chronic migraine | Lundbeck | NCT04965675; 2020-001009-22 | |
| 1005058 | Long-term, open-label (dose-blinded), extension study of eptinezumab in children and adolescents with chronic or episodic migraine | Lundbeck | NCT05164172 ; 2020-001649-38 | |
| 1005083 | A single (assessor) blinded, randomised, parallel-group, monotherapy trial to evaluate the pharmacokinetic and safety of tralokinumab in children (age 2 to <12 years) with moderate-to-severe atopic dermatitis | LEO Pharma | NCT05355818 ; 2021-005573-12 | |
| 1005138 | A Multi-Cohort, Randomised, Placebo-Controlled Phase 2a Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Ascending Doses of RXC007 in Patients with Idiopathic Pulmonary Fibrosis | Redx Pharma | ISRCTN60385283; 2022-000498-15 | |
| 1005142 | COLO-PREVENT – A phase 2/3 randomised platform trial assessing the efficacy of aspirin, aspirin plus metformin, or resveratrol, for colorectal polyp prevention in patients undergoing surveillance in the Bowel Cancer Screening Programme | University of Leicester | ISRCTN13526628; 2022-000531-23 | |
| 1005152 | A phase Ib/II, open label study of siremadlin monotherapy and in combination with donor lymphocyte infusion as a treatment for patients with acute myeloid leukemia post-allogeneic stem cell transplantation who are in complete remission but at high risk for relapse | Novartis | NCT05447663; 2021-003596-34 | |
| 1005194 | An open-label, randomized, Phase 3 clinical trial of IO102-IO103 in combination with pembrolizumab versus pembrolizumab alone in patients with previously untreated, unresectable, or metastatic (advanced) melanoma | IO Biotech | NCT05155254; 2021-004594-32 | |
| 1005207 | A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Patients with Previously Untreated, Locally Advanced, Inoperable or Metastatic Triple-Negative Breast Cancer Whose Tumors do not Express PD-L1 or in Patients Previously Treated With Anti-PD-(L)1 Agents in the Early Setting whose Tumors do Express PD-L1 | Gilead | NCT05382299; 2021-005743-79 | |
| 1005245 | A randomised non-inferiority trial with nested PK to assess DTG/3TC fixed dose formulations for the maintenance of virological suppression in children with HIV infection aged 2 to <15 years old | Penta | ISRCTN17157458; NCT04337450; 2020-001426-57 | |
| 1005247 | A multi-centre, single arm, open-label extension study to evaluate the long-term safety of GSK3511294 (Depemokimab) in adult and adolescent participants with severe asthma with an eosinophilic phenotype from studies 206713 or 213744 | GlaxoSmithKline | NCT05243680; 2020-004334-38 | |
| 1005253 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Clinical Study to Assess the Effectiveness of CRD-740 in Subjects with Chronic Heart Failure | Cardurion Pharma | NCT05409183; 2021-005768-23 | |
| 1005284 | An Open-Label, Phase 2a Single Dose Study in Patients With Alcohol Use Disorder | Beckley Psytech | NCT05674929; 2022-000810-33 | |
| 1005286 | A Phase 1, Open-label Study to Evaluate the Effects of NST-1024 on the Pharmacokinetics of Caffeine, Flurbiprofen, Omeprazole, Metoprolol, and Midazolam in Healthy Subjects | NorthSea Therapeutics | NCT05368831; 2022-000730-42 | |
| 1005288 | A Phase 2 Multi-Cohort, Open-Label, Multi-Center Clinical Study Evaluating the Efficacy and Safety of Disitamab Vedotin (RC48-ADC) Alone and in Combination with Pembrolizumab in Subjects with HER2-Expressing Locally-Advanced Unresectable or Metastatic Urothelial Carcinoma That Expresses HER2 | Seagen | NCT04879329 | |
| 1005325 | A Phase 3 Trial Of Fianlimab (Regn3767, Anti-Lag-3) + Cemiplimab Versus Pembrolizumab In Patients With Previously Untreated Unresectable Locally Advanced Or Metastatic Melanoma | Regeneron | NCT05352672; 2021-004453-23 | |
| 1005344 | A First-in-Human, Single-Centre, Single Ascending Dose, Multiple Dose and Pilot Food Effect Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV367 in Healthy Participants | Medicines for Malaria Venture | ISRCTN17423851; 2022-000918-33 | |
| 1005366 | A Phase 1, Open-Label, Single-Dose Study Designed to Assess the Absorption, Distribution, Metabolism and Excretion of [14C]-RLY-4008 in Healthy Male Participants | Relay Therapeutics | ISRCTN27020581; 2022-001467-27 | |
| 1005379 | A Phase 2/3 Adaptive, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VX-147 in Subjects Aged 18 Years and Older With APOL1-mediated Proteinuric Kidney Disease | Vertex | NCT05312879; 2021-004762-35 | |
| 1005387 | A Phase 1, open label, single-center, 3-period, 1-sequence, 3-treatment, crossover study assessing the effect of food on systemic clearance and bioavailability of tolebrutinib and assessing the contribution of intestinal first pass CYP3A4 metabolism using grapefruit juice on tolebrutinib given as a single oral dose and as intravenous radiolabeled microdose in healthy participants | Sanofi-Aventis | ISRCTN49135540 | |
| 1005389 | A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating the Effects of VX-150 on C-Nociceptor Action Potentials in Healthy Subjects | Vertex | NCT05418712; 2022-000167-41 | |
| 1005395 | A 52-week, randomized, double-blind, double-dummy, parallel-group, multi-centre, non-inferiority study to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA) receiving standard of care (SoC) therapy | GlaxoSmithKline | NCT05263934; 2021-005726-15 | |
| 1005398 | Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled Study of BOTOX (Botulinum Toxin Type A) for the Prevention of Migraine in Subjects with Episodic Migraine | AbbVie | NCT05028569; 2021-001979-16 | |
| 1005415 | A single-arm, open-label, Phase III trial to evaluate the safety and tolerability of intra-articular injections of RTX-GRT7039 in subjects with moderate to severe pain associated with osteoarthritis of the knee | Grunenthal | NCT05449132; 2021-005046-15 | |
| 1005438 | A Long-term Extension (LTE) Study to Characterize the Safety and Efficacy of Danicopan as an Add-on Therapy to a Complement Component 5 Inhibitor (C5i) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Previously Treated with Danicopan in an Alexion-sponsored Clinical Study | Alexion | NCT05389449; 2021-004253-22 | |
| 1005468 | A randomized, double-blind, placebo controlled, 3-arm multicenter phase 3 study to assess the efficacy and safety of ianalumab in patients with active Sjögren’s syndrome (NEPTUNUS-2) | Novartis | NCT05349214; 2021-005687-22 | |
| 1005473 | A Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose and Food Effect Evaluation Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of AQ280 in Healthy Subjects | Aqilion | ISRCTN14453297 | |
| 1005494 | A Phase 2/3, Multicenter, Double-Blind, Randomized Study to Determine the Efficacy and Safety of DNL310 vs Idursulfase in Pediatric Participants With Neuronopathic or Non-Neuronopathic Mucopolysaccharidosis Type II | Denali | ISRCTN11652897; 2021-005200-35 | |
| 1005523 | A Phase 1 Randomised, Double-Blind, Placebo-Controlled Study to assess the Safety, Tolerability and Pharmacokinetics of AZD7798 following Single Ascending Dose Administration to Healthy Subjects | AstraZeneca | NCT05452304; 2022-001438-12 | |
| 1005531 | A randomized, double-blind, placebo-controlled, parallel-group, dose ranging study to assess the efficacy, safety, and tolerability of subcutaneous amlitelimab in adult participants with moderate to-severe asthma | Sanofi-Aventis | NCT05421598; 2022-000065-41 | |
| 1005566 | A Phase1, randomized, open-label, single dose, 2 period crossover study to evaluate the effect of food on the pharmacokinetics of linerixibat tablets in healthy adult participants | GlaxoSmithKline | NCT05435170; 2022-000884-27 | |
| 1005624 | A randomised, phase 1b, double-blind, placebo-controlled study to evaluate the safety, pharmacokinetics and antiviral activity of RV299 against Respiratory Syncytial Virus in the viral challenge model | ReViral | ISRCTN11937043 | |
| 1005634 | A Phase 1, Open-label Study to Evaluate the Safety and Pharmacokinetics of PTC518 in Healthy Japanese and Caucasian Participants | PTC Therapeutics | 2022-001143-25 | |
| 1005650 | A Single-group, Phase 1, Open-label Study to Investigate the Absorption, Distribution, Metabolism and Excretion of [’4C]-S-217622 Following Oral Dose Administration as a Suspension in Healthy Adult Male Participants | Shionogi | ISRCTN90993148; 2022-000356-11 |
Clinical trials given a REC favourable opinion in July 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 256935 | AMPLE-3: A Randomised Study Comparing Combined Indwelling Pleural Catheter (IPC) and Talc Pleurodesis with Video-Assisted Thoracoscopic Surgery (VATS) for the Management of Patients with Malignant Pleural Effusion | Institute for Respiratory Health | ACTRN12618001013257 | |
| 273150 | NEAT - Non-Permanent Alignment Tattoos for Breast Cancer Radiotherapy. A randomised controlled trial investigating the efficacy of using non-permanent ink and micropigmentation technology for radiotherapy alignment marks versus permanent-ink tattoos for breast cancer radiotherapy | University College London | ||
| 279065 | Haemorrhage risk reduction using endovascular Embolisation in place of vessel Ligation for Patients undergoing transoral Robotic surgery | The Royal Marsden NHS Foundation Trust | NCT05477992 | |
| 279946 | Evaluation of hypofractionated adaptive radiotherapy using the MR Linac in localised pancreatic cancer | University of Oxford | ISRCTN10557832 | |
| 280391 | Micro-EMG: A novel multielectrode system for intramuscular imaging of human motor units | Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University | NCT05713474 | |
| 281516 | The Cystic Fibrosis Home Sputum-induction Trial (CF-HomeSpIT) - self management for better microbiology surveillance | Cardiff & Vale University Health Board | ISRCTN86523335 | |
| 282441 | Post-market Clinical Study to Evaluate the Clinical Performance and Safety of CELOX™ RAPID Haemostatic Z-Fold Gauze in Civilians with Life Threatening Bleeding Treated in a Pre-Hospital Setting | Medtrade Products | Withdrawn before any participants recruited | |
| 283270 | Evaluation of the use of Volume Ultrasound Imaging in Neonatal Hip Screening for Developmental Dysplasia of the Hip | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ||
| 284315 | Electronic Neuromuscular Stimulation versus Intermittent Pneumatic Compression Devices for the Prevention of Venous Thromboembolic Disease in Critically Ill Adults: a randomised feasibility study | Manchester University NHS Foundation Trust | NCT05208216 | |
| 285628 | A real-world comparison of second stage methods of induction of labour (Propess Prostaglandin pessary 10 versus the Cooks double cervical balloon) and evaluation of feasibility outcomes | Hywel Dda University Health Board | ||
| 286636 | Pre-Operative Oncotype DX testing: A decision impact study | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN14337451 | |
| 289799 | Developing an integrated model of care for people with severe mental illness and type 2 diabetes: the PsychOsis and Diabetes Service Model (PODS) | King’s College London | NCT05496907 | |
| 292577 | Evaluation of a novel game-based neurodevelopmental assessment for young children | Brightlobe | NCT05780853 | |
| 293158 | The effects of transcutaneous electrical stimulation on arm functions in individuals with cervical spinal cord injury | University of Leeds | NCT05801536 | |
| 293329 | Clinical trial of Ashwagandha for promoting recovery from COVID-19 in the UK | London School of Hygiene & Tropical Medicine | ISRCTN12368131; 2020-005789-33 | |
| 293670 | Non-invasive spinal cord stimulation combined with activity-based therapy in chronic complete high level spinal cord injury | NHS Greater Glasgow & Clyde | NCT05522920 | |
| 296904 | A prospective study looking at improving diagnostic capability of bladder diaries by improving accuracy of voided volume, measured by a self-administered automatic measuring vessel, in an ambulatory setting, in adult women with lower urinary tract symptoms | Birmingham Women`s and Children`s NHS Foundations Trust | NCT05702294 | |
| 297909 | A Phase 1/2 First-in-human, 2-part Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses (Part 1: Open-label) and Repeat Doses (Part 2: Randomized, Double-blind, Placebo-controlled) of UX053 in Patients with GSD III | Ultragenyx | 2021-000903-19 | |
| 299389 | Development of the Imperial Implantable Electro-Mechanical Coupling Loop Recorder (ILR) - In Vivo Testing | Imperial College London | ||
| 300113 | Global, Multicenter, and Prospective Post-Market Clinical Follow-Up Study of the G7® Acetabular System with Vivacit-E® and Longevity® Highly Crosslinked Polyethylene (HXLPE) Liners & Instrumentation | Zimmer Biomet | NCT04754087 | |
| 302854 | A Phase 1/2, Single-arm Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of Avapritinib in Pediatric Patients with Solid Tumors Dependent on KIT or PDGFRA Signaling | Blueprint Medicines | NCT04773782; 2020-005234-15 | |
| 303303 | Evaluate Treatment Outcomes for AI-Enabled Information Collection Tool for Clinical Assessment in Mental Healthcare | Limbic | NCT05495126 | |
| 303427 | Eosinophil associated proteins and microbiome profiling in adults with eosinophilic oesophagitis at a single UK tertiary centre | St George’s University Hospitals NHS Foundation Trust | NCT06159218 | Found through search but HRA not notified |
| 303457 | Missing Touch 1: Human factors validation and acceptability testing of a neuro-engineered C-tactile stimulation device | University of Liverpool | ||
| 303928 | An Open-Label, Multicenter, Phase 1b/2 Study of E7386 in Combination With Pembrolizumab in Previously Treated Subjects With Selected Solid Tumors | Eisai | NCT05091346; 2021-001568-10 | |
| 305543 | A co designed project-based intervention (PBI) to support positive family communication interactions for people recovering from Traumatic Brain Injury; a feasibility study | Glasgow Caledonian University | Sponsor no longer considers this a clinical trial | |
| 306415 | PRophylactic cerebral Irradiation or active MAgnetic resonance imaging surveillance in small-cell Lung cancer patients (PRIMALung study) | European Organisation for Research and Treatment of Cancer (EORTC) | NCT04790253 | |
| 306628 | A randomised, double-blind, placebo-controlled trial evaluating the influence of probiotic lactobacillus, prebiotic inulin and vitamin D3 on antibody titres post Covid-19 booster vaccination | Bedfordshire Hospitals NHS Foundation Trust | 2021-002826-26 | |
| 307199 | A speech recognition application as a communication aid for critical care patients with tracheostomies | Queen's University Belfast | NCT06027866 | |
| 307228 | Assessment of the Safety and Performance of the AB1 Electrosurgical System for Bronchoscopic Microwave Ablation of Lung Tissue | Creo Medical | NCT05786625 | |
| 307316 | Feasibility and acceptability of a randomised controlled trial, examining a transdiagnostic DBT-informed skills group intervention delivered by Protocolised Based Intervention Facilitators (P-BIFS) for adults in community mental health settings | King’s College London | NCT06237608 | Found through search but HRA not notified |
| 307899 | Is the naturally occurring prebiotic Lactoferrin an acceptable alternative to antibiotic/antifungal tablets for women with bacterial vaginosis or thrush? The LISA (Lactoferrin InStead of Antibiotics/antifungals) randomised feasibility study | St George's University of London | NCT05434104 | |
| 308776 | OPTIM-PARK II - A new intervention for optimisation of community resources and systems of support to enhance the process of living with Parkinson’s Disease: a feasibility trial | University of Southampton | NCT05583994 | |
| 309731 | Feasibility and Acceptability of home-based Computerised Cognitive Training after cardiac surgery (FACCT Study) | Barts Health NHS Trust | NCT05298540 | |
| 309760 | Pharmacy Homeless Outreach Engagement Non-medical Independent prescribing Rx (PHOENIx) community pharmacy based pilot randomised controlled trial | University of Birmingham | ISRCTN88146807 | |
| 309854 | Optimised Inhalers to Reduce COPD Exacerbation Re-Admissions and Mortality - a Feasibility Study | Royal Free London NHS Foundation Trust | ISRCTN16732324 | |
| 310213 | Targeting investigation and treatment in patients with type 2 myocardial infarction (TARGET-Type 2): A pilot randomised control trial | University of Edinburgh | NCT05419583 | |
| 311616 | Use of Platelet Rich Fibrin in healing of dental extraction sockets and its role in prevention of osteoradionecrosis in head and neck cancer patients-A prospective, Triple blind ,randomised controlled pilot trial | Swansea Bay University Health Board | ||
| 312178 | Clinical and Radiographic outcomes of reverse shoulder arthroplasty performed with 36-mm CoCrMo vs 40-mm cross-linked UHMWPE glenospheres at minimum 2-years follow-up | Lima Corporate | NCT05339815 | |
| 312208 | Talking in Primary Care: A cluster-randomized controlled trial in primary care to test the effectiveness and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement | University of Southampton | ISRCTN18010240 | |
| 312281 | A Multicentre, Prospective, Randomized, Parallel Group, Open-label Design to Determine the Efficacy and Safety of Endovascular Thrombectomy for ischemic stroke patients with symptomatic Acute Medium Vessel Intracranial Occlusions (ESCAPE-MeVO Trial) | University of Calgary | NCT05151172 | |
| 312405 | The Threshold for Platelets (T4P) study: a prospective randomised trial to define the platelet count below which critically ill patients should receive a platelet transfusion prior to an invasive procedure | University of Oxford | ISRCTN79371664 | |
| 312420 | A Pilot study to evaluate the feasibility and acceptibility of exercise in the Prevention of leg Ulcer Recurrence (P-PURE) | Imperial College London | Sponsor no longer considers this a clinical trial | |
| 312701 | Smart Watch Insights to Prevent Exacerbations and Enhance Rehabilitation - Cardiac Rehabilitation Study | Imperial College Healthcare NHS Trust | NCT06011395 | |
| 312954 | CP334. A confirmatory, multi-centre, randomised, open label, controlled study confirming performance of a single-use intermittent micro-hole zone catheter in a population of adult male intermittent catheter users | Coloplast | NCT05485935 | |
| 312969 | Design and Feasibility Trial of a Co-produced Parenting Programme for Psychiatric Inpatients (COPPPI) | University of Sussex | Sponsor no longer considers this a clinical trial | |
| 313159 | Setting hearing aids for older adults: the effect of compression speed on self-reported benefit and preference | Royal Berkshire NHS Foundation Trust | ||
| 313838 | A prospective, post-marketing study evaluating clinical and radiographic early outcomes of Total Knee Arthroplasty with Multigen Plus CCK alone or involving the AMF TT cones | Lima Corporate | NCT05314491 | |
| 313910 | Evaluation of safety and efficacy of a resorbable collagen IMplant in treatment of High Grade PArtial ThiCkness Tears; A prospective, multicenter, randomized, control trial (IMPACT Study) | Smith + Nephew | NCT05444465 | |
| 314061 | Effect of tight urate control in gouty arthritis compared to flare based treatment escalation (TICOGA), a randomised clinical trial | University of Edinburgh | NCT05507723 | |
| 314073 | Palliative Long-term Abdominal Drains Versus Repeated Drainage in Untreatable Ascites Due to Advanced Cirrhosis: A Randomised Controlled Trial (REDUCe 2 Study) | University of Sussex | ||
| 314379 | Randomised trial of the clinical and cost effectiveness of a supraglottic airway device versus intubation during in-hospital cardiac arrest | University Hospitals Bristol and Weston NHS Foundation Trust | ISRCTN17720457 | |
| 314529 | A mixed methods study to assess the clinical effectiveness and acceptability of behold.ai red dot® v2 artificial intelligence software to prioritise chest X-ray (CXR) interpretation | NHS Greater Glasgow & Clyde | ||
| 315088 | MiSight® Effect of Uncorrected Astigmatism on Visual Acuity Non-Dispensing Study | CooperVision | ISRCTN28719734 | |
| 315215 | TYRX™ Pocket Health Study | Medtronic | NCT05356546 | Found through search but HRA not notified |
| 316034 | Is Method of Levels (MOL) an acceptable and feasible psychological intervention for people using community-based crisis services? A case series. | University of Manchester | NCT05484518 | |
| 316506 | First In Human Clinical Investigation of the FIRE1 System in Heart Failure Patients | FIRE1 | NCT04203576 | |
| 316723 | OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure | NHS Greater Glasgow & Clyde | NCT05575453 | |
| 317394 | A single-dose, randomised, double-blind, controlled, 2-way cross-over study to assess the potential for bronchoconstriction of the new propellant HFA-152a versus the marketed HFA-134a propellant, in adult subjects with mild asthma | Chiesi Farmaceutici | NCT05472662 | |
| 1003938 | A Two-cohort, Open-label, Single arm, Multicenter Study to Evaluate Efficacy, Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of Emapalumab in Children and Adults with Macrophage Activation Syndrome (MAS) in Still’s disease (Including Systemic Juvenile Idiopathic Arthritis and Adult onset Still’s disease) or with MAS in Systemic Lupus Erythematous | Swedish Orphan Biovitrum (SOBI) | 2021-001577-24 | |
| 1004127 | A Randomized, Double-blind, Placebo-controlled Phase 1/2a Study for Safety and Immunogenicity Evaluations of various RSV.preF-based Vaccine Formulations in Adults Aged 60 Years and Older | Janssen-Cilag International | NCT05327816; 2022-001015-14 | |
| 1004190 | Phase 2 non-randomized, open-label, multi-cohort, multicenter study assessing the clinical benefit of SAR444245 (THOR-707) with or without other anticancer therapies for the treatment of adults and adolescents with relapsed or refractory B cell lymphoma (Pegathor Lymphoma 205) | Sanofi-Aventis | NCT05179603; 2021-002150-91 | |
