Multiparametric Stratification of Indeterminate Lung Nodules MISIL1
Research type
Research Study
Full title
Multiparametric Investigation and Stratification of Indeterminate Lung Nodules MISIL1
IRAS ID
279875
Contact name
Frank McCaughan
Contact email
Sponsor organisation
Cambridge University Hospital NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Background-
Lung cancer kills more people than any other cancer in the UK and internationally. There has been an increase in the use of CT scanning of the chest to detect lung cancer because studies have shown that if people who have been smokers and who are over the age of 50 are scanned routinely more lung cancers can be detected early.
One consequence of this is that we find small nodules in the lung. Often it is unclear if these are a cancer or are benign and patients either need to have a biopsy or come back for more scans. This is concerning for patients although many of the nodules are not cancer.
The purpose of this study is to find out if we are there are less invasive tests that can be done to tell us whether the nodules are cancerous without requiring a biopsy or further follow-up.Method-
In this pilot study we will be aiming to recruit 90 patients in 1 year across Cambridgeshire and Manchester who meet the criteria for one of three groups- a test group of 30 patients with lung nodules before they are biopsied, a positive control group of 30 patients who have an early stage lung cancer, and a negative control group of 30 patients who come to a lung clinic but don’t have lung cancer or a significant nodule on their chest scans. We will take blood and sputum samples from all three groups. We aim to use these samples to perform tests including looking for biomarkers of cancer. By combining these results and using a computer learning model we hope to create a new test for early lung cancer. This pilot will be to find out if these biomarkers can help to distinguish between lung cancer and benign nodules.
REC name
London - London Bridge Research Ethics Committee
REC reference
20/PR/0622
Date of REC Opinion
16 Dec 2020
REC opinion
Further Information Favourable Opinion