Imaging in childhood uveitis
Research type
Research Study
Full title
OCT imaging for the eyes of children with or without uveitis
IRAS ID
258724
Contact name
Ameenat Lola Solebo
Contact email
Sponsor organisation
UCL GOS ICH
Clinicaltrials.gov Identifier
Z6364106/2019/03/208 , UCL Data protection
Duration of Study in the UK
6 years, 0 months, 1 days
Research summary
Paediatric uveitis (inflammation inside the eye) is an uncommon disorder which carries the risk of blindness. In the most common form of the disorder, anterior uveitis, the front chamber of the eye is affected. Inadequate treatment of active inflammation has been shown to be related to poor outcome. Currently, disease activity is assessed using bio-microscopic examination of the anterior chamber of the eye, undertaken by an ophthalmologist (eye doctor), who grades the degree of inflammation using an internationally agreed scale. This scale has not been validated for use in children, and when used in adults it is open to considerable variability between doctors.
A new adaptation of an existing imaging technology, optical coherence tomography, has been shown to be able to detect and measure inflammation inside the eye in animal studies and small pilot studies in adults. Another new adaptation, OCT angiography, can image blood flow within the different tissues in the eye. OCT cameras are in common clinical use to assess inflammation in the back of the eye (choroid and retina). A previous pilot study (215685, REC 18/LO/0252) has demonstrated the feasibility of OCT/A image capture in children. We now aim to validate OCT detection of anterior chamber activity, and OCTA classification of disease type, in children.REC name
South Central - Oxford B Research Ethics Committee
REC reference
19/SC/0283
Date of REC Opinion
12 Jun 2019
REC opinion
Further Information Favourable Opinion