| 1004295 | Seizure control via pH manipulation: a phase II double blind RCT of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus | Newcastle upon Tyne Hospitals NHS Foundation Trust | ISRCTN52731862; 2021-005367-49 | |
| 1004382 | A Phase III, Multicentre, Randomised, Double-Blind Study to Assess the Safety and Efficacy ofEmactuzumab vs. Placebo in Subjects with Tenosynovial Giant Cell Tumour | SynOx Therapeutics | NCT05417789; 2021-001716-29 | |
| 1004433 | KontRASt-02: A randomized, controlled, open label, phase III study evaluating the efficacy and safety of JDQ443 versus docetaxel in previously treated subjects with locally advanced or metastatic KRAS G12C mutant non-small cell lung cancer | Novartis | NCT05132075; 2021-002605-10 | |
| 1004588 | A multicenter, randomized, open-label, blinded endpoint evaluation, phase 3 study comparing the effect of abelacimab relative to apixaban on venous thromboembolism (VTE) recurrence and bleeding in patients with cancer associated VTE | Anthos Therapeutics | NCT05171049; 2021-003076-14 | |
| 1004630 | Phase 2/3, Multistage, Multicenter, Randomized, Double-Blind, Placebo-Controlled Parallel Group Withdrawal Study to Evaluate the Efficacy and Safety of Nipocalimab Administered to Adults with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) | Janssen-Cilag International | NCT05327114; 2021-003234-37 | |
| 1004660 | COmBining memantine And cholinesterase inhibitors in Lewy body dementia Treatment trial | Cumbria Northumberland Tyne and Wear NHS Foundation Trust | ISRCTN79794378; 2021-003232-88 | |
| 1004692 | Brightline-1: A Phase II/III, randomized, open-label, multi-center study of BI 907828 compared to doxorubicin as first line treatment of patients with advanced dedifferentiated liposarcoma | Boehringer Ingelheim | NCT05218499; 2021-002392-20 | |
| 1004746 | A multicenter, randomized, open-label, blinded endpoint evaluation, phase 3 study comparing the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal (GI)/genitourinary (GU) cancer associated VTE (Magnolia) | Anthos Therapeutics | NCT05171075; 2021-003085-12 | |
| 1004764 | RAPID-PROTECTION: An adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus | Cardiff University | ISRCTN53507177; 2021-006703-15 | |
| 1004778 | A Phase IIIb, Multicenter, Randomized,Visual Assessor-Masked Study Of Theeffectiveness And Safety Of A 36-Weekrefill Regimen For The Port Deliverysystem With Ranibizumab Vs Aflibercepttreat & Extend In Subjects Withneovascular Age-Related Maculardegeneration (Diagrid) | Roche | NCT05126966; 2021-003226-71 | |
| 1004794 | A randomized, double-blind, placebo-controlled, multisite, Phase 3 study to investigate the efficacy and safety of cannabidiol oral solution (GWP42003-P) in children and adolescents with epilepsy with myoclonic-atonic seizures | GW Research | NCT05288283; 2021-003094-61 | |
| 1004869 | An open-label, multi-center, non-randomized pivotal Phase 3 study to evaluate the efficacy and safety of [18F]florbetaben Positron Emission Tomography (PET) imaging to diagnose cardiac AL amyloidosis | Life Molecular Imaging | NCT05184088; 2022-000117-14 | |
| 1004892 | REgimen optimisation: Feasibility of sImplifying NucleotidE therapy in HIV/HBV coinfection (REFINE-B study) | King’s College Hospital NHS Foundation Trust | ISRCTN11675563; 2021-005910-32 | |
| 1004894 | CONNected Electronic Inhalers Asthma Control Trial 3 (“CONNECT 3”), a 24-Week Treatment, Multicenter, Open-Label, Randomized, Parallel Group Comparison Study of Standard of Care Treatment Versus the Budesonide/Formoterol Digihaler Digital System, to Optimize Outcomes in Adult Patients with Asthma | Teva Branded Pharmaceutical Products R&D | 2021-003951-41 | |
| 1004899 | A Phase IIb, Prospective, Multicentre, Single Arm, Open Label Clinical Trial To Evaluate Safety And Efficacy Of Defibrotide In Patients With Severe Covid-19 | King’s College Hospital NHS Foundation Trust | 2021-006645-35 | |
| 1004912 | A Phase I/II, observer-blind, randomised, placebo-controlled study to assess safety, immunogenicity and efficacy of GSK S. aureus candidate vaccine when administered to healthy adults (dose-escalation) and to adults 18 to 64 years of age with a recent S. aureus skin and soft tissue infection (SSTI) | GlaxoSmithKline | NCT04420221; 2021-006215-29 | |
| 1004924 | A Phase 1, Open-label, Nonrandomized Study to Investigate the Mass Balance Recovery and Metabolic Profile of 14C-bemcentinib Following Single Oral Administration in Healthy Male Subjects | Bergenbio | ISRCTN14340698; 2021-005631-24 | |
| 1004949 | A Phase 2b Randomized, Double-blind, Placebo-controlled, Repeat-dose, Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects with Idiopathic Pulmonary Fibrosis | Horizon Therapeutics | NCT05032066; 2021-001253-32 | |
| 1004983 | A Phase II, Multicenter, Randomized, Open Label, Parallel-Arm, Umbrella Study of Avelumab (MSB0010718C) in Combination with Other Anti-Tumor Agents as a Maintenance Treatment in Participants with Locally Advanced or Metastatic Urothelial Carcinoma Whose Disease Did Not Progress with First Line Platinum-Containing Chemotherapy | Merck KGaA | NCT05327530; 2021-003669-36 | |
| 1004985 | An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of TL-895 Combined with Ruxolitinib in Janus-associated Kinase Inhibitor (JAKi) Treatment-Naïve Myelofibrosis (MF) Subjects and Subjects with MF who have a Suboptimal Response to Ruxolitinib | Telios Pharma | NCT05280509; 2021-005724-38 | |
| 1005011 | Romiplostim for thrombocytopenia induced by lomustine at first progression of MGMT promoter-methylated glioblastoma: a randomized phase II open label multicenter study | European Organisation for Research and Treatment of Cancer (EORTC) | NCT04933942; 2020-005429-10 | |
| 1005021 | A Phase 1b/2, Multicenter, Open-label Basket Study Evaluating the Safety and Efficacy of Bemarituzumab Monotherapy in Solid Tumors with FGFR2b Overexpression (FORTITUDE 301) | Amgen | NCT05325866; 2021-006386-38 | |
| 1005062 | A Double Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of PRA023 in Subjects with Systemic Sclerosis Associated with Interstitial Lung Disease (SSc-ILD) | Prometheus Biosciences | NCT05270668; 2021-005206-10 | |
| 1005077 | HERTHENA–Lung02: A Phase 3, Randomized, Open-label Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced Epidermal Growth Factor Receptor-mutated (EGFRm) Non-small Cell Lung Cancer (NSCLC) After Failure of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) Therapy | Daiichi Sankyo | NCT05338970; 2021-005879-40 | |
| 1005097 | Reintroduction of anti-tuberculosis therapy following drug-induced liver injury: a randomised controlled trial (TB-DILI) | Nottingham University Hospitals NHS Trust | ISRCTN92067975; 2020-004193-21 | |
| 1005143 | A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to valuate the Efficacy, Safety, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in participants with Pulmonary Arterial Hypertension | Insmed | NCT05147805; 2021-001528-16 | |
| 1005146 | An Open-Label, First in Human, Phase 1/2 Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of the CTPS1 Inhibitor STP938 in Adult Subjects with Relapsed/Refractory B-Cell and T-Cell Lymphomas | Step Pharma | NCT05463263; 2022-000848-30 | |
| 1005169 | A Phase 2/3 Study To Evaluate The Efficacy And Safety Of Unesbulin In Unresectable Or Metastatic, Relapsed Or Refractory Leiomyosarcoma | PTC Therapeutics | NCT05269355; 2022-000073-12 | |
| 1005170 | A Phase 1 Study of SGN‑ALPV in Advanced Solid Tumors | Seagen | NCT05229900; 2021-005266-18 | |
| 1005185 | A Phase 2, Randomised, Double-Blind, Placebo and Active Comparator-Controlled Study to Assess Efficacy and Safety of Multiple Dose Levels of AZD5718 Given Orally Once Daily for Twelve Weeks in Adults with Moderate-to-Severe Uncontrolled Asthma | AstraZeneca | NCT05251259; 2021-000338-35 | |
| 1005195 | A randomized, double-blind, placebo-controlled, Phase III trial to evaluate the efficacy and safety of a single intra-articular injection of RTX-GRT7039 in adult subjects with pain associated with osteoarthritis of the knee | Grunenthal | NCT05449132; 2021-005020-38 | |
| 1005206 | A Phase 2, Open-Label, Multicenter Study of the Combination of RMC-4630 and Sotorasib for Non-Small Cell Lung Cancer Subjects with KRASG12C Mutation After Failure of Prior Standard Therapies | Revolution Medicines | NCT05054725; 2021-003254-23 | |
| 1005230 | A Phase Ib, Open-Label, Multicenter Study Evaluating The Safety, Pharmacokinetics, And Efficacy Of Mosunetuzumab Or Glofitamab In Combination With Cc-220 And Cc-99282 In Patients With B-Cell Non-Hodgkin Lymphoma | Roche | NCT05169515; 2021-005745-33 | |
| 1005233 | A study comparing the effect and safety of once weekly dosing of somapacitan with daily Norditropin® as well as evaluating long-term safety of somapacitan in a basket study design in children with short stature either born small for gestational age or with Turner syndrome ,Noonan syndrome, or idiopathic short stature | Novo Nordisk | NCT05330325; 2021-005607-13 | |
| 1005265 | An Exploratory Phase 1b/2a Multicenter, Open-Label, Novel-Novel Combination Study toAssess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of CC-92480(BMS-986348) in Novel Therapeutic Combinations in Participants with Relapsed or RefractoryMultiple Myeloma | Celgene | NCT05372354; 2021-005167-51 | |
| 1005268 | A Multi-arm, Adaptive, Group-sequential trial NETwork to evaluate drug efficacy in patients with Amyotrophic Lateral Sclerosis (ALS) | TRICALS | ISRCTN15671139; 2020-000579-19 | |
| 1005282 | A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis | MSD | NCT04583423; 2019-003048-63 | |
| 1005365 | A Study to EvaLuate the EffIcacy and Safety of XyloCore, a Glucose SparIng ExpeRimental Solution, for Peritoneal Dialysis | Iperboreal Pharma | ISRCTN16169961; NCT03994471; 2019-004183-21 | |
| 1005407 | A Pilot Study to Assess the Use of Methylone in the Treatment of Post-Traumatic Stress Disorder (PTSD) | Transcen | NCT05741710; 2022-000484-42 | |
| 1005432 | A phase 2a clinical trial of GH001 in patients with postpartum depression | GH Research | NCT05804708; 2021-006879-42 | |
| 1005456 | A Phase 1b Dose Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Antitumor Activity of Furmonertinib in Patients with Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) with Activating EGFR or HER2 Mutations, Including Exon 20 Insertion Mutations | ArriVent | ISRCTN99682126; 2021-005831-22 | |
| 1005475 | A phase Ia/Ib, open label, dose-escalation study of the combination of BI 907828 with BI 754091 (ezabenlimab) and BI 754111 and the combination of BI 907828 with BI 754091(ezabenlimab) followed by expansion cohorts, in patients with advanced solid tumors | Boehringer Ingelheim | NCT03964233; 2019-001173-84 | |
| 1005476 | A Phase 2 Study to Evaluate the Safety and Pharmacokinetics of Berotralstat Phrophylaxis in Children with Hereditary Angioedema who are 2 to < 12 Years of Age | BioCryst | NCT05453968; 2021-005932-50 | |
| 1005481 | A Phase 3, Randomized, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Guselkumab in Participants with Fistulizing, Perianal Crohn’s Disease | Janssen-Cilag International | ISRCTN15970897; NCT05347095; 2021-000491-10 | |
| 1005491 | A Randomized Double-Blind Phase IIa Study Evaluating The Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Crovalimab As Adjunct Treatment In Prevention Of Vaso-Occlusive Episodes (Voe) In Sickle Cell Disease (Scd) | Roche | ISRCTN14514128; 2020-004839-25 | |
| 1005547 | A Randomized, Double-blind, Placebo-controlled First-in-Human Study of Single and Multiple Doses of ALXN2080 in Healthy Participants | Alexion | NCT05428696; 2022-000555-36 | |
| 1005562 | A Phase 3, Double-blind, Randomized, Placebo-controlled Trial of Adjunctive Ganaxolone (GNX) Treatment in Children and Adults with Tuberous Sclerosis Complex (TSC)-related Epilepsy (TrustTSC) | Marinus | NCT05323734; 2021-003441-38 | |
| 1005571 | A randomized, double-blind, placebo-controlled, parallel-group, multicenter Phase 3 study to investigate the efficacy and safety of FInerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease | Bayer | NCT05047263; 2021-000421-27 | |
| 1005574 | A Phase 1/2 Open-label Study to Investigate the Safety and Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Modakafusp Alfa (TAK-573) as a Single Agent in Patients With Relapsed Refractory Multiple Myeloma | Takeda | NCT03215030; 2021-006038-37 | |
| 1005625 | A RandomizEd trial of two diFferent antIplatelet strategies in patieNts with acutE coronary syndromes planned for Coronary Artery Bypass Graft surgery - the REFINE CABG study | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN17514416 | |
| 1005626 | A First in Person Trial of a Modified Vaccina Ankara vectored anti Zika vaccine MVAZIKB administered on two occasions 28 days apart at dose levels of 5x107 and 1x108 plaque forming units in healthy adults | University of Liverpool | ISRCTN13726895; 2021-005868-21 | |
| 1005653 | A Single-group, Phase 1, Open-label Study to Investigate the Absorption, Distribution, Metabolism and Excretion of [14C]-BPN14770 Following Oral Dose Administration as a Capsule in Healthy Adult Male Participants. | Shionogi | ISRCTN14188712; 2022-000395-19 | |
| 1005666 | A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) versus Ibrutinib in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314) | Loxo Oncology | NCT05254743; 2021-003206-41 | |
| 1005693 | OptIMMize-2: A Phase 3 Multicenter, Single-arm, Open-label Extension Study to Assess the Safety, Tolerability, and Efficacy of Risankizumab in Subjects With Moderate to Severe Plaque Psoriasis Who Have Completed Participation in Study M19-977 (OptIMMize-1)1 | AbbVie | NCT04862286; 2021-000090-82 | |
| 1005721 | A Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Combination K-757 and K-833 in Healthy Volunteers. | Kallyope | 2022-001578-78 | |
| 1005742 | A Repeat Open Application Patch Test (ROAT) using a New Controlled Release Formulation of Dithranol (Dithranol/ProSilic®) Cream in Healthy Volunteer Subjects, preceded by a Preliminary Safety Phase | Soterios Ltd | ISRCTN84166928; 2022-001272-34 | |
| 1005772 | Phase 3 Randomized, Placebo-Controlled Study to Assess Safety, Tolerability, and Efficacy of Garetosmab in Patients with Fibrodysplasia Ossificans Progressiva | Regeneron | 2022-000880-40 | |
| 1005792 | A Single Ascending and Multiple Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3873862 in Healthy Participants | Eli Lilly and Company | NCT05492201; 2022-000500-36 | |
| 1005885 | A randomised, double-blind, placebo-controlled, Phase 2 study to assess the safety, tolerability, and prophylactic antiviral activity against influenza of Neumifil via a human viral challenge model in healthy adult participants | Pneumagen | NCT05507567; 2022-001853-22 | |
| 1005897 | A Phase 1, open-label study in healthy subjects to assess the effect of paroxetine, a strong CYP2D6 inhibitor, on the pharmacokinetics of a single oral dose of NBI-1117568 | Heptares Therapeutics | ISRCTN34662787; 2022-001954-47 | |
| 1005900 | A multi-site, open-label, sequential-group, multiple-ascending-dose study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamic effects of Lu AG13909 in patients with congenital adrenal hyperplasia | Lundbeck | 2022-000781-18 | |
| 1005905 | Efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) once-weekly in participants with overweight or obesity and type 2 diabetes | Novo Nordisk | NCT05394519; 2021-005121-24 |
Clinical trials given a REC favourable opinion in August 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 84388 | Nasal Allergen Challenge: standardisation for house dust mite and silver birch allergen extracts | Guy's & St Thomas' NHS Foundation Trust | NCT05378594 | |
| 107586 | Measurement and Validation of Fetal Heart and Fetal Movement Signals Detected via Non-adhesive Sensors | University of Manchester | ||
| 242609 | Prospective Multicenter Confirmatory Clinical Evaluation of Novilase® Interstitial Laser Therapy for the Focal Destruction of Malignant Breast Tumours ≤15 mm (BR-003) | Novian Health | NCT03463954 | |
| 272214 | Developing Dynamic Substrate Targeted Personalised Treatment Strategies in AF | Barts Health NHS Trust | NCT05633303 | |
| 276171 | Pilot study of dorsal genital nerve stimulation for management of bladder overactivity following spinal cord injury | University College London | NCT05502614 | Found through search but HRA not notified |
| 276275 | Electrical Impedance Tomography imaging of functional anatomy and selective stimulation of fascicles within the vagus nerve | University College London | NCT05664854 | |
| 278762 | Markers and Response to CRT in non-LBBB | Maastricht University Medical Center | NCT04120909 | |
| 284675 | A pre-post intervention feasibility study to explore the impact of a piano-based occupational therapy programme on hand function and quality of life in children and adolescents (aged 5-15) with cerebral palsy who receive treatment at Sheffield Children's Hospital | Sheffield Children's NHS Foundation Trust | Withdrawn before any participants recruited | |
| 285660 | Blue Whiting protein hydrolysates and sarcopenia outcomes in older adults residing in residential care facilities (SARCO_CARE) | Ulster University | NCT05637450 | |
| 286484 | Personalise antidepressant treatment for unipolar depression combining individual choices, risks and big data | University of Oxford | NCT05608330 | |
| 288405 | A multicentre, randomised controlled, non-inferiority trial, comparing surfactant administration by supraglottic airway compared to endotracheal catheter in preterm infants (the SURFSUP Trial) | Monash Newborn | ACTRN12620001184965 | |
| 292907 | A single-centre, randomised, parallel design pilot study to assess use of real-time continuous glucose monitoring in comparison to conventional capillary blood glucose monitoring in hospitalised patients with diabetes mellitus | Manchester University NHS Foundation Trust | NCT04797208 | |
| 298458 | Peripheral arterial disease, High blood pressure and Aneurysm Screening Trial (PHAST) - a cluster randomised trial of screening men for peripheral arterial disease, high blood pressure and abdominal aortic aneurysm vs screening men for abdominal aortic aneurysm | University of Leicester | ISRCTN17320335 | Found through search but HRA not notified |
| 300572 | A GLP-1 receptor PET imaging add-on study within the Ver-A-T1D trial investigating the effects on beta cell mass (Image-VER-A-T1D) | Radboud University Medical Center | NCT04615910; 2020-004966-20 | |
| 301630 | Effect of introduction of FreeStyle Libre monitoring on glycaemic control in people with type 2 diabetes mellitus (T2DM) | Hull University Teaching Hospitals NHS Trust | NCT05597293 | |
| 301711 | Performance, safety and clinical benefits of a noble metal alloy-coated intramedullary nail: a multicenter, prospective trial with a retrospective control | Zimmer Biomet | NCT05022485 | |
| 302762 | Manchester Intermittent Diet in Gestational Diabetes Acceptability Study (MIDDAS-GDM): A randomised feasibility trial of an intermittent low energy diet (ILED) vs best NHS care in women with gestational diabetes and obesity | Manchester University NHS Foundation Trust | NCT05344066 | |
| 302896 | Indocyanine green (ICG) and near infrared fluorescence (NIRF) guided assessment of the bowel and oesophageal anastomosis during repair of oesophageal atresia with distal trachea-oesophageal fistula (OA/dTOF): a cohort pilot study | Birmingham Women`s and Children`s NHS Foundations Trust | NCT05735964 | |
| 303256 | Probiotics in Paget's Disease | University of Edinburgh | ISRCTN12180483 | |
| 304665 | Can Mandibular Advancement Device Treatment For Obstructive Sleep Apnoea Reduce Nocturnal Gastro-Oesophageal Reflux: A Feasibility Study | Guy's & St Thomas' NHS Foundation Trust | ISRCTN16013232 | |
| 304696 | An intervention using mental health support workers as link workers to improve dental visiting in people with severe mental illness: The Mouth Matters in Mental Health Trial | Lancaster University | ISRCTN13650779; NCT05545228 | |
| 304944 | Pavlik harness treatment vs monitoring for treatment of Developmental Dysplasia of the Hip (DDH) in babies diagnosed with Graf type 2 hips | Maidstone & Tunbridge Wells NHS Trust | ||
| 306121 | The acceptability of exercise snacking to improve leg strength in memory clinic outpatients: a pilot study | University of Bath | NCT05439252 | |
| 306274 | A mixed-methods study exploring the efficacy of a personalised digital prehabilitation programme, Fit 4 Surgery (F4S), for patients undergoing major surgery: A feasibility study | University of Birmingham | ISRCTN10633072 | |
| 306411 | Exploring the role of contact with nature in the context of brief psychological interventions for young people experiencing depressive symptoms | University of Exeter | Not aware of requirement | |
| 306600 | A Prospective, Non-Interventional, Post Market Clinical Follow-up Study to Evaluate the Safety of Pre-Pectoral Breast Reconstruction with ARTIA™ Reconstructive Tissue Matrix after Mastectomy | AbbVie | ||
| 306966 | Hearts and Minds Study | Imperial College Healthcare NHS Trust | ||
| 307335 | Perform™ Humeral System Study (PHS) | Tornier | NCT05067543 | |
| 307403 | REMOTES Study: REmote Monitoring for preOperaTive risk assEssment for major abdominal Surgery | University of Leeds | NCT06042023 | |
| 307417 | Comparison of unilateral CI vs. Bimodal stimulation in prosodic perception | Guy's & St Thomas' NHS Foundation Trust | NCT06128161 | Found through search but HRA not notified |
| 307544 | “Super Rehab”: A novel approach to reverse atrial fibrillation? (a randomised controlled trial) | Royal United Hospital NHS Foundation Trust | NCT05596175 | |
| 307686 | The Meniscal Transplant surgery or Optimised Rehabilitation full randomised trial (MeTeOR2) | University of Warwick | ISRCTN87336549 | |
| 308485 | Multi-modality local consolidative treatment versus conventional care of advanced lung cancer after first line systemic anti-cancer treatment: a multi-centre randomised controlled trial with an internal pilot | Guy's & St Thomas' NHS Foundation Trust | ISRCTN11613852 | |
| 308915 | A holistic patient-centred intervention to improve outcomes of older people living with frailty and chronic heart failure | University of Leicester | ||
| 309742 | A prospective, open-label, multicenter, single-arm clinical study to evaluate the safety and performance of the Gastric Bypass Stent System as a weight loss treatment for obesity | Hangzhou Tangji Medical Technology | NCT05249608 | |
| 310361 | Evaluation of the effectiveness of the Super Enhanced Singlevision Lens 01 (SESL01) on Computer Vision Syndrome: a double-blind, two-arm parallel randomised controlled trial | Carl Zeiss Vision UK | NCT05545878 | |
| 310645 | An International, Multicenter, Evaluator-blinded, Randomized, Parallel-Group, Controlled Study of the Safety and Effectiveness of HArmonyCa Lidocaine Injectable Gel for Mid Face Soft Tissue Augmentation | AbbVie | NCT05452070 | Found through search but HRA not notified |
| 311080 | Non-invasive assessment of bowel function after abdominal surgery – an early feasibility study | University of Leeds | ||
| 311086 | A randomised controlled feasibility trial to determine whether families are willing to change baby bathing practice during the first months of life | St George's University of London | ISRCTN51491794 | |
| 311370 | A pilot randomized controlled trial of the effectiveness of e-cigarettes for tobacco smoking cessation and harm reduction in (treated) opiate use disorder | Change Grow Live | ||
| 311465 | Project VerioVue Enhancements Regulatory Clinical Evaluation – Professional Comparison to a Validated Method - Neonate Study | LifeScan | NCT06052371 | |
| 311668 | Supporting Physical Activity through Co-production in people with Severe Mental Illness (SPACES): a randomised feasibility study of an intervention aimed at increasing the physical activity of people with severe mental ill health | Sheffield Health and Social Care Trust | ISRCTN83877229 | |
| 311721 | A multi-centre, prospective study exploring the use of neuronal signals to identify the ideal location to implant and apply Deep Brain Stimulation (DBS) in the Treatment of Parkinson’s Disease | The Bionics Institute of Australia | ACTRN12621001323819 | |
| 311874 | The use of a novel wearable medical device (AcuPebble SA100) to remotely monitor patients with obstructive sleep apnoea (OSA) on continuous positive airway pressure therapy (CPAP) | Royal Free London NHS Foundation Trust | NCT06097949 | |
| 312280 | Supervised versus self-managed rehabilitation for people after acute patellar dislocation: a multicentre external pilot randomised controlled trial and qualitative study | University of Oxford | ISRCTN14235231 | |
| 312370 |
"RECOGNISE” – taRgeted intermittEnt gluCose mOnitoring for the management of GestatioNal dIabeteS mEllitus– A Feasibility Study |
North Bristol NHS Trust | ISRCTN42125256 | |
| 312386 | Effects of Bacillus subtilis PXN21 on blood and gut biomarkers in Parkinson’s disease | University of Edinburgh | Currently registering | |
| 312523 | Supporting Adolescents with Self-Harm (SASH) | City University of London | ISRCTN81846131 | |
| 312553 | CAMELOT - Continuous rectus sheath Analgesia in eMErgency LaparOTomy. Multi-centre, randomised sham controlled trial of rectus sheath catheter-delivered local anaesthetic infusion compared with usual care in patients undergoing emergency bowel surgery. | University Hospital Southampton NHS Foundation Trust | ISRCTN15475290 | |
| 312883 | A randomised controlled feasibility trial of a prehabilitation intervention in frail older people undergoing total hip or knee replacement | North Bristol NHS Trust | ISRCTN11121506 | |
| 312924 | Isometric exercise training in patients with heart failure with preserved ejection fraction: a randomised controlled study. | St George’s University Hospitals NHS Foundation Trust | NCT05551663 | Found through search but HRA not notified |
| 313373 | Remotely delivered yoga for military veterans with post-traumatic stress disorder: a single case experimental design | Royal Holloway University of London | Sponsor no longer considers this a clinical trial | |
| 313499 | Sustainable return to work: A pilot cluster randomised controlled trial of a multicomponent workplace ‘IGLOO’ intervention compared with usual return-to-work support | Rotherham Doncaster and South Humber NHS Foundation Trust | ISRCTN11788559 | |
| 313977 | Transcutaneous Pulse Oximetry Brain Monitoring Study (UK) | Cyban | ACTRN12620000828921 | |
| 314047 | Assessment of GORE® SYNECOR Biomaterial in Focused Patient Populations and Long-Term Application | Gore | NCT05094089 | |
| 314367 | A prospective interventional study analysing gastric residual volumes and pH in infants fed breast milk 3 hours prior to general anaesthesia | King’s College Hospital NHS Foundation Trust | NCT05355428 | |
| 315330 | A randomised, controlled study to compare visual performance at distance, intermediate and near, refractive outcome, contrast sensitivity, stereoacuity, patient satisfaction and patient related health economics following bilateral, micro-monovision insertion of two monofocal, aspheric, hydrophobic acrylic intraocular lenses: The TECNIS Eyhance® ICB00 and the Alcon IQ SN60WF lenses | Guy's & St Thomas' NHS Foundation Trust | ||
| 315359 | Exploring the role of gastric neuromuscular function in the pathophysiology of proton pump inhibitor (PPI) refractory gastro-oesophageal reflux disease (GORD) | Functional Gut Clinic | NCT05719168 | Found through search but HRA not notified |
| 315512 | A Multi-centre Prospective Observational study of the User Experience of Catheterisation and Quality of Life in patients prescribed GentleCath™ Air for Men Intermittent Catheter with FeelClean™ Technology | ConvaTec | NCT05470751 | |
| 316125 | Feasibility study of delivery of a breastfeeding planning card as part of standard antenatal care | University of Stirling | Currently registering | |
| 316137 | Views and experiences of ethnic minority family carers on internet-delivered guided self-help Acceptance and Commitment Therapy for family carers of people with dementia (iACT4CARERS): A qualitative study | University of East Anglia | ISRCTN15520542 | |
| 316173 | DIAMONDS - Improving diabetes self-management for people with severe mental illness | University of York | ISRCTN22275538 | |
| 316297 | The True Efficacy of Burst Spinal Cord Stimulation in the Management of Failed Back Surgery Syndrome | Abbott | NCT06030284 | Found through search but HRA not notified |
| 317335 | A multi-centre, randomised, double-blind, parallel, placebo-controlled, phase III clinical study to evaluate the efficacy and safety of Pyramax in mild-to-moderate COVID-19 patients | Shin Poong Pharmaceuticals | NCT05084911 | |
| 317373 | Diagnostic Protocol for VENTANA FGFR2b (FPR2-D) RxDx Assay in Amgen Study 20210098 | Roche | NCT05111626; 2021-003477-61 | |
| 317614 | Entia Liberty: Home Study. Evaluation of patient preference for a novel full blood count home testing device versus routine venous monitoring | Entia | NCT05462288 | |
| 1003615 | A Randomised Phase III Trial Comparing Intermittent with Continuous Treatment Strategies in Chronic Lymphocytic Leukaemia (CLL) | University of Leeds | ISRCTN51675454; 2021-005854-27 | |
| 1003954 | A multicentre phase II randomised controlled trial to evaluate the efficacy of Adaptive Therapy (AT) with carboplatin, based on changes in CA125, in patients with relapsed platinum-sensitive high grade serous or high grade endometrioid ovarian cancer | University College London | NCT05080556; 2021-003412-40 | |
| 1004131 | A Phase 2 Open-Label Study to Evaluate Safety and Clinical Activity of FT-4202 in Patients with Thalassemia or Sickle Cell Disease | Forma Therapeutics Inc. | NCT04987489; 2021-005267-48 | |
| 1004219 | A Phase 1, Open-Label, Multicenter Study of INCB123667 as Monotherapy in Participants With Selected Advanced Solid Tumors | Incyte | NCT05238922; 2021-005357-91 | |
| 1004283 | A phase I-II, study of autologous CD34+ haematopoietic stem cells transduced ex vivo with CD11B lentiviral vector encoding human IDS tagged with ApoEII in patients with neuronopathic mucopolysaccharidosis type II (nMPS II, Hunters syndrome) | University of Manchester | ISRCTN12458940; 2021-000400-38 | |
| 1004289 | A Phase 3 Randomized Controlled Study Of Renal Autologous Cell Therapy (REACT) In Subjects With Type 2 Diabetes And Chronic Kidney Disease (Regen-006) | ProKidney | NCT05099770; 2020-004293-21 | |
| 1004372 | A phase 1b TiTE-CRM dose escalation clinical trial of tolinapant (ASTX660) in combination with standard radical chemoradiotherapy in cervical cancer | University Hospital Southampton NHS Foundation Trust | ISRCTN18574865; 2021-006555-34 | |
| 1004396 | A randomised, double-blind, placebo-controlled study to investigate the safety and tolerability of EP395 in patients with chronic obstructive pulmonary disease (COPD) | EpiEndo Pharmaceuticals | NCT05572333; 2021-005787-22 | |
| 1004451 | A multicentre, prospective, open-label, uncontrolled Phase 3 study to assess the efficacy, safety and pharmacokinetics of Atenativ in patients with congenital antithrombin deficiency undergoing surgery or delivery | Octapharma | NCT04918173; 2021-004307-40 | |
| 1004465 | A Pragmatic, Off-Label, Randomised Controlled Trial of Variable Inhaled Corticosteroid Dosing by Blood Eosinophil level and Medication Adherence Digital Evaluation in Airways Disease | University of Leicester | ISRCTN14101933; 2021-005934-41 | |
| 1004474 | A double-blind, randomized, placebo-controlled study to assess the safety and efficacy of nebulized PC945 when added to systemic antifungal therapy for the treatment of refractory invasive pulmonary aspergillosis | Pulmocide | NCT05238116; 2021-004554-32 | |
| 1004529 | A Phase 1/2 Intracerebroventricular and Intravitreal Administration of NGN-101 for Treatment of Neuronal Ceroid Lipofuscinosis Subtype 5 (CLN5) Disease | Neurogene | NCT05228145; 2022-000091-20 | |
| 1004563 | Phase II proof of concept study of baricitinib in individuals who are considered at risk of developing inflammatory arthritis: ExIST | University of Leeds | ISRCTN53678960; 2017-001248-36 | |
| 1004572 | A Phase 2, Randomized, Open-Label, Multicenter Study To Evaluate Safety And Efficacy Of Single Agent Selinexor Versus Treatment Of Physician’S Choice In Patients With Previously Treated Myelofibrosis | Karyopharm Therapeutics | NCT04562870; 2020-003809-60 | |
| 1004663 | A phase 1b double-blind, randomized, placebo-controlled, multicentre, dose titration study to evaluate the safety, tolerability, and pharmacokinetics of 4 weeks treatment with BAY 2413555 in participants with heart failure and implanted cardiac defibrillator or cardiac resynchronization devices | Bayer | NCT05532046; 2021-005751-36 | |
| 1004705 | Switch from stable cART containing ABA/3TC or TAF/FTC plus dolutegravir or bictegravir to TDF/3TC/doravirine in people living with HIV: Impact on lipids, body composition, insulin sensitivity, neuroendocrine function and inflammation markers | Chelsea and Westminster Hospital NHS Foundation Trust | ISRCTN42856592; NCT05289986; 2021-006507-15 | |
| 1004768 | A 2-Part Seamless Part A (Phase 2)/Part B (Phase 3) Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of BIIB059 in Participants with Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus with or without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST) | Biogen | NCT05531565; 2020-000727-40 | |
| 1004770 | A Phase I-III, Multicenter Study Evaluating The Efficacy And Safety Of Multiple Therapies In Cohorts Of Patients Selected According To Biomarker Status, With Locally Advanced, Unresectable, Stage Iii Non-Small Cell Lung Cancer | Roche | NCT05170204; 2021-004149-19 | |
| 1004779 | A Phase 2 Study of Magrolimab Combination Therapy in Patients With Head and Neck Squamous Cell Carcinoma | Gilead | NCT04854499; 2020-005708-20 | |
| 1004789 | A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Guselkumab Subcutaneous Induction Therapy in Participants with Moderately to Severely Active Crohn's Disease | Janssen-Cilag International | NCT05197049; 2020-006165-11 | |
| 1004974 | A Phase 1 Open-label, Multicenter Study Evaluating the Safety and Efficacy of KITE-363, an Autologous Anti-CD19/CD20 CAR T-cell Therapy, in Subjects With Relapsed and/or Refractory B-cell Lymphoma | Kite | NCT04989803; 2020-000562-41 | |
| 1004977 | A Randomized, Multicenter, Open-label, Phase III Study of Lurbinectedin Single-Agent or Lurbinectedin in Combination with Irinotecan versus Investigator’s Choice (Topotecan or Irinotecan) in Relapsed Small Cell Lung Cancer (SCLC) Patients (LAGOON Trial) | Pharma Mar | NCT05153239; 2021-004471-13 | |
| 1005014 | A Phase 2b Multicenter, Long-Term Extension, Dose-ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis | Janssen-Cilag International | ISRCTN15135908; NCT05364554; 2021-004320-16 | |
| 1005084 | A Phase 3, Prospective, Randomized, Multicenter, Single-blind, Controlled Study evaluating Arteriovenous fistula outcomes with and without a Perivascular Sirolimus-eluting Collagen Implant | Vascular Therapies | NCT05425056; 2021-006718-36 | |
| 1005117 | A randomised, double-blind, placebo-controlled, Phase 2 study evaluating efficacy and safety of inupadenant in combination with carboplatin and pemetrexed in adults with nonsquamous non-small cell lung cancer who have progressed on immunotherapy | iTeos Therapeutics | NCT05403385; 2021-005487-22 | |
| 1005119 | [14C]-Vamifeport – A Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion Following a Single Oral Dose in Healthy Male Subjects | Vifor | ISRCTN88307799; 2021-006641-35 | |
| 1005197 | A Phase II, Multi-center, Open-Label Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of R3R01 in Alport Syndrome Patients with Uncontrolled Proteinuria on ACE/ARB Inhibition and in Patients with Primary Steroid-Resistant Focal Segmental Glomerulosclerosis | River 3 Renal | NCT05267262; 2021-004192-13 | |
| 1005204 | A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer, Whose Tumors Express PD-L1 | Gilead | NCT05382286; 2021-005742-14 | |
| 1005273 | A First-in-Human, Phase 1/2, Dose Escalation Study of BOXR1030 T cells in Subjects With Advanced GPC3-Positive Solid Tumors | SOTIO Biotech | ISRCTN15110275; NCT05120271; 2021-005086-41 | |
| 1005290 | PICCOLO: A Phase 2, Single Arm Study of Mirvetuximab Soravtansine in Recurrent Platinum-Sensitive, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression | ImmunoGen | ISRCTN12633596; NCT05041257; 2021-003592-34 | |
| 1005308 | An Open-Label, Single-Period Study Designed to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-ATH434 in Healthy Male Subjects | Alterity Therapeutics | ISRCTN10603388Â ; 2022-000516-66 | |
| 1005321 | A Phase 3 Randomized, Open-Label, Multicenter Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects with Relapsed/Refractory Follicular Lymphoma | Kite | NCT05371093; 2021-003260-28 | |
| 1005413 | A Phase 1b Study of JNJ-75276617 in Combination with AML Directed Therapies for Participants with Acute Myeloid Leukemia Harboring KMT2A or NPM1 Alterations | Janssen-Cilag International | NCT05453903; 2021-003999-14 | |
| 1005448 | A Phase 4, Multi-centre, Randomized, Evaluatorblinded, Active-controlled Study to Determine the Incidence of Squamous Cell Carcinoma and Evaluate the Long-term Safety of Tirbanibulin 10 mg/g Ointment and Diclofenac Sodium 3% Gel for the Treatment of Adult Patients with Actinic Keratosis on the Face or Scalp | Almirall | NCT05387525; 2021-004349-18 | |
| 1005501 | A First-in-Human, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of Gene Therapy with RGX-381 for the Ocular Manifestations Associated with Neuronal Ceroid Lipofuscinosis Type 2 (CLN2) Disease | REGENXBIO | NCT05791864; 2021-000173-92 | |
| 1005537 | A Randomized, Double-Blind, Placebo-Controlled, Two-Part Study to Evaluate the Pharmacodynamic Efficacy and Clinical Benefit of AT 007 in Patients with Sorbitol Dehydrogenase (SORD) Deficiency | Applied Therapeutics | NCT05397665; 2022-000491-18 | |
| 1005551 | A Phase Ib, Randomized, Double-Blind, Placebo-Controlled, Single-Center Study To Evaluate The Safety And Pharmacokinetics Of Multiple Ascending Doses Of Gdc-6988 With And Without Albuterol Pretreatment In Healthy Adult Subjects | Roche | ISRCTN30841680; 2022-000455-36 | |
| 1005578 | Global Registry for Long-Term Follow-up of Patients Participating in Clinical Trials with Posoleucel (ALVR105) | AlloVir | ISRCTN31439492; 2022-000763-45 | |
| 1005591 | Efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema s.c. 2.4 mg/2.4 mg) once-weekly in participants with overweight or obesity | Novo Nordisk | NCT05567796; 2020-005435-75 | |
| 1005637 | Randomized, double-blind, multiple ascending dose, placebo-controlled, multi-center, safety, tolerability, efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) phase 1b/2a clinical trial with AC01 in patients with heart failure with reduced ejection fraction (HFrEF) | AnaCardio | NCT05642507; 2022-000813-15 | |
| 1005663 | Long-Term Follow-up of Fabry Disease Subjects who were Treated with ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy | Sangamo Therapeutics | NCT05039866; 2022-001411-86 | |
| 1005686 | An Open Label, Single-Dose, Single-Period Study Designed to Assess the Pharmacokinetics and Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-MBS2320 in Healthy Male Subjects | Modern Biosciences | ISRCTN16794199; 2022-001537-36 | |
| 1005691 | A Phase 1, Single Center, Randomized, Open-Label Study Investigating the Effect of Formulation, and Active Pharmaceutical Ingredient Particle Size on the Pharmacokinetics of Fenebrutinib in Healthy Subjects | Genentech | ISRCTN17780768; 2022-000888-42 | |
| 1005744 | A Phase 3 Open-Label Extension Study of PTC923 in Phenylketonuria | PTC Therapeutics | NCT05166161; 2021-000497-28 | |
| 1005749 | A Randomized, Blinded, Placebo-Controlled, Dose-Ranging Phase 1b Study of the Safety, Pharmacokinetics, and Antiviral Activity of ABI-H3733 in Subjects with Chronic Hepatitis B Virus Infection | Assembly Biosciences | NCT05414981; 2022-000318-32 | |
| 1005752 | A Phase 3 Randomized Clinical Study of MK-4280A (coformulated favezelimab [MK-4280] plus pembrolizumab [MK-3475]) Versus Physician’s Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma | MSD | NCT05508867; 2022-000371-39 | |
| 1005767 | A Multiple Dose Study to Evaluate the Pharmacokinetics of an Acoramidis (AG10) Modified Release Tablet Formulation in Healthy Subjects | Eidos Therapeutics | ISRCTN11628974 | |
| 1005774 | Interventional, Randomised, Partially Double-blind, Crossover, Positive controlled, Single dose Trial Investigating the Effect of LEO 152020 on Cardiac Repolarisation in Healthy Men and Women | LEO Pharma | NCT05508776 | |
| 1005791 | A Long-Term Follow-Up Study in Subjects with Severe Hemophilia A Who Received BMN 270, an Adeno-Associated Virus Vector–Mediated Gene Transfer of Human Factor VIII in a Prior BioMarin Clinical Trial | BioMarin | 2022-001246-38 | |
| 1005817 | A Phase III, open-label, randomized, controlled, multi-country study to evaluate the immune response, safety and reactogenicity of an RSVPreF3 OA investigational vaccine when co-administered with FLU aQIV (inactivated influenza vaccine – adjuvanted) in adults aged 65 years and above | GlaxoSmithKline | 2022-000623-21 | |
| 1005829 | A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled, 48-Week, Parallel-Group Study of the Efficacy and Safety of Losmapimod in Treating Patients with Facioscapulohumeral Muscular Dystrophy | Fulcrum Therapeutics | NCT05397470; 2022-000389-16 | |
| 1005861 | A Phase II Randomized, Open-label, Multicenter, Dose-ranging Study in Adults and Pediatric Individuals ≥ 12 years of Age to Assess the Safety, Immunogenicity, Pharmacokinetics, andPharmacodynamics of AZD7442, a Combination Product of Two Monoclonal Antibodies (Tixagevimab and Cilgavimab), for Pre-exposure Prophylaxis of COVID-19 | AstraZeneca | NCT05375760; 2022-001014-20 | |
| 1005892 | An Open-Label Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamic and Exploratory Efficacy of Intravenous Dosing of SPL026 (DMT Fumarate [A Serotonergic Psychedelic]) Alone or in Combination with Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder | Small Pharma | NCT05553691; 2022-001767-27 | |
| 1005899 | A Phase 1/2a, open-label, randomised, controlled, multi-country, doseescalation study to assess the safety and immunogenicity of AS37 in combination with the Hepatitis B surface antigen (HBsAg), according to a 0-1-month schedule, in healthy, HBs naïve, adults aged 18-45 years | GlaxoSmithKline | NCT05561673; 2021-005629-25 | |
| 1005916 | A phase I, open-label, randomised-sequence, two-way crossover study to assess the relative oral bioavailability of 25 mg and 5 mg strength capsules of COMP360 in healthy volunteers | COMPASS Pathfinder | ISRCTN16636661 | |
| 1005925 | A Phase III, Randomized, Doubleblind, Placebo-controlled, Multicentre, International Study of Durvalumab plus Domvanalimab (AB154) in Participants with Locally Advanced (Stage III), Unresectable Non-small Cell Lung Cancer Whose Disease has not Progressed Following Definitive Platinum based Concurrent Chemoradiation Therapy (PACIFIC-8) | AstraZeneca | NCT05211895; 2021-004327-32 | |
| 1005952 | A randomised open-label, 3-way crossover, relative bioavailability study of nicotine delivered by an electronic inhaler, Nicorette® Inhalator and Nicorette® QuickMist | Ventus Medical | ISRCTN17715270; 2022-001982-10 | |
| 1005958 | An Open-Label, One-Sequence, Two-Part Drug-Drug Interaction Study in Healthy Volunteers to Assess the CYP1A2 and CYP3A4 Perpetrator Interaction Potential and CYP1A2 Victim Potential of TEV-56286 (anle138b) | MODAG | NCT05532358 | |
| 1005966 | Intratumoral injection of IP-001 following thermal ablation in patients with advanced solid tumors. A multicenter Phase 1b/2a trial in colorectal cancer, non-small cell lung cancer, and soft tissue sarcoma patients | Immunophotonics | ISRCTN16103145; 2022-000176-19 | |
| 1005971 | A single-dose, open-label, single arm study to investigate PK of xevinapant and its metabolite, MET1 in healthy East Asian participants | Merck KGaA | NCT05519540; 2022-002182-15 | |
| 1005986 | A proof-of-concept, randomised, double-blind, placebo-controlled, phase 2a study to assess the prophylactic antiviral activity against influenza, safety, tolerability, and pharmacokinetics of cd388 via a human viral challenge model | Cidara Therapeutics | ISRCTN14841526; NCT05523089 | |
| 1006041 | A Phase I, Randomized, Single-Blind, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD0780 Following Single and Multiple Ascending Dose Administration to Healthy Subjects with or without Elevated LDL-C Levels | AstraZeneca | NCT05384262; 2022-002221-10 | |
| 1006047 | A Five-part, Phase 1, Open-label, Drug-drug Interaction Study Examining the Effect of Gemfibrozil, Fluconazole and Carbamazepine on the Safety, Tolerability and Pharmacokinetics of REN001, and the effect of REN001 on the Safety, Tolerability and Pharmacokinetics of Fexofenadine and Rosuvastatin in Healthy Subjects | Reneo Pharma | ISRCTN12840543; 2022-002224-13 | |
| 1006115 | Placebo-controlled randomised trial of tecovirimat in non-hospitalised monkeypox patients (PLATINUM) | University of Oxford | ISRCTN17461766 | |
| 313640/317637 | A Cluster Randomised Trial of Clinically Assisted Hydration in Patients in the Last Days of Life | University of Surrey | ISRCTN65858561 |
Clinical trials given a REC favourable opinion in September 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 286913 | Vision and balance changes after bilateral implantation of Toric versus non-Toric intraocular lenses in Cataract patients with astigmatism | University Hospital Plymouth NHS Trust | NCT05629078 | |
| 290045 | A dual-cohort feasibility study to investigate the usage of a child-friendly home-monitoring tool for vision assessment for treatment planning in optic pathway gliomas | Barts Health NHS Trust | ||
| 293053 | MagTech: Cost Effectiveness and benefits of Magtrace® versus Technetium in sentinel node biopsy for breast cancer | Manchester University NHS Foundation Trust | ISRCTN11807786 | |
| 293735 | Critical Arrhythmogenic Sites In Human Ventricular Tachycardia: Mechanistic Insights And Determinants Of Clinical Outcomes From Non-Invasive Imaging And Ultra-High Density Activation Mapping | Queen Mary University of London | NCT05152784 | |
| 297914 | Vertical Ridge Augmentation Strategies. An Adaptive Randomised Controlled Clinical Trial | University College Hospital Hospitals NHS Foundation Trust | NCT06242782 | Found through search but HRA not notified |
| 299004 | Triggered post-treatment Imaging in Glioblastoma based on clinical outcome Evaluation compared to Routine: a feasibility study | King’s College Hospital NHS Foundation Trust | ||
| 299171 | An Open-label, Long-term Extension Study of Brazikumab in Participants With Moderately to Severely Active Crohn’s Disease (INTREPID OLE) | AstraZeneca | 2019-001866-14 | |
| 301069 | Bronchoscopic Lung Ablation with Steam Therapy in Lower lobe Predominant Emphysema | Nottingham University Hospitals NHS Trust | ||
| 301923 | JAGUAR Trial (Outside United States; OUS): ObJective Analysis to GaUge EVAR Outcomes Through Randomization | Endologix | NCT05409118 | |
| 302132 | Feasibility of a psychoeducational group intervention to improve parental reflective functioning and bonding in prenatal depression | King’s College London | NCT05628675 | |
| 303834 | Evaluation of Neuromotor Pen in early identification of dementia and differential of dementia subtypes : A feasibility study | Northumbria Healthcare NHS Foundation Trust | ISRCTN11610863 | |
| 304739 | A Feasibility and Acceptability study with Randomised Controlled Trial, to explore Delivery of a Brief Intervention – Food Addiction Screening Tool (FAST) to Address ‘Food addiction’ in Patients Living with Obesity (PLWO) who access Dietetic Services | Coventry University | ISRCTN12138612 | |
| 305331 | A Randomised Controlled Trial of a group CBT intervention for young people with parental depression treatment optimisation: Skills for adolescent WELLbeing (SWELL) | Cardiff University | ISRCTN13924193 | |
| 305713 | Cognitive Restructuring and Imagery Modification for Feelings of Contamination Associated with Post Traumatic Stress Disorder in Refugees Feasibility Study | University College London | ||
| 307706 | A Phase 3 Study to Evaluate the Safety and Efficacy of a Single Dose of CTX001 in Pediatric Subjects With Severe Sickle Cell Disease | Vertex | 2021-002173-26 | |
| 307811 | Clinical Performance of Elecsys® Troponin T hs Gen 6 in Subjects with Symptoms of Acute Coronary Syndrome | Roche | Sponsor no longer considers this a clinical trial | |
| 308638 | Feasibility randomised controlled trial of digital physical activity promotion materials for young people with Cystic Fibrosis | Royal Devon University Hospitals NHS Foundation Trust | ISRCTN21222766 | |
| 309240 | A pilot study of U-RHYTHM technology to investigate 24-hour catecholamine measurements | University of Bristol | ISRCTN64279315 | |
| 310195 | Randomized Prospective Trial of Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer | CairnSurgical | NCT04397185 | |
| 311133 | Primary care Screening to Rapidly Detect Multi-organ Complications For people with Prediabetes and Type 2 Diabetes | University of Liverpool | ||
| 311164 | Effects of simultaneous ETA and AT1 receptor antagonism on endothelial function and vascular stiffness in ANCA-associated vasculitis | University of Edinburgh | NCT05630612 | |
| 311719 | Randomised feasibility study of eye movement desensitisation and reprocessing therapy (EMDR) for functional neurological disorder (FND) | South West London & St George's NHS Mental Health Trust | NCT05455450 | |
| 312253 | An Investigation into the Safety, Acceptability and Feasibility of a Brief Compassion-Focused Intervention for People Who Experience Distressing Mood Swings: A Case Series | King’s College London | NCT05860101 | Found through search but HRA not notified |
| 312382 | A Clinical Evaluation of the RheOx Bronchial Rheoplasty System for the Treatment of the Symptoms of Chronic Bronchitis in Adult Patients with COPD | Gala Therapeutics | NCT04677465 | |
| 313136 | Exploring the experience of engaging with the remote DIALOG+ intervention following preliminary testing of the prototype and post-delivery interviews with naïve participants | East London NHS Foundation Trust | ||
| 313252 | Post-Market Clinical Follow-up Study on the ZNN™ Bactiguard ® Retrograde Femoral Nails (Implants and Instrumentation) - A Multicenter, Prospective, Consecutive series | Zimmer Biomet | NCT05276674 | |
| 313485 | Standard versus accelerated weaning from non-invasive ventilation (NIV) in chronic obstructive pulmonary disease directed by the NIV Outcomes score: a randomised controlled trial | Northumbria Healthcare NHS Foundation Trust | ISRCTN64639614 | |
| 313730 | Acceptance and Commitment Therapy (ACT) for Functional Cognitive Disorders (FCD) - an NIHR funded feasibility study | South West London & St George's NHS Mental Health Trust | ISRCTN12939037 | |
| 313998 | Stryker PEEK Customized Implant: A Prospective Post Market Follow Up to Evaluate Safety, Performance and Effectiveness | Stryker European Operations | NCT05362370 | |
| 314107 | Managing pain in people with Crohn's Disease: Feasibility Testing of an Acceptance and Commitment Group Therapy intervention | King’s College London | NCT05418062 | |
| 314417 | Assessing the feasibility, accessibility, usability of a multi-domain digital lifestyle coach and a virtual clinic to drive behaviour change in middle-aged adults | Five Lives | Sponsor no longer considers this a clinical trial | |
| 314460 | Intraoperative assessment of tumour excision margins using the LightPath® Imaging System for Cerenkov luminescence imaging (CLI) combined with flexible autoradiography (FAR) in women undergoing breast-conserving surgery (BCS) | King’s College London | NCT05496101 | |
| 314590 | Investigation Into The Gastrointestinal Tolerance, Acceptability, Compliance And Patient Preference To Precise Thickn Instant Thickener | Trisco Foods | ISRCTN14298840 | |
| 314752 | Mesh Augmented Reinforcement of Abdominal Wall Suture Line in Patients Undergoing Midline Laparotomy to Limit the Rate of Incisional Hernia (IH) Occurrence | Sofradim Production | NCT05424484 | |
| 315259 | Exploring the feasibility of the OKKO Health app to monitor and predict disease activity caused by age-related macular degeneration | Okulo | NCT05433766 | |
| 315284 | EASE: Evaluating an AI driven stress echocardiography system (Ultromics EchoGo) | London South Bank University | ISRCTN15113915; NCT05028179 | |
| 315483 | Rehabilitation through Exercise prescription for Cardiac patients using an Artificial Intelligence based Programme - RECAP | South Tees Hospitals NHS Foundation Trust | ISRCTN97352737 | |
| 315609 | LiquId Guide Catheter Extension Safety Study | Seigla Medical | NCT05406596 | |
| 315764 | Point of care testing using FebriDx to improve antibiotic use for respiratory tract infections in primary care: a mixed methods feasibility study | University of Southampton | NCT05534555 | |
| 315792 | An open-label, multi-centre, randomised, two arm single period parallel study to assess the efficacy, safety and utility of hybrid closed-loop glucose control compared to standard insulin therapy combined with continuous glucose monitoring in young people (≥16 years) and adults with Cystic Fibrosis related diabetes (CL4P-CF study) | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | NCT05562492 | |
| 316392 | Emotion Regulation in Children (ERiC): A Randomised Clinical Trial to Evaluate the Clinical and Cost Effectiveness of Mentalization Based Treatment (MBT) vs Treatment as Usual for School-Age Children with Mixed Emotional and Behavioural Difficulties | The Anna Freud Centre | ISRCTN11620914 | |
| 316504 | Study looking at Patient Outcomes with Ostique’s Onovus Solo | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ||
| 316640 | A study to evaluate the performance of Adex Gel in the treatment of atopic eczema using SCORAD and Quality of Life Assessments | Dermal Laboratories | NCT05454722 | |
| 316754 | A Prospective, Open, Multicenter Clinical Trial Evaluating The Efficacy And Safety Of Miniject Integrated System Cs627 Combined With Cataract Surgery In Patients With Open Angle Glaucoma Uncontrolled By Topical Hypotensive Medications And Operable Age-Related Cataract Diagnosis | iSTAR Medical | NCT05432245 | |
| 317502 | Comparing the effectiveness of computer-aided-design computer-aided-manufacture (CAD/CAM) insoles manufactured from foam-box cast vs direct scan on patient reported outcome measures: A double-blinded, randomised controlled trial | NHS Greater Glasgow & Clyde | NCT05444192 | |
| 317616 | Randomised Evaluation of SOdium dialysate Levels on Vascular Events | University College London | NCT02823821 | |
| 317628 | An evaluation of a novel point of care device for the detection of sepsis in patients admitted to hospital | Liverpool School of Tropical Medicine | Sponsor no longer considers this a clinical trial | |
| 317662 | European Clinical Registry for Optilume® Urethral Drug Coated Balloon | EAU Research Foundation | NCT05479422 | |
| 319057 | A multi-centre randomised controlled trial examining the effects of temporarily pausing Bruton Tyrosine Kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination and its impact on immune responses in patients with Chronic Lymphocytic Leukaemia | University of Birmingham | ISRCTN14197181 | |
| 319664 | A Trial Evaluating Novel Technologies for the Diagnosis of Asthma | Portsmouth Hospitals University NHS Trust | NCT05819944 | Found through search but HRA not notified |
| 1004250 | DARC in patients with naïve wet Age-related macular degeneration as a Biomarker for macular atrophy development in patients undergoing anti-VEGF treatment (DAB) | Imperial College Healthcare NHS Trust | ISRCTN22122298; 2021-005248-31 | |
| 1004254 | A randomised, phase II, double blind, controlled mechanistic study of obinutuzumab versus rituximab in ANCA-associated vasculitis (ObiVas) | Cambridge University Hospitals NHS Foundation Trust | ISRCTN13069630; 2021-005218-32 | |
| 1004445 | A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib | Novartis | NCT05147220; 2020-005899-36 | |
| 1004609 | A Phase 2, Open-label, Randomized Controlled Trial of BMS-986218 or BMS-986218 Plus Nivolumab in Combination with Docetaxel in Participants with Metastatic Castration-resistant Prostate Cancer | Bristol-Myers Squibb | 2021-003990-74 | |
| 1004755 | PARASTOP - Paracetamol with Strong Opioids - A randomized, double-blind, parallel-group non-inferiority phase III withdrawal trial of paracetamol versus placebo in conjunction with opioids for moderate to severe cancer-related pain | Olso University Hospital Clinical Trials Unit | NCT05051735; 2020-005123-36 | |
| 1004819 | A two-part, open-label, clinical study to assess the safety, tolerability and activity of intravenous doses of ICT01 in combination with low-dose subcutaneous interleukin-2 in patients with advanced solid tumors (EVICTION-2) | Imcheck Therapeutics | NCT05307874; 2021-005110-34 | |
| 1004841 | A Phase 4 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Rimegepant in Episodic Migraine Prevention with Multiple Dosing Regimens | Biohaven | NCT05217927; 2021-005239-22 | |
| 1004860 | A Study to Assess the Effects of the Endothelin Receptor Antagonist Zibotentan and the SGLT2 Inhibitor Dapagliflozin in Patients with Type 2 Diabetes and Elevated Albuminuria: a Randomized Double Blind Cross-Over Trial | University Medical Center Groningen | NCT05570305; 2021-001324-18 | |
| 1004889 | A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study of RAD011 (Cannabidiol Oral Solution) for the Treatment of Patients with Prader-Willi Syndrome | Radius Pharmaceuticals | NCT05098509; 2021-005331-23 | |
| 1004920 | Allogeneic T cells expressing T cell receptor-KDEL and the chimeric antigen receptor CAT19 for the treatment of advanced CD19+ malignancies | University College London | NCT05391490; 2021-002878-88 | |
| 1004964 | An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900, an Oral Plasma Kallikrein Inhibitor, for On-demand Treatment of Angioedema Attacks in Adolescent and Adult Patients with Hereditary Angioedema Type I or I | KalVista Pharmaceuticals | ISRCTN98539585; NCT05505916; 2021-001176-42 | |
| 1004993 | A Multicenter, Open-Label Extension Study To Evaluate The Long-Term Safety And Tolerability Of The Port Delivery System With Ranibizumab In Patients With Neovascular Age-Related Macular Degeneration (Portal) | Roche | 2020-004427-16 | |
| 1005029 | A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study to Investigate Safety, Tolerability, Pharmacokinetics, and Efficacy of NBI-921352 as Adjunctive Therapy in Adult Subjects with Focal Onset Seizures (FOS) | Neurocrine Biosciences | 2021-001433-39 | |
| 1005054 | A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of Sibeprenlimab Administered Subcutaneously in Subjects with Immunoglobulin A Nephropathy | Otsuka | NCT05248646; 2022-000814-32 | |
| 1005061 | A Phase II, double-blind, randomized, multiple dose, cross over, three-treatment, three-period, six sequence placebo controlled trial to evaluate efficacy, pharmacokinetics (PK), pharmacodynamics (PD) and safety and tolerability of glycopyrronium (bromide) in children from 6 to less than 12 years of age with asthma | Novartis | NCT05222529; 2021-004972-32 | |
| 1005070 | Optimizing MATRix as remission induction in PCNSL: De-escalated induction treatment in newly diagnosed primary CNS lymphoma - a randomized phase III trial | Klinikum der Landeshauptstadt Stuttgart gaR | NCT04931368; 2018-002115-96 | |
| 1005081 | A Phase 1, Single-Centre, Open-Label, Two-Part, Sequential Cross-Over Study Designed to assess the Pharmacokinetic Profile of BLU-5937 following Administration of Extended Release Formulation Prototypes and an Immediate Release Reference Formulation in Healthy Male and Female Subjects | Bellus Health Inc. | NCT05570539; 2022-000396-39 | |
| 1005087 | A Phase 3 Open-Label, Randomized, Controlled, Global Study of Telisotuzumab Vedotin (ABBV-399) Versus Docetaxel in Subjects with Previously Treated c-Met Overexpressing, EGFR Wildtype, Locally Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer | AbbVie | NCT04928846; 2021-001811-94 | |
| 1005130 | A multicenter, randomized, double-blind, parallel group, placebo controlled study to assess safety, tolerability, pharmacokinetics and pharmacodynamics of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis | Boehringer Ingelheim | NCT05213624; 2020-000384-23 | |
| 1005184 | A Phase 3 Study of Rusfertide (PTG-300) in Patients with Polycythemia Vera | Protagonist Therapeutics | NCT05210790; 2021-004732-29 | |
| 1005234 | A Randomized, Double-blind, Placebo-controlled, Multicenter, Seamless, Adaptive, Safety, Dose-finding, and Phase 3 Clinical Study of UX701 AAV-mediated Gene Transfer for the Treatment of Wilson Disease | Ultragenyx | NCT04884815; 2020-005266-34 | |
| 1005251 | Open-label clinical study to assess the safety and adequacy of the effectiveness of the SpectraCure P18 System (Interstitial multiple diode lasers and IDOSE® Software) and verteporfin for injection (VFI) for the treatment of recurrent prostate cancer | SpectraCure | NCT03067051; 2017-004224-30 | |
| 1005362 | Open-label, phase 1b, single-ascending dose and optional re-dosing study to evaluate the safety of VERVE-101 administered to patients with heterozygous familial hypercholesterolemia, atherosclerotic cardiovascular disease, and uncontrolled hypercholesterolemia | Verve Therapeutics | NCT05398029; 2022-000749-33 | |
| 1005369 | A 12-week double-blind, randomised, parallel, placebo-controlled, phase IIa, clinical trial to assess the efficacy and safety of psilocybin-assisted psychotherapy versus psychotherapy alone for the treatment of adjustment disorder due to incurable cancer followed by a 9-month observation period and optional open label extension | Psyence | 2022-000564-22 | |
| 1005403 | A Study of LOXO-783 Administered as Monotherapy and in Combination with Anticancer Therapies for Patients with Advanced Breast Cancer and Other Solid Tumors with a PIK3CA H1047R Mutation | Eli Lilly and Company | NCT05307705; 2022-000175-40 | |
| 1005447 | A Randomised feasibility trial on the Minimisation of Immunosuppression In Elderly Renal Transplant Recipients | University College London | ISRCTN15218460; NCT05073822; 2022-000051-36 | |
| 1005499 | Subcutaneous CT-P13 monotherapy vs combination with immunomodulation when switching from intravenous infliximab in inflammatory bowel disease – A Multicentre, Randomised Withdrawal Trial | Guy's & St Thomas' NHS Foundation Trust | ISRCTN95420128; 2021-006803-13 | |
| 1005627 | A randomized, double-blind, placebo controlled, dose-finding study to assess the efficacy and safety of SAR443122 in adult patients with moderate to severe ulcerative colitis | Sanofi-Aventis | NCT05588843 | |
| 1005687 | A Single-Part, Five-Period, Sequential, Open-Labelled Study Designed to Evaluate the Safety and Pharmacokinetic Profile of Varying Doses of Aprepitant Following Administration of a Lipidic Capsule Formulation (LipAprep) in Healthy Subjects | Oxilio | ISRCTN51392723 | |
| 1005699 | BRCA-P: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, International Phase 3 Study to determine the Preventive Effect of Denosumab on Breast Cancer in Women carrying a BRCA1 Germline Mutation | Manchester University NHS Foundation Trust | ISRCTN77394655; NCT05382286; 2017-002505-35 | |
| 1005702 | A Phase Ib, Single-Arm, Open-Label Study Evaluating The Pharmacokinetics, Pharmacodynamics, And Safety Of Tocilizumab In Pediatric Patients Hospitalized With Covid-19 | Roche | NCT05164133; 2021-005332-27 | |
| 1005707 | Two Arm Bridging Study to Evaluate the Efficacy of Romiplostim in the Treatment of Non Asian Adult Severe Aplastic Anemia (SAA) Subjects who are Either Previously Untreated With Immunosuppressive Therapy (IST) or Refractory to IST | Amgen | NCT05323617; 2022-001257-22 | |
| 1005724 | Long-Term, Open-Label Extension Study to Evaluate the Safety and Tolerability of NBI-827104 in Pediatric Subjects with Epileptic Encephalopathy with Continuous Spike-and-Wave During Sleep | Neurocrine Biosciences | NCT05301894; 2021-006788-11 | |
| 1005737 | A Multicohort, Open Label, Phase 2 Study Of Botensilimab (Agen1181) For Treatment Of Advanced Melanoma Refractory To Prior Checkpoint Inhibitor Therapy | Agenus | NCT05529316 | |
| 1005748 | A Phase 1b, Multicenter, Open-Label Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Mezagitamab (TAK-079) in Patients With Primary IgA Nephropathy in Combination With Stable Background Therapy | Takeda | NCT05174221; 2021-005023-20 | |
| 1005760 | A placebo-controlled, proof-of-concept study to evaluate the safety and efficacy of Lanifibranor alone and in combination with the sodium-glucose transport protein 2 (SGLT2) inhibitor EmpaGliflozin in patiEnts with Non- alcoholic steatohepatitis (NASH) and type 2 Diabetes mellitus (T2DM) | Inventiva | NCT05232071; 2021-005057-87 | |
| 1005777 | An Open-Label, Long Term Safety and Efficacy Study of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE) | Ionis | NCT05392114; 2022-000757-93 | |
| 1005795 | SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor | Sparrow Pharmaceuticals | NCT05436639; 2022-000748-32 | |
| 1005801 | An open-label, single-arm, multicenter study to evaluate the efficacy and safety of caplacizumab and immunosuppressive therapy without first line therapeutic plasma exchange in adults with immune-mediated thrombotic thrombocytopenic purpura | Sanofi-Aventis | NCT05468320; 2022-001177-31 | |
| 1005812 | A Single Period Open-Label Study Designed to Evaluate the Pharmacokinetics of Empli-03 Buccal Tablet Formulation in Naltrexone-Blocked Healthy Subjects | Emplicure | ISRCTN12656966 | |
| 1005836 | A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study To Evaluate The Pharmacodynamics, Safety, Tolerability, Pharmacokinetics, And Efficacy Of Ro7204239 In Participants With Facioscapulohumeral Muscular Dystrophy | Roche | NCT05115110; 2021-006255-34 | |
| 1005851 | A randomized, double-blind, double-dummy, parallel-group study, comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis, followed by extended treatment with open-label remibrutinib | Novartis | NCT05156281 ; 2020-005929-89 | |
| 1005870 | A Phase 2/3, Multicenter, Open-label Trial to Evaluate the Long-term Safety, Tolerability, and Efficacy of Sibeprenlimab Administered Subcutaneously in Subjects with Immunoglobulin A Nephropathy | Otsuka | NCT05248659; 2021-005526-17 | |
| 1005889 | A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis | Vertex | NCT05444257; 2021-000713-17 | |
| 1005898 | An Open-Label, Phase 2a, Single Dose Study to Evaluate the Safety Tolerability and Pharmacodynamics of BPL-003 in Patients with Treatment Resistant Depression | Beckley Psytech | NCT05660642; 2022-002502-24 | |
| 1005901 | An Open-Label, Fixed Sequence Study in Healthy Post Menopausal Female Subjects to Assess the Pharmacokinetics of Camizestrant (AZD9833) when Administered Alone and in Combination with Itraconazole | AstraZeneca | NCT05551897; 2022-002011-35 | |
| 1005911 | An Open-Label, Single-Center, 2-Part, Parallel Study to Determine the Absolute Bioavailability and the Absorption, Metabolism, and Elimination Properties of [14C]E7386 in Healthy Male Subjects | Eisai | 2022-000954-27 | |
| 1005913 | A Randomized, Open-Label, Parallel-Group, Two-Arm, Phase 4 Study to Evaluate the Long-Term Efficacy and Safety of Tirzepatide Compared with Intensified Conventional Care in Adults When Initiating Treatment Early in the Course of Type 2 Diabetes (SURPASS-EARLY) | Eli Lilly and Company | NCT05433584 | |
| 1005924 | A Randomized, Placebo-Controlled, Multiple Ascending Dose Study Assessing Safety, Tolerability, Pharmacodynamics, Efficacy, and Pharmacokinetics of DYNE-101 Administered to Participants with Myotonic Dystrophy Type 1 | Dyne Therapeutics | NCT05481879; 2022-000889-18 | |
| 1005934 | Positron Emission Tomography Repeatability Evaluation Of Tissue Zirconium 89Zr Crefmirlimab Berdoxam Uptake (Pretzcel) | ImaginAb | ISRCTN71215418; 2022-000944-31 | |
| 1005950 | An 18-month, open-label, single-arm safety extension study of an age-and bodyweight-adjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children and young adults from 1 to 18 years of age with chronic kidney disease and proteinuria | Bayer | NCT05457283; 2021-002905-89 | |
| 1005951 | A Phase 1, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeated Daily Doses of SFX-01 Tablets in Healthy Male Participants | Evgen Pharma | ISRCTN96285652; 2022-001601-43 | |
| 1006005 | A Phase 1b/2, Open-Label Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants with Advanced or Metastatic Colorectal Cancer | Janssen-Cilag International | NCT05379595; 2021-006629-23 | |
| 1006064 | A Phase 2 Study to Evaluate Efficacy, Safety and Tolerability of VIR-2218 and VIR-3434 in Participants with Chronic Hepatitis D Virus Infection (SOLSTICE) | Vir Biotechnology | NCT05461170; 2022-001993-78 | |
| 1006109 | Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP547 in Subjects with Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis | Escient Pharmaceuticals | NCT05525520; 2021-002526-25 | |
| 1006119 | A Randomized, Double-Blind, 12-Week (with an Extension to 52 weeks in a subset of Participants), Multi-Center Study to Assess the Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) Delivered by MDI HFO Compared to BGF delivered by MDI HFA in Participants with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) | AstraZeneca | NCT05573464; 2022-001476-33 | |
| 1006129 | A Phase 2a Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-4482 in Healthy Participants Inoculated with Experimental Respiratory Syncytial Virus | MSD | NCT05559905 | |
| 1006162 | A multicentre, phase III, double-blind, randomised clinical trial to assess the efficacy and safety of LPRI-424 (dienogest 2.00 mg / ethinyl estradiol 0.02 mg) in the treatment of polycystic ovary syndrome (PCOS) versus placebo during 9 cycles | Chemo Research | ISRCTN76318215; 2021-002178-17 | |
| 1006208 | An Open-Label Study to Evaluate BPL-003 as Adjunctive Therapy in Patients with Major Depressive Disorder and Non or Partial Response to Selective Serotonin Reuptake Inhibitor (SSRI) Treatment | Beckley Psytech | 2022-002641-18 |
Clinical trials given a REC favourable opinion in October 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 273255 | Evaluation of Footwear Fit Guidelines Under Pressure in At-Risk Feet | University Hospitals of Leicester NHS Trust | NCT06025422 | |
| 285922 | Shortening Duration of Untreated Illness in First Episode Eating Disorders: A Randomised Controlled Feasibility Trial of a Smart-Phone Friendly Multi-Modal Decision Making Tool (FREED-Mobile; FREED-M) to Improve Help-Seeking | King’s College London | ISRCTN15662055 | |
| 289975 | Point of Care Testing (POCT) for Advanced Practitioners (Paramedics) in urgent and emergency care: a single site feasibility study | University of Bradford | NCT05054049 | |
| 299201 | Is there a role for focussed ultrasound in assessment of shunt function | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ||
| 299606 | Structural Magnetic Resonacen Imaging in comparison with Computed Tomography Imaging in infants with Lung Disease | Sheffield Children's NHS Foundation Trust | ||
| 299674 | Rapid respiratory microbiological point-of-care-testing in primary care: a randomised controlled efficacy trial with internal pilot and qualitative and quantitative investigation of microbial, behavioural and antibiotic mechanisms (the RAPID-TEST RCT) | University of Bristol | ISRCTN16039192 | |
| 302603 | Evaluating the efficacy of an Advance Care Planning Programme for Health Decisions in patients with Advanced Heart Failure | Liverpool John Moores University | NCT04424680 | |
| 303912 | A Randomised, Open Label, Parallel Group Study in Adult Smokers to Evaluate Changes in Biomarkers of Tobacco Exposure After Switching to Exclusive Use of the JUUL2 System | Juul Labs | ISRCTN27662176Â | |
| 304119 | The ClearCoast™ Magnetic Resonance Outcome Post Marketing Surveillance Study | ClearCut Medical | NCT05458739 | |
| 304398 | A multi-centre open-label randomised non-inferiority trial of robot assisted laparoscopic surgery versus laparotomy in women with early stage cervical cancer | Karolinska University Hospital | NCT03719547 | |
| 306338 | EF-32 (TRIDENT): A PIVOTAL RANDOMIZED, OPEN-LABEL STUDY OF OPTUNE® (TTFIELDS, 200KHZ) CONCOMITANT WITH RADIATION THERAPY AND TEMOZOLOMIDE FOR THE TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA | Novocure | NCT04471844 | |
| 307911 | Acceptability and feasibility of digital assessment of falls risk, frailty and mobility impairment using wearable sensors in people with HIV as part of HIV care | University Hospitals Sussex NHS Foundation Trust | Sponsor no longer considers this a clinical trial | |
| 308114 | Improving life quality in chronic obstructive pulmonary disease (COPD) by increasing uptake and completion of pulmonary rehabilitation with lay health workers: a cluster randomised controlled trial | King’s College London | ISRCTN12658458 | |
| 308254 | An efficacy and mechanism evaluation of transcutaneous vagal nerve stimulation for upper limb recovery post-stroke – a randomised, controlled, multi-arm, multi-stage, adaptive design trial | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN20221867 | |
| 308279 | Post-Market Clinical Follow-up Study on the ZNN™ Bactiguard ® Antegrade Femoral Nails (Implants and Instrumentation) - A Multicenter, Prospective, Consecutive series | Zimmer Biomet | NCT05339360 | |
| 308356 | Assessment, Monitoring and Optimisation of prehabilitation patients using wearable fitness trackers | Imperial College London | ||
| 308642 | Ketone supplementation to Improve Cardiac Energetics and Function | University of Leeds | ISRCTN24885065 | |
| 309190 | Clinical and cost effectiveness of an online integrated bipolar parenting intervention: A randomised controlled trial | Lancaster University | ISRCTN15962574 | |
| 309424 | A Case Control Study of women aged 30-39 to augment breast cancer risk prediction and assess acceptability and preference of a systematic risk prediction approach through primary care | Manchester University NHS Foundation Trust | NCT05305963 | |
| 310355 | Reducing Oxygen Consumption in Critical care (ROCC) | Guy's & St Thomas' NHS Foundation Trust | NCT05796817 | Found through search but HRA not notified |
| 311297 | TRANSFORMII: Sirolimus-coated balloon versus drug-eluting stent in native coronary vessels | Fondazione Ricerca e Innovazione Cardiovascolare | NCT04893291 | |
| 312339 | A comparative single centre study assessing the relationship between acoustic breath sounds as measured by a commercially available sound recording device against standard of care (spirometry) in the assessment of airflow obstruction in patients who plan to undergo spirometry testing | University Hospitals Birmingham NHS Foundation Trust | NCT06039943 | |
| 312522 | EXO4UL- Assessment of a robotic exoskeleton for upper limb rehabilitation of spinal cord injured patients | University of Liverpool | NCT05615766 | |
| 312857 | A Multi-site mixed-methods evaluation of brief IAPT staff training to adapt practice for secondary personality difficulties | University of Exeter | ISRCTN81104604 | |
| 313158 | A single-centre, randomised, 3-way cross-over, clinical investigation comparing denture fixative versus no fixative performance in full denture wearers and an exploratory sub-study in partial denture wearers | Reckitt | NCT05689814 | |
| 313223 | Investigating the use of behavioural science informed messages to facilitate attendance at Lung Health Checks | Imperial College Healthcare NHS Trust | ||
| 313369 | Prospective, observational, open-label, clinical investigation of intra-articular Arthrosamid® injection in subjects with knee osteoarthritis (“LUNA”) | Contura International | NCT05057559 | |
| 313848 | Reverse or Anatomical replacement for Painful Shoulder Osteoarthritis - Differences between Interventions: a multi-centre, pragmatic, parallel group, superiority randomised controlled trial | Wrightington, Wigan & Leigh NHS Foundation Trust | ISRCTN12216466 | |
| 314769 | Post COVID REspiratory Mechanisms and the Efficacy of a breathing exercise intervention for DYsregulated breathing | University of Nottingham | NCT05732571 | |
| 315128 | Is Reducing Flow In Affected Branch Pulmonary Arteries In Patients With Partial Anomalous Pulmonary Venous Drainage Using A Percutaneous Approach Safe And Efficacious? – A Pilot Study | Leeds Teaching Hospitals NHS Trust | NCT06048679 | Found through search but HRA not notified |
| 315303 | A person-centred approach to improving uptake of Fracture Prevention drug Treatments (iFraP): a randomised controlled trial of the iFraP intervention in Fracture Liaison Services | Keele University | ISRCTN10606407 | |
| 315581 | BIOSYM - A Feasibility Randomised Controlled Trial Comparing Biological Matrices with Synthetic Meshes in Women Undergoing One Stage Implant Based Breast Reconstruction | University Hospitals Derby & Burton NHS Foundation Trust | NCT05449691 | |
| 315656 | Does stoma feeding improve the microflora in the distal limb of loop ileostomy patients and is this linked to a reduction in post-operative complications? | Lancashire Teaching Hospitals NHS Foundation Trust | NCT06288464 | |
| 315951 | Assessing psychological support for people with emotional distress and difficulties in relationships: The SPS study | Imperial College London | ISRCTN13918289 | |
| 316042 | Controlling malodour in fungating wounds using a cinnamon-based dressing: Observational study | CEMAG Care | NCT05650762 | |
| 316162 | An evaluation of quality improvement collaboratives aligned to a national audit to improve the uptake of insulin pumps for people with diabetes | Northumbria University | ISRCTN82176651 | |
| 316323 | EvaLuation of thE MiNiMed 780 System iN Young Paediatric Subjects (2-6 years old) with Type 1 Diabetes in a Home Setting (Lenny Study) | Medtronic | NCT05574062 | Found through search but HRA not notified |
| 316749 | Personalised treatment packages for adults with learning disabilities who display aggression in community settings: a cluster randomised controlled trial | Camden & Islington NHS Foundation Trust | ISRCTN71781827 | |
| 317330 | A feasibility trial evaluating mobility and strength training with and without protein supplements in pre-frail/frail older adults with low protein intake. | University of Oxford | ISRCTN30405954 | |
| 317378 | A feasibility randomised controlled study to test the use of Indocyanine green Fluorescence Image-Guidance in liver Surgery compared to standard liver surgery alone in reducing microscopic positive tumour resection rate (I-FIGS) | University Hospital Plymouth NHS Trust | NCT05616039 | |
| 317494 | Mobile Health Biometrics to prescribe immediate remote physical activity for enhancing uptake to cardiac rehabilitation- MOTIVATE-CR+ | Liverpool John Moores University | NCT05774587 | |
| 317587 | The HistoSonics System for treatment of primary solid renal tumors using histotripsy (CAIN) | HistoSonics | NCT05432232 | |
| 317899 | Continuous Ambulatory Vestibular Assessment (CAVA) - Development of a System to Provide an Automatic Diagnosis for Vestibular Conditions | Norfolk and Norwich University Hospitals NHS Foundation Trust | NCT05984901 | |
| 318010 | A case series evaluation of Augmented Depression Therapy (ADepT) for the treatment of complex depression | University of Exeter | ISRCTN75828354 | |
| 318098 | Site of disease BIOmolecule capture and analysis in PATienTs with established coronary disease undERgoing iNtracoronary assessment (BIOPATTERN) | PlaqueTec | NCT06259019 | Found through search but HRA not notified |
| 318316 | Evaluation of a rumination intervention for individuals with PTSD: A case series | University of Oxford | NCT05625126 | |
| 318332 | Strategies, processes, contextual factors, outcomes, and costs of implementing Digital Mobile Mental Health in routine care in four European countries: a parallel-group cluster randomized controlled trial | Central Institute of Mental Health | ISRCTN15109760 | |
| 318451 | Optimization of Prostate Biopsy - Micro-Ultrasound versus MRI: a 3-arm randomized controlled trial evaluating the role of 29MHz micro-ultrasound in guiding prostate biopsy in men with clinical suspicion of prostate cancer | Exact Imaging | NCT05220501 | |
| 319324 | Biofinity® Multifocal Contact Lenses Fitting Methods Comparison | CooperVision | ISRCTN51153627 | |
| 319600 | A randomised controlled trial of a brief cognitive task intervention to support NHS staff experiencing intrusive memories of traumatic events from working in the COVID-19 pandemic | P1vital | NCT05616676 | |
| 319963 | OKKO Health hyperacuity, contrast and colour game validation in age-related macular degeneration | Okulo | NCT05569226 | |
| 320023 | CREST EDOF Contact Lenses vs MiSight® 1Day Contact Lenses | Brien Holden Vision Institute | ISRCTN76313384 | |
| 1003871 | A randomised, double-blind, placebo-controlled, two-part study to evaluate the pharmacokinetics, safety and tolerability, and preliminary efficacy of two dose levels of golexanolone in subjects with primary biliary cholangitis, fatigue, and cognitive dysfunction | Umecrine Cognition | 2022-000422-16 | |
| 1003943 | OCTOPUS - Optimal Clinical Trials Platform for Progressive Multiple Sclerosis | University College London | ISRCTN14048364; 2021-003034-37 | |
| 1004427 | A randomised controlled phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma | University of Birmingham | ISRCTN11460478; 2021-005214-34 | |
| 1004522 | A randomised, controlled, assessor-blind, parallel groups, multicentre, multinational trial comparing the ovarian response of a starting dose of 15 µg follitropin delta (REKOVELLE) to a starting dose of 225 IU follitropin alfa (GONAL-F) in conventional regimens in controlled ovarian stimulation in women undergoing an assisted reproductive technology programme | Ferring Pharmaceuticals | NCT05263388; 2021-001785-38 | |
| 1004637 | A Phase 3, Multicenter Study to Evaluate the Safety and Efficacy of AGN-151586 for the Treatment of Glabellar Lines | AbbVie | NCT05248867; 2021-003667-10 | |
| 1005067 | Can edoxaban and rivaroxaban be prescribed for breastfeeding mothers? | King’s College Hospital NHS Foundation Trust | ISRCTN57583139 | |
| 1005095 | Validation of a novel composite of skin biomarkers as a primary outcome measure for evaluating the safety of treatments for atopic dermatitis study 2: a randomised controlled trial (phase 2) comparing the effects of crisaborole 2% ointment to betamethasone valerate 0.025% cream on skin structure and function in participants with atopic dermatitis | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN52806782; 2022-000560-21 | |
| 1005105 | A Randomized, Double-blind, Placebo-controlled Phase 2 Study with Open-label Extension to Assess the Efficacy and Safety of Namilumab in Subjects with Chronic Pulmonary Sarcoidosis | Kinevant | NCT05314517; 2021-004794-31 | |
| 1005137 | A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measures in Adults and Adolescents with Becker Muscular Dystrophy | Edgewise Therapeutics | NCT05291091; 2021-006819-28 | |
| 1005172 | A multicentre, phase III, double-blind, randomised clinical trial to assess the efficacy and safety of LPRI-CF113 in the treatment of Endometriosis versus placebo after 3 medication cycles followed by 3 open-label medication cycles | Chemo Research | 2021-001424-17 | |
| 1005193 | A Multicenter, Open-Label, Phase I/II Study of EOS884448 in combination with standard of care and/or investigational therapies in participants with advanced solid tumors | iTeos Therapeutics | NCT05060432; 2021-001329-29 | |
| 1005215 | Multi-Centre, Multi-National, Open Label, Safety Study of Etripamil Nasal Spray for Patients with Paroxysmal Supraventricular Tachycardia | Milestone Pharmaceuticals | NCT04072835; 2019-001857-13 | |
| 1005257 | A phase 2, open-label, single-arm, multicenter study of SOT101 in combination with pembrolizumab to evaluate the efficacy and safety in patients with selected advanced/refractory solid tumors | SOTIO Biotech | 2021-005774-25 | |
| 1005334 | A Phase 1-2, Open-Label Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Activity of Tolinapant in Combination with Oral Decitabine/Cedazuridine and Oral Decitabine/Cedazuridine Alone in Subjects with Relapsed/Refractory Peripheral T-cell Lymphoma | Astex | NCT05403450; 2021-005338-40 | |
| 1005451 | A multi-site, open-label, Phase II, randomized, controlled trial to compare the efficacy of RO7198457 versus watchful waiting in resected, Stage II (high risk) and Stage III colorectal cancer patients who are ctDNA positive following resection | BioNTech | NCT04486378; 2020-000451-12 | |
| 1005453 | A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122 in Participants with Parkinson’s Disease | Biogen | NCT05348785; 2021-004849-20 | |
| 1005465 | CYCLONE 3: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Abemaciclib in Combination with Abiraterone plus Prednisone in Men with High-Risk Metastatic Hormone-Sensitive Prostate Cancer | Eli Lilly and Company | NCT05288166 | |
| 1005498 | A Phase 3 open-label, controlled, randomised, multi-centre trial comparing imlifidase and standard-of-care with standard-of-care alone in the treatment of severe anti-GBM antibody disease (Goodpasture disease) | Hansa Biopharma | NCT05679401 | |
| 1005598 | A Randomized, Double-blind, Placebo-Controlled, Phase 2 Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous TAK-341 in Subjects With Multiple System Atrophy | Takeda | NCT05526391; 2022-000336-28 | |
| 1005632 | A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing CC-92480, Bortezomib And Dexamethasone (480Vd) Versus Pomalidomide, Bortezomib And Dexamethasone (PVd) In Subjects With Relapsed Or Refractory Multiple Myeloma (RRMM) | Celgene | NCT05519085; 2021-001957-30 | |
| 1005642 | Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN10615985; 2022-002659-20 | |
| 1005671 | A Phase 1, Adaptive, Open-Label, Single Ascending Dose to Single-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-0184 in Participants with Chronic Heart Failure | ModernaTX | ISRCTN79552451; 2022-000784-46 | |
| 1005683 | A Modular Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD9574 as Monotherapy and in Combination with Anti-cancer Agents in Patients with Advanced Solid Malignancies (CERTIS1) | AstraZeneca | NCT05417594; 2021-006227-17 | |
| 1005698 | A Phase 1, Multicenter, Open-Label Study Of BMS-986403 In Subjects With Relapsed And/Or Refractory Chronic Lymphocytic Leukemia (CLL) Or Small Lymphocytic Lymphoma (SLL) | Celgene | NCT05244070; 2021-003274-31 | |
| 1005710 | A Phase 2 Randomized, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of XmAb®13676 (Plamotamab) Combined with Tafasitamab Plus Lenalidomide Versus Tafasitamab Plus Lenalidomide in Subjects with Relapsed or Refractory Diffuse Large B-Cell Lymphoma | Xencor | 2021-003658-22 | |
| 1005728 | A Phase II, Multicentre, Open-Label Study to Assess the Efficacy and Safety of Olaparib Monotherapy and Olaparib Plus Durvalumab Combination as Neoadjuvant Therapy in Patients with BRCA Mutations and Early Stage HER2-Negative Breast Cancer (OlympiaN) | AstraZeneca | 2021-005231-22 | |
| 1005783 | A Phase III, Open-label, Randomised, Multicentre Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Without Actionable Genomic Alterations, and Whose Disease Has Progressed On or After Prior Anti-PD- (L)1 Therapy and Platinum-based Chemotherapy: LATIFY | AstraZeneca | NCT05450692; 2022-000493-26 | |
| 1005784 | Phase 1/2 Open-Label Study of the Safety, Pharmacokinetics, and Preliminary Activity of ASTX295 in Subjects with Wild-Type TP53 Advanced Solid Tumors | Astex | NCT03975387; 2021-005033-16 | |
| 1005794 | A Phase 1 Study of JNJ-80038114, a T-Cell Redirecting Agent Targeting Prostate Specific Membrane Antigen (PSMA), for Advanced Stage Prostate Cancer | Janssen-Cilag International | ISRCTN16457874; NCT05441501; 2022-001263-27 | |
| 1005853 | Study Evaluating Safety and Efficacy of CORT113176 (Dazucorilant) in Patients with Amyotrophic Lateral Sclerosis (DAZALS) | Corcept Therapeutics | 2021-005611-31 | |
| 1005888 | A Phase II, Multicentre, Open-label, Master Protocol to Evaluate the Efficacy and Safety of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours (TROPION-PanTumor03) | AstraZeneca | NCT05489211; 2022-000776-19 | |
| 1005902 | BURAN: Effects of Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma using Functional Respiratory Imaging Parameters | AstraZeneca | NCT05552508; 2022-000152-11 | |
| 1005929 | A randomized, double-blind, controlled, multi-center study to evaluate the efficacy and safety of dose de-escalation of orally administered filgotinib in subjects with ulcerative colitis in clinical remission | Galapagos | NCT05479058; 2022-000719-30 | |
| 1005931 | A Phase Ib, randomised, double-blind, placebo-controlled study to investigate the safety, tolerability, and pharmacokinetics of an intravenous monoclonal antibody (mAb) after single ascending doses in subjects affected by idiopathic pulmonary fibrosis | Chiesi Farmaceutici | NCT05513950; 2022-001079-15 | |
| 1005946 | A Phase 2a, Randomized, Blinded, Multicenter Study Investigating a Combination of AB 729 and VTP-300 in Virologically-Suppressed Chronic Hepatitis B Participants | Arbutus Biopharma | 2022-001946-39 | |
| 1005964 | A phase 3b, open-label, multi-country, multi-centre, long-term follow-up study of ZOSTER-049 (follow-up of ZOSTER-006/022 studies) to assess the prophylactic efficacy, safety and persistence of immune response of a Herpes Zoster subunit vaccine and assessment of persistence of immune response and safety of 1 or 2 additional doses administered in ZOSTER-049 in 2 subgroups of older adults | GlaxoSmithKline | NCT05371080; 2021-005319-30 | |
| 1005987 | An open-label, phase 1, first-in-human, dose escalation and expansion study to evaluate the safety, tolerability, maximum tolerated or administered dose, pharmacokinetics, pharmacodynamics, and tumour response profile of the diacylglycerol kinase zeta inhibitor (DGKzi) BAY 2965501 in participants with advanced solid tumours | Bayer | NCT05614102; 2022-002016-23 | |
| 1006000 | A Phase 3, Randomized, Observer-blind, Active-controlled Study to Evaluate the Safety and Efficacy of mRNA-1010 Candidate Seasonal Influenza Vaccine in Adults 50 Years and Older | ModernaTX | NCT05566639; 2022-001638-12 | |
| 1006010 | Pan-European proof-of-concept study comparing Decentralised Clinical Trial (DCT) and hybrid approaches to conventional clinical trial approaches in patients with Type 2 diabetes mellitus treated with Toujeo® | University Medical Center Utrecht | NCT05780151 | |
| 1006019 | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy, Safety, and Tolerability of BIIB080 in Subjects with Mild Cognitive Impairment Due to Alzheimer’s Disease or Mild Alzheimer’s Disease Dementia | Biogen | NCT05399888; 2021-006036-13 | |
| 1006035 | A Phase 2a/2b, Open-label, Proof of Concept (Phase 2a) and Double-blind, Randomized, Placebo-Controlled (Phase 2b), Multicenter, Efficacy, and Safety Study of AG-946 in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes | Agios | ISRCTN10304854; NCT05490446 | |
| 1006069 | A Real-World Evidence Study Evaluating Quality of Life Parameters Following Treatment with Otrivine (Xylometazoline hydrochloride) | GlaxoSmithKline | ISRCTN74996920 | |
| 1006080 | A two-part, open-label systemic gene delivery study to evaluate the safety and expression of RO7494222 (SRP-9001) in subjects under the age of four with Duchenne muscular dystrophy | Roche | 2022-000691-19 | |
| 1006096 | A Phase II, randomised, placebo-controlled, double-blind, parallel-group, efficacy and safety study of at least 48 weeks of oral BI 685509 treatment in adults with early progressive diffuse cutaneous systemic sclerosis | Boehringer Ingelheim | NCT05559580 | |
| 1006127 | An Open Label, Single-dose, Single-period Study Designed to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-CORT125329 in Healthy Male Subjects | Corcept Therapeutics | ISRCTN20653849; 2022-002574-90 | |
| 1006153 | A Phase 1, Double-Blind Study Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous and Intramuscular Dosing of SPL028 (Deuterated DMT Fumarate [A Serotonergic Psychedelic]) in Healthy Volunteers (Part A); Followed by an Open-Label Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Exploratory Efficacy of SPL028 in Patients with Major Depressive Disorder (Part B) | Small Pharma | 2022-002618-17 | |
| 1006173 | A Randomized, Double-blind, Placebo-controlled, Dose Ranging Phase 2 Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis | Aristea Therapeutics | NCT05194839; 2021-003029-31 | |
| 1006217 | A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Study of Investigational Agents With or Without Pembrolizumab in Participants with PD-1/L1 Refractory Locally Advanced or Metastatic Urothelial Carcinoma (KEYMAKER-U04): Substudy 04A | MSD | NCT05562830; 2020-004544-28 | |
| 1006219 | A Randomized, Open-Label, Multicenter, Global, Phase 2 Trial To Evaluate The Efficacy And Safety Of Epcoritamab (Gen3013; Duobody®-Cd3×Cd20) As Monotherapy Or In Combination With Lenalidomide As First-Line Therapy For Anthracycline-Ineligible Subjects With Diffuse Large B Cell Lymphoma | Genmab | NCT05660967; 2021-005744-29 | |
| 1006227 | An open-label, cross-over study of intramuscular (IM) and intravenous (IV) doses of SPL026 drug product (DMT fumarate [a serotonergic psychedelic]), in healthy, psychedelic experienced participants (Part A: IM and IV doses) and participants with little to no psychedelic experience (Part B: IM dose only) | Small Pharma | NCT05644093; 2022-002775-10 | |
| 1006243 | An exploratory pharmacoscintigraphic single centre, open-label, crossover study in healthy volunteers to evaluate novel oral modified release semaglutide tablets | BDD | ISRCTN60358675; 2022-002566-32 | |
| 1006255 | A Multicenter, Open-label Extension (OLE) Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-004 in Patients with C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) | Wave Life Sciences | NCT05683860; 2022-002267-29 | |
| 1006291 | A Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Depemokimab in Adults with Hypereosinophilic Syndrome (HES) | GlaxoSmithKline | NCT05334368; 2021-005692-39 | |
| 1006297 | Phase 1b, open label study to evaluate the safety, tolerability, and efficacy of a 1% topical formulation of KM-001 for the treatment of type I Punctate Palmoplantar Keratoderma or Pachyonychia Congenita | Kamari Pharma | ISRCTN67285394 | |
| 1006328 | A Phase I Randomized, Double-blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Ciraparantag for Reversal of Supratherapeutic Doses of Anticoagulants in Healthy Adults | Norgine | ISRCTN28849775; 2022-002756-39 | |
| 1006388 | A Phase 3B/4 Open-Label Multicenter Study Extension Study to Further Evaluate Safety, Tolerability and Efficacy of Intracerebroventricular AX 250 Treatment in Mucopolysaccharidosis Type IIIB (MPS IIIB, Sanfilippo Syndrome Type B) Patients | Allievex | NCT05492799; 2022-002762-33 | |
| 302675/319555 | A multi-centre, single arm feasibility study of a complex intervention to improve Recovery after an Episode of Delirium in adults over 65 years: the RecoverED study | Royal Devon University Hospitals NHS Foundation Trust | ISRCTN15676570 |
Clinical trials given a REC favourable opinion in November 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 250915 | Trial Of Neurostimulation Treatment And Investigation For Causes Of Functional Motor Symptoms (Tonics): A Pilot Study | King’s College London | NCT05829005 | Found through search but HRA not notified |
| 262246 | Stereotactic Ablative Radiotherapy for the treatment of refractory ventricular tachycardia | Queen Mary University of London | NCT05696522 | |
| 275073 | The clinical impact of customised Positive Airway Pressure (PAP) therapy interfaces vs usual care in the treatment of patients with sleep disordered breathing | University College London | ISRCTN74082423 | |
| 276018 | Noninvasive Monitoring for noninvasive ventilation: Use of transcutaneous carbon dioxide monitoring to guide acute Noninvasive ventilation in patients with acute hypercapnic respiratory failure: A multi center study | Nottingham University Hospitals NHS Trust | NCT05674760 | |
| 280418 | Prospective Evaluation of Applied ‘Lite’ Compression for leg ulcer Healing, a pragmatic, multi-centre randomized controlled non-inferiority trial | North Cumbria Integrated Care NHS Foundation Trust | ISRCTN37496076 | |
| 282818 | Improved diagnostics in food allergy (ID-in-FA) Study | Imperial College London | NCT06097572 | |
| 287633 | Assessing Response to Therapy in Malignant Glioma using 68Ga-FAPI PET-MRI: A Pilot Study | University College London | ||
| 289709 | Clinical Evaluation of the Nova Max Pro Statsensor Point of Care Creatinine measuring device in the clinical outpatient and home setting & assessment of the patient experience | Royal Free London NHS Foundation Trust | ||
| 293461 | Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital imaging? The Digital Imaging versus Ophthalmoscopy (DIvO) study | Cambridge University Hospitals NHS Foundation Trust | NCT05282147 | |
| 294472 | Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot | University College London | NCT05437393 | |
| 302037 | A Single-Blinded, Randomised Controlled Trial Comparing the Use of Intravaginal Laser Therapy to Sham in Post-Menopausal Women with Recurrent Urinary Tract Infections (rUTIs) and the Impact on the Microbiome. A Feasibility Study | King’s College London | NCT06124820 | Found through search but HRA not notified |
| 303773 | 360° Video Virtual Reality Graded Exposure Therapy (VRET) for Public Speaking Anxiety in a Clinical Sample: a randomised control trial | Queen's University Belfast | ||
| 305932 | A prospective cross-sectional study to determine the reliability and validity of arthrometry and clinical tests for diagnosing anterior cruciate ligament (ACL) injury | Liverpool University Hospitals NHS Foundation Trust | NCT05416632 | |
| 305985 | A prospective parallel group feasibility study of the use of electroencephalogram based sedation depth monitoring in adults receiving venovenous extracorporeal membrane oxygenation | University of Salford | ISRCTN79335747 | |
| 306758 | Comparison of the standard Maximal 6-Minute Walk Test against a Normal-speed 6-Minute Walk Test as an alternative and accurate assessment for ambulatory oxygen requirement | Hampshire Hospitals NHS Foundation Trust | NCT05630092 | |
| 307026 | ACT for Young People: The role of psychological flexibility in Anxiety-Based School Refusal | University of Lincoln | ||
| 307628 | A Pragmatic Randomised Control Trial Evaluating the Clinical and Cost-Effectiveness of Serratus Anterior Plane Block with Catheter Insertion compared to Usual Care in Patients with Multiple Rib Fractures | University of Birmingham | ISRCTN16156075 | |
| 307881 | A post-market study evaluating clinical and radiographic outcomes of total elbow arthroplasty with TEMA | Lima Corporate | NCT05180071 | |
| 308343 | MicroPulse Transscleral Laser Therapy: A Prospective UK Study | Imperial College Healthcare NHS Trust | NCT05593354 | |
| 308993 | In vivo double-blind, randomized, placebo controlled, crossover investigation of the effect of oral administration of oxygen nanobubbles on the distance covered in a 6 Minute Walk Test in patients with pulmonary fibrosis | University of Oxford | NCT05711290 | |
| 311565 | A randomised controlled trial and feasibility study of the effects of an e-health intervention ‘iSupport’ for reducingdistress of dementia carers, especially in the ongoing pandemic of COVID-19 | Bangor University | ISRCTN17420703 | |
| 311583 | Effectiveness and Acceptability of Formulation and Brief-ACT intervention for Functional Neurological Disorders | University of Southampton | ISRCTN48373551 | |
| 311670 | Medium-chain triglyceride supplementation and growth in infants with biliary atresia: a feasibility study | King’s College London | ISRCTN81936667 | |
| 311736 | Strengthening Mental Abilities with Relational Training (SMART) for Mild Cognitive Impairment (MCI): A feasibility trial | University of Lincoln | ISRCTN29378862 | |
| 311784 | Examining the feasibility and acceptability of a remotely monitored exercise intervention on clinical, immunological and psychological aspects of health in patients with Systemic Lupus Erythematosus | University of Birmingham | ISRCTN72757645 | |
| 311802 | Transcutaneous electrical nerve stimulation of the hypoglossal nerve in Obstructive Sleep Apnoea compared with placebo device | Morgan Innovation and Technology | ISRCTN84984622 | |
| 312212 | A multi-centre open randomised controlled trial to assess the effect of related haplo-donor haematopoietic stem cell transplantation versus standard of care (no transplant) on treatment failure at 24 month in adults with severe sickle cell disease | King’s College Hospital NHS Foundation Trust | ISRCTN90484310; NCT05392894 | |
| 312269 | Digital diabetes remission trial (DIGEST), an open-label, prospective, parallel design, randomised study comparing Habitual Programme (diet replacement and digital therapeutic) against standard usual care in achieving remission in type 2 diabetes mellitus (T2D) | Habitual Health | ISRCTN73786674 | |
| 313200 | Mechanisms of neurodynamic treatments (MONET) | University of Oxford | NCT05859412 | |
| 313203 | Large de-NOVo coronary artEry disease treated with sirolimus Drug Eluting Balloon: prospective evaluation of safety & efficacy of SELUTION SLR TM drug eluting balloon (LOVE-DEB Registry) | Wrightington, Wigan & Leigh NHS Foundation Trust | NCT05915468 | |
| 313455 | ExACT-CF: Exercise as an Airway Clearance Technique in people with Cystic Fibrosis – A randomised pilot trial | University Hospitals Southampton NHS Foundation Trust | NCT05482048 | |
| 313482 | Online guided self-help intervention for sexual distress following sexual assault: A single case experimental study | Royal Holloway University of London | NCT05717023 | |
| 313495 | Poly-ε-lysine hydrogel bandage contact lenses | Liverpool University Hospitals NHS Foundation Trust | ||
| 313557 | Evaluation of the GORE® VIAFORT Vascular Stent for Treatment of Symptomatic Inferior Vena Cava Obstruction with or without Combined Iliofemoral Obstruction | Gore | NCT05409976 | |
| 313559 | Real time computer aided detection and characterisation of colorectal polyps; a prospective multi-centre randomised controlled superiority trial (ColoVision) | Portsmouth Hospitals University NHS Trust | ISRCTN68236490 | |
| 313853 | OPTIMAL - OsteoPorosis Treatment Identification using Machine Learning | NHS Greater Glasgow & Clyde | NCT05678569 | |
| 314272 | Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: a randomised multi-arm multi-stage (MAMS) adaptive trial | Keele University | ISRCTN12418153 | |
| 314366 | Understanding the role of right atrial ectopy-triggering ganglionated plexuses in atrial fibrillation | Imperial College London | NCT05539040 | |
| 314582 | Adhesive Capsulitis Corticosteroid and Dilation Randomised Controlled Trial: A Feasibility Study in Primary Care | Barts Health NHS Trust | ISRCTN14209869 | Found through search but HRA not notified |
| 314744 | Optical coherence tomography angiography (OCTA) to assess cardiac output and cerebral perfusion at the time of children’s cardiac surgery | Great Ormond Street Hospital for Children NHS Trust | NCT05568849 | |
| 315079 | Optimising and Assessing electrical stimulation of the optic nerve | Cambridge University Hospitals NHS Foundation Trust & University of Cambridge | ||
| 315098 | Time is of the essence: the impact of early initiated upper-body aerobic exercise on cardiovascular health following spinal cord injury | University of Birmingham | ISRCTN99941302 | |
| 315223 | Feasibility study: Can reducing periodontal infection (gum disease) slow the progression of cognitive impairment associated with Alzheimer's disease | United Hospitals Bristol NHS Foundation Trust | ISRCTN11832395 | |
| 315730 | Genicular Artery Embolisation as a minimally invasive intervention to manage patients with mild-moderate osteoarthritis of the knee – setting up a new innovative service for Welsh patients | Aneurin Bevan University Hospital | ISRCTN82978621 | |
| 315954 | A feasibility multicentre randomised controlled trial comparing Wide-awake Local Anaesthesia No Tourniquet (WALANT) versus General and Regional Anaesthesia (GA/RA) for Flexor Tendon Repair (WAFER Trial) | Royal Free London NHS Foundation Trust | ISRCTN15052559 | |
| 315990 | Mobile MRI for Immediate Radiological Acute Cerebral Lesion Evaluation in Stroke | NHS Greater Glasgow & Clyde | Sponsor no longer considers this a clinical trial | |
| 316058 | REthiNking Approaches to Excess Weight in AdoLescents (RENEWAL): a randomised feasibility trial to assess a digital Intervention for managing excess weight in adolescents with overweight and obesity | University of Oxford | ISRCTN17811210 | |
| 316117 | iCLAS™ Cryoablation System Post-Market Clinical Follow-up (PMCF) Study; CS-086 | Adagio Medical | NCT05416086 | |
| 316434 | Randomised trial of Suction for Primary Pneumothorax Early Resolution | University of Oxford | ISRCTN18017504 | |
| 316435 | Brief Solution Focused Therapy (BSFT) in 10–17-year-olds presenting at police custody: A Randomised Controlled Trial with internal pilot | Lancashire and South Cumbria NHS Trust | ISRCTN14195235 | |
| 316524 | The Utility of Frequency-Modulated Electromagnetic Neural Stimulation (FREMS) as a Third Line Treatment in Patients with Painful Diabetes-Related Peripheral Neuropathy: A Randomised Controlled Trial | University of Birmingham | ISRCTN11665378 | |
| 316710 | CareCoach WP3 - A feasibility trial to assess the design and deliverability of a multi-centre randomised controlled trial of the CareCoach package, part of the CareCoach programme: adapting and testing an intervention for carers of people with dementia | University of Exeter | ISRCTN12540555 | |
| 316798 | Improving the oral health of older adults using milk supplemented with fluoride and probiotics: An interventional feasibility study and pilot RCT | Teesside University | ISRCTN18536057 | |
| 316873 | A prospective study to assess the impact and benefits of an AI system in double reading for breast cancer screening | Kheiron Medical | ISRCTN95571932 | |
| 316876 | A feasibility randomised controlled trial examining the effect of a positive mood intervention and vitamin D supplementation on the immunological responses to a boosting COVID-19 and/or influenza vaccination in healthy adults | University of Nottingham | ISRCTN12950625 | |
| 316959 | A randomised control trial of the efficacy of an early mobilisation programme in acute respiratory illness in a DGH setting | Medway NHS Foundation Trust | ||
| 316986 | Multicentre trial of the clinical and cost-effectiveness of a novel urinary catheter design in reducing catheter-associated urinary tract infection compared with the traditional Foley design for adults requiring long-term catheterisation (CaDeT) | University Hospital Southampton NHS Foundation Trust | ISRCTN11092188 | |
| 317261 | Effects of closed-loop automatic control of the inspiratory fraction of oxygen (FiO2-C) on outcome of extremely preterm infants – a randomized controlled parallel group multicenter trial for safety and efficacy | University Hospital Tuebingen | NCT03168516 | |
| 317281 | A Multi-Ethnic, multi-centre raNdomised, controlled trial of a low-energy Diet for improving functional status in Heart failure with PRESERVED ejection fraction (AMEND) | University of Leicester | NCT05887271 | Found through search but HRA not notified |
| 317327 | The effect of interrupting sitting with regular active breaks on glycaemia and daily insulin dose in sedentary people with type 1 diabetes | Liverpool John Moores University | NCT05706298 | |
| 317409 | Cognitive Muscular Therapy for people awaiting knee joint replacement | University of Salford | NCT05801510 | |
| 317426 | Does closed-loop automated oxygen control during mechanical ventilation reduce the duration of supplementary oxygen treatment and the amount of time spent in hyperoxia? A randomised controlled trial in ventilated infants born at or near term | King’s College London | NCT05657795 | Found through search but HRA not notified |
| 317814 | SurePulse Oximeter – a Targeted Oxygenation Observation: A Controlled Desaturation Study to establish the accuracy and precision of the SurePulse VS Patch Newborn Vital Sign Monitor (VSP) | SurePulse Medical | NCT05756816 | |
| 318068 | Relational Approach to Treating Self-Harm (RelATe): A Feasibility Study of Cognitive Analytic Therapy for People who Self-Harm | Greater Manchester Mental Health NHS Foundation Trust | ISRCTN75661422 | |
| 318142 | Recovery in Open and Closed Tibial Shaft Fractures Innovative (ROCI) Physical Rehabilitation: A Feasibility Study Of Standardised Physical Rehabilitation In Previous Open and Closed Tibial Shaft Fracture Patients | Cardiff & Vale University Health Board | ||
| 318439 | The clinical and cost-effectiveness of the DESMOND-ID education programme for adults with intellectual disability and Type 2 diabetes | University of Ulster | ISRCTN83150600 | |
| 318551 | Relating Therapy for the Anorexic Voice: Exploratory Case Series (R2AV) | Sussex Partnership NHS Foundation Trust | ISRCTN13697342 | |
| 318937 | Fibre Supplements for pre-diabetes (FLORA) | Myota | NCT05593926 | |
| 319225 | Transcatheter Mitral Valve Replacement with the Medtronic Intrepid™ TMVR Transfemoral System in patients with severe symptomatic mitral regurgitation | Medtronic | NCT05496998 | |
| 319297 | Parenting course for parents of children with fetal alcohol spectrum disorders (FASD) versus waitlist: a randomised controlled feasibility study of the SPECIFIC (Salford Parents and carers’ Education Course for Improvements in Fasd outcomes In Children) Programme | Surrey and Borders Partnership NHS Foundation Trust | ISRCTN14483801 | |
| 320408 | A randomised, double-blind, placebo-controlled study to evaluate the performance and safety of SPL7013 Nasal Spray in non-hospitalised patients with COVID-19 | Starpharma | ISRCTN70449927 | |
| 320712 | Wound Assessment Using Spectral Imaging (WAUSI) | Spectral MD | NCT05581966 | |
| 1004314 | A Phase 2, Multicenter, Randomized, Open-Label Trial of GEN1046 as Monotherapy and in Combination With Pembrolizumab in Subjects With Relapsed/Refractory Metastatic Non-Small Cell Lung Cancer After Treatment With Standard of Care Therapy With an Immune Checkpoint Inhibitor | Genmab | NCT05117242; 2021-001928-17 | |
| 1004693 | INVEST: Phase I study of Intravesical immunotherapy for bladder cancer patients undergoing radical cystectomy | Sheffield Teaching Hospitals NHS Foundation Trust | ISRCTN15842444; 2021-006537-19 | |
| 1004712 | TOLERANCE: a 3 arm randomized study on healTh-related quality Of Life of EldeRly pAtients with advaNced soft tissue sarComa undergoing doxorubicin every three weeks or doxorubicin weekly or cyclophosphamide plus predniso(lo)ne treatment | European Organisation for Research and Treatment of Cancer (EORTC) | NCT04780464; 2021-000125-27 | |
| 1004875 | A Phase 2b, Open-label, Multicenter, Randomized, Controlled, 2-Arm Study to Assess the Efficacy and Safety of Orally Administered NS-018 versus Best Available Therapy in Subjects with Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis with Severe Thrombocytopenia (Platelet Count <50,000/μL) | NS Pharma | NCT01423851; 2021-000369-34 | |
| 1004878 | A randomised controlled trial of STeroid Administration Routes For Idiopathic Sudden sensorineural Hearing loss: The STARFISH Trial | University of Birmingham | ISRCTN10535105; 2022-000085-17 | |
| 1005090 | Aspirin after hospitalisation with Pneumonia to prevent cardiovascular Events randomised Controlled Trial (ASPECT) | North Bristol NHS Trust | ISRCTN85630652; 2022-001856-40 | |
| 1005141 | Phase Ib, Double-Blind, Randomized,Placebo-Controlled, Multicenterstudy To Evaluate The Safety,Tolerability, And Pharmacokinetics Ofmultiple-Ascending Doses Of Ro7303509In Patients With Systemic Sclerosis | Genentech | NCT05462522; 2021-004578-68 | |
| 1005202 | Supraneural versus Infraneural Approach to transforaMinal Epidural StEroid injection for unilateral lumbosacral radicular pain (SIAMESE): A randomised controlled non-inferiority trial | NHS Grampian | ISRCTN36195887; 2022-000679-38 | |
| 1005225 | Targeted drug intervention in men at risk of progression on active surveillance for early prostate cancer: A randomised trial – Therapeutics in Active Prostate cancer Surveillance (TAPS02) | Cambridge University Hospitals NHS Foundation Trust | NCT05191680; 2021-006106-75 | |
| 1005226 | A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination with Immuno-Oncology Agents in Subjects with Unresectable Advanced or Metastatic Solid Tumors | Exelixis | NCT05176483; 2021-004855-18 | |
| 1005271 | Randomised Controlled Trial of PENTOCLO* in Mandibular Osteoradionecrosis *(Pentoxifylline, Tocopherol & Clodronate) | University of Liverpool | ISRCTN34217298; 2022-000728-39 | |
| 1005300 | An Integrated Pharmacokinetic and Safety Open-label Basket Trial of Daprodustat for the Treatment of Anemia Associated with Chronic Kidney Disease in Male and Female Children and Adolescents Aged 3 Months to Under 18 Years Requiring or Not Requiring Dialysis | GlaxoSmithKline | 2021-002013-34 | |
| 1005394 | Phase 2a Study of the Effect of Serine Supplementation and Fenofibrate Treatment on Serum Deoxysphinganine Levels in Patients with Macular Telangiectasia (MacTel) Type 2 (SAFE Study) | Lowy Medical Research Institute (LMRI) | NCT04907084; 2021-002874-21 | |
| 1005469 | Anticoagulation for New-Onset Post-Operative Atrial Fibrillation after CABG (PACeS) | South Tees Hospitals NHS Foundation Trust | NCT04045665 | |
| 1005472 | A Phase II, open label, single arm study to assess the efficacy of intratumoural tigilanol tiglate in various head and neck solid malignancies | Qbiotics | NCT05608876 | |
| 1005480 | Stimulant Medication for ADHD and Tics - Understanding Response versus Non-stimulants (SATURN): a randomised trial of the clinical and cost-effectiveness of methylphenidate versus guanfacine for ADHD in children and young people with a co-existing tic disorder | University of Nottingham | ISRCTN14910154; 2022-002425-10 | |
| 1005500 | A Phase 3 Randomized Study Comparing Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Ciltacabtagene Autoleucel versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in Participants with Newly Diagnosed Multiple Myeloma who are Transplant Eligible | European Myeloma Network (EMN) | NCT05257083; 2021-003284-10 | |
| 1005590 | A double-blind, single-center, randomized, placebo- and positive-controlled, parallel-group trial with a nested crossover part on the electrocardiographic effects of 100 and 400 mg Pritelivir per day in healthy subjects: a thorough QT/QTc trial | Richmond Pharmacology | NCT05671029; 2022-000203-12 | |
| 1005595 | A Randomized Open-Label Phase 3 Study of XL092 + Atezolizumab vs Regorafenib in Subjects with Metastatic Colorectal Cancer (STELLAR-303) | Exelixis | NCT05425940; 2021-003243-21 | |
| 1005669 | A Single Arm, Open Label, Phase 1/2 Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients with Sickle Cell Disease | Forma Therapeutics Inc. | 2022-001689-36 | |
| 1005674 | An Open-Label, Phase 1/2, Non-comparative, Clinical Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MTL-CEBPA in Paediatric Participants with Mucopolysaccharidosis Type 1H (MPS1H, Hurler Syndrome) (SMART in MPS1H) | MiNA Alpha | ISRCTN10369994; 2022-001379-15 | |
| 1005679 | Phase 1/2, randomised, placebo-controlled study of EDP2939 in healthy volunteers and participants with moderate plaque psoriasis | MAC Clinical Research | 2022-001631-82 | |
| 1005770 | A Phase 2B, Randomized, Double Blind, Vehicle Controlled, Parallel Group Study To Assess The Efficacy, Safety, Tolerability And Pharmacokinetics Of Multiple Dose Levels Of Pf-07038124 Ointment For 12 Weeks In Participants 12 Years And Older And With Mild-To-Moderate Atopic Dermatitis Or Mild-To-Severe Plaque Psoriasis | Pfizer | NCT05375955 | |
| 1005780 | Phase 1b, Multi-center, Randomized, Double-Blind, Placebo-Controlled, Rising Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of VK0214, in Subjects with the Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD) | Viking Therapeutics | NCT04973657; 2022-000791-19 | |
| 1005788 | An Open-Label Study of CK-3773274 for Patients with Symptomatic Hypertrophic Cardiomyopathy (HCM) | Cytokinetics | NCT04848506; 2020-003571-17 | |
| 1005789 | KontRASt-06: An open-label phase II trial evaluating the activity and safety of JDQ443 single-agent as first-line treatment for patients with locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer with a PD-L1 expression < 1% or a PD-L1 expression ≥ 1% and an STK11 co-mutation | Novartis | NCT05445843; 2022-001088-29 | |
| 1005813 | A Phase I/IIa First-in-human, Open-label Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of AZD8853 in Participants with Selected Advanced/Metastatic Solid Tumours | AstraZeneca | NCT05397171; 2021-005438-41 | |
| 1005838 | A Phase 2a Study of TPN-101 in Patients with Aicardi-Goutières Syndrome (AGS) | Transposon | ISRCTN15569205; 2022-000064-21 | |
| 1005842 | A Phase 1, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-901 as Monotherapy in Patients with Selected Advanced Solid Tumors | ADC Therapeutics | NCT04972981; 2021-002292-19 | |
| 1005865 | A long-term extension study to evaluate the long-term safety, tolerability and efficacy of subcutaneous amlitelimab in adult participants with moderate to severe atopic dermatitis who participated in KY1005-CT05 (DRI17366) | Sanofi-Aventis | NCT05492578; 2021-002344-73 | |
| 1005881 | A Randomised, Placebo-Controlled, 3-Arm, Double-Blind, Multicentre, Phase 4 Study to Assess the Efficacy of OM-85 (Broncho Vaxom) Short- and Long-Term Treatment vs. Placebo in the Prevention of Respiratory Tract Infections in Children Aged Between 6 Months and 5 Years with Wheezing Lower Respiratory Illness | OM Pharma | NCT05677763; 2022-000886-42 | |
| 1005882 | A Phase III, Multicentre, Randomised, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Safety of Dirocaftor/Posenacaftor/Nesolicaftor in Subjects with Cystic Fibrosis Aged 18 Years or Older (CHOICES) | University Medical Center Utrecht | 2022-500410-26 | |
| 1005896 | A Phase 3 Multicenter, Open-label Study to Evaluate the Efficacy, Pharmacokinetics, Safety, and Immunogenicity of Subcutaneously Administered Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis (PSUMMIT-Jr) | Janssen-Cilag International | NCT05083182; 2020-005503-40 | |
| 1005940 | A Phase 2b Randomized, Double-blind, Active-and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy with Guselkumab and Golimumab in Participants with Moderately to Severely Active Ulcerative Colitis | Janssen-Cilag International | NCT05242484; 2021-005528-39 | |
| 1005992 | A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Nipocalimab in Participants with Active Idiopathic Inflammatory Myopathies | Janssen-Cilag International | ISRCTN98762360; NCT05379634; 2021-005202-98 | |
| 1006014 | A pragmatic, multicentre, placebo controlled, double blind, parallel, randomised controlled trial of liquid alginate (Gaviscon Advance) for the treatment of persistent throat symptoms | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN13949559; 2022-001449-19 | |
| 1006034 | A double-blind, randomized, placebo-controlled multicentre study to investigate efficacy and safety of elinzanetant for the treatment of vasomotor symptoms caused by adjuvant endocrine therapy, over 52 weeks in women with, or at high risk for developing hormone-receptor positive breast cancer | Bayer | NCT05587296; 2022-000095-18 | |
| 1006036 | A Phase III, Randomised, Open-label, Multicentre, Global Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Durvalumab and Carboplatin Versus Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Locally Advanced or Metastatic NSCLC Without Actionable Genomic Alterations (D926NC00001; AVANZAR) | AstraZeneca | NCT05687266; 2021-004606-21 | |
| 1006044 | A first human dose study investigating safety, tolerability, and pharmacokinetics of single subcutaneous injections of NNC0581-0001 in healthy adults | Novo Nordisk | NCT05599945; 2022-001359-18 | |
| 1006068 | An Open-Label, Phase 1b Study of SL-172154 (SIRPα-Fc-CD40L) Administered with Either Pegylated Liposomal Doxorubicin or Mirvetuximab Soravtansine in Subjects with Platinum-Resistant Ovarian Cancers | Shattuck Labs | NCT05483933; 2022-000698-17 | |
| 1006088 | A Phase 1/2, First-in-Human, Single and Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Participants With Glanzmann Thrombasthenia | Hemab Therapeutics | ISRCTN66310879; 2022-001583-10 | |
| 1006104 | A Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of intravenous efzofitimod in patients with pulmonary sarcoidosis | aTyr Pharma | NCT05415137; 2022-001012-26 | |
| 1006106 | A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122/DNL151 in Participants with Parkinson’s Disease and Pathogenic LRRK2 Variants | Biogen | NCT05352919; 2022-000747-77 | |
| 1006143 | Phase 1, First-in-Human, Dose Escalation Study of JNJ-79635322, a Trispecific Antibody, in Participants with Relapsed or Refractory Multiple Myeloma | Janssen-Cilag International | ISRCTN13185938; NCT05652335; 2022-001465-12 | |
| 1006147 | An Open-Label, Single-Dose, Single-Period Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-pelabresib in Healthy Male Subjects | Constellation Pharmaceuticals | ISRCTN10750305Â | |
| 1006155 | Phase 1 First-In-Human Study to Explore the Safety, Tolerability, and Pharmacokinetics of AMG 794 in Subjects With Claudin 6-positive Advanced/Metastatic Non-squamous Non-small Cell Lung Cancer or Epithelial Ovarian Cancer | Amgen | NCT05317078; 2022-002277-28 | |
| 1006165 | A multicenter, randomized, double-blind, placebo-controlled, parallel, phase 3 study to assess the efficacy and safety of Fibrinogen concentrate (FGTW) in the management of bleeding in patients undergoing complex cardiac surgery (involving CPB) | LFB Biotechnologies | 2022-001759-17 | |
| 1006200 | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults with Obesity | Eli Lilly and Company | NCT05556512 | |
| 1006203 | A Randomized, Double-Blind, Placebo-Controlled, Phase 1b, Dose Escalation, Safety, Tolerability and Pharmacodynamic Biomarker Study of Caveolin-1-Scaffolding-Protein-Derived Peptide (LTI-03) in Recently Diagnosed, Treatment Naïve Subjects with Idiopathic Pulmonary Fibrosis | Lung Therapeutics | NCT05954988; 2022-000083-21 | |
| 1006206 | A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 2a, Proof-Of-Concept Study To Evaluate The Efficacy And Safety Of Rozanolixizumab To Treat Adult Study Participants With Severe Fibromyalgia Syndrome | UCB | NCT05643794; 2022-001523-32 | |
| 1006215 | A Phase 2, Open-Label, Parallel Cohort Study of Subcutaneous Amivantamab in Multiple Regimens in Patients with Advanced or Metastatic Solid Tumors including EGFR-mutated Non-Small Cell Lung Cancer | Janssen-Cilag International | ISRCTN11527992; NCT05498428; 2022-000526-21 | |
| 1006240 | A phase 1, open-label, fixed-sequence trial to investigate the effect of coadministration of probenecid or cyclosporine on the pharmacokinetics of LEO 152020 in healthy subjects | LEO Pharma | NCT04203836 | |
| 1006241 | A Phase 1, Open-Label, Randomized, Two-Period Trial to Investigate the Pharmacokinetics of Single Oral Doses of Two Different Formulations of LEO 152020 in Healthy Subjects | LEO Pharma | ||
| 1006253 | An Operationally Seamless Phase 2/3 Randomized, Open-label, Multicenter, Active-Controlled Study to Evaluate the Safety and Efficacy of Bictegravir/Lenacapavir Versus Stable Baseline Regimen in Virologically Suppressed People With HIV-1 on Stable Complex Treatment Regimens | Gilead | NCT05502341; 2022-500929-33 | |
| 1006269 | A double-blind, randomized, placebo-controlled, interventional, multicenter, phase III clinical trial to investigate the safety and efficacy of ABCB5-positive mesenchymal stromal cells (ABCB5+ MSCs) on epidermolysis bullosa (EB) | RHEACELL | NCT05464381; 2021-006076-16 | |
| 1006281 | A Phase IIa Randomised, Double-Blind, Placebo Controlled, Parallel Arm, Multi-Centre Study to Evaluate the Efficacy and Safety of AZD4831, for 12-24 Weeks, in Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) | AstraZeneca | NCT05492877; 2022-002441-18 | |
| 1006327 | An Open-Label, Randomized, 3-Period, 3-Way Crossover Study to Compare the Pharmacokinetics of Norethindrone (NE) and Ethinyl Estradiol (EE) Administered as an MP0008 Orally Disintegrating Tablet and Minastrin® 24 Fe Chewable Tablet and to Evaluate the Effect of a High-Fat/High-Calorie Meal on the Pharmacokinetics of NE and EE in Healthy Female Subjects | Millicent Pharma | 2022-002845-16 | |
| 1006333 | A Phase 1, Open-Label, Single-Centre Study to Evaluate the Absorption, Distribution, Metabolism and Excretion (ADME) of Oral [14C]-Ibrexafungerp in Healthy Male Subjects After Repeat Dosing | Scynexis | NCT05668429; 2022-002824-10 | |
| 1006335 | A Phase 3 Open-label, Randomised Study of Datopotamab Deruxtecan (DatoDXd) With or Without Durvalumab Versus Investigator’s Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Who Have Residual Invasive Disease in the Breast and/or Axillary Lymph Nodes at Surgical Resection Following Neoadjuvant Systemic Therapy (TROPIONBreast03) | AstraZeneca | NCT05629585; 2022-002680-30 | |
| 1006348 | BOTOX (Botulinum Toxin Type A) for the Reduction of Masseter Muscle Prominence: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study | AbbVie | 2022-500568-37 | |
| 1006356 | A Phase 2b, Randomized, Double Blind, Two Arm Study to Investigate the Effects of BNC210 Tablet Formulation Compared to Placebo in Adults with Post-Traumatic Stress Disorder (PTSD) | Bionomics | NCT04951076; 2022-002738-15 | |
| 1006383 | A Phase 3, Randomized, Double-blind, Active Comparator-controlled Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine-naive Adults 50 Years of Age or Older | MSD | NCT05569954; 2022-001785-35 | |
| 1006400 | An Open-Label, Bioavailability Study to Compare Liquid vs Two Solid Formulations of IP2015 in Healthy Male Subjects (Study code: IP2015CS04) | Initiator Pharma | NCT05728671; 2022-002657-26 | |
| 1006402 | A Parallel Group Study in Healthy Participants to Quantify Subclinical Gastrointestinal Blood Loss Following Administration of Aspirin Alone or aspirin in Combination with Rivaroxaban | Regeneron | NCT05546957; 2022-002761-15 | |
| 1006431 | A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Center Study To Evaluate The Safety, Tolerability, Pharmacokinetics, Andpharmacodynamics Of Single Ascending Doses Of Regn7508, A Monoclonal Antibody Against Factor Xi, In Healthy Adult Subjects | Regeneron | NCT05603195; 2022-002001-20 | |
| 1006487 | A 3-month, phase 2, single-blind, randomised, no-treatment controlled study assessing efficacy and safety of Renaparin® for improvement of kidney graft function in deceased-donor transplant recipients, with an additional 9-month follow-up | Corline Biomedical | 2021-003787-27 | |
| 1006507 | A multi-centre, randomised, double-blind placebo-controlled, Phase 2 study to investigate efficacy, safety and tolerability of SLN360 in participants with elevated lipoprotein(a) at high risk of atherosclerotic cardiovascular disease events | Silence Therapeutics | NCT05537571; 2022-001876-32 | |
| 1006539 | A single-center, double-blind, randomized, placebo-controlled Phase 1 study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses of IDOR-1117-2520 in healthy subjects | Idorsia | ISRCTN28892128; 2022-002852-38 | |
| 1006619 | A Randomized, Open-label, Parallel-group, Ethno-bridging Study Comparing the Pharmacokinetics and Safety of a Single Dose of UPB-101 in Healthy Japanese and Non-Japanese Non-East Asian Adults | Richmond Pharmacology | NCT05653479; 2022-002698-26 |
Clinical trials given a REC favourable opinion in December 2022
| IRAS ID | Full study title | Sponsor organisation | Registration number | Further information |
| 212836 | Liver point and 2-D elastography for non-invasive assessment of fibrosis and fat quantification techniques for assessment of fatty change in chronic liver disease | King’s College Hospital NHS Foundation Trust | NCT06111859 | |
| 272195 | A Study to Assess the Safety, Effectiveness and Prognostic Utility of a Smart Device App to Guide the Timing of Valve Intervention in Patients with Asymptomatic Severe Aortic Stenosis (APRAISE-AS) | University of Birmingham | ISRCTN19413194 | |
| 280225 | A randomised feasibility study COmparing Urolift and Standard Transurethral resection of prostate Ahead of Radiotherapy in men with urinary symptoms secondary to prostate enlargement | The Royal Marsden NHS Foundation Trust | NCT05840549 | |
| 287898 | LIMIT P Ca – inviting men for prostate cancer screening using luminal index, bi-parametric and PSA density, to identify men with suspicious lesions and to evaluate acceptability | University College London | ISRCTN45191339 | |
| 287942 | Digital Innovation with Remote Management and Predictive Modelling to Integrate COPD Care with Artificial Intelligence-based Insights: An Acceptability, Feasibility and Safety Study | NHS Greater Glasgow & Clyde | NCT05914220 | |
| 293491 | A Randomised Trial of Plain Angioplasty vs Viabhan Stent Graft as First Intervention For Venous Stenosis in Arteriovenous Grafts | NHS Greater Glasgow & Clyde | ISRCTN47220776 | |
| 295725 | Pre and Post-Operative Voice therapy (PaPOV) for benign vocal fold lesions: Non-randomised, multicentre feasibility trial with nested process evaluation | Nottingham University Hospitals NHS Trust | ISRCTN17438192 | |
| 296113 | Closed-Loop Electronic Stimulation (ES)- Mechanomyogram Sensor (MMG) system for Passive Tremor Suppression | St George’s University Hospitals NHS Foundation Trust | ISRCTN10416636 | |
| 299267 | Scan Optimisation of Single Heartbeat Computed Tomography Coronary Angiography | East and North Hertfordshire NHS Trust | ||
| 299511 | Randomised Controlled Multicentre Trial on the Clinical Impact of the Basophil Activation Test and the Mast Cell Activation Test as Food Allergy Biomarkers in Children and Young People | King’s College London | NCT05309772 | |
| 302681 | The neural mechanisms of music intervention for chronic arm hemiparesis following stroke: A single case series EEG study | Anglia Ruskin University | NCT06223529 | Found through search but HRA not notified |
| 302866 | RIGHT: Removal of Intrauterine Retained products of conception (RPOC) after miscarriage Guided by Hysteroscopy Trial: a randomized controlled trial | UZ Gent | NCT04804332 | |
| 304514 | A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir® System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (SPRAY-CB) | CSA Medical | NCT03893370 | |
| 307468 | A randomised controlled trial of a web-based early intervention (RELAX) targeting repetitive negative thinking (RNT) in pregnant women: an evaluation of its impact on perinatal anxiety and the mechanism of change | King’s College London | ISRCTN12754931 | |
| 308868 | A Prospective Investigation to Assess the Accurate Tool Placement in Pulmonary Nodule(s) using a Robotic Navigational Bronchoscopy System with Adjunct Real-time Imaging | Intuitive Surgical | NCT05867953 | |
| 309119 | Does a Phased Approach Enhance Outcomes for Trauma-Focused Cognitive Therapy (CT-PTSD) for Complex Posttraumatic Stress Disorder (CPTSD)? | Queen's University Belfast | ISRCTN13869856 | |
| 309601 | Feasibility study of the clinical and cost-effectiveness of contemporary diagnostics for patients with suspected Hospital-Acquired Pneumonia (HAP) | University of Liverpool | NCT05483309 | |
| 311219 | A randomised placebo-controlled trial to investigate the effect of lactolycopene on sperm quality in men with a low total motile sperm count: a pilot study | Sheffield Teaching Hospitals NHS Foundation Trust | NCT05671562 | |
| 311525 | UPDATE: Investigating the effects of Ultra-Processed versus minimally processed Diets following UK dietAry guidance on healTh outcomEs: an 8-week community-based crossover randomised controlled trial in people with overweight or obesity, followed by a 6-month behavioural intervention | University College London | NCT05627570 | Found through search but HRA not notified |
| 312660 | A prospective, double blind, single-centre, Randomised controlled Trial comparing Arthroscopic autologous matrix induced chondrogenesis (AMIC®) to Microfracture alone in the treatment of osteochondral and chondral lesion in the Ankle. (AMARTA) | Geistlich | NCT05741983 | |
| 313462 | Follow-up and structured monitoring for adults offered an NHS hearing aid for the first time (FAMOUS): a cluster randomised controlled trial | Manchester University NHS Foundation Trust | ISRCTN10589817 | |
| 313487 | A Randomised Controlled Trial to Explore the Effect of Physiological Intracytoplasmic Sperm Injection (PICSI) on Miscarriage Rates in Assisted Conception | Shrewsbury and Telford Hospitals NHS Trust | NCT05762770 | |
| 314351 | Adjunctive contingency management (CM) to incentivise adherence to treatment in alcohol-related liver disease (ARLD): a mixed-methods study | King’s College London | NCT06183710 | |
| 314408 |
Intervention To Preserve Vision In Idiopathic Intracranial Hypertension: Evaluation Of Clinical Effectiveness And Cost Effectiveness |
University of Birmingham | ISRCTN57142415 | |
| 314709 | FIBRE study: Feasibility of an Intervention using precision fibre Blends as a self-management tool in pRE- and type 2 diabetes | Myota | ||
| 314712 | Distal Radius Acute Fracture Trial 3 – Cast versus Splint (DRAFT3-CASP): a randomised non-inferiority trial comparing clinical and cost-effectiveness of a standard care cast versus removable splint for adults with a distal radius fracture that does not require manipulation | University of Oxford | ISRCTN66692543 | |
| 314721 | A Prospective, Multicenter Study of the Indigo Aspiration System Seeking to Evaluate the Long-Term Safety and Outcomes of Treating Pulmonary Embolism | Penumbra | NCT04798261 | |
| 314917 | An open, prospective, multicenter investigation to evaluate the clinical outcome of OmniTaper EV implant in extraction sockets and healed ridges – A 5 year follow-up | Dentsply Sirona | NCT05355792 | |
| 315251 | Colo-Pro_2: A feasibility randomised controlled double blinded trial to compare standard bolus dosed cefuroxime prophylaxis to bolus-continuous infusion dosed cefuroxime prophylaxis for the prevention of infections after colorectal surgery | University of Leeds | NCT05609240 | |
| 315388 | Study of Technologies for the Diagnosis of Angle Closure glaucoma | Queen's University Belfast | ISRCTN15115867 | |
| 315829 | A feasibility trial of remotely-delivered Video Interaction Guidance [VIG] for families of children with a learning disability referred to specialist mental health services | Tavistock & Portman NHS Foundation Trust | ISRCTN13171328 | |
| 315855 | A randomised controlled investigation comparing the clinical performance and cost effectiveness of Biatain® Silicone with Standard of Care dressing including filler in chronic wounds | Coloplast | NCT05786612 | |
| 316164 | Wearable technology for personalised physical activity feedback in cardiac patients: A feasibility study | University of Bath | NCT05605015 | |
| 316234 | The RELISH Study: A prospective observational study to assess compliance and palatability of foRtifiEd porridge compared to standard LIquid-baSed oral nutritional supplementation in Hospitalised older adults with malnutrition | University Hospital Southampton NHS Foundation Trust | NCT05620082 | |
| 316330 | A Post-Market, Prospective, Randomized, Controlled, Multicenter International Study to Assess the Safety of the Temporarily Implanted Nitinol Device (iTind) Compared to the UroLift® System in Subjects with Symptomatic Benign Prostatic Hyperplasia (BPH) | Olympus | NCT04757116 | |
| 316335 | Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): A randomised controlled trial to investigate the efficacy of a treatment approach targeted at key appraisal change | Greater Manchester Mental Health NHS Foundation Trust | ISRCTN13363197 | |
| 316547 | Head injury Evaluation and Ambulance Diagnosis to avoid HOspital eMErgency admission: a HEAD HOME feasibility study | University of Manchester | ISRCTN92566288 | |
| 316644 | Developing precision computerised cognitive behavioural therapy (cCBT) for adolescent depression: a pilot and feasibility randomised controlled trial (SPARX-UK) | University of Nottingham | ISRCTN15124804 | |
| 316753 | An open-label, multi-centre, randomized study of TaRgeted Intratumoural Placement of Phosphorous-32 (OncoSil™) in addition to FOLFIRINOX chemotherapy versus FOLFIRINOX chemotherapy alone in patients with unresectable locally advanced pancreatic adenocarcinoma | OncoSil | NCT05466799 | |
| 316755 | Randomised controlled trial of the clinical and cost-effectiveness of cervical spine immobilisation following blunt trauma (SIS trial) | Imperial College London | ISRCTN13721611 | |
| 316863 | Investigating the relationship between endothelial cell activation and total pulmonary resistance in pulmonary artery hypertension (PAH) | Imperial College London | NCT06035861 | |
| 317212 | Soluble corn fibre and markers of immunity and inflammation in older adults: a randomised controlled trial | University of Southampton | ISRCTN15979195 | |
| 317448 | DESTINATION-MRL A phase II study of Dose dE-eScalaTion IN prostATe radIOtherapy usiNg the MRL | The Royal Marsden NHS Foundation Trust | NCT05709496 | |
| 317589 | Implementation of a Decision Support System and its effect on early optimisation of Lipid-Lowering Therapies in patients with Acute Coronary Syndrome: a cluster Randomised Controlled Trial | Imperial College London | NCT05844566 | |
| 318413 | Clinical Evaluation of the Panbio™ COVID-19/Flu A&B Rapid Panel Professional Use Device and the Panbio™ COVID-19/Flu A&B Rapid Panel Self-Test Device. | Abbott | NCT05630365 | |
| 318625 | Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥65 Year-olds (PRIMARY) | South Tees Hospitals NHS Foundation Trust | NCT05051033 | |
| 318628 | Targeting insomnia to treat depression: An explanatory randomised controlled trial of sleep restriction therapy | University of Oxford | ISRCTN73764282 | |
| 318662 | The PARTIAL study: A randomised trial of the clinical and cost effectiveness of complex PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma | Newcastle Upon Tyne Hospitals NHS Foundation Trust | ISRCTN11293415 | |
| 318827 | Single center Proof-Of-Concept study to determine the flow changes when stimulating two neural targets for the treatment of obstructive sleep apnea | Invicta Medical | ||
| 319585 | Targeted Assessment in high-Risk paTients with dIAbetes to ideNtify undiagnosed Heart Failure | NHS Greater Glasgow & Clyde | NCT05705869 | |
| 319624 | Telehealth for Pre- and Post-Operative Monitoring of Cardiac Surgery Patients - A Randomised Controlled Trial | Liverpool Heart and Chest Hospital | NCT05621954 | |
| 320523 | A randomised CONtrolled trial of Tailored Acceptance and Commitment Therapy for older people with treatment resistant Generalised Anxiety Disorder (CONTACT-GAD) | Camden & Islington NHS Foundation Trust | ISRCTN85462326 | |
| 320627 | Behavioural therapy for inter-episode bipolar symptoms: A multiple baseline case series evaluation | University of Exeter | ISRCTN19416314 | |
| 320705 | A prospective study to evaluate the real-world diagnostic accuracy and potential clinical impact of the Veros COVID-19 test in adults presenting to the Emergency Department with suspected COVID-19: ED-POC | University Hospital Southampton NHS Foundation Trust | ISRCTN66255490 | Found through search but HRA not notified |
| 320847 | Shaping care home COVID-19 testing policy: A pragmatic cluster randomised controlled trial of an intervention to promote regular, asymptomatic testing in care home staff. (VIVALDI-CT) | University College London | ISRCTN13296529; NCT05639205 | |
| 322100 | PocDoc Lipids Usability Study for Self-test Use | Vital Signs Solutions | ||
| 323072 | A Post Market Clinical Follow Up (PMCF) Study to Assess the Safety and Efficacy of Use of Perfectha Subskin Lidocaine in the Treatment of Significant Loss of Volume in the Cheeks, Jawline and/or Chin | Sinclair Pharma | ISRCTN63865080 | |
| 1004930 | A multi-centre randomised controlled trial of the clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury | King’s College London | ISRCTN17518945; 2022-000072-18 | |
| 1004947 | CLEAR: (CLozapine in EARly psychosis) A Multi-Centre, Randomised Controlled trial of Clozapine for Young People with Treatment Resistant Psychosis in Real World Settings | King’s College London | ISRCTN37176025; 2021-006248-28 | |
| 1005189 | A Phase 3, Multicenter, Open-Label, Randomized Study of Nemvaleukin Alfa in Combination With Pembrolizumab Versus Investigator’s Choice Chemotherapy in Patients With Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARTISTRY-7) | Alkermes | NCT05092360; 2021-002326-24 | |
| 1005213 | A multicenter, randomized, double-blind, placebo-controlled study of enzastaurin for the prevention of arterial events in patients with vascular Ehlers-Danlos Syndrome (vEDS) confirmed with COL3A1 mutations, followed by an open label extension (OLE) | Aytu BioPharma | NCT05463679; 2021-006574-23 | |
| 1005243 | A Phase Ib/II open label, multi-arm, parallel cohort dose finding and expansion study to assess the safety, pharmacokinetics and efficacy of NUC-3373, a nucleotide analogue, given in combination with standard approved agents in patients with advanced solid tumours | NuCana | NCT05714553; 2022-000722-14 | |
| 1005310 | A Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study Assessing Safety, Tolerability, Pharmacodynamics, Efficacy, and Pharmacokinetics of DYNE-251 Administered to Participants with Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping | Dyne Therapeutics | 2021-005478-24 | |
| 1005401 | A Phase 3b Extension Study to Evaluate the Long-term Safety of Vedolizumab Intravenous in Pediatric Patients With Ulcerative Colitis or Crohn’s Disease | Takeda | NCT05442567; 2021-000630-34 | |
| 1005441 | The 3TR Molecular Pathobiology-Driven Precision Therapy in RA (3TR Precis-The-RA) study | Queen Mary University of London | ISRCTN44988547; 2022-001074-56 | |
| 1005488 | A modular, multi-arm, first in human trial to evaluate the safety and tolerability of MDX-124 alone and in combination with anti-cancer treatments, in participants with locally advanced, unresectable or metastatic solid malignancies | MedAnnex | ISRCTN78740398 | |
| 1005579 | A proof of concept trial with safety run of tepotinib and pembrolizumab in NSCLC patients with and without MET exon 14 mutations (POTENT) | The Institute of Cancer Research | NCT05782361; 2021-005134-42 | |
| 1005607 | A New Combined Treatment for Post Concussion Syndrome: Pilot Trial | Durham University | ISRCTN45733939 | |
| 1005608 | A Phase 1, Open-Label, Multicenter Study of INCA00186 as Monotherapy or in Combination With Immunotherapy in Participants With Advanced Solid Tumors | Incyte | NCT04989387; 2021-001263-24 | |
| 1005709 | A Phase Ia clinical trial to assess the safety and immunogenicity of the blood-stage malaria candidate vaccines RH5.1 in Matrix-MTM and R78C in Matrix-MTM, both alone and in combination, in healthy UK adults | University of Oxford | NCT05385471 | |
| 1005764 | A multi-center, randomized, double-blind, placebo-controlled multiple ascending dose study to evaluate the safety and tolerability of QRL-201 in Amyotrophic Lateral Sclerosis | QurAlis | NCT05633459; 2022-001606-22 | |
| 1005781 | A Randomized, Double-Blind, Placebo-controlled, Phase 2/3 Study to Assess the Efficacy and Safety of Setrusumab in Subjects with Osteogenesis Imperfecta | Ultragenyx | NCT05125809; 2021-006597-23 | |
| 1005939 | A Phase 2b Randomized, Double-blind, Active-and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy with Guselkumab and Golimumab in Participants with Moderately to Severely Active Crohn’s Disease | Janssen-Cilag International | NCT05242471; 2021-003314-39 | |
| 1006043 | Sugammadex for prevention of post-operative pulmonary complications | Belfast Health and Social Care Trust | ISRCTN15109717 | |
| 1006057 | A Phase 1/2 Open-label Platform Study to Evaluate the Safety and Efficacy of Multiple Amivantamab-based Therapeutic Combinations in Participants with Advanced, Unresectable Lung Cancer (LC) | Janssen-Cilag International | ISRCTN23584582; NCT05488314; 2022-500729-34 | |
| 1006067 | A Phase 2, Randomized, Open-label Platform Study Utilizing a Master Protocol to Evaluate Novel Immunotherapy Combinations in Participants with Previously Untreated Locally Advanced/Metastatic Programmed Death Ligand 1-Positive Non Small Cell Lung Cancer | GlaxoSmithKline | NCT05565378; 2021-005115-32 | |
| 1006101 | A Parallel-group Phase 4, Open-label, Two-arm Study to Assess the Safety and Efficacy of Intravitreal (IVT) Aflibercept with Proactive customized Treatment Intervals in Patients ≥50 Years of Age with No Fluid Due to Choroidal Neovascularization (CNV) Lesions Secondary to Neovascular (wet) Age-related Macular Degeneration (nAMD) Following Treatment Initiation with Aflibercept | Bayer | NCT05473715; 2022-000690-73 | |
| 1006123 | An Open-Label, Safety Study For Previously Treated Vatiquinone (Ptc743) Subjects With Inherited Mitochondrial Disease | PTC Therapeutics | NCT04378075; 2022-000375-39 | |
| 1006124 | Phase Ia, first in human open label dose escalation trial evaluating intravenous BI 1703880 in combination with intravenous ezabenlimab for treatment of advanced solid tumours | Boehringer Ingelheim | NCT05471856; 2022-000298-22 | |
| 1006134 | A Phase 2B, Randomized, Double Blind, Active Comparator, Multicenter, Safety, and Efficacy Trial of ATX 101 in Subjects Undergoing Total Knee Arthroplasty (SPARK) | Allay Therapeutics | NCT05260008 | |
| 1006145 | A Phase 1, Randomized, Double-blind, Placebo-controlled, Single- and Multiple-dose Escalation Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of VX‑993 in Healthy Adults | Vertex | NCT05653323 ; 2022-002413-42 | |
| 1006170 | A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing CC-92480 (BMS-986348), Carfilzomib, and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants with Relapsed or Refractory Multiple Myeloma (RRMM) | Celgene | NCT05552976 | |
| 1006242 | A three-part, randomised, double-blind, placebo-controlled, single, and multiple ascending dose study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of MDI-26478 in healthy participants | Cardiff University | ISRCTN81436702Â ; 2022-002562-33 | |
| 1006245 | A double blind, randomized, placebo-controlled trial evaluatingthe efficacy and safety of BI 1015550 over at least 52 weeks inpatients with Idiopathic Pulmonary Fibrosis (IPF) | Boehringer Ingelheim | NCT05321069; 2022-001091-34 | |
| 1006251 | A randomized, double-blind, multicenter phase III study to evaluate the long-term efficacy and safety of ABX464 25 mg or 50 mg once daily as a maintenance therapy in subjects with moderately to severely active ulcerative colitis | Abivax | NCT05535946 | |
| 1006257 | A Phase I/III Randomized, Double-blind Study to Evaluate the Safety and Neutralizing Activity of AZD5156/AZD3152 for Pre-exposure Prophylaxis of COVID-19 in Participants with Conditions Causing Immune Impairment | AstraZeneca | NCT05648110; 2022-002378-95 | |
| 1006258 | A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs) | Boehringer Ingelheim | NCT05321082; 2022-001134-11 | |
| 1006279 | A Phase 2a, Randomised, Double-blind, External Placebo-controlled and Internal Comparator-controlled Study to Evaluate the Safety, Immunogenicity, and Efficacy of Influenza Virus Vaccines (modRNA and saRNA) in a Human Viral Challenge Model in Healthy Adult Participants | hVIVO | ISRCTN13789612 | |
| 1006326 | A pivotal, open label, randomised, balanced, two-way crossover bioequivalence study of a single oral dose of 2 x 200 mg Ibuprofen Formulation A (reference) and 2 x 200 mg Ibuprofen Formulation B (test) in healthy, adult, human (male and female) participants under fasting conditions. | Reckitt | ISRCTN91129283 | |
| 1006358 | A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel, Multicenter Study to Evaluate the Safety and Efficacy of ALXN1720 in Adults with Generalized Myasthenia Gravis | Alexion | NCT05556096; 2022-000460-21 | |
| 1006381 | An open-label, adaptive design study in healthy male participants to characterize the occupancy of NR2B subunit containing NMDA receptors in the brain following a single intravenous dose of MIJ821 using positron emission tomography (PET) with the radioligand [11C]Me-NB1 | Novartis | 2022-002317-42 | |
| 1006411 | A multi-center, randomized, double-blind, parallel-group, 20-week dose-finding study to evaluate efficacy, safety, and tolerability of XXB750 in patients with resistant hypertension | Novartis | NCT05562934; 2021-005738-41 | |
| 1006418 | A Single-blind, Randomized, Placebo-controlled Study to Investigate the Safety, Tolerability and Pharmacokinetics of oral AZD6793 Following Single and Multiple Ascending Doses in Healthy Subjects | AstraZeneca | NCT05662033; 2022-002951-21 | |
| 1006499 | A Phase 1, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Study in Healthy Adult Subjects to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Food Effect, and Effect on Tenofovir Pharmacokinetics of an Oral Formulation of the NTCP Inhibitor A2342 | Albireo | ISRCTN13265717 | |
| 1006501 | An Open-label, Multicenter, Phase 3 Randomized, Active-Comparator-Controlled Clinical Study of Pembrolizumab (MK-3475) in Combination With Sacituzumab Govitecan Versus MK-3475 Monotherapy as First-line Treatment in Participants With PD L1 TPS Greater than or Equal to 50% Metastatic Non-small Cell Lung Cancer (KEYNOTE D46/EVOKE-03) | MSD | NCT05609968; 2022-000836-49 | |
| 1006508 | A phase 2B, multicenter, randomized, double-blind, placebo-controlled, dose-finding, efficacy and safety study of HRO350 in patients with mild-to-moderate psoriasis (the ‘HeROPA’ study) | Arctic Bioscience | NCT06125808; 2021-003684-96 | |
| 1006510 | A Phase 1, Randomized, Double-Blind, Placebo Controlled, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered ALN-TTRSC04 in Healthy Subjects | Alnylam | NCT05661916 | |
| 1006526 | A first-in-human (FIH) study of IDRX-42 in participants with metastatic and/or unresectable gastrointestinal stromal tumors (GIST) | IDRx | NCT05489237; 2022-001192-14 | |
| 1006534 | A Phase IIa, Randomized, Parallel, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Enpatoran in Dermatomyositis and Polymyositis Participants receiving Standard of Care (NEPTUNIA) | Merck KGaA | NCT05650567 | |
| 1006558 | A Two-Part Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of UNI-494 with an Optional Third-Part to Assess the Relative Bioavailability Compared to Nicorandil in Healthy Male and Female Subjects | Unicycive Therapeutics Inc. | ISRCTN16476560; 2022-003223-17 | |
| 1006620 | A Phase 2/3 Randomized, Placebo-Controlled, Double-blind, Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants with Heart Failure due to Systemic Left Ventricular Systolic Dysfunction (VALOR) | MSD | NCT05714085; 2021-004399-33 | |
| 1006658 | A Randomized, Double-Blind, Placebo-Controlled Dose Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single (Intravenous Infusion) and Multiple (Continuous Intravenous Infusion Over 7 Days) Doses of KNS366 In Healthy Adult Participants | Kynos Therapeutics | ISRCTN10496020; 2022-003179-41 | |
| 1006659 | A multicenter, international, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor asundexian (BAY 2433334) for the prevention of ischemic stroke in male and female participants aged 18 years and older after an acute non-cardioembolic ischemic stroke or high-risk TIA | Bayer | NCT05686070; 2022-001067-27 | |
| 1006711 | A Phase 1, Multicenter, Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Intravenously Administered KT-413 in Adult Patients with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma | Kymera | NCT05233033; 2022-003102-74 | |
| 1006766 | A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA). | AstraZeneca | NCT05624450; 2022-003107-15 |
Download the full data set in a CSV file.